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The map label for this gene is PrsA

Identifier: 20808920

GI number: 20808920

Start: 2460986

End: 2461936

Strand: Reverse

Name: PrsA

Synonym: TTE2571

Alternate gene names: 20808920

Gene position: 2461936-2460986 (Counterclockwise)

Preceding gene: 20808921

Following gene: 20808919

Centisome position: 91.54

GC content: 44.79

Gene sequence:

>951_bases
ATGGCGAGGTATACTAACTCACTTAAGATTTTTACGGGAAATTCAAATCCTAAGCTGGCCAGTGAAATAGCTGAACACTT
GGGTCTTAAACTGGCAGATTCAGAAGTTGGCACATTTAGCGATGGAGAAATAAGTGTGAGAATAGGGGAGAGCGTAAGGG
GAGCAAGCGTTTTTGTAATTCAGTCGACTTGTGCTCCTGTGAACAACAATTTGATGGAGCTTCTCATAATGATTGACGCT
TTCAAAAGAGCTTCAGCTGCTGAGATTAACGCAGTCATACCCTATTACGGGTACGCAAGGCAGGACAGGAAAGCAAAAGC
TAGAGACCCTATAACTGCTAAACTGGTGGCTGACCTCATCACAGCAGCAGGAGCCCACAGAGTAGTCACGATGGACTTGC
ACGCTCCTCAGATTCAAGGGTATTTTAACATTCCTGTAGACCATCTATTAGGTGGGCCTATTCTTGCCAAGTACTTCATG
GATAAGGAATTGGGAGATGATGTGGTGGTTGTGTCTCCTGACCATGGAAGTGTCACAAGGGCAAGGTATTTTGCAGAAAA
ATTAAATGCTCCTCTGGCCATCATTGACAAGAGAAGGCCAAAAGCAAATGTAGCCGAGGTTATGAATATAATTGGCGATG
TCAAGGGTAAAAAAGCGATACTTGTAGACGACCTAATTGACACTGCAGGGACGCTTGTACAGGCGGCAGAAGCCCTTTTA
GACCACGGAGCAGTGGAGATTTATGCCTGTGCAACACATGGTGTGCTTTCAGGTCCTGCCATTGAAAGGCTTAAAGAATC
TCCTATCAAGGAAGTTGTCATAACCGATACCATTCCTCTCCCTGAAGAAAAGAAGATTGACAAGATAAAAGTGAGGTCTG
TGGCGCCGCTTTTTGCAGAGGCAATTTTGAGAATACACGAGGGCATGTCTGTCAGCAAGCTTTTCACATAA

Upstream 100 bases:

>100_bases
GATGTGCCTGAAGGAGCCCTCGCCATTGCGAGGAGCAGACAGACCAATAAAGAGGGCTGGGTAGAGGAAAGAATAAAAAA
AGGGAGGCTTTAGTGTAAAA

Downstream 100 bases:

>100_bases
GGCACTTTATGTGCCTTTTTTGTTTATGGTATAATTTAAAAAAGAACATATGATACAGAGGGTGGTTTTGTGGGAGAAAG
CCAGAAGATTTATGTGGTGG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MARYTNSLKIFTGNSNPKLASEIAEHLGLKLADSEVGTFSDGEISVRIGESVRGASVFVIQSTCAPVNNNLMELLIMIDA
FKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLITAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFM
DKELGDDVVVVSPDHGSVTRARYFAEKLNAPLAIIDKRRPKANVAEVMNIIGDVKGKKAILVDDLIDTAGTLVQAAEALL
DHGAVEIYACATHGVLSGPAIERLKESPIKEVVITDTIPLPEEKKIDKIKVRSVAPLFAEAILRIHEGMSVSKLFT

Sequences:

>Translated_316_residues
MARYTNSLKIFTGNSNPKLASEIAEHLGLKLADSEVGTFSDGEISVRIGESVRGASVFVIQSTCAPVNNNLMELLIMIDA
FKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLITAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFM
DKELGDDVVVVSPDHGSVTRARYFAEKLNAPLAIIDKRRPKANVAEVMNIIGDVKGKKAILVDDLIDTAGTLVQAAEALL
DHGAVEIYACATHGVLSGPAIERLKESPIKEVVITDTIPLPEEKKIDKIKVRSVAPLFAEAILRIHEGMSVSKLFT
>Mature_315_residues
ARYTNSLKIFTGNSNPKLASEIAEHLGLKLADSEVGTFSDGEISVRIGESVRGASVFVIQSTCAPVNNNLMELLIMIDAF
KRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLITAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFMD
KELGDDVVVVSPDHGSVTRARYFAEKLNAPLAIIDKRRPKANVAEVMNIIGDVKGKKAILVDDLIDTAGTLVQAAEALLD
HGAVEIYACATHGVLSGPAIERLKESPIKEVVITDTIPLPEEKKIDKIKVRSVAPLFAEAILRIHEGMSVSKLFT

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=48.7179487179487, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=48.2200647249191, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=47.7564102564103, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=47.4358974358974, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=39.4202898550725, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=38.4839650145773, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI310128524, Length=140, Percent_Identity=35, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310115209, Length=140, Percent_Identity=35, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310118259, Length=140, Percent_Identity=35, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310119946, Length=140, Percent_Identity=35, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=54.6623794212219, Blast_Score=341, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=48.0769230769231, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=48.0769230769231, Blast_Score=294, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=48.2200647249191, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=48.0769230769231, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=341, Percent_Identity=36.3636363636364, Blast_Score=207, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=47.7707006369427, Blast_Score=285, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=47.7987421383648, Blast_Score=282, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6321776, Length=313, Percent_Identity=46.6453674121406, Blast_Score=271, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=44.8979591836735, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324511, Length=109, Percent_Identity=43.1192660550459, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=48.0769230769231, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=44.7761194029851, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=38.0952380952381, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=38.0952380952381, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=38.0952380952381, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=38.0952380952381, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45552010, Length=205, Percent_Identity=39.0243902439024, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24651462, Length=205, Percent_Identity=39.0243902439024, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24651464, Length=205, Percent_Identity=39.0243902439024, Blast_Score=141, Evalue=6e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_THETN (Q8R753)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624091.1
- ProteinModelPortal:   Q8R753
- SMR:   Q8R753
- GeneID:   997404
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2571
- NMPDR:   fig|273068.3.peg.2052
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK01259
- BioCyc:   TTEN273068:TTE2571-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 34175; Mature: 34044

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYTNSLKIFTGNSNPKLASEIAEHLGLKLADSEVGTFSDGEISVRIGESVRGASVFVI
CCCCCCCEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
QSTCAPVNNNLMELLIMIDAFKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLI
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
TAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFMDKELGDDVVVVSPDHGSVTR
HHCCCCEEEEEECCCCCCCCEECCCHHHHHCCHHHHHHHHHHCCCCCEEEECCCCCCHHH
ARYFAEKLNAPLAIIDKRRPKANVAEVMNIIGDVKGKKAILVDDLIDTAGTLVQAAEALL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHH
DHGAVEIYACATHGVLSGPAIERLKESPIKEVVITDTIPLPEEKKIDKIKVRSVAPLFAE
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
AILRIHEGMSVSKLFT
HHHHHHCCCCHHHHCC
>Mature Secondary Structure 
ARYTNSLKIFTGNSNPKLASEIAEHLGLKLADSEVGTFSDGEISVRIGESVRGASVFVI
CCCCCCEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEE
QSTCAPVNNNLMELLIMIDAFKRASAAEINAVIPYYGYARQDRKAKARDPITAKLVADLI
ECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
TAAGAHRVVTMDLHAPQIQGYFNIPVDHLLGGPILAKYFMDKELGDDVVVVSPDHGSVTR
HHCCCCEEEEEECCCCCCCCEECCCHHHHHCCHHHHHHHHHHCCCCCEEEECCCCCCHHH
ARYFAEKLNAPLAIIDKRRPKANVAEVMNIIGDVKGKKAILVDDLIDTAGTLVQAAEALL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHH
DHGAVEIYACATHGVLSGPAIERLKESPIKEVVITDTIPLPEEKKIDKIKVRSVAPLFAE
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
AILRIHEGMSVSKLFT
HHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336