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The map label for this gene is glmU

Identifier: 20808921

GI number: 20808921

Start: 2461944

End: 2463317

Strand: Reverse

Name: glmU

Synonym: TTE2572

Alternate gene names: 20808921

Gene position: 2463317-2461944 (Counterclockwise)

Preceding gene: 20808922

Following gene: 20808920

Centisome position: 91.59

GC content: 42.94

Gene sequence:

>1374_bases
GTGGAAGAGCTAGTAAGTGTGATTCTGGCGGCTGGGTTAGGGAAACGAATGAAGTCAAAGTATCCAAAGGTTGTTCACAA
AGTGTGCGGCAAGCCAATGGTAAAATGGGTAGTGGAGGCAGCACAAGAAGCAGGCAGCAAGGAAGTAATCGTTGTAGTGG
GGCACGGCCGGGAAATGGTAGAGGAAGTGCTTGGGGATGAGGTGAAGTACGCATACCAGAAAGTTCAGCTTGGAACAGGT
CATGCTGTGATGATGGCAGAAGAGTTTTTGCCTCTTGAGGGAATGGTTTTAATACTCACAGGGGATACTCCTCTTATCAC
TTCTGACACCTTGAGAAAGCTTGTAGAGTATCACATCAGCGAAGGAAATGATGTTACTATTTTATCTTCTATTTTTGACG
ACCCTACAGGCTATGGAAGGATAATAAGGGATGAAAGTGGAAACGTTGTAAAGATTGTGGAAGAAAAGGACGCAAGCGAA
GAAGAAAAAAGAGTAAAAGAGATAAATTCGGGGATGTACGTTGTGGATATCGCGAAATTAAGAGCTGCTTTAAAGGAGAT
AACTAATGATAACGCTCAAGGAGAATACTATTTGACAGATGCTGTAGAGATTATAAGGAATATGGGAGGAAAAATTGGTG
CTGTAGTTGGGGAGTCAGAAGAGATAATAGGAGTAAATTCCCGAGTTCAGCTCTCAAATGCGGAAAAGGTGATGAGAAGG
AGAATAAATGAAAAGCACATGGAAAATGGAGTAACGATAATAGACCCAGACAGCACTTATATAGATGCAGAAGTTGAAAT
TGGACGGGATACTGTTATCTTGCCAGGAACTATTCTGCAGGGTAAGACTAAGATAGGGGAAGACTGTGAAATAGGGCCTA
ATTCGAGGATTGTGGACTCTACCATTGGAAATGGATGCAATGTTATGTATTCGGTAGTGCTCTCATCAAGTGTGGGCAAC
AATGTTAAAATAGGGCCTTTCGCCCACATAAGGCCTGAATCTGTGATAAAAAATAATGTCAAGATTGGCGATTTTGTTGA
GATAAAGAAGTCTGTGATTGATGAGGGGAGTAAAGTGCCTCACCTCACTTATGTAGGAGATGCAGAGCTTGGGAAGAATG
TCAACATGGGTTGCGGTTCGATCACTGTAAATTATGACGGAAAGCAGAAGCACAAGACCATTATTGGGGACAATGTGTTT
GTGGGTTGCAATGTCAACCTTGTAGCACCTGTGAAAATTGGCAATAATGCGTATATTGCTGCGGGGTCTACTATTACAGA
AGATGTGCCTGAAGGAGCCCTCGCCATTGCGAGGAGCAGACAGACCAATAAAGAGGGCTGGGTAGAGGAAAGAATAAAAA
AAGGGAGGCTTTAG

Upstream 100 bases:

>100_bases
AGGAGCTCGTCTCCTTTTTATTTTTTTGTTGAACTTTGCGGGAATTATAGTTAAAATAGTATAGGGCGGAATAGTAGATT
TTTTATAGAAGGTGGGTAAA

Downstream 100 bases:

>100_bases
TGTAAAAATGGCGAGGTATACTAACTCACTTAAGATTTTTACGGGAAATTCAAATCCTAAGCTGGCCAGTGAAATAGCTG
AACACTTGGGTCTTAAACTG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEELVSVILAAGLGKRMKSKYPKVVHKVCGKPMVKWVVEAAQEAGSKEVIVVVGHGREMVEEVLGDEVKYAYQKVQLGTG
HAVMMAEEFLPLEGMVLILTGDTPLITSDTLRKLVEYHISEGNDVTILSSIFDDPTGYGRIIRDESGNVVKIVEEKDASE
EEKRVKEINSGMYVVDIAKLRAALKEITNDNAQGEYYLTDAVEIIRNMGGKIGAVVGESEEIIGVNSRVQLSNAEKVMRR
RINEKHMENGVTIIDPDSTYIDAEVEIGRDTVILPGTILQGKTKIGEDCEIGPNSRIVDSTIGNGCNVMYSVVLSSSVGN
NVKIGPFAHIRPESVIKNNVKIGDFVEIKKSVIDEGSKVPHLTYVGDAELGKNVNMGCGSITVNYDGKQKHKTIIGDNVF
VGCNVNLVAPVKIGNNAYIAAGSTITEDVPEGALAIARSRQTNKEGWVEERIKKGRL

Sequences:

>Translated_457_residues
MEELVSVILAAGLGKRMKSKYPKVVHKVCGKPMVKWVVEAAQEAGSKEVIVVVGHGREMVEEVLGDEVKYAYQKVQLGTG
HAVMMAEEFLPLEGMVLILTGDTPLITSDTLRKLVEYHISEGNDVTILSSIFDDPTGYGRIIRDESGNVVKIVEEKDASE
EEKRVKEINSGMYVVDIAKLRAALKEITNDNAQGEYYLTDAVEIIRNMGGKIGAVVGESEEIIGVNSRVQLSNAEKVMRR
RINEKHMENGVTIIDPDSTYIDAEVEIGRDTVILPGTILQGKTKIGEDCEIGPNSRIVDSTIGNGCNVMYSVVLSSSVGN
NVKIGPFAHIRPESVIKNNVKIGDFVEIKKSVIDEGSKVPHLTYVGDAELGKNVNMGCGSITVNYDGKQKHKTIIGDNVF
VGCNVNLVAPVKIGNNAYIAAGSTITEDVPEGALAIARSRQTNKEGWVEERIKKGRL
>Mature_457_residues
MEELVSVILAAGLGKRMKSKYPKVVHKVCGKPMVKWVVEAAQEAGSKEVIVVVGHGREMVEEVLGDEVKYAYQKVQLGTG
HAVMMAEEFLPLEGMVLILTGDTPLITSDTLRKLVEYHISEGNDVTILSSIFDDPTGYGRIIRDESGNVVKIVEEKDASE
EEKRVKEINSGMYVVDIAKLRAALKEITNDNAQGEYYLTDAVEIIRNMGGKIGAVVGESEEIIGVNSRVQLSNAEKVMRR
RINEKHMENGVTIIDPDSTYIDAEVEIGRDTVILPGTILQGKTKIGEDCEIGPNSRIVDSTIGNGCNVMYSVVLSSSVGN
NVKIGPFAHIRPESVIKNNVKIGDFVEIKKSVIDEGSKVPHLTYVGDAELGKNVNMGCGSITVNYDGKQKHKTIIGDNVF
VGCNVNLVAPVKIGNNAYIAAGSTITEDVPEGALAIARSRQTNKEGWVEERIKKGRL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=444, Percent_Identity=44.8198198198198, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320148, Length=368, Percent_Identity=23.9130434782609, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355443, Length=391, Percent_Identity=22.5063938618926, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644084, Length=391, Percent_Identity=22.5063938618926, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_THETN (Q8R752)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624092.1
- ProteinModelPortal:   Q8R752
- SMR:   Q8R752
- GeneID:   997536
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2572
- NMPDR:   fig|273068.3.peg.2053
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14354
- BioCyc:   TTEN273068:TTE2572-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49708; Mature: 49708

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 361-361 BINDING 73-73 BINDING 139-139 BINDING 154-154 BINDING 169-169 BINDING 385-385 BINDING 421-421 BINDING 438-438

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELVSVILAAGLGKRMKSKYPKVVHKVCGKPMVKWVVEAAQEAGSKEVIVVVGHGREMV
CHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCHHHH
EEVLGDEVKYAYQKVQLGTGHAVMMAEEFLPLEGMVLILTGDTPLITSDTLRKLVEYHIS
HHHHCHHHHHHHHHEECCCCCEEEEHHHCCCCCCEEEEEECCCCEECHHHHHHHHHHHCC
EGNDVTILSSIFDDPTGYGRIIRDESGNVVKIVEEKDASEEEKRVKEINSGMYVVDIAKL
CCCCEEEEHHHHCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEHHHH
RAALKEITNDNAQGEYYLTDAVEIIRNMGGKIGAVVGESEEIIGVNSRVQLSNAEKVMRR
HHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCCEEECCCEEEECCHHHHHHH
RINEKHMENGVTIIDPDSTYIDAEVEIGRDTVILPGTILQGKTKIGEDCEIGPNSRIVDS
HHHHHHHHCCCEEECCCCCEEEEEEEECCCEEEECCCEECCCCCCCCCCCCCCCCEEEEC
TIGNGCNVMYSVVLSSSVGNNVKIGPFAHIRPESVIKNNVKIGDFVEIKKSVIDEGSKVP
CCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCC
HLTYVGDAELGKNVNMGCGSITVNYDGKQKHKTIIGDNVFVGCNVNLVAPVKIGNNAYIA
EEEEECCHHCCCCCCCCCCEEEEECCCCCCCCEEECCCEEEECCEEEEEEEEECCCEEEE
AGSTITEDVPEGALAIARSRQTNKEGWVEERIKKGRL
ECCCHHCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MEELVSVILAAGLGKRMKSKYPKVVHKVCGKPMVKWVVEAAQEAGSKEVIVVVGHGREMV
CHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCHHHH
EEVLGDEVKYAYQKVQLGTGHAVMMAEEFLPLEGMVLILTGDTPLITSDTLRKLVEYHIS
HHHHCHHHHHHHHHEECCCCCEEEEHHHCCCCCCEEEEEECCCCEECHHHHHHHHHHHCC
EGNDVTILSSIFDDPTGYGRIIRDESGNVVKIVEEKDASEEEKRVKEINSGMYVVDIAKL
CCCCEEEEHHHHCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEHHHH
RAALKEITNDNAQGEYYLTDAVEIIRNMGGKIGAVVGESEEIIGVNSRVQLSNAEKVMRR
HHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCCEEECCCEEEECCHHHHHHH
RINEKHMENGVTIIDPDSTYIDAEVEIGRDTVILPGTILQGKTKIGEDCEIGPNSRIVDS
HHHHHHHHCCCEEECCCCCEEEEEEEECCCEEEECCCEECCCCCCCCCCCCCCCCEEEEC
TIGNGCNVMYSVVLSSSVGNNVKIGPFAHIRPESVIKNNVKIGDFVEIKKSVIDEGSKVP
CCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCC
HLTYVGDAELGKNVNMGCGSITVNYDGKQKHKTIIGDNVFVGCNVNLVAPVKIGNNAYIA
EEEEECCHHCCCCCCCCCCEEEEECCCCCCCCEEECCCEEEECCEEEEEEEEECCCEEEE
AGSTITEDVPEGALAIARSRQTNKEGWVEERIKKGRL
ECCCHHCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336