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The map label for this gene is DegQ2 [H]

Identifier: 20808917

GI number: 20808917

Start: 2457216

End: 2458559

Strand: Reverse

Name: DegQ2 [H]

Synonym: TTE2568

Alternate gene names: 20808917

Gene position: 2458559-2457216 (Counterclockwise)

Preceding gene: 20808918

Following gene: 20808916

Centisome position: 91.42

GC content: 41.82

Gene sequence:

>1344_bases
ATGAGCATGGACTATGAAAGAGATTTTGAAAATAATATTGAAAAAAAGGACCCTGAAAGCATGGTTCCTCCACAGGAAAA
TTTAGAGGATATGCCACAGGAGATGTCGGAAAAACCTTCTGTGGACACAGCTTCTCCTGCTCCAAAAGTGGAGTTCAGGA
ACAATAAAAAGAGCATAGGGCGAATGGTCAAGAGGTTCAGAAGAAAGCTGATTGCCTCTTTTGTGGCAGTTGCTTTAATC
GCCGCTATAATTGGTGGCGGTGTGACAGGAGCTGTGATGAAATACTATGGAACCCAAAATGATGCGTCAACACAAGTTGT
TACAAGATATTTACCTCTAGATGCTACTTCATCAGACGAAAGCGGTATTTTAAATTTGATACCTAATATTTACAAAATTG
TAAGCCCAGCAGTTGTGGAAATTGACACAAGTACCGCTTATAGAAGTGGCTACAGGACAGAATACGTGCCTAAAGGAAGT
GGCTCTGGATTTATCATAAGCACAGATGGATATATTGTCACAAACAATCACGTCATTGAAGGAGCTTCAAAGATTACAGT
AAAACTTTTAGATGGCAGAAGTGCTGATGCGAAATTGATAGGTAAAGACCCAAGGACAGACCTTGCAGTTTTAAAGATTA
ACCTTCCTAATTTACCTGTTGTAAAACTTGGAGATTCTTCTAAATTGCAACCTGGTGAACTGGCAATAGCTATAGGCAAT
CCTCTGGGAGATTCCTTTGCAGGTACAGTGACAGCAGGGATAATAAGCGGACTCAACAGAAACTTGCAAAGTGATTACGG
GCCTGTAAAACTCATACAGACAGATGCGGCTATAAACCCCGGTAACAGCGGTGGACCTCTTGTAAACAGCAAAGCAGAGG
TTATAGGTATAACAAGTGTCAAGCTTACTTCTATAGGACCTAGCATCCAAGACCCATTTGGGCTTTTCCAGGGGCAGAGC
ACTCCAGTTGAAGGCATGGGATTTGCTATTCCGATAAACGAAGCTAAGCCTATAATTGAGCAGCTCATAAAGCACGGGTA
CGTTGAAAGGCCTATGATGGGAATAGGTGCTCAGACAATAACGCCACAAGATGCAGCTCAATACAACTTGCCAGTAGGAG
TATATGTGGTACAGGTTCAGCCTGGAAGCGGTGCAGAAAAAGCAGGAATTCAACCAGGAGATGTGATAATAAAAGCGGAT
GGCAAGCAGATTAAGTCTTTTGAAGACCTACAGAGCGTTATAAACAGCCACAAAGTTGGAGATGTTATAAATGTCACCAT
CTGGAGAAATGGAAGGACATTCACAGTTTCTGTAGAATTGCAAAGCAGTGCAAACTTTCAATAA

Upstream 100 bases:

>100_bases
TCTTAATAAAAACTACCCAAAATCTTTACATGGTGTTCATAATTTGTTAATAAAAAGGAAGTATAATTAGAATCGAGAAA
AGGAAAGGGAGTGAGTGAGG

Downstream 100 bases:

>100_bases
AAAATAAAAGGCCTCCCACGCACCTGCCTGCCGACTTTACAGTCGGCAGGTTGTTTTTTATTGACTACATATGTATAATT
AATCTTATAAGGAAGGGTGA

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSMDYERDFENNIEKKDPESMVPPQENLEDMPQEMSEKPSVDTASPAPKVEFRNNKKSIGRMVKRFRRKLIASFVAVALI
AAIIGGGVTGAVMKYYGTQNDASTQVVTRYLPLDATSSDESGILNLIPNIYKIVSPAVVEIDTSTAYRSGYRTEYVPKGS
GSGFIISTDGYIVTNNHVIEGASKITVKLLDGRSADAKLIGKDPRTDLAVLKINLPNLPVVKLGDSSKLQPGELAIAIGN
PLGDSFAGTVTAGIISGLNRNLQSDYGPVKLIQTDAAINPGNSGGPLVNSKAEVIGITSVKLTSIGPSIQDPFGLFQGQS
TPVEGMGFAIPINEAKPIIEQLIKHGYVERPMMGIGAQTITPQDAAQYNLPVGVYVVQVQPGSGAEKAGIQPGDVIIKAD
GKQIKSFEDLQSVINSHKVGDVINVTIWRNGRTFTVSVELQSSANFQ

Sequences:

>Translated_447_residues
MSMDYERDFENNIEKKDPESMVPPQENLEDMPQEMSEKPSVDTASPAPKVEFRNNKKSIGRMVKRFRRKLIASFVAVALI
AAIIGGGVTGAVMKYYGTQNDASTQVVTRYLPLDATSSDESGILNLIPNIYKIVSPAVVEIDTSTAYRSGYRTEYVPKGS
GSGFIISTDGYIVTNNHVIEGASKITVKLLDGRSADAKLIGKDPRTDLAVLKINLPNLPVVKLGDSSKLQPGELAIAIGN
PLGDSFAGTVTAGIISGLNRNLQSDYGPVKLIQTDAAINPGNSGGPLVNSKAEVIGITSVKLTSIGPSIQDPFGLFQGQS
TPVEGMGFAIPINEAKPIIEQLIKHGYVERPMMGIGAQTITPQDAAQYNLPVGVYVVQVQPGSGAEKAGIQPGDVIIKAD
GKQIKSFEDLQSVINSHKVGDVINVTIWRNGRTFTVSVELQSSANFQ
>Mature_446_residues
SMDYERDFENNIEKKDPESMVPPQENLEDMPQEMSEKPSVDTASPAPKVEFRNNKKSIGRMVKRFRRKLIASFVAVALIA
AIIGGGVTGAVMKYYGTQNDASTQVVTRYLPLDATSSDESGILNLIPNIYKIVSPAVVEIDTSTAYRSGYRTEYVPKGSG
SGFIISTDGYIVTNNHVIEGASKITVKLLDGRSADAKLIGKDPRTDLAVLKINLPNLPVVKLGDSSKLQPGELAIAIGNP
LGDSFAGTVTAGIISGLNRNLQSDYGPVKLIQTDAAINPGNSGGPLVNSKAEVIGITSVKLTSIGPSIQDPFGLFQGQST
PVEGMGFAIPINEAKPIIEQLIKHGYVERPMMGIGAQTITPQDAAQYNLPVGVYVVQVQPGSGAEKAGIQPGDVIIKADG
KQIKSFEDLQSVINSHKVGDVINVTIWRNGRTFTVSVELQSSANFQ

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=338, Percent_Identity=34.6153846153846, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI22129776, Length=313, Percent_Identity=35.1437699680511, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI24308541, Length=331, Percent_Identity=31.4199395770393, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI7019477, Length=332, Percent_Identity=31.9277108433735, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1786356, Length=291, Percent_Identity=42.2680412371134, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1789629, Length=343, Percent_Identity=37.9008746355685, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1789630, Length=314, Percent_Identity=37.8980891719745, Blast_Score=159, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24646839, Length=325, Percent_Identity=34.1538461538462, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 47759; Mature: 47628

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMDYERDFENNIEKKDPESMVPPQENLEDMPQEMSEKPSVDTASPAPKVEFRNNKKSIG
CCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHH
RMVKRFRRKLIASFVAVALIAAIIGGGVTGAVMKYYGTQNDASTQVVTRYLPLDATSSDE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCC
SGILNLIPNIYKIVSPAVVEIDTSTAYRSGYRTEYVPKGSGSGFIISTDGYIVTNNHVIE
CCHHHHHHHHHHHHCCEEEEEECCHHHHCCCCCCCCCCCCCCEEEEECCCEEEECCEEEC
GASKITVKLLDGRSADAKLIGKDPRTDLAVLKINLPNLPVVKLGDSSKLQPGELAIAIGN
CCCEEEEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEECC
PLGDSFAGTVTAGIISGLNRNLQSDYGPVKLIQTDAAINPGNSGGPLVNSKAEVIGITSV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEE
KLTSIGPSIQDPFGLFQGQSTPVEGMGFAIPINEAKPIIEQLIKHGYVERPMMGIGAQTI
EEEECCCCCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHCCCCCCC
TPQDAAQYNLPVGVYVVQVQPGSGAEKAGIQPGDVIIKADGKQIKSFEDLQSVINSHKVG
CCCCCHHCCCCEEEEEEEEECCCCCHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCC
DVINVTIWRNGRTFTVSVELQSSANFQ
CEEEEEEEECCEEEEEEEEECCCCCCC
>Mature Secondary Structure 
SMDYERDFENNIEKKDPESMVPPQENLEDMPQEMSEKPSVDTASPAPKVEFRNNKKSIG
CCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHH
RMVKRFRRKLIASFVAVALIAAIIGGGVTGAVMKYYGTQNDASTQVVTRYLPLDATSSDE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCC
SGILNLIPNIYKIVSPAVVEIDTSTAYRSGYRTEYVPKGSGSGFIISTDGYIVTNNHVIE
CCHHHHHHHHHHHHCCEEEEEECCHHHHCCCCCCCCCCCCCCEEEEECCCEEEECCEEEC
GASKITVKLLDGRSADAKLIGKDPRTDLAVLKINLPNLPVVKLGDSSKLQPGELAIAIGN
CCCEEEEEEECCCCCCCEEECCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCEEEEECC
PLGDSFAGTVTAGIISGLNRNLQSDYGPVKLIQTDAAINPGNSGGPLVNSKAEVIGITSV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEE
KLTSIGPSIQDPFGLFQGQSTPVEGMGFAIPINEAKPIIEQLIKHGYVERPMMGIGAQTI
EEEECCCCCCCCHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHCCCCCCC
TPQDAAQYNLPVGVYVVQVQPGSGAEKAGIQPGDVIIKADGKQIKSFEDLQSVINSHKVG
CCCCCHHCCCCEEEEEEEEECCCCCHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCC
DVINVTIWRNGRTFTVSVELQSSANFQ
CEEEEEEEECCEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10692364; 9353931; 9384377; 10568751; 11133960 [H]