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The map label for this gene is Pth

Identifier: 20808916

GI number: 20808916

Start: 2456554

End: 2457111

Strand: Reverse

Name: Pth

Synonym: TTE2567

Alternate gene names: 20808916

Gene position: 2457111-2456554 (Counterclockwise)

Preceding gene: 20808917

Following gene: 20808915

Centisome position: 91.36

GC content: 41.76

Gene sequence:

>558_bases
ATGTACATAATAGCTGGTCTTGGAAATCCGGGAAAAGAATACGAGGGCACGAGGCACAATGTAGGCTTTATGGTGATAGA
TGCCCTTTCAAAAAAGCTTGGGATAGAGGTTTCAAGGCTTAAATTCAAGTCCCTCATGGGGGAAGGGCATTTTAAAGGCG
AAAAAGTGATACTTTTGAAGCCTCAGACGTTTATGAATTTGAGTGGCGAAGCCCTGTACGATGCTGTAAATTTTTATAAA
ATTCCGCTTGAAAATGTAATTGTGGTATATGATGATAAAGACCTTGAGGTGGGAAAAATAAGGATAAGGAGAAAAGGAAG
TTCAGGCGGTCACAATGGCATGAACTCAATAATATATCTTTTAAACAGCGAAGACTTTCCTAGAGTGAGAATAGGTATTG
GGAAGCCAGAAGATGGCGACCTTGTAAGGCACGTTCTGGGGCGATTTAGCGATGAAGAGAAAAAGGTGATAGATGAGGCG
GTGGAAAGAGCAGCAGAAGCCGTGATTGACATAATGGAGAATGGAATAGAGCATGCCATGAGCAGATTTAATGGCTAG

Upstream 100 bases:

>100_bases
TAAAAGGCCTCCCACGCACCTGCCTGCCGACTTTACAGTCGGCAGGTTGTTTTTTATTGACTACATATGTATAATTAATC
TTATAAGGAAGGGTGAGAGC

Downstream 100 bases:

>100_bases
AGGAGTTTGAGGATGTGGGTTTTATCAGGAATGGCAGGTATTGTTGTAGCATATCTTTTAAATAGCGCTGTGGTGAAAAG
GTATGGTGAGAGGGCTGTAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MYIIAGLGNPGKEYEGTRHNVGFMVIDALSKKLGIEVSRLKFKSLMGEGHFKGEKVILLKPQTFMNLSGEALYDAVNFYK
IPLENVIVVYDDKDLEVGKIRIRRKGSSGGHNGMNSIIYLLNSEDFPRVRIGIGKPEDGDLVRHVLGRFSDEEKKVIDEA
VERAAEAVIDIMENGIEHAMSRFNG

Sequences:

>Translated_185_residues
MYIIAGLGNPGKEYEGTRHNVGFMVIDALSKKLGIEVSRLKFKSLMGEGHFKGEKVILLKPQTFMNLSGEALYDAVNFYK
IPLENVIVVYDDKDLEVGKIRIRRKGSSGGHNGMNSIIYLLNSEDFPRVRIGIGKPEDGDLVRHVLGRFSDEEKKVIDEA
VERAAEAVIDIMENGIEHAMSRFNG
>Mature_185_residues
MYIIAGLGNPGKEYEGTRHNVGFMVIDALSKKLGIEVSRLKFKSLMGEGHFKGEKVILLKPQTFMNLSGEALYDAVNFYK
IPLENVIVVYDDKDLEVGKIRIRRKGSSGGHNGMNSIIYLLNSEDFPRVRIGIGKPEDGDLVRHVLGRFSDEEKKVIDEA
VERAAEAVIDIMENGIEHAMSRFNG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=173, Percent_Identity=34.6820809248555, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=39.247311827957, Blast_Score=109, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321983, Length=174, Percent_Identity=29.3103448275862, Blast_Score=78, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_THETN (Q8R757)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624087.1
- ProteinModelPortal:   Q8R757
- SMR:   Q8R757
- GeneID:   997835
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2567
- NMPDR:   fig|273068.3.peg.2040
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   TTEN273068:TTE2567-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20654; Mature: 20654

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIIAGLGNPGKEYEGTRHNVGFMVIDALSKKLGIEVSRLKFKSLMGEGHFKGEKVILLK
CEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEC
PQTFMNLSGEALYDAVNFYKIPLENVIVVYDDKDLEVGKIRIRRKGSSGGHNGMNSIIYL
CHHHHCCCCHHHHHHHHHEEECCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCEEEE
LNSEDFPRVRIGIGKPEDGDLVRHVLGRFSDEEKKVIDEAVERAAEAVIDIMENGIEHAM
ECCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRFNG
HHCCC
>Mature Secondary Structure
MYIIAGLGNPGKEYEGTRHNVGFMVIDALSKKLGIEVSRLKFKSLMGEGHFKGEKVILLK
CEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEC
PQTFMNLSGEALYDAVNFYKIPLENVIVVYDDKDLEVGKIRIRRKGSSGGHNGMNSIIYL
CHHHHCCCCHHHHHHHHHEEECCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCEEEE
LNSEDFPRVRIGIGKPEDGDLVRHVLGRFSDEEKKVIDEAVERAAEAVIDIMENGIEHAM
ECCCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRFNG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336