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The map label for this gene is ipk

Identifier: 20808908

GI number: 20808908

Start: 2447075

End: 2447938

Strand: Reverse

Name: ipk

Synonym: TTE2559

Alternate gene names: 20808908

Gene position: 2447938-2447075 (Counterclockwise)

Preceding gene: 20808909

Following gene: 20808907

Centisome position: 91.02

GC content: 36.57

Gene sequence:

>864_bases
ATGAAGCTTAGAATAAAGGCCTATGCAAAAGTAAATCTCACGCTTGACGTTTTGTCAAAGAGGGAAGATGGATATCATGA
AATTTTAAGTGTGATGCAGTCAATTGACCTGGCTGATGTGATTGAATTTGAGAAAGCAAAGGAAATTTTGTTTGAATGCG
ACCATGAGAGAGTTCCCAAAGGAGAAGAAAACCTCATAATGAAGGCTTTTAATGCGATAAGAGATAGGTATTTTTTAAAT
GAAGGTATAAAAATAAAGCTTTTTAAAAATATTCCTTTGGCTGCCGGCCTTGCTGGAGGAAGTGCAGATGCTGCTGCTAC
AATTGTAGCATTAGATAAGCTCTGGAATTTAAACCTTACAGAAAAAGAGATGGAAGAAATAGCGTCAGAAGTAGGGTCTG
ACGTGCCTTTCTGCCTTAAGGGAGGAACAAAGCTTGCTAGTGGAAGAGGAGAAAAGCTTCAAGATTTAGAGGGAATTCCT
TTGAATTTGCTTCTTGTCAAGCCTGATTTAGAAATTTCTACAAAAGAAGTTTACACTGAATGGGATAATTCCGGGTTTAA
AAGCTTAAACTCTACTTTTTTATTTGTTGAGGCTTTGAAGAAGGGGGATTTATTAGAAATTGCTAGGAATATAAGCAATG
ACCTTGAAAGAGTGACCTCTCAAAAGTATAGAGTGATTGAAGATATAAAGAAAAGTTTGATAGAGAAAGGAGCTCTATCT
GCTTCTATGACAGGAAGCGGTCCTACGGTATACGGTGTTTTTAATGATGTTGAAAAGCTTGTAAGGGCTTATCATGACCT
TAAGGGAGTTTATCCTTTTGTTGCCATTTCTAAAACTATAGACAAGGGGTTAGAAATATTATGA

Upstream 100 bases:

>100_bases
AAAGTGAGTTTTTATGCGCAGTCTACTGCGTATTTTTTTTACAGAAAATTTGTTGTATAATGTATAATATGAAACTATAA
TATTGAGTAGGGAGAGTTAA

Downstream 100 bases:

>100_bases
GCGAGTTTTTTACTCTGGAAAATTACAAGCCGCTACGGGATCTGGTTTTTGACTACATGAAAGAAGCTATAATAACAGGG
AAGCTAAAGCCAGGAGAAAG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKLRIKAYAKVNLTLDVLSKREDGYHEILSVMQSIDLADVIEFEKAKEILFECDHERVPKGEENLIMKAFNAIRDRYFLN
EGIKIKLFKNIPLAAGLAGGSADAAATIVALDKLWNLNLTEKEMEEIASEVGSDVPFCLKGGTKLASGRGEKLQDLEGIP
LNLLLVKPDLEISTKEVYTEWDNSGFKSLNSTFLFVEALKKGDLLEIARNISNDLERVTSQKYRVIEDIKKSLIEKGALS
ASMTGSGPTVYGVFNDVEKLVRAYHDLKGVYPFVAISKTIDKGLEIL

Sequences:

>Translated_287_residues
MKLRIKAYAKVNLTLDVLSKREDGYHEILSVMQSIDLADVIEFEKAKEILFECDHERVPKGEENLIMKAFNAIRDRYFLN
EGIKIKLFKNIPLAAGLAGGSADAAATIVALDKLWNLNLTEKEMEEIASEVGSDVPFCLKGGTKLASGRGEKLQDLEGIP
LNLLLVKPDLEISTKEVYTEWDNSGFKSLNSTFLFVEALKKGDLLEIARNISNDLERVTSQKYRVIEDIKKSLIEKGALS
ASMTGSGPTVYGVFNDVEKLVRAYHDLKGVYPFVAISKTIDKGLEIL
>Mature_287_residues
MKLRIKAYAKVNLTLDVLSKREDGYHEILSVMQSIDLADVIEFEKAKEILFECDHERVPKGEENLIMKAFNAIRDRYFLN
EGIKIKLFKNIPLAAGLAGGSADAAATIVALDKLWNLNLTEKEMEEIASEVGSDVPFCLKGGTKLASGRGEKLQDLEGIP
LNLLLVKPDLEISTKEVYTEWDNSGFKSLNSTFLFVEALKKGDLLEIARNISNDLERVTSQKYRVIEDIKKSLIEKGALS
ASMTGSGPTVYGVFNDVEKLVRAYHDLKGVYPFVAISKTIDKGLEIL

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=263, Percent_Identity=28.5171102661597, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_THETN (Q8R765)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624079.1
- ProteinModelPortal:   Q8R765
- SMR:   Q8R765
- GeneID:   996175
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2559
- NMPDR:   fig|273068.3.peg.2032
- HOGENOM:   HBG734593
- OMA:   VSTKEVY
- ProtClustDB:   PRK00128
- BioCyc:   TTEN273068:TTE2559-MONOMER
- BRENDA:   2.7.1.148
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31917; Mature: 31917

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRIKAYAKVNLTLDVLSKREDGYHEILSVMQSIDLADVIEFEKAKEILFECDHERVPK
CEEEEEEEEEEEEEHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
GEENLIMKAFNAIRDRYFLNEGIKIKLFKNIPLAAGLAGGSADAAATIVALDKLWNLNLT
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHCCCCC
EKEMEEIASEVGSDVPFCLKGGTKLASGRGEKLQDLEGIPLNLLLVKPDLEISTKEVYTE
HHHHHHHHHHHCCCCCEEECCCCEECCCCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHH
WDNSGFKSLNSTFLFVEALKKGDLLEIARNISNDLERVTSQKYRVIEDIKKSLIEKGALS
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ASMTGSGPTVYGVFNDVEKLVRAYHDLKGVYPFVAISKTIDKGLEIL
CCCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLRIKAYAKVNLTLDVLSKREDGYHEILSVMQSIDLADVIEFEKAKEILFECDHERVPK
CEEEEEEEEEEEEEHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
GEENLIMKAFNAIRDRYFLNEGIKIKLFKNIPLAAGLAGGSADAAATIVALDKLWNLNLT
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCCHHHHHHHHHHHHHCCCCC
EKEMEEIASEVGSDVPFCLKGGTKLASGRGEKLQDLEGIPLNLLLVKPDLEISTKEVYTE
HHHHHHHHHHHCCCCCEEECCCCEECCCCCCHHHHCCCCCEEEEEECCCCCCCHHHHHHH
WDNSGFKSLNSTFLFVEALKKGDLLEIARNISNDLERVTSQKYRVIEDIKKSLIEKGALS
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ASMTGSGPTVYGVFNDVEKLVRAYHDLKGVYPFVAISKTIDKGLEIL
CCCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336