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The map label for this gene is ProP12 [H]

Identifier: 20808854

GI number: 20808854

Start: 2388979

End: 2390127

Strand: Reverse

Name: ProP12 [H]

Synonym: TTE2499

Alternate gene names: 20808854

Gene position: 2390127-2388979 (Counterclockwise)

Preceding gene: 20808858

Following gene: 20808853

Centisome position: 88.87

GC content: 34.55

Gene sequence:

>1149_bases
ATGGGATATTCAGCTATTATCTATTATTATTTCATAATCTTTTACGCAGTATTTTTTATGGGTGGAGCTATTTATGGCAC
TTTTGTGCCGGTTTATCTGGACTACATAGGTTATAGTAAGAGTGAAATTGGAATTTTGATGTCTTTAGGTCCTTTTGTCG
CTATAATAGCTCAGCCATTTTGGGGGATTACAAGCGACAGAGCGAGGTCTAAAAATTTTGTCTTGCAAATTTTATTTTTA
GCCAGTATTTTCATTATGGCGTTGTTCCCTTTGTCGCGCAACTTTTACTATCTGGTAGCCGTTATAACACTTTTCACATT
TTTTCAGACTTCTACTGGCCCCATAAGTGATGCCATAACATTGGAATATTTAAGTGGGACAGGTCAAAGTTTTGGACCAA
TTAGGATGGCAGGCACAATTGGATATGCAGTAATGTCAGTTATAGCAGGATGGTTTGCCCAAAGACATATTGGGAGTATT
TTTATTTTGAACATTATAGTGATGTTCATAGCCTTTATGATTGTCTATAAACTTCCGGTCGTAAAAGGACATCAGTTTGG
GAAAGAGAAAATTTCCATATGGAAACTTTTTTCAAATAGAAATTTAGTGGTGTTAATGCTTCTTAATTTTTTAATCCAGA
CTACTTTGGGGTTTTATTATACGTATTTTCCCATCTACTTTAGAAAGATAGGAGGGAGCAACGAACTTCTGGGATTAGCC
TATTTTATTTCTGCAATGAGCGAAATACCGTTTTTGTTGTATGCTGACAAGATACTTAAACGAATAGGAACAAGGTGGGC
ATTAATAGGAGCAAGTGGAGTAGCGGCTTTAAGGTGGCTTATTATATCGTTTATTCCTAATGCATATTTAGTTTTGCCTT
TTCAGCTTTTGCACGGATTGATTTTTATAGTATTGTACTATTCCATGGCAACTTATATTAATCAAGAAGTACCAAAAGAA
CTAAAAGCGTCGGGGCAGACTGTGAACAATCTAATAGGTATGGGAATTTCGAGAATTGTTGGAAGTTTATTGGGAGGGTT
TTTAAGCGACCTTTATGGAATAAAAATGGTATTTCTTTATAATTCTGTATTAGCTTTTTGTATAGCATTAATTTTTGGGT
ACATCTTTTTAAAAAAAGCGTCAAAATAA

Upstream 100 bases:

>100_bases
ACACGTGAAATAAATTGTCAATATGTATTTGCTATTTGGAGTAAGTTTTTTTATAATTATGTAAAATCAAATTTCATCCA
CAAAAGAAAGAGGGAGATAA

Downstream 100 bases:

>100_bases
TTTGGCAAATTTTAGGAAGAAAATTTTTTTGAAAAAACTCTTGAAAAAATTTTTTTCGATGCTATAATGGTAATAAAGGC
TGCATAAATATAAATTAAAT

Product: major facilitator superfamily permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MGYSAIIYYYFIIFYAVFFMGGAIYGTFVPVYLDYIGYSKSEIGILMSLGPFVAIIAQPFWGITSDRARSKNFVLQILFL
ASIFIMALFPLSRNFYYLVAVITLFTFFQTSTGPISDAITLEYLSGTGQSFGPIRMAGTIGYAVMSVIAGWFAQRHIGSI
FILNIIVMFIAFMIVYKLPVVKGHQFGKEKISIWKLFSNRNLVVLMLLNFLIQTTLGFYYTYFPIYFRKIGGSNELLGLA
YFISAMSEIPFLLYADKILKRIGTRWALIGASGVAALRWLIISFIPNAYLVLPFQLLHGLIFIVLYYSMATYINQEVPKE
LKASGQTVNNLIGMGISRIVGSLLGGFLSDLYGIKMVFLYNSVLAFCIALIFGYIFLKKASK

Sequences:

>Translated_382_residues
MGYSAIIYYYFIIFYAVFFMGGAIYGTFVPVYLDYIGYSKSEIGILMSLGPFVAIIAQPFWGITSDRARSKNFVLQILFL
ASIFIMALFPLSRNFYYLVAVITLFTFFQTSTGPISDAITLEYLSGTGQSFGPIRMAGTIGYAVMSVIAGWFAQRHIGSI
FILNIIVMFIAFMIVYKLPVVKGHQFGKEKISIWKLFSNRNLVVLMLLNFLIQTTLGFYYTYFPIYFRKIGGSNELLGLA
YFISAMSEIPFLLYADKILKRIGTRWALIGASGVAALRWLIISFIPNAYLVLPFQLLHGLIFIVLYYSMATYINQEVPKE
LKASGQTVNNLIGMGISRIVGSLLGGFLSDLYGIKMVFLYNSVLAFCIALIFGYIFLKKASK
>Mature_381_residues
GYSAIIYYYFIIFYAVFFMGGAIYGTFVPVYLDYIGYSKSEIGILMSLGPFVAIIAQPFWGITSDRARSKNFVLQILFLA
SIFIMALFPLSRNFYYLVAVITLFTFFQTSTGPISDAITLEYLSGTGQSFGPIRMAGTIGYAVMSVIAGWFAQRHIGSIF
ILNIIVMFIAFMIVYKLPVVKGHQFGKEKISIWKLFSNRNLVVLMLLNFLIQTTLGFYYTYFPIYFRKIGGSNELLGLAY
FISAMSEIPFLLYADKILKRIGTRWALIGASGVAALRWLIISFIPNAYLVLPFQLLHGLIFIVLYYSMATYINQEVPKEL
KASGQTVNNLIGMGISRIVGSLLGGFLSDLYGIKMVFLYNSVLAFCIALIFGYIFLKKASK

Specific function: Could Be Involved In Nucleoside Transport (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lacY/rafB permease family. HcaT subfamily [H]

Homologues:

Organism=Homo sapiens, GI144953907, Length=336, Percent_Identity=23.8095238095238, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788415, Length=343, Percent_Identity=23.6151603498542, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788886, Length=336, Percent_Identity=23.2142857142857, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24580953, Length=276, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653694, Length=145, Percent_Identity=30.3448275862069, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45550435, Length=293, Percent_Identity=23.8907849829352, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 42966; Mature: 42835

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GYSAIIYYYFIIFYAVFFMGGAIYGTFVPVYLDYIGYSKSEIGILMSLGPFVAIIAQPF
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
WGITSDRARSKNFVLQILFLASIFIMALFPLSRNFYYLVAVITLFTFFQTSTGPISDAIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LEYLSGTGQSFGPIRMAGTIGYAVMSVIAGWFAQRHIGSIFILNIIVMFIAFMIVYKLPV
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VKGHQFGKEKISIWKLFSNRNLVVLMLLNFLIQTTLGFYYTYFPIYFRKIGGSNELLGLA
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
YFISAMSEIPFLLYADKILKRIGTRWALIGASGVAALRWLIISFIPNAYLVLPFQLLHGL
HHHHHHHHCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IFIVLYYSMATYINQEVPKELKASGQTVNNLIGMGISRIVGSLLGGFLSDLYGIKMVFLY
HHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSVLAFCIALIFGYIFLKKASK
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]