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The map label for this gene is pepB [H]

Identifier: 20808843

GI number: 20808843

Start: 2374948

End: 2376711

Strand: Direct

Name: pepB [H]

Synonym: TTE2488

Alternate gene names: 20808843

Gene position: 2374948-2376711 (Clockwise)

Preceding gene: 20808834

Following gene: 20808844

Centisome position: 88.31

GC content: 35.09

Gene sequence:

>1764_bases
ATGAGGTGGTCTTTAGAAGCTCTTTATACTTCCTTTGACAGTGAAGAATTTCAAAAAGATGTCGAAAAAATAACTTCATC
AATCGAACACATACGGTCTTGGACTGAAGAAAACTTTACAACATATGAAAAGTCCAAAGAAAAACTCGAATACTACATAA
GATTTAAAAATGAACTGGGAGATTTAATGGTAAAAGTAAGAGGATATTCTGCTTTATCTTTAAGCGTGGATGTAAAAAAT
GAAAAGGCATTAAAAGCTTTGGAATCTCTTGAAAACATCAGCACAATGCTTGCAGAGCCAGAGACCAAATTCAAAAGATG
GCTTTTGAACATGCCGAACTTGGAAGAAACAATCCAGTCTTCCTCCTATCTTAAGGAACACGAATTTTTTATAAAAGAGA
CAGTCAAAGAAGCAATGCACCTACTTTCAGAAAAAGAAGAGATGATAATAGCTAAGATGAAAAACACAGGGTCAGAAGCT
TGGGCAAAACTTCATGACCTTTTGACCTCTACACTCCTTGTAGACATAAATATAAACGGCGAAGAGAAAAAATTGCCTCT
TTCCGTTGTAAGAAATATGGCTTATGACAAAGACCCTTACATAAGAAAGACAGCTTATTTTGCCGAATTAAATTCCTATA
AAAAAATAGAAGACGCTTCAGCAGCATGTCTTAATGGAATAAAAGGCGAGGTACTGACTGTTACAGAATTAAGAAAATAT
TCCTCTCCGTTAGAGATGACTCTTCAGCGTTCCCGCATGGACTCTGAAACACTTGAGGCAATGCTTGAAGCTATAGAAGA
GTATTTGCCAGAATTTAGAAGATATTTAAAAGAAAAAGCCCGCCTTTTAGGTCATAAAGATGGACTACCTTTCTATGACC
TTTTTGCTCCAGTAGGAAAATTGGACAAAAAATTTACATTTGATGAAGCGAAAGAATTTATAGTAGAAAATTTTAACTCC
TTCAGTGAGGACCTTGCACAATTTGCTAAAAAAGCCTTTGAAAACAGCTGGATTGATGCAGAGCCAAGAGAAGGCAAAAG
AGGAGGAGCCTTTTGCTACAACCTCCATCCAATAAAAGAAAGCAGAATACTGGCAAATTTTGATGGGAGTTTTTCTAATG
TTCTAACTCTGGCTCATGAATTAGGGCATGGATATCACGGCCATTTGCTAGCAAATGAAACATTAATAAATTCAAGATAC
CCGATGCCTATAGCGGAAACAGCATCAATTTTCAACGAGCATATTATAGTGAATTCTGCATTAAAAACGGCTTCTAAAGA
AGAGAAATTATCAATTATAGAAAACTCACTGCAGCGCTCAACACAAACCATCGTAGACATTTACTCAAGATTCTTATTTG
AAGATGAAGTCATAAAAAGAAGAAAAGACCATTCTTTATCTGTTGAAGAATTAAAACAAATTATGATAGAGGCTCAGAAG
AAAACATACGGGGATGGCCTTGACCAAAATTACCTGCACCCTTACATGTGGATAAACAAGCCCCATTATTACGATGCCGA
TTTAAACTACTACAACTTCCCATATGCATTTGGGGAATTATTTGTAAAAGGCCTAATTTACAAGTACAATCAAGAAGGCA
AAAAATTTGTAGAAGAATATAAAAACCTTCTTCCTCAGACAGGGAAGAAAAATCTCTATGATTTAGGAAAAATCGTAGGA
TTTGACTTGCACTCTAAAGACTTCTGGAGAAAATCTTTAGATGTCATAAAAGAAGAAATCAACCAATTTATATCTTTAAT
ATAA

Upstream 100 bases:

>100_bases
CAAAAAGCTCTTACACCATTTCCCTGAAAAGGTTTGACTTATCTTTAAAAATATTTTACAATCAAATTGGCAAATATTAT
ACAAAATGGGGGAGAGGTAA

Downstream 100 bases:

>100_bases
TTCAAACACTGGAAGAGGTTCTTCTCATTCGAATTTTATTTTGAAGTAAAATATCTAAAAGGGGACCCGGGTTTTGTACA
AAGAGCGGTCCCCTTTCATA

Product: oligoendopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MRWSLEALYTSFDSEEFQKDVEKITSSIEHIRSWTEENFTTYEKSKEKLEYYIRFKNELGDLMVKVRGYSALSLSVDVKN
EKALKALESLENISTMLAEPETKFKRWLLNMPNLEETIQSSSYLKEHEFFIKETVKEAMHLLSEKEEMIIAKMKNTGSEA
WAKLHDLLTSTLLVDININGEEKKLPLSVVRNMAYDKDPYIRKTAYFAELNSYKKIEDASAACLNGIKGEVLTVTELRKY
SSPLEMTLQRSRMDSETLEAMLEAIEEYLPEFRRYLKEKARLLGHKDGLPFYDLFAPVGKLDKKFTFDEAKEFIVENFNS
FSEDLAQFAKKAFENSWIDAEPREGKRGGAFCYNLHPIKESRILANFDGSFSNVLTLAHELGHGYHGHLLANETLINSRY
PMPIAETASIFNEHIIVNSALKTASKEEKLSIIENSLQRSTQTIVDIYSRFLFEDEVIKRRKDHSLSVEELKQIMIEAQK
KTYGDGLDQNYLHPYMWINKPHYYDADLNYYNFPYAFGELFVKGLIYKYNQEGKKFVEEYKNLLPQTGKKNLYDLGKIVG
FDLHSKDFWRKSLDVIKEEINQFISLI

Sequences:

>Translated_587_residues
MRWSLEALYTSFDSEEFQKDVEKITSSIEHIRSWTEENFTTYEKSKEKLEYYIRFKNELGDLMVKVRGYSALSLSVDVKN
EKALKALESLENISTMLAEPETKFKRWLLNMPNLEETIQSSSYLKEHEFFIKETVKEAMHLLSEKEEMIIAKMKNTGSEA
WAKLHDLLTSTLLVDININGEEKKLPLSVVRNMAYDKDPYIRKTAYFAELNSYKKIEDASAACLNGIKGEVLTVTELRKY
SSPLEMTLQRSRMDSETLEAMLEAIEEYLPEFRRYLKEKARLLGHKDGLPFYDLFAPVGKLDKKFTFDEAKEFIVENFNS
FSEDLAQFAKKAFENSWIDAEPREGKRGGAFCYNLHPIKESRILANFDGSFSNVLTLAHELGHGYHGHLLANETLINSRY
PMPIAETASIFNEHIIVNSALKTASKEEKLSIIENSLQRSTQTIVDIYSRFLFEDEVIKRRKDHSLSVEELKQIMIEAQK
KTYGDGLDQNYLHPYMWINKPHYYDADLNYYNFPYAFGELFVKGLIYKYNQEGKKFVEEYKNLLPQTGKKNLYDLGKIVG
FDLHSKDFWRKSLDVIKEEINQFISLI
>Mature_587_residues
MRWSLEALYTSFDSEEFQKDVEKITSSIEHIRSWTEENFTTYEKSKEKLEYYIRFKNELGDLMVKVRGYSALSLSVDVKN
EKALKALESLENISTMLAEPETKFKRWLLNMPNLEETIQSSSYLKEHEFFIKETVKEAMHLLSEKEEMIIAKMKNTGSEA
WAKLHDLLTSTLLVDININGEEKKLPLSVVRNMAYDKDPYIRKTAYFAELNSYKKIEDASAACLNGIKGEVLTVTELRKY
SSPLEMTLQRSRMDSETLEAMLEAIEEYLPEFRRYLKEKARLLGHKDGLPFYDLFAPVGKLDKKFTFDEAKEFIVENFNS
FSEDLAQFAKKAFENSWIDAEPREGKRGGAFCYNLHPIKESRILANFDGSFSNVLTLAHELGHGYHGHLLANETLINSRY
PMPIAETASIFNEHIIVNSALKTASKEEKLSIIENSLQRSTQTIVDIYSRFLFEDEVIKRRKDHSLSVEELKQIMIEAQK
KTYGDGLDQNYLHPYMWINKPHYYDADLNYYNFPYAFGELFVKGLIYKYNQEGKKFVEEYKNLLPQTGKKNLYDLGKIVG
FDLHSKDFWRKSLDVIKEEINQFISLI

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 68390; Mature: 68390

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWSLEALYTSFDSEEFQKDVEKITSSIEHIRSWTEENFTTYEKSKEKLEYYIRFKNELG
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DLMVKVRGYSALSLSVDVKNEKALKALESLENISTMLAEPETKFKRWLLNMPNLEETIQS
HHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
SSYLKEHEFFIKETVKEAMHLLSEKEEMIIAKMKNTGSEAWAKLHDLLTSTLLVDINING
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEECCC
EEKKLPLSVVRNMAYDKDPYIRKTAYFAELNSYKKIEDASAACLNGIKGEVLTVTELRKY
CCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHH
SSPLEMTLQRSRMDSETLEAMLEAIEEYLPEFRRYLKEKARLLGHKDGLPFYDLFAPVGK
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LDKKFTFDEAKEFIVENFNSFSEDLAQFAKKAFENSWIDAEPREGKRGGAFCYNLHPIKE
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
SRILANFDGSFSNVLTLAHELGHGYHGHLLANETLINSRYPMPIAETASIFNEHIIVNSA
CCEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHH
LKTASKEEKLSIIENSLQRSTQTIVDIYSRFLFEDEVIKRRKDHSLSVEELKQIMIEAQK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KTYGDGLDQNYLHPYMWINKPHYYDADLNYYNFPYAFGELFVKGLIYKYNQEGKKFVEEY
HHCCCCCCCCCCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
KNLLPQTGKKNLYDLGKIVGFDLHSKDFWRKSLDVIKEEINQFISLI
HHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRWSLEALYTSFDSEEFQKDVEKITSSIEHIRSWTEENFTTYEKSKEKLEYYIRFKNELG
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DLMVKVRGYSALSLSVDVKNEKALKALESLENISTMLAEPETKFKRWLLNMPNLEETIQS
HHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
SSYLKEHEFFIKETVKEAMHLLSEKEEMIIAKMKNTGSEAWAKLHDLLTSTLLVDINING
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEECCC
EEKKLPLSVVRNMAYDKDPYIRKTAYFAELNSYKKIEDASAACLNGIKGEVLTVTELRKY
CCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHH
SSPLEMTLQRSRMDSETLEAMLEAIEEYLPEFRRYLKEKARLLGHKDGLPFYDLFAPVGK
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LDKKFTFDEAKEFIVENFNSFSEDLAQFAKKAFENSWIDAEPREGKRGGAFCYNLHPIKE
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCC
SRILANFDGSFSNVLTLAHELGHGYHGHLLANETLINSRYPMPIAETASIFNEHIIVNSA
CCEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCEECCCCCCCHHHHHHHHHHHHHHHHH
LKTASKEEKLSIIENSLQRSTQTIVDIYSRFLFEDEVIKRRKDHSLSVEELKQIMIEAQK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KTYGDGLDQNYLHPYMWINKPHYYDADLNYYNFPYAFGELFVKGLIYKYNQEGKKFVEEY
HHCCCCCCCCCCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
KNLLPQTGKKNLYDLGKIVGFDLHSKDFWRKSLDVIKEEINQFISLI
HHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]