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The map label for this gene is AvtA4 [H]

Identifier: 20808798

GI number: 20808798

Start: 2331669

End: 2332835

Strand: Reverse

Name: AvtA4 [H]

Synonym: TTE2440

Alternate gene names: 20808798

Gene position: 2332835-2331669 (Counterclockwise)

Preceding gene: 20808799

Following gene: 20808797

Centisome position: 86.74

GC content: 37.1

Gene sequence:

>1167_bases
ATGAATCCTAATAAATACATATCTGATGTAGTAAAGAAAATACCACCTTCTGGGATTAGGAAATTTTTTGACCTTGTTAC
CAACTCAAAGGATATAATATCACTGGGCGTAGGGGAACCGGATTTTGTAACTCCATGGGAAATAAGAAAAGAGGGGATTG
AAACACTGTGCAGGGGAAATACCACATACACATCAAATTTAGGCTTGCTTGAACTGAGGATAGCCATCTCCTATTTTTTA
AAGACACATTATGACTTAAACTACGACCCTGAAAAAGAAATTATGGTTACTATTGGTGCAAGTGAGGCTATTGATTTAGC
ACTTAGAGCTCTTTTAAATGATGGAGATGAGGTTTTAATTCCGGAACCCAGTTACGTTTCCTATGCTCCTTGCGTAATTC
TCACAAGAGGTGTCCCAGTGTTTATACCTACAGACGAAAAAAACAATTTTATACTCACTCCTGATGATTTAAGATCCAAA
ATAACTTCAAAGACAAAAGCATTAATCTTACTCTATCCTAACAATCCTACAGGTGCAATCATGAAAAAAGAAGACCTGGA
AGAGATTGTAGATGTAATAATTGAAAAAGACCTTATTGTAATTTCTGATGAAATATACAGCGAGCTGACTTATGAAGGAA
AACACGTAAGCATAGCCTCTCTTCCAGGGATGAAAGAAAGGACAATCCTCATAAACGGTTTTTCAAAAGCTTTTGCCATG
ACTGGATGGAGGTTAGGGTACATTGCGGCAGAGCATGAATTTATAGAAGCGATGAACAAAATCCACCAATATACAACAAT
ATGTGCTCCGATAACTGCCCAGTACGCAGCCATAAAGGGTATATACGAATGCGAAGAAGATATAATAAAAATGAGGGAAA
CCTACGACCAAAGAAGGCGGTTTATCGTAAATGGATTCCGCGAAATAGGTCTTGACTGTTTTGAACCCAAAGGAGCGTTT
TACATTTTTCCTTCAATAAAAAAGACAGGCATGACTTCTGAAGAGTTCTGCGAAAAACTTTTAAAAGAAGAAAAAGTAGC
AGTAGTACCCGGAAATGCCTTTGGTCCAAGTGGTGAAGGTTATGTTAGGGTCTCGTATGCGTATTCTATAGATAAAATAG
CAAAGGCACTTGAAAGGATAAAACGCTTTGCTGAAAAAATATTATAA

Upstream 100 bases:

>100_bases
GCGTCCTGAGTATCACAACTCATTTTATACTTAAAAGGTATAAAGAGGACGGCGTATTATATGAAGAGAATCAAGATGAT
AAAAGACTGGTGATAGCACC

Downstream 100 bases:

>100_bases
AAGAATGAGAAAGTGGGGCTAAATTATTATGAGCCCCATTTTTTAGCAAAGTTAATTTTCTTTATTCAATTTGTACTCTA
TTGAATCAACGAGAGCTTTC

Product: PLP-dependent aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNPNKYISDVVKKIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGIETLCRGNTTYTSNLGLLELRIAISYFL
KTHYDLNYDPEKEIMVTIGASEAIDLALRALLNDGDEVLIPEPSYVSYAPCVILTRGVPVFIPTDEKNNFILTPDDLRSK
ITSKTKALILLYPNNPTGAIMKKEDLEEIVDVIIEKDLIVISDEIYSELTYEGKHVSIASLPGMKERTILINGFSKAFAM
TGWRLGYIAAEHEFIEAMNKIHQYTTICAPITAQYAAIKGIYECEEDIIKMRETYDQRRRFIVNGFREIGLDCFEPKGAF
YIFPSIKKTGMTSEEFCEKLLKEEKVAVVPGNAFGPSGEGYVRVSYAYSIDKIAKALERIKRFAEKIL

Sequences:

>Translated_388_residues
MNPNKYISDVVKKIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGIETLCRGNTTYTSNLGLLELRIAISYFL
KTHYDLNYDPEKEIMVTIGASEAIDLALRALLNDGDEVLIPEPSYVSYAPCVILTRGVPVFIPTDEKNNFILTPDDLRSK
ITSKTKALILLYPNNPTGAIMKKEDLEEIVDVIIEKDLIVISDEIYSELTYEGKHVSIASLPGMKERTILINGFSKAFAM
TGWRLGYIAAEHEFIEAMNKIHQYTTICAPITAQYAAIKGIYECEEDIIKMRETYDQRRRFIVNGFREIGLDCFEPKGAF
YIFPSIKKTGMTSEEFCEKLLKEEKVAVVPGNAFGPSGEGYVRVSYAYSIDKIAKALERIKRFAEKIL
>Mature_388_residues
MNPNKYISDVVKKIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGIETLCRGNTTYTSNLGLLELRIAISYFL
KTHYDLNYDPEKEIMVTIGASEAIDLALRALLNDGDEVLIPEPSYVSYAPCVILTRGVPVFIPTDEKNNFILTPDDLRSK
ITSKTKALILLYPNNPTGAIMKKEDLEEIVDVIIEKDLIVISDEIYSELTYEGKHVSIASLPGMKERTILINGFSKAFAM
TGWRLGYIAAEHEFIEAMNKIHQYTTICAPITAQYAAIKGIYECEEDIIKMRETYDQRRRFIVNGFREIGLDCFEPKGAF
YIFPSIKKTGMTSEEFCEKLLKEEKVAVVPGNAFGPSGEGYVRVSYAYSIDKIAKALERIKRFAEKIL

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=323, Percent_Identity=30.9597523219814, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI169881279, Length=323, Percent_Identity=30.9597523219814, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI56713254, Length=390, Percent_Identity=31.5384615384615, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI56713256, Length=390, Percent_Identity=31.5384615384615, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI169881281, Length=228, Percent_Identity=32.0175438596491, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4507369, Length=389, Percent_Identity=25.1928020565553, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI215599424, Length=392, Percent_Identity=24.4897959183673, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI19263340, Length=392, Percent_Identity=24.4897959183673, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI187936925, Length=395, Percent_Identity=24.0506329113924, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI14211921, Length=395, Percent_Identity=24.0506329113924, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788722, Length=365, Percent_Identity=33.1506849315069, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786816, Length=378, Percent_Identity=27.7777777777778, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788627, Length=373, Percent_Identity=32.7077747989276, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1788332, Length=229, Percent_Identity=27.5109170305677, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790797, Length=310, Percent_Identity=24.8387096774194, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=406, Percent_Identity=29.064039408867, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994472, Length=406, Percent_Identity=29.064039408867, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17567369, Length=397, Percent_Identity=26.9521410579345, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17567663, Length=404, Percent_Identity=29.2079207920792, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322401, Length=323, Percent_Identity=27.5541795665635, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323118, Length=369, Percent_Identity=25.2032520325203, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320317, Length=351, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573069, Length=405, Percent_Identity=26.6666666666667, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646114, Length=405, Percent_Identity=26.6666666666667, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28573067, Length=405, Percent_Identity=26.6666666666667, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28573065, Length=405, Percent_Identity=26.6666666666667, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI18859735, Length=390, Percent_Identity=25.6410256410256, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24641770, Length=398, Percent_Identity=22.8643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641760, Length=398, Percent_Identity=22.8643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641768, Length=398, Percent_Identity=22.8643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641766, Length=398, Percent_Identity=22.8643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641764, Length=398, Percent_Identity=22.8643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551451, Length=398, Percent_Identity=22.8643216080402, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 43809; Mature: 43809

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNKYISDVVKKIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGIETLCRGN
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCC
TTYTSNLGLLELRIAISYFLKTHYDLNYDPEKEIMVTIGASEAIDLALRALLNDGDEVLI
CEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEE
PEPSYVSYAPCVILTRGVPVFIPTDEKNNFILTPDDLRSKITSKTKALILLYPNNPTGAI
CCCCCCCCCCEEEEECCEEEEEECCCCCCEEECCHHHHHHHCCCCEEEEEEECCCCCCCC
MKKEDLEEIVDVIIEKDLIVISDEIYSELTYEGKHVSIASLPGMKERTILINGFSKAFAM
CCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCHHHHHH
TGWRLGYIAAEHEFIEAMNKIHQYTTICAPITAQYAAIKGIYECEEDIIKMRETYDQRRR
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVNGFREIGLDCFEPKGAFYIFPSIKKTGMTSEEFCEKLLKEEKVAVVPGNAFGPSGEG
HHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
YVRVSYAYSIDKIAKALERIKRFAEKIL
EEEEEEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPNKYISDVVKKIPPSGIRKFFDLVTNSKDIISLGVGEPDFVTPWEIRKEGIETLCRGN
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCC
TTYTSNLGLLELRIAISYFLKTHYDLNYDPEKEIMVTIGASEAIDLALRALLNDGDEVLI
CEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEE
PEPSYVSYAPCVILTRGVPVFIPTDEKNNFILTPDDLRSKITSKTKALILLYPNNPTGAI
CCCCCCCCCCEEEEECCEEEEEECCCCCCEEECCHHHHHHHCCCCEEEEEEECCCCCCCC
MKKEDLEEIVDVIIEKDLIVISDEIYSELTYEGKHVSIASLPGMKERTILINGFSKAFAM
CCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCHHHHHH
TGWRLGYIAAEHEFIEAMNKIHQYTTICAPITAQYAAIKGIYECEEDIIKMRETYDQRRR
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVNGFREIGLDCFEPKGAFYIFPSIKKTGMTSEEFCEKLLKEEKVAVVPGNAFGPSGEG
HHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCC
YVRVSYAYSIDKIAKALERIKRFAEKIL
EEEEEEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]