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The map label for this gene is ComEC2 [H]

Identifier: 20808791

GI number: 20808791

Start: 2321374

End: 2322300

Strand: Reverse

Name: ComEC2 [H]

Synonym: TTE2430

Alternate gene names: 20808791

Gene position: 2322300-2321374 (Counterclockwise)

Preceding gene: 20808792

Following gene: 20808787

Centisome position: 86.35

GC content: 38.19

Gene sequence:

>927_bases
ATGTTTAGACTAAAGGTAGCAGCACTTTTTACAGTAATGCTTTTAATATTTACTTTTTCAGGATGTACGTCTTTTCCACA
CAGTGAGTTTTCAAATGCTCAGAAATCTTATGACTCAATTACCGACAATTGCCAATTGCCAGCAATTTCAAGTGAAGATT
TATCCTCCAAACTGGTTGTCAGTTTCATAGATGTGGGGCAGGGAGACAGCATATTTATAAAAACCCCTTCTGACAAGACA
ATGCTAATAGATGCTGGTACTCCTGAGATGGGGGAAAGGGTGGTTAATTATATAAAAAAGCAGGGCGTAAGGAAGATAGA
TGTATTGGTGGGCACGCACCCTCACACTGACCACATAGGGGGGCTTCCGGAAGTAATTCAAAATTTTGATATAGGTAAAT
TTTATATGCCAAAAGTAACTACGACTACTAGCGCATTTGAGAATGTATTAAAAGCGGCAAAAGCAAAAAAATTGCCAATA
TACGTGGCAAAGGCAGGGGTAACACTTTATTTAGGAACGGAAATAGAGGCTAAAATGCTTGCTCCAAACAGCTCTTACTA
TGAAGATTTAAATAACTACAGTGCAGTTATAAAAATAACTTATGGGGATACTGCATTTCTATTTACGGGTGATGCAGAAA
AAGAATCGGAAAGAGAAATGCTTAACGAAAACTATAATTTAAAGGCGGACGTACTAAAAGTAGGGCATCATGGAAGTTCT
TCATCTTCTTCATGGAGTTTTCTGAAAGAAGTGAGGCCCAAATATGCAGTTATCTCTTGCGGGAAAAATAATGAATACGG
CCATCCCCACGGAGAGACTCTGGAAAAATTAAGTGAGTTGGGGATAACCGTATACAGGACAGATGAATGTGGCACAATTG
TGGCAGTAAGTGATGGAAAGACAGTATCTTTTTTTAGAATCAAATAG

Upstream 100 bases:

>100_bases
TAAATTTGAAGTTATGGTAGATGAAGAAGAGACAAAAAGAAAGAAGGAAAGGATTGAAAAGCTTGCAGATGAGCTTTTTA
CAGAGGAGGAATAGTAGCAC

Downstream 100 bases:

>100_bases
GGTATAGCGTAAAATAGTTTATAAAATATTAATAGGATTTAGCCTATTTCTATGGAAGGATTGCTCGAGTCAAGGAAAAA
TGCTGATGTTTTGGTGCCAA

Product: hydrolase of metallo-beta-lactamase fold

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MFRLKVAALFTVMLLIFTFSGCTSFPHSEFSNAQKSYDSITDNCQLPAISSEDLSSKLVVSFIDVGQGDSIFIKTPSDKT
MLIDAGTPEMGERVVNYIKKQGVRKIDVLVGTHPHTDHIGGLPEVIQNFDIGKFYMPKVTTTTSAFENVLKAAKAKKLPI
YVAKAGVTLYLGTEIEAKMLAPNSSYYEDLNNYSAVIKITYGDTAFLFTGDAEKESEREMLNENYNLKADVLKVGHHGSS
SSSSWSFLKEVRPKYAVISCGKNNEYGHPHGETLEKLSELGITVYRTDECGTIVAVSDGKTVSFFRIK

Sequences:

>Translated_308_residues
MFRLKVAALFTVMLLIFTFSGCTSFPHSEFSNAQKSYDSITDNCQLPAISSEDLSSKLVVSFIDVGQGDSIFIKTPSDKT
MLIDAGTPEMGERVVNYIKKQGVRKIDVLVGTHPHTDHIGGLPEVIQNFDIGKFYMPKVTTTTSAFENVLKAAKAKKLPI
YVAKAGVTLYLGTEIEAKMLAPNSSYYEDLNNYSAVIKITYGDTAFLFTGDAEKESEREMLNENYNLKADVLKVGHHGSS
SSSSWSFLKEVRPKYAVISCGKNNEYGHPHGETLEKLSELGITVYRTDECGTIVAVSDGKTVSFFRIK
>Mature_308_residues
MFRLKVAALFTVMLLIFTFSGCTSFPHSEFSNAQKSYDSITDNCQLPAISSEDLSSKLVVSFIDVGQGDSIFIKTPSDKT
MLIDAGTPEMGERVVNYIKKQGVRKIDVLVGTHPHTDHIGGLPEVIQNFDIGKFYMPKVTTTTSAFENVLKAAKAKKLPI
YVAKAGVTLYLGTEIEAKMLAPNSSYYEDLNNYSAVIKITYGDTAFLFTGDAEKESEREMLNENYNLKADVLKVGHHGSS
SSSSWSFLKEVRPKYAVISCGKNNEYGHPHGETLEKLSELGITVYRTDECGTIVAVSDGKTVSFFRIK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 33965; Mature: 33965

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLKVAALFTVMLLIFTFSGCTSFPHSEFSNAQKSYDSITDNCQLPAISSEDLSSKLVV
CEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEE
SFIDVGQGDSIFIKTPSDKTMLIDAGTPEMGERVVNYIKKQGVRKIDVLVGTHPHTDHIG
EEEECCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCC
GLPEVIQNFDIGKFYMPKVTTTTSAFENVLKAAKAKKLPIYVAKAGVTLYLGTEIEAKML
CHHHHHHCCCCCCEECCCEECHHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCEEEEE
APNSSYYEDLNNYSAVIKITYGDTAFLFTGDAEKESEREMLNENYNLKADVLKVGHHGSS
CCCCHHHHHCCCCEEEEEEEECCEEEEEECCCCCHHHHHHHCCCCCCEEEEEEECCCCCC
SSSSWSFLKEVRPKYAVISCGKNNEYGHPHGETLEKLSELGITVYRTDECGTIVAVSDGK
CCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEECCCC
TVSFFRIK
EEEEEEEC
>Mature Secondary Structure
MFRLKVAALFTVMLLIFTFSGCTSFPHSEFSNAQKSYDSITDNCQLPAISSEDLSSKLVV
CEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEE
SFIDVGQGDSIFIKTPSDKTMLIDAGTPEMGERVVNYIKKQGVRKIDVLVGTHPHTDHIG
EEEECCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCC
GLPEVIQNFDIGKFYMPKVTTTTSAFENVLKAAKAKKLPIYVAKAGVTLYLGTEIEAKML
CHHHHHHCCCCCCEECCCEECHHHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCEEEEE
APNSSYYEDLNNYSAVIKITYGDTAFLFTGDAEKESEREMLNENYNLKADVLKVGHHGSS
CCCCHHHHHCCCCEEEEEEEECCEEEEEECCCCCHHHHHHHCCCCCCEEEEEEECCCCCC
SSSSWSFLKEVRPKYAVISCGKNNEYGHPHGETLEKLSELGITVYRTDECGTIVAVSDGK
CCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEECCCC
TVSFFRIK
EEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]