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The map label for this gene is BioF [C]

Identifier: 20808769

GI number: 20808769

Start: 2294889

End: 2296121

Strand: Direct

Name: BioF [C]

Synonym: TTE2406

Alternate gene names: 20808769

Gene position: 2294889-2296121 (Clockwise)

Preceding gene: 20808768

Following gene: 20808770

Centisome position: 85.33

GC content: 39.82

Gene sequence:

>1233_bases
ATGCCGCTTTCACGAATAACCCAGGTTTTATCACAGGAATTAGAAGAATTAAGGTCAGAAGGACGAGCAAAAGGAAAAGA
ATTTATAGTGGTGGACGTGAAAAAACCCCAAAACGGAAAGGGACCGCGATTTTTCTTAAAAGGATATGGTGATAAAGAAT
TTATAAGGATGAATTCCAACTCCTACCTCGGGATGCAATTTAATGATGAAGTAATAAAGGCTGAAGAAGAAGCCGCAAGG
AAATTTGGTGTAGGCCCCGGCGCAGTGAGATTTATAAGCGGCACCTACGTAACCCACAGAGACCTGGAAAAAAGGCTGGC
TCGGTTCCATCAAAGGGAAGATGCAATGATCTTTAGCTCTGCCTATATGACAGTAGTAGGAATAATATCTTCCCTGACAA
CCCCTGAAACAGGCATAATAAGCGATGAACTGAATCACAACTGCATTATCAACGCCATAAGGCTTTCAAGGCCTAAAGAA
AGGTATGTATACAAGCATCTTGACTACGATGACTTAGAAAACGGTATAAAAAGCCTCATAGGCAAAGTAAAGCGAGTAAT
AGTGGTAACTGATGGAGTATTCAGCATGAGAGGAGACTACGCGAATTTAAAGAAGATAGAAGAAATTACCTCTAAATATG
ACGAAAAATTTGAAGAAAATATAATAACCATTGTGGACGATTCCCACGGTGTTGGCGCTTTTGGTGATACAGGAAGAGGT
ACAGAAGAAGTCACTGGAGGAAAGGCAGACCTTTTAATAGGCACAATGGGAAAAGCTTATGGGGTAAATGGAGGATATGT
AGTATCCAGTGAAGTTATTACGACTTACCTGAGAGAAAAAGCAATAACCTACATTTACTCCAACCCCATCACTCCTTCAG
AAGCCGCTTCTGTATTAAAAGTCTTGGAGATAATAGATAGCGATGAAGGCAAGAAGAAGCTCTCCCATCTGAAGGAGATG
GCTAAAAGATTTAGAGAAGGGCTTTTAAATTTGGGATATGAGACTGTCGTAAGTGAACATCCTATAGTACCTCTTCTTGT
GAGAGATACAAAAAAGACAGTAGAGTTAGTAAATTATCTCGTAGAAAACGGAATACTCGCAACAGCCATTAATTACCCAG
TGGTGCCCAAAGGCGATGAAAGCATCAGATTTCAGATAAATGCGGACCACACTCCTTCTGATATAGACTACGTTTTAGAA
GTTCTAAGGCATTACAAAGAAAAAAATAATTAA

Upstream 100 bases:

>100_bases
ACCCACACATTCCCTCTTACCGAATACCAGAAGGGAATGGAACTCATGATAAAAGGGCAGTGCGGTAAAGTCGTATTATA
TCCGTAAAGGAGTGATTTTA

Downstream 100 bases:

>100_bases
AGCCCCTCCCTCGGGGGCTTTTTTCTATAGACAAACCCTTTTTCATGTGATATAATTAGAAAGAAAAATTGAAAAAACCC
TTTAATTTAGCCCAGCGAGG

Product: 7-keto-8-aminopelargonate synthetase and related enzyme

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MPLSRITQVLSQELEELRSEGRAKGKEFIVVDVKKPQNGKGPRFFLKGYGDKEFIRMNSNSYLGMQFNDEVIKAEEEAAR
KFGVGPGAVRFISGTYVTHRDLEKRLARFHQREDAMIFSSAYMTVVGIISSLTTPETGIISDELNHNCIINAIRLSRPKE
RYVYKHLDYDDLENGIKSLIGKVKRVIVVTDGVFSMRGDYANLKKIEEITSKYDEKFEENIITIVDDSHGVGAFGDTGRG
TEEVTGGKADLLIGTMGKAYGVNGGYVVSSEVITTYLREKAITYIYSNPITPSEAASVLKVLEIIDSDEGKKKLSHLKEM
AKRFREGLLNLGYETVVSEHPIVPLLVRDTKKTVELVNYLVENGILATAINYPVVPKGDESIRFQINADHTPSDIDYVLE
VLRHYKEKNN

Sequences:

>Translated_410_residues
MPLSRITQVLSQELEELRSEGRAKGKEFIVVDVKKPQNGKGPRFFLKGYGDKEFIRMNSNSYLGMQFNDEVIKAEEEAAR
KFGVGPGAVRFISGTYVTHRDLEKRLARFHQREDAMIFSSAYMTVVGIISSLTTPETGIISDELNHNCIINAIRLSRPKE
RYVYKHLDYDDLENGIKSLIGKVKRVIVVTDGVFSMRGDYANLKKIEEITSKYDEKFEENIITIVDDSHGVGAFGDTGRG
TEEVTGGKADLLIGTMGKAYGVNGGYVVSSEVITTYLREKAITYIYSNPITPSEAASVLKVLEIIDSDEGKKKLSHLKEM
AKRFREGLLNLGYETVVSEHPIVPLLVRDTKKTVELVNYLVENGILATAINYPVVPKGDESIRFQINADHTPSDIDYVLE
VLRHYKEKNN
>Mature_409_residues
PLSRITQVLSQELEELRSEGRAKGKEFIVVDVKKPQNGKGPRFFLKGYGDKEFIRMNSNSYLGMQFNDEVIKAEEEAARK
FGVGPGAVRFISGTYVTHRDLEKRLARFHQREDAMIFSSAYMTVVGIISSLTTPETGIISDELNHNCIINAIRLSRPKER
YVYKHLDYDDLENGIKSLIGKVKRVIVVTDGVFSMRGDYANLKKIEEITSKYDEKFEENIITIVDDSHGVGAFGDTGRGT
EEVTGGKADLLIGTMGKAYGVNGGYVVSSEVITTYLREKAITYIYSNPITPSEAASVLKVLEIIDSDEGKKKLSHLKEMA
KRFREGLLNLGYETVVSEHPIVPLLVRDTKKTVELVNYLVENGILATAINYPVVPKGDESIRFQINADHTPSDIDYVLEV
LRHYKEKNN

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=403, Percent_Identity=34.4913151364764, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI284448556, Length=422, Percent_Identity=33.4123222748815, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI83977442, Length=353, Percent_Identity=30.8781869688385, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI83977444, Length=353, Percent_Identity=30.8781869688385, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI83977440, Length=353, Percent_Identity=30.8781869688385, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4502025, Length=350, Percent_Identity=33.1428571428571, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI40316939, Length=350, Percent_Identity=33.1428571428571, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=28.2608695652174, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI4758668, Length=368, Percent_Identity=27.445652173913, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI5454084, Length=300, Percent_Identity=26.3333333333333, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=34.8370927318296, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=34.0909090909091, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71994529, Length=363, Percent_Identity=38.0165289256198, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=29.7297297297297, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17560914, Length=367, Percent_Identity=27.7929155313352, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=367, Percent_Identity=27.7929155313352, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=282, Percent_Identity=26.241134751773, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=282, Percent_Identity=26.241134751773, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320267, Length=370, Percent_Identity=30.5405405405405, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320438, Length=364, Percent_Identity=29.3956043956044, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=307, Percent_Identity=24.7557003257329, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24662918, Length=403, Percent_Identity=33.4987593052109, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=32.183908045977, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI17136286, Length=366, Percent_Identity=30.6010928961749, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653280, Length=399, Percent_Identity=25.5639097744361, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24653276, Length=399, Percent_Identity=25.5639097744361, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24653278, Length=399, Percent_Identity=25.5639097744361, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 46000; Mature: 45869

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSRITQVLSQELEELRSEGRAKGKEFIVVDVKKPQNGKGPRFFLKGYGDKEFIRMNSN
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCEEEEECCC
SYLGMQFNDEVIKAEEEAARKFGVGPGAVRFISGTYVTHRDLEKRLARFHQREDAMIFSS
CEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHH
AYMTVVGIISSLTTPETGIISDELNHNCIINAIRLSRPKERYVYKHLDYDDLENGIKSLI
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHCCCCHHHHHHHCCCHHHHHHHHHHHH
GKVKRVIVVTDGVFSMRGDYANLKKIEEITSKYDEKFEENIITIVDDSHGVGAFGDTGRG
HHHHEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCC
TEEVTGGKADLLIGTMGKAYGVNGGYVVSSEVITTYLREKAITYIYSNPITPSEAASVLK
CHHCCCCCCEEEEEECCHHHCCCCCEEEHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
VLEIIDSDEGKKKLSHLKEMAKRFREGLLNLGYETVVSEHPIVPLLVRDTKKTVELVNYL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCHHHHHHHHHHH
VENGILATAINYPVVPKGDESIRFQINADHTPSDIDYVLEVLRHYKEKNN
HHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLSRITQVLSQELEELRSEGRAKGKEFIVVDVKKPQNGKGPRFFLKGYGDKEFIRMNSN
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCEEEEECCC
SYLGMQFNDEVIKAEEEAARKFGVGPGAVRFISGTYVTHRDLEKRLARFHQREDAMIFSS
CEEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHH
AYMTVVGIISSLTTPETGIISDELNHNCIINAIRLSRPKERYVYKHLDYDDLENGIKSLI
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHCCCCHHHHHHHCCCHHHHHHHHHHHH
GKVKRVIVVTDGVFSMRGDYANLKKIEEITSKYDEKFEENIITIVDDSHGVGAFGDTGRG
HHHHEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCC
TEEVTGGKADLLIGTMGKAYGVNGGYVVSSEVITTYLREKAITYIYSNPITPSEAASVLK
CHHCCCCCCEEEEEECCHHHCCCCCEEEHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHH
VLEIIDSDEGKKKLSHLKEMAKRFREGLLNLGYETVVSEHPIVPLLVRDTKKTVELVNYL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCHHHHHHHHHHH
VENGILATAINYPVVPKGDESIRFQINADHTPSDIDYVLEVLRHYKEKNN
HHCCEEEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA