Click here to switch to the map view.

The map label for this gene is tdh [H]

Identifier: 20808768

GI number: 20808768

Start: 2293823

End: 2294875

Strand: Direct

Name: tdh [H]

Synonym: TTE2405

Alternate gene names: 20808768

Gene position: 2293823-2294875 (Clockwise)

Preceding gene: 20808766

Following gene: 20808769

Centisome position: 85.29

GC content: 41.5

Gene sequence:

>1053_bases
ATGTCTATTATGGATGGACTTATGACCGCCGTGGTAAAACAATACCACAAAGAAGGGGCAGATATAGTAAAAAAGGAAAT
ACCAAAGATAGGCCCTGATGAAGTTTTGATAAAAGTTAAAGCTACTTCTATTTGCGGCACAGACGTTCACATATACGTCT
GGAATGAATGGGCAAAAAGTAGAATAAAACCTCCAAAAACGATGGGACACGAATTTGTAGGAGAGGTTGTAGAAATTGGA
GAAAATGTCACATCAGTAAAAGTGGGAGACTTAGTAAGCGCAGAAACTCATATAGTATGCGGAAAGTGCAGAGCCTGCAG
AACCGGCAACGCTCACATATGTGAAAATACCCTCATTTTAGGCGTTGACACAGATGGAGCTTTTGCAGAATACATCAAAG
TTCCTGAAAGCAATGTGTGGATAAACGACAAAAACATACCTCTAGAGATACTATCCATACAGGAACCTCTTGGAAACGCA
GTCCACACTGTTTTTTCAGGAGACGTAGTTGGAAAATCTGTAGCTGTCATAGGATGCGGCCCAATAGGAATGATGGCAAT
ACCACTTCTTAAAAGAACAGGTGCTGCAGCAATATTCGCGATTGAACCTGCTGACTACAGGAGAGAGTTGGCTCACAAGC
TTGGTGCAACAAGGGTTATAAATCCTCTCCGCGAAGACGTTGTCAGCATAATAAAAAGTGAAACAGAAGGCTATGGAGCA
GATGTAGTTTTGGACTTTTCAGGTAACCCAACCGCCATAAGGCAGGGTCTAGAGTACATTGCAAAAGGTGGCAGAATGTC
TATTCTAGGCCTTCCTGACAATGAAGTTCCAATTGACATCACAAATAATGTGGTATTCAAAGGAATAACTATACAAGGCA
TAACTGGAAGAAGAATGTACGATACCTGGTACACCGTAAAGGGCTTACTAAAATCAGGTCTTGCAGAAGATTTAAAGCCA
ATAATCACCCACACATTCCCTCTTACCGAATACCAGAAGGGAATGGAACTCATGATAAAAGGGCAGTGCGGTAAAGTCGT
ATTATATCCGTAA

Upstream 100 bases:

>100_bases
TTTAATAATACCTTTTCAAATTTTTTTGTACTTGCAAGGAGGAATTTGTACAAAAATATAGAATATATTATGTAGTAAAA
TTAGTGTACAAGTAAAGGAG

Downstream 100 bases:

>100_bases
AGGAGTGATTTTAATGCCGCTTTCACGAATAACCCAGGTTTTATCACAGGAATTAGAAGAATTAAGGTCAGAAGGACGAG
CAAAAGGAAAAGAATTTATA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSIMDGLMTAVVKQYHKEGADIVKKEIPKIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRIKPPKTMGHEFVGEVVEIG
ENVTSVKVGDLVSAETHIVCGKCRACRTGNAHICENTLILGVDTDGAFAEYIKVPESNVWINDKNIPLEILSIQEPLGNA
VHTVFSGDVVGKSVAVIGCGPIGMMAIPLLKRTGAAAIFAIEPADYRRELAHKLGATRVINPLREDVVSIIKSETEGYGA
DVVLDFSGNPTAIRQGLEYIAKGGRMSILGLPDNEVPIDITNNVVFKGITIQGITGRRMYDTWYTVKGLLKSGLAEDLKP
IITHTFPLTEYQKGMELMIKGQCGKVVLYP

Sequences:

>Translated_350_residues
MSIMDGLMTAVVKQYHKEGADIVKKEIPKIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRIKPPKTMGHEFVGEVVEIG
ENVTSVKVGDLVSAETHIVCGKCRACRTGNAHICENTLILGVDTDGAFAEYIKVPESNVWINDKNIPLEILSIQEPLGNA
VHTVFSGDVVGKSVAVIGCGPIGMMAIPLLKRTGAAAIFAIEPADYRRELAHKLGATRVINPLREDVVSIIKSETEGYGA
DVVLDFSGNPTAIRQGLEYIAKGGRMSILGLPDNEVPIDITNNVVFKGITIQGITGRRMYDTWYTVKGLLKSGLAEDLKP
IITHTFPLTEYQKGMELMIKGQCGKVVLYP
>Mature_349_residues
SIMDGLMTAVVKQYHKEGADIVKKEIPKIGPDEVLIKVKATSICGTDVHIYVWNEWAKSRIKPPKTMGHEFVGEVVEIGE
NVTSVKVGDLVSAETHIVCGKCRACRTGNAHICENTLILGVDTDGAFAEYIKVPESNVWINDKNIPLEILSIQEPLGNAV
HTVFSGDVVGKSVAVIGCGPIGMMAIPLLKRTGAAAIFAIEPADYRRELAHKLGATRVINPLREDVVSIIKSETEGYGAD
VVLDFSGNPTAIRQGLEYIAKGGRMSILGLPDNEVPIDITNNVVFKGITIQGITGRRMYDTWYTVKGLLKSGLAEDLKPI
ITHTFPLTEYQKGMELMIKGQCGKVVLYP

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=26.9938650306748, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=27.2479564032698, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501929, Length=352, Percent_Identity=28.6931818181818, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI34577061, Length=356, Percent_Identity=28.6516853932584, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=27.1468144044321, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=382, Percent_Identity=28.7958115183246, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=28.8409703504043, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4501933, Length=352, Percent_Identity=28.125, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565152, Length=359, Percent_Identity=25.9052924791086, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71565154, Length=352, Percent_Identity=25.5681818181818, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=45.4545454545455, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1788073, Length=326, Percent_Identity=31.9018404907975, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI226510992, Length=315, Percent_Identity=29.8412698412698, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788075, Length=339, Percent_Identity=29.4985250737463, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787863, Length=335, Percent_Identity=29.5522388059701, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI87082125, Length=346, Percent_Identity=30.9248554913295, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786825, Length=381, Percent_Identity=27.8215223097113, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1790718, Length=322, Percent_Identity=27.0186335403727, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=24.8520710059172, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786552, Length=356, Percent_Identity=29.7752808988764, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=28.3582089552239, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787572, Length=205, Percent_Identity=27.8048780487805, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786518, Length=297, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=29.2035398230088, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=197, Percent_Identity=31.9796954314721, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=279, Percent_Identity=29.0322580645161, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=284, Percent_Identity=27.8169014084507, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=300, Percent_Identity=27, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=319, Percent_Identity=32.2884012539185, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=28.023598820059, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=28.023598820059, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=357, Percent_Identity=30.2521008403361, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=372, Percent_Identity=30.6451612903226, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=290, Percent_Identity=30, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319621, Length=299, Percent_Identity=29.0969899665552, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=299, Percent_Identity=28.7625418060201, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=300, Percent_Identity=30.6666666666667, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=326, Percent_Identity=28.8343558282209, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319949, Length=290, Percent_Identity=25.8620689655172, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=211, Percent_Identity=28.9099526066351, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=26.9461077844311, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17737897, Length=331, Percent_Identity=26.2839879154079, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17737895, Length=349, Percent_Identity=28.6532951289398, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38056; Mature: 37925

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIMDGLMTAVVKQYHKEGADIVKKEIPKIGPDEVLIKVKATSICGTDVHIYVWNEWAKS
CCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEEEEEECCEEEEEEECHHHHC
RIKPPKTMGHEFVGEVVEIGENVTSVKVGDLVSAETHIVCGKCRACRTGNAHICENTLIL
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCEEECCEEEE
GVDTDGAFAEYIKVPESNVWINDKNIPLEILSIQEPLGNAVHTVFSGDVVGKSVAVIGCG
EECCCCHHHHHHCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEECC
PIGMMAIPLLKRTGAAAIFAIEPADYRRELAHKLGATRVINPLREDVVSIIKSETEGYGA
CHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
DVVLDFSGNPTAIRQGLEYIAKGGRMSILGLPDNEVPIDITNNVVFKGITIQGITGRRMY
EEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCEEEEEEEEECCCCCEEH
DTWYTVKGLLKSGLAEDLKPIITHTFPLTEYQKGMELMIKGQCGKVVLYP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEECCCCEEEECC
>Mature Secondary Structure 
SIMDGLMTAVVKQYHKEGADIVKKEIPKIGPDEVLIKVKATSICGTDVHIYVWNEWAKS
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEEEEEEECCEEEEEEECHHHHC
RIKPPKTMGHEFVGEVVEIGENVTSVKVGDLVSAETHIVCGKCRACRTGNAHICENTLIL
CCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEECCCCCCCCCCCEEECCEEEE
GVDTDGAFAEYIKVPESNVWINDKNIPLEILSIQEPLGNAVHTVFSGDVVGKSVAVIGCG
EECCCCHHHHHHCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEECC
PIGMMAIPLLKRTGAAAIFAIEPADYRRELAHKLGATRVINPLREDVVSIIKSETEGYGA
CHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
DVVLDFSGNPTAIRQGLEYIAKGGRMSILGLPDNEVPIDITNNVVFKGITIQGITGRRMY
EEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCEEEEEEEEECCCCCEEH
DTWYTVKGLLKSGLAEDLKPIITHTFPLTEYQKGMELMIKGQCGKVVLYP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]