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The map label for this gene is Map [H]

Identifier: 20808639

GI number: 20808639

Start: 2164580

End: 2165326

Strand: Reverse

Name: Map [H]

Synonym: TTE2270

Alternate gene names: 20808639

Gene position: 2165326-2164580 (Counterclockwise)

Preceding gene: 20808640

Following gene: 20808638

Centisome position: 80.51

GC content: 41.37

Gene sequence:

>747_bases
ATGATATACATTAAATCTGAAAAAGAAATTGAGCTCATGAGAGTAGCTGGGAAAGTGATAGCAAACCTCTTTGAGGTTTT
AGAGAAGGTGATAAAGCCTGGTGTTACTACTTTAGAGCTTGATAGAATTGCAGAAGAGTTTATAATAAAAAATGGATGCA
TTCCTGCTTTTAAAGGACTTTATGGCTTCCCAGCGAGCATATGTGCTTCTGTGAATGACGAAGTTGTGCACGGGATACCT
GGTTTAAGAAAGCTTCAAGAAGGCGATATTATAAGTATAGACCTGGGAGCCAATTACAAGGGCTACAATGCTGATGCAGC
GAGGACCTTTCCTGTAGGGGAGATATCTGATGAAGCTAAAAAGCTTATTGAAGTGACAAGAGAGAGTTTTTTTGAAGGCA
TAAAATACGCTAGAGAAGGCAATAGATTGTCAGATATTTCCCACGCAATACAGGTATATGTGGAAAGCCACGGCTTTTCA
GTGGTGAGAGATTACGTGGGGCATGGAATAGGGAGAAAAATGCATGAAGACCCCCAAATTCCCAATTTTGGACCTCCAGG
CAAAGGGCCAAGGTTAAAAAGAGGGATGACTCTTGCAATAGAGCCCATGGTGAATGCAGGGCATTACTCTGTTAGAACTT
TAGAAGATAACTGGACAGTGGTAACAGTAGATGGCAGTCTTTCGGCTCACTATGAAAACACGATTGTCATTACAGAAGGG
GAGCCGGAAATACTGACCATTTTGTAA

Upstream 100 bases:

>100_bases
TATTATACAAAAAAAGGTATTTTGGTAAACATCGATGGAAATAAATCAATTGATGAGGTATTTGAAGACATAAAAAAGGC
TTTGTTAGGAGATAGGAGAG

Downstream 100 bases:

>100_bases
GAGGTGAAGAAGTTAATGGACGATTTGCAACTTGGCCAGGTAGTGAGGAGTAAAGCTGGTCGAGACAAGGGCAGAGTATT
TGTTGTAGTAGGTAGAGTAG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIYIKSEKEIELMRVAGKVIANLFEVLEKVIKPGVTTLELDRIAEEFIIKNGCIPAFKGLYGFPASICASVNDEVVHGIP
GLRKLQEGDIISIDLGANYKGYNADAARTFPVGEISDEAKKLIEVTRESFFEGIKYAREGNRLSDISHAIQVYVESHGFS
VVRDYVGHGIGRKMHEDPQIPNFGPPGKGPRLKRGMTLAIEPMVNAGHYSVRTLEDNWTVVTVDGSLSAHYENTIVITEG
EPEILTIL

Sequences:

>Translated_248_residues
MIYIKSEKEIELMRVAGKVIANLFEVLEKVIKPGVTTLELDRIAEEFIIKNGCIPAFKGLYGFPASICASVNDEVVHGIP
GLRKLQEGDIISIDLGANYKGYNADAARTFPVGEISDEAKKLIEVTRESFFEGIKYAREGNRLSDISHAIQVYVESHGFS
VVRDYVGHGIGRKMHEDPQIPNFGPPGKGPRLKRGMTLAIEPMVNAGHYSVRTLEDNWTVVTVDGSLSAHYENTIVITEG
EPEILTIL
>Mature_248_residues
MIYIKSEKEIELMRVAGKVIANLFEVLEKVIKPGVTTLELDRIAEEFIIKNGCIPAFKGLYGFPASICASVNDEVVHGIP
GLRKLQEGDIISIDLGANYKGYNADAARTFPVGEISDEAKKLIEVTRESFFEGIKYAREGNRLSDISHAIQVYVESHGFS
VVRDYVGHGIGRKMHEDPQIPNFGPPGKGPRLKRGMTLAIEPMVNAGHYSVRTLEDNWTVVTVDGSLSAHYENTIVITEG
EPEILTIL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=39.0243902439024, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=38.0566801619433, Blast_Score=171, Evalue=6e-43,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=45.5645161290323, Blast_Score=221, Evalue=3e-59,
Organism=Escherichia coli, GI1788728, Length=208, Percent_Identity=27.4038461538462, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789275, Length=149, Percent_Identity=26.1744966442953, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=38.4615384615385, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=38.2113821138211, Blast_Score=177, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=41.2244897959184, Blast_Score=203, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=36.3265306122449, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27371; Mature: 27371

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIKSEKEIELMRVAGKVIANLFEVLEKVIKPGVTTLELDRIAEEFIIKNGCIPAFKGL
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHH
YGFPASICASVNDEVVHGIPGLRKLQEGDIISIDLGANYKGYNADAARTFPVGEISDEAK
CCCCHHHHHCCCCHHHHCCCCHHHHCCCCEEEEECCCCCCCCCCCCCEECCCCCCCHHHH
KLIEVTRESFFEGIKYAREGNRLSDISHAIQVYVESHGFSVVRDYVGHGIGRKMHEDPQI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCC
PNFGPPGKGPRLKRGMTLAIEPMVNAGHYSVRTLEDNWTVVTVDGSLSAHYENTIVITEG
CCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCEEECCCCEEEEECC
EPEILTIL
CCCEEEEC
>Mature Secondary Structure
MIYIKSEKEIELMRVAGKVIANLFEVLEKVIKPGVTTLELDRIAEEFIIKNGCIPAFKGL
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCHHHHHH
YGFPASICASVNDEVVHGIPGLRKLQEGDIISIDLGANYKGYNADAARTFPVGEISDEAK
CCCCHHHHHCCCCHHHHCCCCHHHHCCCCEEEEECCCCCCCCCCCCCEECCCCCCCHHHH
KLIEVTRESFFEGIKYAREGNRLSDISHAIQVYVESHGFSVVRDYVGHGIGRKMHEDPQI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCC
PNFGPPGKGPRLKRGMTLAIEPMVNAGHYSVRTLEDNWTVVTVDGSLSAHYENTIVITEG
CCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCEEECCCCEEEEECC
EPEILTIL
CCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842; 7559358 [H]