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The map label for this gene is adk

Identifier: 20808640

GI number: 20808640

Start: 2165313

End: 2165978

Strand: Reverse

Name: adk

Synonym: TTE2271

Alternate gene names: 20808640

Gene position: 2165978-2165313 (Counterclockwise)

Preceding gene: 20808641

Following gene: 20808639

Centisome position: 80.54

GC content: 41.14

Gene sequence:

>666_bases
ATGCGGGTGGTGCTTCTGGGCCCCCCTGGTGCCGGAAAAGGGACCCAAGCGCTTAAAATTGCTAAGGAGTTTGACATTCC
TCACATATCTACAGGCGATATTTTTAGGCAAAATCTGAGAGACAATACAGAGTTAGGTAAACTGGCAAAGGAGTATATGG
ACAAAGGACTTTTGGTCCCCGATGAAGTGACTAACAGGATAGTAGAAGACAGGCTGGAAAAAGAGGACTGCAAAAAGGGG
TTTTTGCTGGACGGATATCCGCGGAATATACCTCAGGCGGAGGAACTGGATAAATTTTTGGAGGAGAGAGGGCATTCTCT
TACTGCTGTTATAAATATTCAGGTTGAGAGAGAGGCTTTGATAGACAGGATAACAGGCAGAAGGGTATGTCCTGTGTGCG
GTGCTACTTATCACATAAAAACTTCTCCTCCGAAAGTAGATAATGTGTGCGATAAGTGTGGCAGTGAGCTTATACAAAGG
TCAGATGATAAATTGGAGTCTGTGGTAAAAAGGTTGGAAGTGTACGAGAAAGAGACAAAGCCATTAATTGATTATTATAC
AAAAAAAGGTATTTTGGTAAACATCGATGGAAATAAATCAATTGATGAGGTATTTGAAGACATAAAAAAGGCTTTGTTAG
GAGATAGGAGAGATGATATACATTAA

Upstream 100 bases:

>100_bases
TTGATAGCAGTAGGTGTGGCTTTAGATACCATGAAGCAAATAGAAGGTCACCTGATTATGAGAAATTATCAGGGATTCTT
GAAGTAAAGGGGGAGAAATT

Downstream 100 bases:

>100_bases
ATCTGAAAAAGAAATTGAGCTCATGAGAGTAGCTGGGAAAGTGATAGCAAACCTCTTTGAGGTTTTAGAGAAGGTGATAA
AGCCTGGTGTTACTACTTTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRVVLLGPPGAGKGTQALKIAKEFDIPHISTGDIFRQNLRDNTELGKLAKEYMDKGLLVPDEVTNRIVEDRLEKEDCKKG
FLLDGYPRNIPQAEELDKFLEERGHSLTAVINIQVEREALIDRITGRRVCPVCGATYHIKTSPPKVDNVCDKCGSELIQR
SDDKLESVVKRLEVYEKETKPLIDYYTKKGILVNIDGNKSIDEVFEDIKKALLGDRRDDIH

Sequences:

>Translated_221_residues
MRVVLLGPPGAGKGTQALKIAKEFDIPHISTGDIFRQNLRDNTELGKLAKEYMDKGLLVPDEVTNRIVEDRLEKEDCKKG
FLLDGYPRNIPQAEELDKFLEERGHSLTAVINIQVEREALIDRITGRRVCPVCGATYHIKTSPPKVDNVCDKCGSELIQR
SDDKLESVVKRLEVYEKETKPLIDYYTKKGILVNIDGNKSIDEVFEDIKKALLGDRRDDIH
>Mature_221_residues
MRVVLLGPPGAGKGTQALKIAKEFDIPHISTGDIFRQNLRDNTELGKLAKEYMDKGLLVPDEVTNRIVEDRLEKEDCKKG
FLLDGYPRNIPQAEELDKFLEERGHSLTAVINIQVEREALIDRITGRRVCPVCGATYHIKTSPPKVDNVCDKCGSELIQR
SDDKLESVVKRLEVYEKETKPLIDYYTKKGILVNIDGNKSIDEVFEDIKKALLGDRRDDIH

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=212, Percent_Identity=46.2264150943396, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI4502013, Length=212, Percent_Identity=46.2264150943396, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=43, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=40, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=40, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=40, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=40, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI22749187, Length=214, Percent_Identity=28.5046728971963, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=32.8502415458937, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=30.8056872037915, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI28144897, Length=217, Percent_Identity=27.6497695852535, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI28144899, Length=217, Percent_Identity=27.6497695852535, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=47.0046082949309, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17552384, Length=204, Percent_Identity=44.1176470588235, Blast_Score=180, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=220, Percent_Identity=35, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=30.5418719211823, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=212, Percent_Identity=29.7169811320755, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=212, Percent_Identity=29.7169811320755, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=44.4976076555024, Blast_Score=194, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=38.0487804878049, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=27.2300469483568, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=43.75, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17737899, Length=216, Percent_Identity=40.7407407407407, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24645822, Length=216, Percent_Identity=40.7407407407407, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=24.6445497630332, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=25.5924170616114, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_THETN (Q8R7X4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623811.1
- ProteinModelPortal:   Q8R7X4
- SMR:   Q8R7X4
- GeneID:   997321
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2271
- NMPDR:   fig|273068.3.peg.2452
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   TTEN273068:TTE2271-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 25032; Mature: 25032

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVLLGPPGAGKGTQALKIAKEFDIPHISTGDIFRQNLRDNTELGKLAKEYMDKGLLVP
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
DEVTNRIVEDRLEKEDCKKGFLLDGYPRNIPQAEELDKFLEERGHSLTAVINIQVEREAL
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEEHHHHH
IDRITGRRVCPVCGATYHIKTSPPKVDNVCDKCGSELIQRSDDKLESVVKRLEVYEKETK
HHHHCCCEECHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
PLIDYYTKKGILVNIDGNKSIDEVFEDIKKALLGDRRDDIH
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRVVLLGPPGAGKGTQALKIAKEFDIPHISTGDIFRQNLRDNTELGKLAKEYMDKGLLVP
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
DEVTNRIVEDRLEKEDCKKGFLLDGYPRNIPQAEELDKFLEERGHSLTAVINIQVEREAL
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEEHHHHH
IDRITGRRVCPVCGATYHIKTSPPKVDNVCDKCGSELIQRSDDKLESVVKRLEVYEKETK
HHHHCCCEECHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
PLIDYYTKKGILVNIDGNKSIDEVFEDIKKALLGDRRDDIH
HHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336