Click here to switch to the map view.

The map label for this gene is ThiD [H]

Identifier: 20808610

GI number: 20808610

Start: 2139421

End: 2140212

Strand: Reverse

Name: ThiD [H]

Synonym: TTE2235

Alternate gene names: 20808610

Gene position: 2140212-2139421 (Counterclockwise)

Preceding gene: 20808611

Following gene: 20808609

Centisome position: 79.58

GC content: 39.65

Gene sequence:

>792_bases
ATGAAATTAGCTCTTACAATTGCTGGTTCAGATTCAGGAGGAGGAGCAGGAATCCAGGCAGATTTGAAGACTTTTTCTGC
CCACGGAGTATTTGGAATGAGCGTCATTACTTCAATAACAGCTCAGAACACTATGGGAGTTTTAGGAATTGAAGATGTAA
GCCCTGACATGGTCTATTTGCAGATGAGAGCAATTTTTGAAGACCTGTATCCGGATGCAGTTAAGATAGGCATGGTATCC
AATGAAGAGATTATAAAAACTATCGCAAAGGGCTTAAAAGAATACGGAGTAGAAAAAGTTGTTTTAGACCCAGTCATGAT
TGCGAAGAGTGGAGACCCTCTTTTAAAACCTGAGGCGATGAAAGCATTAAAGGAGGAGCTGTTGCCATTAAGCCTTGTTG
TTACGCCAAATTTGATGGAAGCTAAGGAATTAACAGGAATGGAGATAAAGAACATTTCGGATATGAAGGAAGCTGCAAAG
AAAATTTTAAGTTTAGGCGCAAAGGTAGTTTTGGTAAAGGGCGGACATTTAGAAGGAGAAGCGGTGGATGTGTTTTATGA
TGGAGTAGAATTTTACGAAATTAAAGCGGAGAGAATTAACACTAAAAACACACATGGGACAGGATGCACTTTTTCATCAG
CTATAGCAGCAAACTTGGCTTTAGGATATGATTTGTTAGAGGCGGTGAAGAGGGCTAAAAGGTACATCACAGGAGCCATA
AAAAATTCTCTTTCTATAGGGCATGGAGTGGGACCCACAAATCATTTCTGGAATGTTGAATTTAAAGAATAG

Upstream 100 bases:

>100_bases
ACCAGGGTAATGCCTGCGAAGGGAAGCACGTTTTACGGAATCTGTAAAAAGTGCTCACCTTTTCAGGTGGGCATATTTTT
ATTATCTTGGAGGTGAGTAT

Downstream 100 bases:

>100_bases
AATAAGGAGGATGTTTGTTGTGGAAATAAGAGAACAGGTAGTTCTTGTTACAGGGTCTAGCCGAGGCTTAGGTGCTGCCA
TTGCTAAAGCTTTTGCTAGA

Product: hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKLALTIAGSDSGGGAGIQADLKTFSAHGVFGMSVITSITAQNTMGVLGIEDVSPDMVYLQMRAIFEDLYPDAVKIGMVS
NEEIIKTIAKGLKEYGVEKVVLDPVMIAKSGDPLLKPEAMKALKEELLPLSLVVTPNLMEAKELTGMEIKNISDMKEAAK
KILSLGAKVVLVKGGHLEGEAVDVFYDGVEFYEIKAERINTKNTHGTGCTFSSAIAANLALGYDLLEAVKRAKRYITGAI
KNSLSIGHGVGPTNHFWNVEFKE

Sequences:

>Translated_263_residues
MKLALTIAGSDSGGGAGIQADLKTFSAHGVFGMSVITSITAQNTMGVLGIEDVSPDMVYLQMRAIFEDLYPDAVKIGMVS
NEEIIKTIAKGLKEYGVEKVVLDPVMIAKSGDPLLKPEAMKALKEELLPLSLVVTPNLMEAKELTGMEIKNISDMKEAAK
KILSLGAKVVLVKGGHLEGEAVDVFYDGVEFYEIKAERINTKNTHGTGCTFSSAIAANLALGYDLLEAVKRAKRYITGAI
KNSLSIGHGVGPTNHFWNVEFKE
>Mature_263_residues
MKLALTIAGSDSGGGAGIQADLKTFSAHGVFGMSVITSITAQNTMGVLGIEDVSPDMVYLQMRAIFEDLYPDAVKIGMVS
NEEIIKTIAKGLKEYGVEKVVLDPVMIAKSGDPLLKPEAMKALKEELLPLSLVVTPNLMEAKELTGMEIKNISDMKEAAK
KILSLGAKVVLVKGGHLEGEAVDVFYDGVEFYEIKAERINTKNTHGTGCTFSSAIAANLALGYDLLEAVKRAKRYITGAI
KNSLSIGHGVGPTNHFWNVEFKE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=257, Percent_Identity=45.5252918287938, Blast_Score=229, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=34.9264705882353, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324997, Length=277, Percent_Identity=36.101083032491, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=277, Percent_Identity=34.6570397111913, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28220; Mature: 28220

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLALTIAGSDSGGGAGIQADLKTFSAHGVFGMSVITSITAQNTMGVLGIEDVSPDMVYL
CEEEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
QMRAIFEDLYPDAVKIGMVSNEEIIKTIAKGLKEYGVEKVVLDPVMIAKSGDPLLKPEAM
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCHHHH
KALKEELLPLSLVVTPNLMEAKELTGMEIKNISDMKEAAKKILSLGAKVVLVKGGHLEGE
HHHHHHCCCEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCC
AVDVFYDGVEFYEIKAERINTKNTHGTGCTFSSAIAANLALGYDLLEAVKRAKRYITGAI
EEEEEECCEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNSLSIGHGVGPTNHFWNVEFKE
HHCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKLALTIAGSDSGGGAGIQADLKTFSAHGVFGMSVITSITAQNTMGVLGIEDVSPDMVYL
CEEEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
QMRAIFEDLYPDAVKIGMVSNEEIIKTIAKGLKEYGVEKVVLDPVMIAKSGDPLLKPEAM
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCEEEECCCCCCCCHHHH
KALKEELLPLSLVVTPNLMEAKELTGMEIKNISDMKEAAKKILSLGAKVVLVKGGHLEGE
HHHHHHCCCEEEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCC
AVDVFYDGVEFYEIKAERINTKNTHGTGCTFSSAIAANLALGYDLLEAVKRAKRYITGAI
EEEEEECCEEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNSLSIGHGVGPTNHFWNVEFKE
HHCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]