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The map label for this gene is fabG [H]

Identifier: 20808609

GI number: 20808609

Start: 2138640

End: 2139410

Strand: Reverse

Name: fabG [H]

Synonym: TTE2234

Alternate gene names: 20808609

Gene position: 2139410-2138640 (Counterclockwise)

Preceding gene: 20808610

Following gene: 20808608

Centisome position: 79.55

GC content: 40.21

Gene sequence:

>771_bases
ATGTTTGTTGTGGAAATAAGAGAACAGGTAGTTCTTGTTACAGGGTCTAGCCGAGGCTTAGGTGCTGCCATTGCTAAAGC
TTTTGCTAGAGAAGGAGCCAGCGTGGTAGTAAATTATTATAAAAGCGAAGAAAAGGCGCAAAAATTGTCAGAGGAGCTGG
GAAGAAATTCTGTTGCTATTAGAGCTGATGTAAGAGATTTTAATCAAGTAGCTTCAATGTTTGAAGAAGCAAAGAAGTAT
TTTGGGAAACCCGTCACTACTATTGTGAACAATGCGCTGATTGACTATGTTTTTGATCCGATGAACAGAAAAACTCCTGA
AACAATTGAGTGGGAAGATTATTTAAAACAATTAGAAGGAGCTGTAAAAGGGGCCTTGAACACTATAAAAGCAGGACTTA
AAGATATGAAAAAGATGCGCTTTGGCCGAATTATAAATATAGGGACTAATTTGTTTCAGAATCCAGTGGTTCCTTACCAC
GATTATACCACTGCTAAAGCTGCTCTGATCGGTTTTACACGCAATATGGCAAAAGAATTGGGAGAGTATGGCATCACTGT
CAACATGGTAAGCGGAGGGCTTTTAAAAGTTACAGATGCGAGTTCGGCTACCAGCAAAGAGGTTTTTGATTTAATTGAAC
AGACCACTCCTTTGAAGAAAGTTACTGCTCATGAAGATTTGGCTGATGTAGTGCTGTTTTTTGCTTCACCTTGGGCGAGA
GCGGTAACAGGGCAAAATTTGGTTGTAGATGGCGGCCTTGTGATGGATTGA

Upstream 100 bases:

>100_bases
TACATCACAGGAGCCATAAAAAATTCTCTTTCTATAGGGCATGGAGTGGGACCCACAAATCATTTCTGGAATGTTGAATT
TAAAGAATAGAATAAGGAGG

Downstream 100 bases:

>100_bases
ATAAGGGGGTAAAGGTTGTGAAGAGGATAGACTTTACTTTGTATGCTATCACTGACAGGTCCTTTATAAAAGGGATGGAC
ATAGCTGAAGCGGTGGAGAT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MFVVEIREQVVLVTGSSRGLGAAIAKAFAREGASVVVNYYKSEEKAQKLSEELGRNSVAIRADVRDFNQVASMFEEAKKY
FGKPVTTIVNNALIDYVFDPMNRKTPETIEWEDYLKQLEGAVKGALNTIKAGLKDMKKMRFGRIINIGTNLFQNPVVPYH
DYTTAKAALIGFTRNMAKELGEYGITVNMVSGGLLKVTDASSATSKEVFDLIEQTTPLKKVTAHEDLADVVLFFASPWAR
AVTGQNLVVDGGLVMD

Sequences:

>Translated_256_residues
MFVVEIREQVVLVTGSSRGLGAAIAKAFAREGASVVVNYYKSEEKAQKLSEELGRNSVAIRADVRDFNQVASMFEEAKKY
FGKPVTTIVNNALIDYVFDPMNRKTPETIEWEDYLKQLEGAVKGALNTIKAGLKDMKKMRFGRIINIGTNLFQNPVVPYH
DYTTAKAALIGFTRNMAKELGEYGITVNMVSGGLLKVTDASSATSKEVFDLIEQTTPLKKVTAHEDLADVVLFFASPWAR
AVTGQNLVVDGGLVMD
>Mature_256_residues
MFVVEIREQVVLVTGSSRGLGAAIAKAFAREGASVVVNYYKSEEKAQKLSEELGRNSVAIRADVRDFNQVASMFEEAKKY
FGKPVTTIVNNALIDYVFDPMNRKTPETIEWEDYLKQLEGAVKGALNTIKAGLKDMKKMRFGRIINIGTNLFQNPVVPYH
DYTTAKAALIGFTRNMAKELGEYGITVNMVSGGLLKVTDASSATSKEVFDLIEQTTPLKKVTAHEDLADVVLFFASPWAR
AVTGQNLVVDGGLVMD

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=31.9838056680162, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=28.6259541984733, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=28.6290322580645, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=31.7269076305221, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=26.8774703557312, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=35.6275303643725, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=29.0697674418605, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082100, Length=257, Percent_Identity=27.6264591439689, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=28.6852589641434, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=29.2, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=28.4584980237154, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=27.34375, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082160, Length=268, Percent_Identity=28.3582089552239, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=27.1653543307087, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787820, Length=227, Percent_Identity=25.5506607929515, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=30.3370786516854, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=263, Percent_Identity=28.8973384030418, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=28.7937743190661, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=29.0836653386454, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=26.171875, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=26.6917293233083, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=272, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=28.8973384030418, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=274, Percent_Identity=31.021897810219, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.9473684210526, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=265, Percent_Identity=26.0377358490566, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=27.34375, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=28.6274509803922, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=201, Percent_Identity=28.3582089552239, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=32, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=27.6, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI23397609, Length=257, Percent_Identity=28.4046692607004, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=26.3565891472868, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=27.5193798449612, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 28154; Mature: 28154

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVEIREQVVLVTGSSRGLGAAIAKAFAREGASVVVNYYKSEEKAQKLSEELGRNSVAI
CEEEEEECEEEEEECCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCEEE
RADVRDFNQVASMFEEAKKYFGKPVTTIVNNALIDYVFDPMNRKTPETIEWEDYLKQLEG
EEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AVKGALNTIKAGLKDMKKMRFGRIINIGTNLFQNPVVPYHDYTTAKAALIGFTRNMAKEL
HHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
GEYGITVNMVSGGLLKVTDASSATSKEVFDLIEQTTPLKKVTAHEDLADVVLFFASPWAR
HHCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHH
AVTGQNLVVDGGLVMD
HHCCCEEEECCCEECC
>Mature Secondary Structure
MFVVEIREQVVLVTGSSRGLGAAIAKAFAREGASVVVNYYKSEEKAQKLSEELGRNSVAI
CEEEEEECEEEEEECCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCEEE
RADVRDFNQVASMFEEAKKYFGKPVTTIVNNALIDYVFDPMNRKTPETIEWEDYLKQLEG
EEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AVKGALNTIKAGLKDMKKMRFGRIINIGTNLFQNPVVPYHDYTTAKAALIGFTRNMAKEL
HHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
GEYGITVNMVSGGLLKVTDASSATSKEVFDLIEQTTPLKKVTAHEDLADVVLFFASPWAR
HHCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHH
AVTGQNLVVDGGLVMD
HHCCCEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9384377; 9534248; 8654983 [H]