Click here to switch to the map view.

The map label for this gene is GlmS

Identifier: 20808572

GI number: 20808572

Start: 2099588

End: 2101414

Strand: Reverse

Name: GlmS

Synonym: TTE2190

Alternate gene names: 20808572

Gene position: 2101414-2099588 (Counterclockwise)

Preceding gene: 20808573

Following gene: 20808571

Centisome position: 78.14

GC content: 40.01

Gene sequence:

>1827_bases
ATGTGTGGGATTGTAGGATATATAGGAGATAAACAAGCAACACCTATACTGCTGGAAGGTTTGACAAGATTAGAGTATAG
GGGATATGATTCGGCAGGAATTGCCATTTTACACAATGGCAATATAAATATAAAGAAAGCTAAAGGAAGGCTCAATGTCT
TAAGAGAACTGGTTGAAAAAGACTATATGGAAGGTACAATAGGTATAGGGCATACCAGATGGGCAACCCACGGAGAACCT
TCTGATACCAATTCGCATCCTCACCTATCCCAGTCAGGCTTAATTGCAGTTGTTCACAACGGGATTATTGAAAACTATCT
TCCTCTGAAGAAATGGCTGATAGAAGAGGGTTATAATTTTATATCAGAAACAGATACGGAAGTGGTTGCAAACTTACTCG
AATATTACTACAATGGCGATATAGTTGAAGCGCTTAGAAAAGTGCTGGATAGGATTGAGGGGTCTTATGCTCTGGGGGTT
TTGTGCAAGGACAATCCGGATATGATAGTAGCAGCAAGAAAAGAAGCTCCTCTTATAGTAGGTATAGGAAATGGTGAGAA
TTTCATTGCTTCAGATATACCTGCAATTTTAAAATACACAAGAAATGTATATTTCCTCGATGACCACGAAATTGCCATAA
TCAAAAAAGACAGTGTAGAATTTATAGATGTTTTTGGAAGGAAGATAGGCAAATCTCTCTTTGAAGTGAAATGGGACGTA
GAAGCAGCTGAAAAGGGCGGCTATGAGCACTTCATGATAAAAGAGATTCATGAGCAGCCTGCCGCAATAAAAGATACTTT
GAGGGGAAGGATAATTAACGATTCCCAGATAGTCCTTGACAATATAAACATCACAAAGGAAGACCTTGAAAAAATAGAAA
AAATCTTTATAGTAGCTTGTGGAACTGCATATCACGCAGGAGTTGTAGGGAAATACGTGATAGAGAGTTTTGCACGAATA
CCTGTTGAGGTAGATGTGGCTTCTGAGTTTAGATACAGGAATCCGATTGTGAATGAAAGAATTCTCACAATTGTTATAAG
CCAGTCAGGGGAGACGGCTGACACAATTGCTGCATTAAAAGAAGCTAAAAGGAAAGGCTCGAGAGTCATAGCTATAACAA
ATGTGGTAGGAAGTTCTGTATCAAGGGAAGCAGATGAAGTCTTGTATACTTGGGCAGGACCTGAAATAGCCGTTGCATCT
ACAAAAGCTTATACTACACAGCTCATAGCTTTATACCTAATTGCGCTGGACTTTGCCTTAAAGAAGGGGACTATGAGCAG
TACAAAGGTTGTAGAGATTATCTCTGAACTTAAAAAACTACCTGACAAAGTTCAATACCTCTTGGACAACAAAGAAGTGA
TACAAAAATTTGCCTCTGAACATTACAATGTGAAAGACGTATTCTATATTGGTAGAGGTCTGGATTACGCTGTTGCCATG
GAAGGGTCTTTAAAGCTCAAAGAGATATCTTACATCCACTCAGAAGCATACCCAGCTGGAGAGTTAAAGCACGGAACGTT
AGCATTGGTAGAAGAAGGTACTTTGATAATTGCACTGGCTACACAGGATGACCTCTTCGAAAAAATGTTGAGCAATATAA
AAGAGGTAAAGGCCAGAGGAGGATATGTGGTTGCTTTTGCAAAGCAAGGAAACCTGCAGCTGGAAGGAGTAGTGGACAAA
GTCATATACATCCCCGACACCTTAAAAGAACTCACTCCTGTGTTGACAGTGGTCCCTCTCCAGCTTCTGGCATATTACAT
GGCTGTAGAAAAAGGCTGTGACGTGGATAAACCGAGGAACCTTGCAAAATCTGTTACTGTGGAGTAA

Upstream 100 bases:

>100_bases
TCCTGCGACCGTTAGAGGACTGGTAAAACCACAGGCGACTGTGGCATAGAGCAGTCCGGGCAGGAAAATTTTATAAACTC
ACAGTGAGAGGAGACGCAAT

Downstream 100 bases:

>100_bases
AATTTAAAGGGATAGGCAGTCTTATACTGCTTGTCCCTTTTTAGTTTATAAAGGCAGTTCTTCCTTCAATAATAAAAAAT
GCAATAAATTTAATTGGTAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGYIGDKQATPILLEGLTRLEYRGYDSAGIAILHNGNINIKKAKGRLNVLRELVEKDYMEGTIGIGHTRWATHGEP
SDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLIEEGYNFISETDTEVVANLLEYYYNGDIVEALRKVLDRIEGSYALGV
LCKDNPDMIVAARKEAPLIVGIGNGENFIASDIPAILKYTRNVYFLDDHEIAIIKKDSVEFIDVFGRKIGKSLFEVKWDV
EAAEKGGYEHFMIKEIHEQPAAIKDTLRGRIINDSQIVLDNINITKEDLEKIEKIFIVACGTAYHAGVVGKYVIESFARI
PVEVDVASEFRYRNPIVNERILTIVISQSGETADTIAALKEAKRKGSRVIAITNVVGSSVSREADEVLYTWAGPEIAVAS
TKAYTTQLIALYLIALDFALKKGTMSSTKVVEIISELKKLPDKVQYLLDNKEVIQKFASEHYNVKDVFYIGRGLDYAVAM
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLIIALATQDDLFEKMLSNIKEVKARGGYVVAFAKQGNLQLEGVVDK
VIYIPDTLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGYIGDKQATPILLEGLTRLEYRGYDSAGIAILHNGNINIKKAKGRLNVLRELVEKDYMEGTIGIGHTRWATHGEP
SDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLIEEGYNFISETDTEVVANLLEYYYNGDIVEALRKVLDRIEGSYALGV
LCKDNPDMIVAARKEAPLIVGIGNGENFIASDIPAILKYTRNVYFLDDHEIAIIKKDSVEFIDVFGRKIGKSLFEVKWDV
EAAEKGGYEHFMIKEIHEQPAAIKDTLRGRIINDSQIVLDNINITKEDLEKIEKIFIVACGTAYHAGVVGKYVIESFARI
PVEVDVASEFRYRNPIVNERILTIVISQSGETADTIAALKEAKRKGSRVIAITNVVGSSVSREADEVLYTWAGPEIAVAS
TKAYTTQLIALYLIALDFALKKGTMSSTKVVEIISELKKLPDKVQYLLDNKEVIQKFASEHYNVKDVFYIGRGLDYAVAM
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLIIALATQDDLFEKMLSNIKEVKARGGYVVAFAKQGNLQLEGVVDK
VIYIPDTLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRNLAKSVTVE
>Mature_608_residues
MCGIVGYIGDKQATPILLEGLTRLEYRGYDSAGIAILHNGNINIKKAKGRLNVLRELVEKDYMEGTIGIGHTRWATHGEP
SDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLIEEGYNFISETDTEVVANLLEYYYNGDIVEALRKVLDRIEGSYALGV
LCKDNPDMIVAARKEAPLIVGIGNGENFIASDIPAILKYTRNVYFLDDHEIAIIKKDSVEFIDVFGRKIGKSLFEVKWDV
EAAEKGGYEHFMIKEIHEQPAAIKDTLRGRIINDSQIVLDNINITKEDLEKIEKIFIVACGTAYHAGVVGKYVIESFARI
PVEVDVASEFRYRNPIVNERILTIVISQSGETADTIAALKEAKRKGSRVIAITNVVGSSVSREADEVLYTWAGPEIAVAS
TKAYTTQLIALYLIALDFALKKGTMSSTKVVEIISELKKLPDKVQYLLDNKEVIQKFASEHYNVKDVFYIGRGLDYAVAM
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLIIALATQDDLFEKMLSNIKEVKARGGYVVAFAKQGNLQLEGVVDK
VIYIPDTLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=37.1888726207906, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI4826742, Length=683, Percent_Identity=36.6032210834553, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI29570798, Length=202, Percent_Identity=27.7227722772277, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=46.6557911908646, Blast_Score=532, Evalue=1e-152,
Organism=Escherichia coli, GI1788651, Length=136, Percent_Identity=35.2941176470588, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=430, Percent_Identity=39.5348837209302, Blast_Score=304, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=38.6574074074074, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=38.6574074074074, Blast_Score=303, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=39.9538106235566, Blast_Score=303, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=32.4074074074074, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=40.5797101449275, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323958, Length=173, Percent_Identity=30.0578034682081, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357745, Length=687, Percent_Identity=37.117903930131, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI28573187, Length=220, Percent_Identity=28.1818181818182, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_THETN (Q8R841)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623743.1
- ProteinModelPortal:   Q8R841
- SMR:   Q8R841
- GeneID:   997509
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2190
- NMPDR:   fig|273068.3.peg.2329
- HOGENOM:   HBG645312
- OMA:   TGIFAYM
- ProtClustDB:   PRK00331
- BioCyc:   TTEN273068:TTE2190-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67446; Mature: 67446

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 603-603

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGDKQATPILLEGLTRLEYRGYDSAGIAILHNGNINIKKAKGRLNVLRELVEK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHH
DYMEGTIGIGHTRWATHGEPSDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLIEEGYNF
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHH
ISETDTEVVANLLEYYYNGDIVEALRKVLDRIEGSYALGVLCKDNPDMIVAARKEAPLIV
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEE
GIGNGENFIASDIPAILKYTRNVYFLDDHEIAIIKKDSVEFIDVFGRKIGKSLFEVKWDV
EECCCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCHHHHHHHHHHHCHHHHEEEECC
EAAEKGGYEHFMIKEIHEQPAAIKDTLRGRIINDSQIVLDNINITKEDLEKIEKIFIVAC
CHHHCCCCCCHHHHHHHHCCHHHHHHHCCEEECCCEEEEECCCCCHHHHHHHHHEEEEEE
GTAYHAGVVGKYVIESFARIPVEVDVASEFRYRNPIVNERILTIVISQSGETADTIAALK
CCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHH
EAKRKGSRVIAITNVVGSSVSREADEVLYTWAGPEIAVASTKAYTTQLIALYLIALDFAL
HHHHCCCEEEEEEEHHCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
KKGTMSSTKVVEIISELKKLPDKVQYLLDNKEVIQKFASEHYNVKDVFYIGRGLDYAVAM
HCCCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEE
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLIIALATQDDLFEKMLSNIKEVKARG
CCCEEEHHHHHHHHCCCCCCCCCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHCC
GYVVAFAKQGNLQLEGVVDKVIYIPDTLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRN
CEEEEEECCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LAKSVTVE
HHHCCCCC
>Mature Secondary Structure
MCGIVGYIGDKQATPILLEGLTRLEYRGYDSAGIAILHNGNINIKKAKGRLNVLRELVEK
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHH
DYMEGTIGIGHTRWATHGEPSDTNSHPHLSQSGLIAVVHNGIIENYLPLKKWLIEEGYNF
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCHH
ISETDTEVVANLLEYYYNGDIVEALRKVLDRIEGSYALGVLCKDNPDMIVAARKEAPLIV
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEE
GIGNGENFIASDIPAILKYTRNVYFLDDHEIAIIKKDSVEFIDVFGRKIGKSLFEVKWDV
EECCCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCCHHHHHHHHHHHCHHHHEEEECC
EAAEKGGYEHFMIKEIHEQPAAIKDTLRGRIINDSQIVLDNINITKEDLEKIEKIFIVAC
CHHHCCCCCCHHHHHHHHCCHHHHHHHCCEEECCCEEEEECCCCCHHHHHHHHHEEEEEE
GTAYHAGVVGKYVIESFARIPVEVDVASEFRYRNPIVNERILTIVISQSGETADTIAALK
CCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHH
EAKRKGSRVIAITNVVGSSVSREADEVLYTWAGPEIAVASTKAYTTQLIALYLIALDFAL
HHHHCCCEEEEEEEHHCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
KKGTMSSTKVVEIISELKKLPDKVQYLLDNKEVIQKFASEHYNVKDVFYIGRGLDYAVAM
HCCCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEE
EGSLKLKEISYIHSEAYPAGELKHGTLALVEEGTLIIALATQDDLFEKMLSNIKEVKARG
CCCEEEHHHHHHHHCCCCCCCCCCCEEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHCC
GYVVAFAKQGNLQLEGVVDKVIYIPDTLKELTPVLTVVPLQLLAYYMAVEKGCDVDKPRN
CEEEEEECCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LAKSVTVE
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336