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The map label for this gene is Alr2

Identifier: 20808552

GI number: 20808552

Start: 2087867

End: 2089033

Strand: Reverse

Name: Alr2

Synonym: TTE2168

Alternate gene names: 20808552

Gene position: 2089033-2087867 (Counterclockwise)

Preceding gene: 20808553

Following gene: 20808551

Centisome position: 77.68

GC content: 38.56

Gene sequence:

>1167_bases
ATGTTTGATGAGATAAGGCCCACAAGGGTAGAGGTAAATTTGGACAGTATAGTCCATAATTTTAGGGAAATAAAGAGGGT
GGTTGGAGATAGGGTTAAAGTGATGGGGGTTGTAAAGGCCAATGCGTATGGCCATGGGGCGTATCACGTTGCGAAAGCAT
TAGTAGAAAATGGTGTTGATTATCTTGCTGTTGCTACAGTAGAAGAGGCATTGGAATTGAGAAGCTACGGGATTACTGCC
CCTGTCCTAATTTTGGGTTACACCCCTTTAAGCCAGGCAGGAGAGGCTGTGGAGAAAGATGTGACTTTTACCGCCTTTGA
TTTAAAGTATGTAAAGGAGTTAGGGGAAATAGCCAGTAGGAAAGGAAAAAAAGCAAAAATTCATGTAAAAATTGATACAG
GGATGGGACGGATAGGGTATACTGATTTTGATTTAGCAGAAAGAGAAATTGAAGAGATGTCAAAGCTTGAAGGGATTGAA
TTGGAAGGCATATTTAGTCATTTTGCTACTTCCGACGAAAAAGATAAGGACTATGCGAGGGAACAGTTTGAAAGATTTGC
GGATATGCTAAAGCGTTTAGAAAAAAGAGGAGTAAATATCACTTTGAAGCATATTGCTAACAGCGGAGCTATAACTGATT
TAAATTATGCATATCTTGACATGGTAAGGCCCGGAATAACTCTTTACGGCAGTTACCCTTCTAATGATGTTAATAAAATT
TTAGACTTAAGACCTGCCATGAACTTTAAGACCAAAATAGTCTACATAAAAGAAGTGCCGGAAAATACTTCTATAAGCTA
TGGAAGAACTTTTATAACTAAAAGGCCTAGCAAAATAGCTACTCTACCGATAGGATATGCGGATGGACTCAACAGACTTC
TTTCAAATAACCATGAAGTGCTGGTTAGAGGTAAATATGTGCCGATAGTAGGTAGAGTATGCATGGACCAGACCATGATA
GATGTGACAGAAGTAGAGGGAGTAGAGGTAGGAGACGAGGTGGTCATATTTGGAGAGCAGGAAGGAAAGAGGATAACGGC
AGATGATATAGCTAAAAAACTTCGCACTATTCCTCACGAAGTATATTGTGGAATATCTAGAAGGGTACCTAGAATATATA
TTTACAGAGGAGAAGTTTTCGATGTAAAAAATTATTTAAAAATTTAA

Upstream 100 bases:

>100_bases
TACCTATAAGGATTTTCAGTATAATCTTAAGCTTCAGGATGACCTGTTTTCTGAAGGAACGATTAAAGAGTCGATGAGAT
GAACAAGAGGGGGATTTTTG

Downstream 100 bases:

>100_bases
CTTTTATAGTATAAAATTTACAAATCGTTGACATCATATATATGGTGGTATATAATGAATTATATAGGTGCGTAAGGAGG
TCCTGAAAGTGGGCGAAACA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MFDEIRPTRVEVNLDSIVHNFREIKRVVGDRVKVMGVVKANAYGHGAYHVAKALVENGVDYLAVATVEEALELRSYGITA
PVLILGYTPLSQAGEAVEKDVTFTAFDLKYVKELGEIASRKGKKAKIHVKIDTGMGRIGYTDFDLAEREIEEMSKLEGIE
LEGIFSHFATSDEKDKDYAREQFERFADMLKRLEKRGVNITLKHIANSGAITDLNYAYLDMVRPGITLYGSYPSNDVNKI
LDLRPAMNFKTKIVYIKEVPENTSISYGRTFITKRPSKIATLPIGYADGLNRLLSNNHEVLVRGKYVPIVGRVCMDQTMI
DVTEVEGVEVGDEVVIFGEQEGKRITADDIAKKLRTIPHEVYCGISRRVPRIYIYRGEVFDVKNYLKI

Sequences:

>Translated_388_residues
MFDEIRPTRVEVNLDSIVHNFREIKRVVGDRVKVMGVVKANAYGHGAYHVAKALVENGVDYLAVATVEEALELRSYGITA
PVLILGYTPLSQAGEAVEKDVTFTAFDLKYVKELGEIASRKGKKAKIHVKIDTGMGRIGYTDFDLAEREIEEMSKLEGIE
LEGIFSHFATSDEKDKDYAREQFERFADMLKRLEKRGVNITLKHIANSGAITDLNYAYLDMVRPGITLYGSYPSNDVNKI
LDLRPAMNFKTKIVYIKEVPENTSISYGRTFITKRPSKIATLPIGYADGLNRLLSNNHEVLVRGKYVPIVGRVCMDQTMI
DVTEVEGVEVGDEVVIFGEQEGKRITADDIAKKLRTIPHEVYCGISRRVPRIYIYRGEVFDVKNYLKI
>Mature_388_residues
MFDEIRPTRVEVNLDSIVHNFREIKRVVGDRVKVMGVVKANAYGHGAYHVAKALVENGVDYLAVATVEEALELRSYGITA
PVLILGYTPLSQAGEAVEKDVTFTAFDLKYVKELGEIASRKGKKAKIHVKIDTGMGRIGYTDFDLAEREIEEMSKLEGIE
LEGIFSHFATSDEKDKDYAREQFERFADMLKRLEKRGVNITLKHIANSGAITDLNYAYLDMVRPGITLYGSYPSNDVNKI
LDLRPAMNFKTKIVYIKEVPENTSISYGRTFITKRPSKIATLPIGYADGLNRLLSNNHEVLVRGKYVPIVGRVCMDQTMI
DVTEVEGVEVGDEVVIFGEQEGKRITADDIAKKLRTIPHEVYCGISRRVPRIYIYRGEVFDVKNYLKI

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=377, Percent_Identity=29.973474801061, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1787439, Length=376, Percent_Identity=27.6595744680851, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR2_THETN (Q8R860)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623723.1
- ProteinModelPortal:   Q8R860
- SMR:   Q8R860
- GeneID:   997486
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2168
- NMPDR:   fig|273068.3.peg.2311
- HOGENOM:   HBG712172
- OMA:   RPIFASI
- ProtClustDB:   CLSK901100
- BioCyc:   TTEN273068:TTE2168-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 43756; Mature: 43756

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 39-39 ACT_SITE 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDEIRPTRVEVNLDSIVHNFREIKRVVGDRVKVMGVVKANAYGHGAYHVAKALVENGVD
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCC
YLAVATVEEALELRSYGITAPVLILGYTPLSQAGEAVEKDVTFTAFDLKYVKELGEIASR
EEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHC
KGKKAKIHVKIDTGMGRIGYTDFDLAEREIEEMSKLEGIELEGIFSHFATSDEKDKDYAR
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHH
EQFERFADMLKRLEKRGVNITLKHIANSGAITDLNYAYLDMVRPGITLYGSYPSNDVNKI
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHHHHHCCCEEEEECCCCCHHHHH
LDLRPAMNFKTKIVYIKEVPENTSISYGRTFITKRPSKIATLPIGYADGLNRLLSNNHEV
HHCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHCCCCEE
LVRGKYVPIVGRVCMDQTMIDVTEVEGVEVGDEVVIFGEQEGKRITADDIAKKLRTIPHE
EEEECCCHHHHHHHHCCHHEEHHHCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHCCHH
VYCGISRRVPRIYIYRGEVFDVKNYLKI
HHCCCCCCCCEEEEEECCEEECHHHHCC
>Mature Secondary Structure
MFDEIRPTRVEVNLDSIVHNFREIKRVVGDRVKVMGVVKANAYGHGAYHVAKALVENGVD
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCC
YLAVATVEEALELRSYGITAPVLILGYTPLSQAGEAVEKDVTFTAFDLKYVKELGEIASR
EEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHC
KGKKAKIHVKIDTGMGRIGYTDFDLAEREIEEMSKLEGIELEGIFSHFATSDEKDKDYAR
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHH
EQFERFADMLKRLEKRGVNITLKHIANSGAITDLNYAYLDMVRPGITLYGSYPSNDVNKI
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHHHHHCCCEEEEECCCCCHHHHH
LDLRPAMNFKTKIVYIKEVPENTSISYGRTFITKRPSKIATLPIGYADGLNRLLSNNHEV
HHCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCEEEEECCHHHHHHHHHCCCCEE
LVRGKYVPIVGRVCMDQTMIDVTEVEGVEVGDEVVIFGEQEGKRITADDIAKKLRTIPHE
EEEECCCHHHHHHHHCCHHEEHHHCCCCCCCCEEEEEECCCCCEECHHHHHHHHHHCCHH
VYCGISRRVPRIYIYRGEVFDVKNYLKI
HHCCCCCCCCEEEEEECCEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336