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The map label for this gene is ThrA [H]

Identifier: 20808540

GI number: 20808540

Start: 2075217

End: 2076497

Strand: Reverse

Name: ThrA [H]

Synonym: TTE2152

Alternate gene names: 20808540

Gene position: 2076497-2075217 (Counterclockwise)

Preceding gene: 20808545

Following gene: 20808539

Centisome position: 77.21

GC content: 39.5

Gene sequence:

>1281_bases
ATGAGGGTAAAGATTGGGTTGATGGGACTTGGAACTGTTGGGACAGGAGTATTTAAAATAGTTAATTCTAGAGGGAGATA
TATCAAGGAGAGTACGGGATTTTATCCGGAGATAAAGAAAGTGCTTGTGAAGGATTTGCACAAAAAGAGAAAAGTCGATG
CAGCAGGGCTTTTGACTAATGATCCTCGGGAGATTTTGGAGGATGAAGAGATAAAGGTGGTGATAGAGGCTATAGGCGGA
ATTTCTCCTGCTTATGAGTACGTCAAAAAGGCACTTCTCTCTGGCAAGCATGTGATTACGGCAAATAAAGAGCTTATCGC
AAAGTACGGAGAAGAGCTTGGGAGCATTGCAGCAGAAAAAGGGGTGTACTTAAGGTGCGAAGCCAGTGTAGGTGGAGCCA
TACCTATACTTCATCAGATAGACAGGCTAAAAATTACAGATGAGATGGATTTCATTGGTGGCATTGTAAACGGGACTACT
AATTACATTCTAACAAAGATGGGAGAAGGCAAAAGCTATAAGGAAGCTCTTAATGAAGCCCAGGAATTGGGCTATGCTGA
GGCTAACCCTGATTACGATGTGAAAGGCTTTGACGCAACTTTTAAGCTTGGCATACTTGTAAAAAGAGTCTTTGGCGTAA
GTGTCCCGGTAGAAATTATACCTCGGAAGGGGATAGAGGAAATCAAAGAGGAAGACGTAGAAAGAGCAAAAGAATGGGGG
TATGAGTTTAAACTTTTTGCATGGGCAAAGAAATTTAAAAATTATATTTCGGCAGGAGTGGAGCCTACTTTAATTCCGGA
AAATAGTTTGCTTTCAAAAGTGAAAGGGGTCAATAACGCAATAATACTGAGGGGAAGTAGCTTCGGGGAATATGTCTTTA
TAGGAAGAGGGGCAGGAGAACTTCCCACTGGAGATGCAATAGTTGCTGATTTGATAGATATACTCATCAATTATAAACTG
GGCAGTAAATCTGAAGTTACAGGAGTCAATTTTAGAGAAGAAAGTTTTACTGATACCTTTTATATAAGGCTGAAGCTCAA
AAAAGACAATGTATGTGGCTTAAAAGAGGTTTTAAAGCTTATAAAAAGGAATTGGGTATCTATTGAAAAGTCATCATTTG
GTGGGAATGGTTTTACCGCTATAGTGAAAGTAAACGGGACAGTGGAAGGGTTAAAAGAGCAATTAGAAAAAGTAGCTGTA
CTGGAGGCTGTTTTTAAGGTTTTGCCTGAAGAAAATTTAAAAGAGAGAAGCGAGTTTGAAAACTTGGTAGAAGTAATGTA
A

Upstream 100 bases:

>100_bases
GGTTACCCAGCCTGAGAGATGAGAGGAGAGGCCGAGTAATTGTGATTACTAGGCCCTCTTCTCATTGAAGAGGGCCTAAG
AATTTTTCTGGAGGTGCAAA

Downstream 100 bases:

>100_bases
AAATTTAGGAAAGAGGAGAGGAAGAATGAGGAGAAAATACGGTTTTTCTACTATAGCAATTCATGAGGGATGGGAACCTG
ACCCTACTACTGGTGCAGTA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRVKIGLMGLGTVGTGVFKIVNSRGRYIKESTGFYPEIKKVLVKDLHKKRKVDAAGLLTNDPREILEDEEIKVVIEAIGG
ISPAYEYVKKALLSGKHVITANKELIAKYGEELGSIAAEKGVYLRCEASVGGAIPILHQIDRLKITDEMDFIGGIVNGTT
NYILTKMGEGKSYKEALNEAQELGYAEANPDYDVKGFDATFKLGILVKRVFGVSVPVEIIPRKGIEEIKEEDVERAKEWG
YEFKLFAWAKKFKNYISAGVEPTLIPENSLLSKVKGVNNAIILRGSSFGEYVFIGRGAGELPTGDAIVADLIDILINYKL
GSKSEVTGVNFREESFTDTFYIRLKLKKDNVCGLKEVLKLIKRNWVSIEKSSFGGNGFTAIVKVNGTVEGLKEQLEKVAV
LEAVFKVLPEENLKERSEFENLVEVM

Sequences:

>Translated_426_residues
MRVKIGLMGLGTVGTGVFKIVNSRGRYIKESTGFYPEIKKVLVKDLHKKRKVDAAGLLTNDPREILEDEEIKVVIEAIGG
ISPAYEYVKKALLSGKHVITANKELIAKYGEELGSIAAEKGVYLRCEASVGGAIPILHQIDRLKITDEMDFIGGIVNGTT
NYILTKMGEGKSYKEALNEAQELGYAEANPDYDVKGFDATFKLGILVKRVFGVSVPVEIIPRKGIEEIKEEDVERAKEWG
YEFKLFAWAKKFKNYISAGVEPTLIPENSLLSKVKGVNNAIILRGSSFGEYVFIGRGAGELPTGDAIVADLIDILINYKL
GSKSEVTGVNFREESFTDTFYIRLKLKKDNVCGLKEVLKLIKRNWVSIEKSSFGGNGFTAIVKVNGTVEGLKEQLEKVAV
LEAVFKVLPEENLKERSEFENLVEVM
>Mature_426_residues
MRVKIGLMGLGTVGTGVFKIVNSRGRYIKESTGFYPEIKKVLVKDLHKKRKVDAAGLLTNDPREILEDEEIKVVIEAIGG
ISPAYEYVKKALLSGKHVITANKELIAKYGEELGSIAAEKGVYLRCEASVGGAIPILHQIDRLKITDEMDFIGGIVNGTT
NYILTKMGEGKSYKEALNEAQELGYAEANPDYDVKGFDATFKLGILVKRVFGVSVPVEIIPRKGIEEIKEEDVERAKEWG
YEFKLFAWAKKFKNYISAGVEPTLIPENSLLSKVKGVNNAIILRGSSFGEYVFIGRGAGELPTGDAIVADLIDILINYKL
GSKSEVTGVNFREESFTDTFYIRLKLKKDNVCGLKEVLKLIKRNWVSIEKSSFGGNGFTAIVKVNGTVEGLKEQLEKVAV
LEAVFKVLPEENLKERSEFENLVEVM

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=140, Percent_Identity=30.7142857142857, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47142; Mature: 47142

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKIGLMGLGTVGTGVFKIVNSRGRYIKESTGFYPEIKKVLVKDLHKKRKVDAAGLLTN
CEEEEEEEECCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DPREILEDEEIKVVIEAIGGISPAYEYVKKALLSGKHVITANKELIAKYGEELGSIAAEK
CHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCC
GVYLRCEASVGGAIPILHQIDRLKITDEMDFIGGIVNGTTNYILTKMGEGKSYKEALNEA
CEEEEEECCCCCCHHHHHHHHHEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
QELGYAEANPDYDVKGFDATFKLGILVKRVFGVSVPVEIIPRKGIEEIKEEDVERAKEWG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCC
YEFKLFAWAKKFKNYISAGVEPTLIPENSLLSKVKGVNNAIILRGSSFGEYVFIGRGAGE
CEEEHHHHHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCC
LPTGDAIVADLIDILINYKLGSKSEVTGVNFREESFTDTFYIRLKLKKDNVCGLKEVLKL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHH
IKRNWVSIEKSSFGGNGFTAIVKVNGTVEGLKEQLEKVAVLEAVFKVLPEENLKERSEFE
HHHCCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NLVEVM
HHHHCC
>Mature Secondary Structure
MRVKIGLMGLGTVGTGVFKIVNSRGRYIKESTGFYPEIKKVLVKDLHKKRKVDAAGLLTN
CEEEEEEEECCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DPREILEDEEIKVVIEAIGGISPAYEYVKKALLSGKHVITANKELIAKYGEELGSIAAEK
CHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCC
GVYLRCEASVGGAIPILHQIDRLKITDEMDFIGGIVNGTTNYILTKMGEGKSYKEALNEA
CEEEEEECCCCCCHHHHHHHHHEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
QELGYAEANPDYDVKGFDATFKLGILVKRVFGVSVPVEIIPRKGIEEIKEEDVERAKEWG
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHCC
YEFKLFAWAKKFKNYISAGVEPTLIPENSLLSKVKGVNNAIILRGSSFGEYVFIGRGAGE
CEEEHHHHHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCC
LPTGDAIVADLIDILINYKLGSKSEVTGVNFREESFTDTFYIRLKLKKDNVCGLKEVLKL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHH
IKRNWVSIEKSSFGGNGFTAIVKVNGTVEGLKEQLEKVAVLEAVFKVLPEENLKERSEFE
HHHCCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NLVEVM
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]