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The map label for this gene is LdhA2 [H]

Identifier: 20808350

GI number: 20808350

Start: 1892873

End: 1893847

Strand: Reverse

Name: LdhA2 [H]

Synonym: TTE1946

Alternate gene names: 20808350

Gene position: 1893847-1892873 (Counterclockwise)

Preceding gene: 20808351

Following gene: 20808349

Centisome position: 70.42

GC content: 40.0

Gene sequence:

>975_bases
ATGTTTAAAGTTTTTGTGACAAGAGCTATTCCAGAGGAGGGACTGGAACTTTTAAGGAAGTATTGCGAAGTGGAGGTGAG
CCCATATGACAGAATGCTTACCAAAGAGGAGCTTTTGGAAAAAATAAAAGACAAGGATGCAGTGATAACACAGCTTACTG
ACAAGGTGGATAAAGAGTTTTTTGAAGCTGCCAAAAATGTAAAGATTGTCGCAAATTATGCTGTGGGCTTTGACAATATA
GATCTAGAAGAAGCTACAAAAAGGGGAGTTTACATAACAAATACGCCCGATGTCTTGACAAATGCTACTGCAGAACTAGC
TTGGGCTCTTTTATTTGCTGCAGCGAGAAGAGTGGTAGAAGCGGATAAATTCATGAGGGCAGGTAAATTTCAGGGCTGGG
CGCCAATGCTTTTCTTAGGAAAAGGTGTAACCGGGAAAACGTTAGGAGTTATAGGCGCAGGGAGAATAGGACAAGCTTTT
GCTAAAATGGCAAAAGGCTTTGAGATGAAGATTTTATATAATGCCAGAACTCCAAAACCCGAATTTGAAAAAGAGACAGG
AGCCAAGTACGTTGATTTGGACACTCTCTTGAAAGAATCCGATTTTGTCTCAATACACCTTCCTTTAACACCTGAGACAA
GGCATTTAATTGGAGAAAGAGAGCTAAAACTTATGAAAAATTCTGCAATATTGATAAACACAGGTAGAGGGCCTGTGGTA
GATGAAAAGGCACTGGTTAAGGCTTTAAAAGAAAAATGGATTTACGCTGCAGGCTTAGACGTCTATGAAAGAGAACCAGA
ATTTGAAAAAGAGCTGGCCGAACTTGACAATGTTGTAATGCTTCCTCACATAGGAAGTGCAACAGAAGAAGCTAGAAGAG
ACATGTCAGTGCTTGTCGCCCAGAACATAATTGATGTGATAGAAGGAAGAGTTCCTCGCACATTGGTTAACAAGGATATT
CTGAATAAAAGATAA

Upstream 100 bases:

>100_bases
CTTCTACAGTAGTCTTCATTGCAAACCTGCTTTCGTTTTTAACAATACCAATATTTTTGGTGTTGATAAATAAACTTTAA
GTGGAGGAGTGATAGCAAGT

Downstream 100 bases:

>100_bases
TCTTTGGGGGTCCCTTTTGGGATTCCTTTTTTAACTCCAAAAATTCCATAAAGGCCAATAAAAAATTTAGAAATAAAGGA
GGATTTTTTGGATTTGTGTA

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MFKVFVTRAIPEEGLELLRKYCEVEVSPYDRMLTKEELLEKIKDKDAVITQLTDKVDKEFFEAAKNVKIVANYAVGFDNI
DLEEATKRGVYITNTPDVLTNATAELAWALLFAAARRVVEADKFMRAGKFQGWAPMLFLGKGVTGKTLGVIGAGRIGQAF
AKMAKGFEMKILYNARTPKPEFEKETGAKYVDLDTLLKESDFVSIHLPLTPETRHLIGERELKLMKNSAILINTGRGPVV
DEKALVKALKEKWIYAAGLDVYEREPEFEKELAELDNVVMLPHIGSATEEARRDMSVLVAQNIIDVIEGRVPRTLVNKDI
LNKR

Sequences:

>Translated_324_residues
MFKVFVTRAIPEEGLELLRKYCEVEVSPYDRMLTKEELLEKIKDKDAVITQLTDKVDKEFFEAAKNVKIVANYAVGFDNI
DLEEATKRGVYITNTPDVLTNATAELAWALLFAAARRVVEADKFMRAGKFQGWAPMLFLGKGVTGKTLGVIGAGRIGQAF
AKMAKGFEMKILYNARTPKPEFEKETGAKYVDLDTLLKESDFVSIHLPLTPETRHLIGERELKLMKNSAILINTGRGPVV
DEKALVKALKEKWIYAAGLDVYEREPEFEKELAELDNVVMLPHIGSATEEARRDMSVLVAQNIIDVIEGRVPRTLVNKDI
LNKR
>Mature_324_residues
MFKVFVTRAIPEEGLELLRKYCEVEVSPYDRMLTKEELLEKIKDKDAVITQLTDKVDKEFFEAAKNVKIVANYAVGFDNI
DLEEATKRGVYITNTPDVLTNATAELAWALLFAAARRVVEADKFMRAGKFQGWAPMLFLGKGVTGKTLGVIGAGRIGQAF
AKMAKGFEMKILYNARTPKPEFEKETGAKYVDLDTLLKESDFVSIHLPLTPETRHLIGERELKLMKNSAILINTGRGPVV
DEKALVKALKEKWIYAAGLDVYEREPEFEKELAELDNVVMLPHIGSATEEARRDMSVLVAQNIIDVIEGRVPRTLVNKDI
LNKR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=314, Percent_Identity=41.0828025477707, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=32.3024054982818, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI61743967, Length=299, Percent_Identity=34.1137123745819, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557497, Length=299, Percent_Identity=34.1137123745819, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI145580575, Length=292, Percent_Identity=32.1917808219178, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580578, Length=299, Percent_Identity=32.1070234113712, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557499, Length=299, Percent_Identity=32.1070234113712, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=40.625, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI1787645, Length=331, Percent_Identity=32.9305135951662, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1789279, Length=308, Percent_Identity=31.4935064935065, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788660, Length=236, Percent_Identity=27.1186440677966, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081824, Length=146, Percent_Identity=30.8219178082192, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=31.6770186335404, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=302, Percent_Identity=27.8145695364238, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=291, Percent_Identity=35.3951890034364, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320925, Length=289, Percent_Identity=33.2179930795848, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322116, Length=289, Percent_Identity=31.1418685121107, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321253, Length=279, Percent_Identity=27.2401433691756, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=210, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=276, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=46.474358974359, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=40.8945686900958, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=40.8945686900958, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=40.8945686900958, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=40.8945686900958, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=40.8945686900958, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=38.9776357827476, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19921140, Length=326, Percent_Identity=33.1288343558282, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=32.5878594249201, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24646446, Length=272, Percent_Identity=33.4558823529412, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646448, Length=272, Percent_Identity=33.4558823529412, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646452, Length=272, Percent_Identity=33.4558823529412, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24646450, Length=272, Percent_Identity=33.4558823529412, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI62472511, Length=273, Percent_Identity=34.4322344322344, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36435; Mature: 36435

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKVFVTRAIPEEGLELLRKYCEVEVSPYDRMLTKEELLEKIKDKDAVITQLTDKVDKEF
CEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FEAAKNVKIVANYAVGFDNIDLEEATKRGVYITNTPDVLTNATAELAWALLFAAARRVVE
HHHHCCEEEEEEEEECCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
ADKFMRAGKFQGWAPMLFLGKGVTGKTLGVIGAGRIGQAFAKMAKGFEMKILYNARTPKP
HHHHHHHCCCCCCCCCEEECCCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCC
EFEKETGAKYVDLDTLLKESDFVSIHLPLTPETRHLIGERELKLMKNSAILINTGRGPVV
CCHHHCCCEEEEHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
DEKALVKALKEKWIYAAGLDVYEREPEFEKELAELDNVVMLPHIGSATEEARRDMSVLVA
CHHHHHHHHHHHHEEECCCHHHHCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
QNIIDVIEGRVPRTLVNKDILNKR
HHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MFKVFVTRAIPEEGLELLRKYCEVEVSPYDRMLTKEELLEKIKDKDAVITQLTDKVDKEF
CEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FEAAKNVKIVANYAVGFDNIDLEEATKRGVYITNTPDVLTNATAELAWALLFAAARRVVE
HHHHCCEEEEEEEEECCCCCCHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
ADKFMRAGKFQGWAPMLFLGKGVTGKTLGVIGAGRIGQAFAKMAKGFEMKILYNARTPKP
HHHHHHHCCCCCCCCCEEECCCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEEECCCCCC
EFEKETGAKYVDLDTLLKESDFVSIHLPLTPETRHLIGERELKLMKNSAILINTGRGPVV
CCHHHCCCEEEEHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
DEKALVKALKEKWIYAAGLDVYEREPEFEKELAELDNVVMLPHIGSATEEARRDMSVLVA
CHHHHHHHHHHHHEEECCCHHHHCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
QNIIDVIEGRVPRTLVNKDILNKR
HHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA