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The map label for this gene is LdhA [H]

Identifier: 20808347

GI number: 20808347

Start: 1889436

End: 1890512

Strand: Reverse

Name: LdhA [H]

Synonym: TTE1943

Alternate gene names: 20808347

Gene position: 1890512-1889436 (Counterclockwise)

Preceding gene: 20808348

Following gene: 20808346

Centisome position: 70.29

GC content: 37.6

Gene sequence:

>1077_bases
TTGTCAGAAAAAATATTGAAAATCACTTTAAAGAGATATTCAGTAAATAAAGAAAGGGCGGTTGAAATGGGTGTAAAAAT
TGCAATTGTGAATTCTAGCAGTTTCGGGAAGCACTTTCCTGAACACATTGAAAGATTAAAAGCATTAGGGCAGGTAGACA
GGTTTGAGCTTCCTCATGACATGAGAGGGAAGGCTCTGGCAGAAAAATTAATGGGCTATTCTATAATAATTGCCAGTGTA
AAGCCCTATTATGATAGGGAGTTTTTTGAGTACAAGGATGAAACTCTTTTAATTGCTCGCCATGGCATAGGTTACGATGC
TATAGATATAGAAAGTGCGACAAAAAAAGGCACTATAGTCACCATAGTTGAAGGAATAGTTGAAAGAGAAGCTGTGGCAG
AAAATGCAGTTGCACTCCTTTTAGATGTGATGAGAAAAGTAAGAGAAGCCTCAATTAAAGTAAAAGAAGGGAAATGGCAT
GAAAGAGCGAATTTCATAGGGTATGAGATAAAGGGCAAGACTGCGGGGATAATAGGTATTGGCAATATTGGAAGTAGAGT
TGCTGAGATATTAAAATACGGCTTTGGGGCGGAAGTTATTGCCTATGATCCAAATCTTTCAAAAGAAGAAATAATAAAGA
GAGAAGCTCGTCCTGTGTCTTTAGAGGAGTTATTAAGGTCATCAGACATAATTTCTCTTAATGCTTCATTAAATGAGAGA
AATTATCACATGCTGTCTTATAAAGAATTTTCTATGATGAAAAATAATGTATTTATTGTTAACACTGCAAGAGGAGAACT
TATAGATACAGAGGCTCTTATAAAAGCCTTAAGGGAAGGGAAAGTCGCCGGGGTTGGACTTGACGTGGTAGAAGGAGAAC
CTATTGATGAAAATCATCCACTCCTTAAATTTGACAATGTTGTGATAACCCCTCACACTTCTGCCTACACATACGAGTGT
TTAAAAGGCATGGGAGATAAAGTTGTTTCAGATGCAGAAAAAGTCCTACGAGGCGAAATACCCGATGGGGTTGTAAATAA
AGAGGTGCTGGAGGGGGAGAAATGGAAAAAGATTTGA

Upstream 100 bases:

>100_bases
ATTAAGCAGCTTTTCCACATCTCTTATGGAGTTTTACTGGAAGAAAGGAAAAAACAAATTTTTGAAGTTTTAAATAAGTA
CGAAGAGGAGCATTACGAAT

Downstream 100 bases:

>100_bases
TTCTTTCTGTTGACATAGGGACGACAAACTTAAAAGCAGGTGTGGTGGACGAAAAAGGAAATATTTTAAGCTTGTACAGG
AAGGAAACGCCTATTGAAAG

Product: lactate dehydrogenase and related dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSEKILKITLKRYSVNKERAVEMGVKIAIVNSSSFGKHFPEHIERLKALGQVDRFELPHDMRGKALAEKLMGYSIIIASV
KPYYDREFFEYKDETLLIARHGIGYDAIDIESATKKGTIVTIVEGIVEREAVAENAVALLLDVMRKVREASIKVKEGKWH
ERANFIGYEIKGKTAGIIGIGNIGSRVAEILKYGFGAEVIAYDPNLSKEEIIKREARPVSLEELLRSSDIISLNASLNER
NYHMLSYKEFSMMKNNVFIVNTARGELIDTEALIKALREGKVAGVGLDVVEGEPIDENHPLLKFDNVVITPHTSAYTYEC
LKGMGDKVVSDAEKVLRGEIPDGVVNKEVLEGEKWKKI

Sequences:

>Translated_358_residues
MSEKILKITLKRYSVNKERAVEMGVKIAIVNSSSFGKHFPEHIERLKALGQVDRFELPHDMRGKALAEKLMGYSIIIASV
KPYYDREFFEYKDETLLIARHGIGYDAIDIESATKKGTIVTIVEGIVEREAVAENAVALLLDVMRKVREASIKVKEGKWH
ERANFIGYEIKGKTAGIIGIGNIGSRVAEILKYGFGAEVIAYDPNLSKEEIIKREARPVSLEELLRSSDIISLNASLNER
NYHMLSYKEFSMMKNNVFIVNTARGELIDTEALIKALREGKVAGVGLDVVEGEPIDENHPLLKFDNVVITPHTSAYTYEC
LKGMGDKVVSDAEKVLRGEIPDGVVNKEVLEGEKWKKI
>Mature_357_residues
SEKILKITLKRYSVNKERAVEMGVKIAIVNSSSFGKHFPEHIERLKALGQVDRFELPHDMRGKALAEKLMGYSIIIASVK
PYYDREFFEYKDETLLIARHGIGYDAIDIESATKKGTIVTIVEGIVEREAVAENAVALLLDVMRKVREASIKVKEGKWHE
RANFIGYEIKGKTAGIIGIGNIGSRVAEILKYGFGAEVIAYDPNLSKEEIIKREARPVSLEELLRSSDIISLNASLNERN
YHMLSYKEFSMMKNNVFIVNTARGELIDTEALIKALREGKVAGVGLDVVEGEPIDENHPLLKFDNVVITPHTSAYTYECL
KGMGDKVVSDAEKVLRGEIPDGVVNKEVLEGEKWKKI

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=254, Percent_Identity=34.251968503937, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557497, Length=286, Percent_Identity=33.2167832167832, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI61743967, Length=286, Percent_Identity=33.2167832167832, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI145580578, Length=287, Percent_Identity=32.7526132404181, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=287, Percent_Identity=32.7526132404181, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=288, Percent_Identity=32.9861111111111, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI6912396, Length=293, Percent_Identity=30.0341296928328, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI87082289, Length=249, Percent_Identity=32.9317269076305, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1787645, Length=262, Percent_Identity=33.206106870229, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789279, Length=230, Percent_Identity=33.4782608695652, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17532191, Length=264, Percent_Identity=32.5757575757576, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=267, Percent_Identity=29.2134831460674, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=36.8852459016393, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=275, Percent_Identity=30.1818181818182, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=310, Percent_Identity=29.0322580645161, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=229, Percent_Identity=29.6943231441048, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=153, Percent_Identity=31.3725490196078, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=186, Percent_Identity=27.9569892473118, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646446, Length=296, Percent_Identity=34.1216216216216, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646448, Length=296, Percent_Identity=34.1216216216216, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646452, Length=296, Percent_Identity=34.1216216216216, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646450, Length=296, Percent_Identity=34.1216216216216, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI62472511, Length=296, Percent_Identity=34.1216216216216, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28571528, Length=307, Percent_Identity=30.6188925081433, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921140, Length=263, Percent_Identity=33.0798479087452, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585516, Length=224, Percent_Identity=32.5892857142857, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=284, Percent_Identity=29.2253521126761, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45552429, Length=245, Percent_Identity=28.1632653061224, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585514, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574282, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574284, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45551003, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 40096; Mature: 39965

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKILKITLKRYSVNKERAVEMGVKIAIVNSSSFGKHFPEHIERLKALGQVDRFELPHD
CCCCEEEEEEHHHCCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHCCCCCC
MRGKALAEKLMGYSIIIASVKPYYDREFFEYKDETLLIARHGIGYDAIDIESATKKGTIV
CCHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCEE
TIVEGIVEREAVAENAVALLLDVMRKVREASIKVKEGKWHERANFIGYEIKGKTAGIIGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHCCEEEEEECCCEEEEEEE
GNIGSRVAEILKYGFGAEVIAYDPNLSKEEIIKREARPVSLEELLRSSDIISLNASLNER
CCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCC
NYHMLSYKEFSMMKNNVFIVNTARGELIDTEALIKALREGKVAGVGLDVVEGEPIDENHP
CEEEEEHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHCCCEEECEEEEECCCCCCCCCC
LLKFDNVVITPHTSAYTYECLKGMGDKVVSDAEKVLRGEIPDGVVNKEVLEGEKWKKI
EEEECCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHCCC
>Mature Secondary Structure 
SEKILKITLKRYSVNKERAVEMGVKIAIVNSSSFGKHFPEHIERLKALGQVDRFELPHD
CCCEEEEEEHHHCCCHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHCCCCCC
MRGKALAEKLMGYSIIIASVKPYYDREFFEYKDETLLIARHGIGYDAIDIESATKKGTIV
CCHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEEEEEECCCCCCEEECCCCCCCCCEE
TIVEGIVEREAVAENAVALLLDVMRKVREASIKVKEGKWHERANFIGYEIKGKTAGIIGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHCCEEEEEECCCEEEEEEE
GNIGSRVAEILKYGFGAEVIAYDPNLSKEEIIKREARPVSLEELLRSSDIISLNASLNER
CCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCC
NYHMLSYKEFSMMKNNVFIVNTARGELIDTEALIKALREGKVAGVGLDVVEGEPIDENHP
CEEEEEHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHCCCEEECEEEEECCCCCCCCCC
LLKFDNVVITPHTSAYTYECLKGMGDKVVSDAEKVLRGEIPDGVVNKEVLEGEKWKKI
EEEECCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]