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The map label for this gene is murB

Identifier: 20808252

GI number: 20808252

Start: 1786305

End: 1787213

Strand: Reverse

Name: murB

Synonym: TTE1836

Alternate gene names: 20808252

Gene position: 1787213-1786305 (Counterclockwise)

Preceding gene: 20808253

Following gene: 20808251

Centisome position: 66.45

GC content: 38.28

Gene sequence:

>909_bases
GTGGCTGAGATACTTGTTGATAAATTGAAAGAAATTTTAAAAGAGGGGAAATTATATTTAAATGAGCCAATGAAAAGGCA
TACCTCTTTTAAAATAGGAGGGCCAGCTGATGTACTAGCTGTTCCGGGAAGCAGAGACGAACTTATTAATCTCATCGCAT
ATTTAAGACAGGAAAAAATACCTTTTTTTATTCTAGGGAATGGCACTAATTTGCTGGTAAGTGAAAAAGGTATAAGAGGC
GTGGTTGTAAAACTTAGTTCTTTGAGGAATGTCATTGTAGAAGGAACTAAGATAATAGCAGAAGCAGGAGCTTCCCTGTC
CTATATTGCAAATGTAGCATTGGTACATGAGCTTACCGGTTTTGAATTTGCAAGTGGCATACCTGGCACTTTGGGTGGGG
CCATAGTGATGAATGCCGGTGCCTATGGGTCTGAGATGAAGGACGTGGTAGAAAAGGTAGAAGTCTTAGATGAAAATAAC
AATATATTGATTCTTTCCAATCAGGAAATGAAGTTCTCTTATAGATATAGCATTTTGCAAGAAAAAGAATGGATAGTTTT
GAGAGCCTGGATTTCTCTTGAAAGAGGGAATTATGAAGAGATAAAAAAGAAGATGGAGGAACTAAATCAGAGGAGAAAAG
AAAAACAGCCTTTAGATTATCCCAGTGCAGGGAGCACTTTTAAAAGGCCTCCAGGGTACTATGCAGGAAAGCTTATTGAA
GATGCGGGGCTCAAAGGGTACTCGATCGGGGGTGCTAAAGTTTCAGAAAAACATTCGGGATTTATTATAAACACTGGGAA
TGCGACTTTTTACGATGTGCTCAACTTGATTGAGTATATCCAGAAAGTAGTAAAAGAGAAATTTGGAGTTGAGCTTATGC
CTGAGATAAAAATTGTGGGGGAAAAATAG

Upstream 100 bases:

>100_bases
AAAGTGGTATTATAAAATTGCACATGGAATGAAATTAACATGTAATTGATAGACTATAGATGGAATAATTTTTTGATTTT
TAATTTTGAGGAGTGGTACA

Downstream 100 bases:

>100_bases
GAGAGAGAACAAATGAGGATTTTTGCAGATTATCACACCCATACGATATACAGCCACGGCAAAGGGACAATAGAAGAAAA
TGTGAAAAAAGCGGTAGAGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MAEILVDKLKEILKEGKLYLNEPMKRHTSFKIGGPADVLAVPGSRDELINLIAYLRQEKIPFFILGNGTNLLVSEKGIRG
VVVKLSSLRNVIVEGTKIIAEAGASLSYIANVALVHELTGFEFASGIPGTLGGAIVMNAGAYGSEMKDVVEKVEVLDENN
NILILSNQEMKFSYRYSILQEKEWIVLRAWISLERGNYEEIKKKMEELNQRRKEKQPLDYPSAGSTFKRPPGYYAGKLIE
DAGLKGYSIGGAKVSEKHSGFIINTGNATFYDVLNLIEYIQKVVKEKFGVELMPEIKIVGEK

Sequences:

>Translated_302_residues
MAEILVDKLKEILKEGKLYLNEPMKRHTSFKIGGPADVLAVPGSRDELINLIAYLRQEKIPFFILGNGTNLLVSEKGIRG
VVVKLSSLRNVIVEGTKIIAEAGASLSYIANVALVHELTGFEFASGIPGTLGGAIVMNAGAYGSEMKDVVEKVEVLDENN
NILILSNQEMKFSYRYSILQEKEWIVLRAWISLERGNYEEIKKKMEELNQRRKEKQPLDYPSAGSTFKRPPGYYAGKLIE
DAGLKGYSIGGAKVSEKHSGFIINTGNATFYDVLNLIEYIQKVVKEKFGVELMPEIKIVGEK
>Mature_301_residues
AEILVDKLKEILKEGKLYLNEPMKRHTSFKIGGPADVLAVPGSRDELINLIAYLRQEKIPFFILGNGTNLLVSEKGIRGV
VVKLSSLRNVIVEGTKIIAEAGASLSYIANVALVHELTGFEFASGIPGTLGGAIVMNAGAYGSEMKDVVEKVEVLDENNN
ILILSNQEMKFSYRYSILQEKEWIVLRAWISLERGNYEEIKKKMEELNQRRKEKQPLDYPSAGSTFKRPPGYYAGKLIED
AGLKGYSIGGAKVSEKHSGFIINTGNATFYDVLNLIEYIQKVVKEKFGVELMPEIKIVGEK

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_THETN (Q8R8Z6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623423.1
- ProteinModelPortal:   Q8R8Z6
- SMR:   Q8R8Z6
- GeneID:   997030
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1836
- NMPDR:   fig|273068.3.peg.1573
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   TTEN273068:TTE1836-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33575; Mature: 33444

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 175-175 ACT_SITE 225-225 ACT_SITE 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEILVDKLKEILKEGKLYLNEPMKRHTSFKIGGPADVLAVPGSRDELINLIAYLRQEKI
CHHHHHHHHHHHHHCCCEEECCHHHHHCCEECCCCCCEEECCCCHHHHHHHHHHHHHCCC
PFFILGNGTNLLVSEKGIRGVVVKLSSLRNVIVEGTKIIAEAGASLSYIANVALVHELTG
CEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FEFASGIPGTLGGAIVMNAGAYGSEMKDVVEKVEVLDENNNILILSNQEMKFSYRYSILQ
CHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEHHHHHC
EKEWIVLRAWISLERGNYEEIKKKMEELNQRRKEKQPLDYPSAGSTFKRPPGYYAGKLIE
CCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
DAGLKGYSIGGAKVSEKHSGFIINTGNATFYDVLNLIEYIQKVVKEKFGVELMPEIKIVG
HCCCCEEECCCCEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEC
EK
CC
>Mature Secondary Structure 
AEILVDKLKEILKEGKLYLNEPMKRHTSFKIGGPADVLAVPGSRDELINLIAYLRQEKI
HHHHHHHHHHHHHCCCEEECCHHHHHCCEECCCCCCEEECCCCHHHHHHHHHHHHHCCC
PFFILGNGTNLLVSEKGIRGVVVKLSSLRNVIVEGTKIIAEAGASLSYIANVALVHELTG
CEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
FEFASGIPGTLGGAIVMNAGAYGSEMKDVVEKVEVLDENNNILILSNQEMKFSYRYSILQ
CHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEHHHHHC
EKEWIVLRAWISLERGNYEEIKKKMEELNQRRKEKQPLDYPSAGSTFKRPPGYYAGKLIE
CCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
DAGLKGYSIGGAKVSEKHSGFIINTGNATFYDVLNLIEYIQKVVKEKFGVELMPEIKIVG
HCCCCEEECCCCEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEECCCEEEEC
EK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336