Click here to switch to the map view.

The map label for this gene is GapA [H]

Identifier: 20808181

GI number: 20808181

Start: 1709334

End: 1710341

Strand: Reverse

Name: GapA [H]

Synonym: TTE1762

Alternate gene names: 20808181

Gene position: 1710341-1709334 (Counterclockwise)

Preceding gene: 20808182

Following gene: 20808180

Centisome position: 63.59

GC content: 41.37

Gene sequence:

>1008_bases
ATGGGTGTTAGAGTAGGAATTAACGGTTTTGGAAGAATAGGAAGGAATGTGTTTAGAGCTGCTTTAAAGAAAAATGCTGA
TTTAGAATTTGTGGCTGTCAATGATTTGACAGATGCTAAAACATTGGCTCACCTTCTCAAATACGACTCTGTCTTAGGGA
AATTTGAAGGGGAGGTTTCTTACACTGATGACTCTCTAATTGTAAATGGGAAAGAGATAAAGATATTCAAGGAAACAGAC
CCAGGTAAGCTTCCATGGGGAGATTTGGGAGTGGACATTGTAATTGAGTCTACAGGAAGATTTACTAACAAAGAGGATGC
TATAAAGCACATACACGGTGGAGCTAAAAAGGTGATAATTACAGCTCCTGCAAAAAATGAGGATGTTACAATTGTGATGG
GTGTAAATGAGCACATGTATGACCCTGCTAATCACCATGTGATTTCAAACGCATCATGTACGACAAACTGCTTGGCTCCT
ATTGCAAAAGTATTGAATGACAAATTCCGCATTAAAAAAGGTATGATGACAACAGTTCACTCTTATACAAATGACCAGAG
AATATTGGATCTTCCTCACAGTGATTTGAGAAGAGCGAGAGCTGCAGCTGTTTCAATAATACCTACGACAACAGGTGCGG
CAAAGGCCATCCACTTGGTAATTCCTGAGTTAAAAGGCAAGATGAACGGTTTTGCAATGAGAGTTCCAACGCCTAACGTT
TCAGTTGTAGATTTGGTGGCTGAAGTAGAAATTCCAACCACGGTAGAGGAAGTAAACGCTGCTATGAAGGAAGCTTCTGA
GACATACATGAAAGGTATCTTGGGATACTCTGAGGACCCATTGGTTTCTGTGGACTACAAGGGAGACGACAGGTCTTCAA
TAGTGGATGCTCCTCTCACAATGGTAGTGGAGGGCACACTCGTTAAAGTAGTTTCCTGGTACGACAACGAATGGGGTTAC
TCCAACAGAGTCGTTGACCTGGCTCTTTATATAGCTGAAAGGATGTAG

Upstream 100 bases:

>100_bases
TGCTCGTGACTGATGAAGGAGCTGCTTTTGAAATTTTAAGAATGGTGTAAAAACACCTTATAAGGTGTTTAACAAAAAAA
CTAACAAGGAGGAGTACATA

Downstream 100 bases:

>100_bases
CAGGGCAAAGGTCCGCGTCCTTCAAGGACCGGACCTTTAAATCCTAATATAGGGGAGGTTTTTGAAGTGAAAAAGAAAAC
TGTGAGAGACATAGACGTTA

Product: glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MGVRVGINGFGRIGRNVFRAALKKNADLEFVAVNDLTDAKTLAHLLKYDSVLGKFEGEVSYTDDSLIVNGKEIKIFKETD
PGKLPWGDLGVDIVIESTGRFTNKEDAIKHIHGGAKKVIITAPAKNEDVTIVMGVNEHMYDPANHHVISNASCTTNCLAP
IAKVLNDKFRIKKGMMTTVHSYTNDQRILDLPHSDLRRARAAAVSIIPTTTGAAKAIHLVIPELKGKMNGFAMRVPTPNV
SVVDLVAEVEIPTTVEEVNAAMKEASETYMKGILGYSEDPLVSVDYKGDDRSSIVDAPLTMVVEGTLVKVVSWYDNEWGY
SNRVVDLALYIAERM

Sequences:

>Translated_335_residues
MGVRVGINGFGRIGRNVFRAALKKNADLEFVAVNDLTDAKTLAHLLKYDSVLGKFEGEVSYTDDSLIVNGKEIKIFKETD
PGKLPWGDLGVDIVIESTGRFTNKEDAIKHIHGGAKKVIITAPAKNEDVTIVMGVNEHMYDPANHHVISNASCTTNCLAP
IAKVLNDKFRIKKGMMTTVHSYTNDQRILDLPHSDLRRARAAAVSIIPTTTGAAKAIHLVIPELKGKMNGFAMRVPTPNV
SVVDLVAEVEIPTTVEEVNAAMKEASETYMKGILGYSEDPLVSVDYKGDDRSSIVDAPLTMVVEGTLVKVVSWYDNEWGY
SNRVVDLALYIAERM
>Mature_334_residues
GVRVGINGFGRIGRNVFRAALKKNADLEFVAVNDLTDAKTLAHLLKYDSVLGKFEGEVSYTDDSLIVNGKEIKIFKETDP
GKLPWGDLGVDIVIESTGRFTNKEDAIKHIHGGAKKVIITAPAKNEDVTIVMGVNEHMYDPANHHVISNASCTTNCLAPI
AKVLNDKFRIKKGMMTTVHSYTNDQRILDLPHSDLRRARAAAVSIIPTTTGAAKAIHLVIPELKGKMNGFAMRVPTPNVS
VVDLVAEVEIPTTVEEVNAAMKEASETYMKGILGYSEDPLVSVDYKGDDRSSIVDAPLTMVVEGTLVKVVSWYDNEWGYS
NRVVDLALYIAERM

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=334, Percent_Identity=50.5988023952096, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI7657116, Length=332, Percent_Identity=47.8915662650602, Blast_Score=318, Evalue=4e-87,
Organism=Escherichia coli, GI1788079, Length=334, Percent_Identity=53.5928143712575, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1789295, Length=335, Percent_Identity=45.0746268656716, Blast_Score=299, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17534677, Length=337, Percent_Identity=53.4124629080119, Blast_Score=341, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17534679, Length=337, Percent_Identity=53.4124629080119, Blast_Score=340, Evalue=8e-94,
Organism=Caenorhabditis elegans, GI32566163, Length=337, Percent_Identity=52.5222551928783, Blast_Score=333, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI17568413, Length=337, Percent_Identity=52.5222551928783, Blast_Score=333, Evalue=9e-92,
Organism=Saccharomyces cerevisiae, GI6321631, Length=333, Percent_Identity=52.5525525525526, Blast_Score=335, Evalue=7e-93,
Organism=Saccharomyces cerevisiae, GI6322468, Length=333, Percent_Identity=52.2522522522522, Blast_Score=335, Evalue=8e-93,
Organism=Saccharomyces cerevisiae, GI6322409, Length=333, Percent_Identity=50.7507507507508, Blast_Score=334, Evalue=1e-92,
Organism=Drosophila melanogaster, GI85725000, Length=333, Percent_Identity=50.1501501501502, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI22023983, Length=333, Percent_Identity=50.1501501501502, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI19922412, Length=328, Percent_Identity=49.390243902439, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI17933600, Length=333, Percent_Identity=49.2492492492492, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI18110149, Length=333, Percent_Identity=49.2492492492492, Blast_Score=320, Evalue=1e-87,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36685; Mature: 36553

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRVGINGFGRIGRNVFRAALKKNADLEFVAVNDLTDAKTLAHLLKYDSVLGKFEGEVS
CCEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEE
YTDDSLIVNGKEIKIFKETDPGKLPWGDLGVDIVIESTGRFTNKEDAIKHIHGGAKKVII
ECCCEEEECCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEE
TAPAKNEDVTIVMGVNEHMYDPANHHVISNASCTTNCLAPIAKVLNDKFRIKKGMMTTVH
ECCCCCCCEEEEEECCHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHCHHHHHH
SYTNDQRILDLPHSDLRRARAAAVSIIPTTTGAAKAIHLVIPELKGKMNGFAMRVPTPNV
HCCCCCEEEECCHHHHHHHHHHEEEEEECCCCCCEEEEEEEHHHCCCCCCEEEECCCCCC
SVVDLVAEVEIPTTVEEVNAAMKEASETYMKGILGYSEDPLVSVDYKGDDRSSIVDAPLT
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEECCCEE
MVVEGTLVKVVSWYDNEWGYSNRVVDLALYIAERM
EEECCHHEEEEEHHCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
GVRVGINGFGRIGRNVFRAALKKNADLEFVAVNDLTDAKTLAHLLKYDSVLGKFEGEVS
CEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEE
YTDDSLIVNGKEIKIFKETDPGKLPWGDLGVDIVIESTGRFTNKEDAIKHIHGGAKKVII
ECCCEEEECCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEE
TAPAKNEDVTIVMGVNEHMYDPANHHVISNASCTTNCLAPIAKVLNDKFRIKKGMMTTVH
ECCCCCCCEEEEEECCHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCHHHHHHCHHHHHH
SYTNDQRILDLPHSDLRRARAAAVSIIPTTTGAAKAIHLVIPELKGKMNGFAMRVPTPNV
HCCCCCEEEECCHHHHHHHHHHEEEEEECCCCCCEEEEEEEHHHCCCCCCEEEECCCCCC
SVVDLVAEVEIPTTVEEVNAAMKEASETYMKGILGYSEDPLVSVDYKGDDRSSIVDAPLT
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEECCCEE
MVVEGTLVKVVSWYDNEWGYSNRVVDLALYIAERM
EEECCHHEEEEEHHCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2684782; 2227448; 2656407; 7408868; 193030; 3586018; 9175858 [H]