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The map label for this gene is pgk

Identifier: 20808180

GI number: 20808180

Start: 1708083

End: 1709267

Strand: Reverse

Name: pgk

Synonym: TTE1761

Alternate gene names: 20808180

Gene position: 1709267-1708083 (Counterclockwise)

Preceding gene: 20808181

Following gene: 20808179

Centisome position: 63.55

GC content: 40.59

Gene sequence:

>1185_bases
GTGAAAAAGAAAACTGTGAGAGACATAGACGTTAGCGGAAAAAGAGTTTTAGTTAGAGTAGATTTTAACGTGCCGATGGA
TGAAAATAAAAACATAACAGATGACAGGCGCATAAGAGAAGCTCTTCCCACCATTGAGTATTTAATAAATCACAACGCAA
AAGTGATACTGGTATCTCACCTGGGGAGACCTAAGGGGAAATTCAATCCGGATTACTCTTTAAAGCCTGTTGCAAAAAGG
CTGTCTGAGCTTTTGAAAAAGCCTGTAATTATGGCAGAGGATGTGATTGGAGAAGATGCTAAGGTAAAAGCTGCTGCCTT
AAAAGAAGGGGAAGTTCTCCTTTTGGAAAATGTTAGATTCCATGCAGAAGAGGAGAAGAATGACCCTGAATTTGCAAAAG
AGCTTGCATCTTTAGCAGATATATACGTAAATGATGCTTTTGGCACTGCTCACAGGGCTCACGCTTCTACTGCAGGAGTT
GCCAAGTATCTTCCAGCAGTGGCAGGTTTTTTAATTGAAAAAGAGCTTTCTATAATGGGAGAAGCGTTGGAGAATCCTAA
GAGACCTTTTGTGGCGATTTTAGGTGGAGCTAAAGTTTCTGATAAAATTGGGGTTATAACAAATCTTCTGGAAAAAGTGG
ACAGCCTGTTAATTGGCGGTGGAATGGCTTATACCTTTATTAAGGCGAAGGGCTACGAAATAGGGAAATCTCTTTTGGAA
GAGGATAAAATTGAACTAGCAAAGGAAATAATGGAAAAAGCAAAGCAGAAGGGCGTAAATTTCATGCTTCCTGTTGATAC
AGTTATCGCGAAAGAGTTAAAATCCGGGGTACCTTATGAAGTGGTTGACATTGACAAAATGCCAGAAGACCAGATAGGAG
TTGACATTGGGCCTAAAACAATAGAAGAGTATTCAAAAGTGATAAAGCATGCCATGACAGTTGTATGGAATGGACCAATG
GGAGTTTTTGAAATACCTGAATTTGCCAAAGGTACAAAAGCTATCGCAAAGGCTTTGAGCGAGTGCAAAGGTACAACAAT
AGTAGGAGGAGGAGATTCTGCAGCTGCCATAGAACAGCTTGGCTATGCTGATAAAGTCACCCACATTTCAACTGGAGGCG
GTGCGTCACTGGAATTTTTAGAGGGGAAAGTCTTGCCGGGAATTGACATTTTGAATGATAAGTAA

Upstream 100 bases:

>100_bases
TGACCTGGCTCTTTATATAGCTGAAAGGATGTAGCAGGGCAAAGGTCCGCGTCCTTCAAGGACCGGACCTTTAAATCCTA
ATATAGGGGAGGTTTTTGAA

Downstream 100 bases:

>100_bases
AGGGGTGTTTTGTTTTGAGAAGGCCTATAATTGCAGGAAATTGGAAAATGCATAAGACCCCTTCAGAGGCAGTGAAATTG
GTAGAAGAGCTGATTCCTCT

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKKKTVRDIDVSGKRVLVRVDFNVPMDENKNITDDRRIREALPTIEYLINHNAKVILVSHLGRPKGKFNPDYSLKPVAKR
LSELLKKPVIMAEDVIGEDAKVKAAALKEGEVLLLENVRFHAEEEKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGV
AKYLPAVAGFLIEKELSIMGEALENPKRPFVAILGGAKVSDKIGVITNLLEKVDSLLIGGGMAYTFIKAKGYEIGKSLLE
EDKIELAKEIMEKAKQKGVNFMLPVDTVIAKELKSGVPYEVVDIDKMPEDQIGVDIGPKTIEEYSKVIKHAMTVVWNGPM
GVFEIPEFAKGTKAIAKALSECKGTTIVGGGDSAAAIEQLGYADKVTHISTGGGASLEFLEGKVLPGIDILNDK

Sequences:

>Translated_394_residues
MKKKTVRDIDVSGKRVLVRVDFNVPMDENKNITDDRRIREALPTIEYLINHNAKVILVSHLGRPKGKFNPDYSLKPVAKR
LSELLKKPVIMAEDVIGEDAKVKAAALKEGEVLLLENVRFHAEEEKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGV
AKYLPAVAGFLIEKELSIMGEALENPKRPFVAILGGAKVSDKIGVITNLLEKVDSLLIGGGMAYTFIKAKGYEIGKSLLE
EDKIELAKEIMEKAKQKGVNFMLPVDTVIAKELKSGVPYEVVDIDKMPEDQIGVDIGPKTIEEYSKVIKHAMTVVWNGPM
GVFEIPEFAKGTKAIAKALSECKGTTIVGGGDSAAAIEQLGYADKVTHISTGGGASLEFLEGKVLPGIDILNDK
>Mature_394_residues
MKKKTVRDIDVSGKRVLVRVDFNVPMDENKNITDDRRIREALPTIEYLINHNAKVILVSHLGRPKGKFNPDYSLKPVAKR
LSELLKKPVIMAEDVIGEDAKVKAAALKEGEVLLLENVRFHAEEEKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGV
AKYLPAVAGFLIEKELSIMGEALENPKRPFVAILGGAKVSDKIGVITNLLEKVDSLLIGGGMAYTFIKAKGYEIGKSLLE
EDKIELAKEIMEKAKQKGVNFMLPVDTVIAKELKSGVPYEVVDIDKMPEDQIGVDIGPKTIEEYSKVIKHAMTVVWNGPM
GVFEIPEFAKGTKAIAKALSECKGTTIVGGGDSAAAIEQLGYADKVTHISTGGGASLEFLEGKVLPGIDILNDK

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family

Homologues:

Organism=Homo sapiens, GI4505763, Length=416, Percent_Identity=48.0769230769231, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI31543397, Length=417, Percent_Identity=47.9616306954436, Blast_Score=358, Evalue=6e-99,
Organism=Escherichia coli, GI1789294, Length=390, Percent_Identity=44.8717948717949, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17508823, Length=413, Percent_Identity=47.6997578692494, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319857, Length=413, Percent_Identity=49.636803874092, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24581203, Length=416, Percent_Identity=48.0769230769231, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI17136394, Length=412, Percent_Identity=45.3883495145631, Blast_Score=335, Evalue=5e-92,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): PGK_THETN (Q8R965)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623351.1
- ProteinModelPortal:   Q8R965
- SMR:   Q8R965
- GeneID:   996811
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1761
- NMPDR:   fig|273068.3.peg.1293
- HOGENOM:   HBG453500
- OMA:   DCIGDEV
- ProtClustDB:   PRK00073
- BioCyc:   TTEN273068:TTE1761-MONOMER
- BRENDA:   2.7.2.3
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_00145
- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824
- Gene3D:   G3DSA:3.40.50.1270
- Gene3D:   G3DSA:3.40.50.1260
- PANTHER:   PTHR11406
- PIRSF:   PIRSF000724
- PRINTS:   PR00477

Pfam domain/function: PF00162 PGK; SSF53748 PGK

EC number: =2.7.2.3

Molecular weight: Translated: 42817; Mature: 42817

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: BINDING 37-37 BINDING 119-119 BINDING 152-152 BINDING 202-202 BINDING 293-293 BINDING 324-324

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKTVRDIDVSGKRVLVRVDFNVPMDENKNITDDRRIREALPTIEYLINHNAKVILVSH
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEC
LGRPKGKFNPDYSLKPVAKRLSELLKKPVIMAEDVIGEDAKVKAAALKEGEVLLLENVRF
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEHHHHCCCCCCEEHHHCCCCCEEEEECCEE
HAEEEKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGVAKYLPAVAGFLIEKELSIMG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALENPKRPFVAILGGAKVSDKIGVITNLLEKVDSLLIGGGMAYTFIKAKGYEIGKSLLE
HHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
EDKIELAKEIMEKAKQKGVNFMLPVDTVIAKELKSGVPYEVVDIDKMPEDQIGVDIGPKT
HHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCCHHH
IEEYSKVIKHAMTVVWNGPMGVFEIPEFAKGTKAIAKALSECKGTTIVGGGDSAAAIEQL
HHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHC
GYADKVTHISTGGGASLEFLEGKVLPGIDILNDK
CCHHHEEEEECCCCCEEHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKKTVRDIDVSGKRVLVRVDFNVPMDENKNITDDRRIREALPTIEYLINHNAKVILVSH
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEC
LGRPKGKFNPDYSLKPVAKRLSELLKKPVIMAEDVIGEDAKVKAAALKEGEVLLLENVRF
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEHHHHCCCCCCEEHHHCCCCCEEEEECCEE
HAEEEKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGVAKYLPAVAGFLIEKELSIMG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALENPKRPFVAILGGAKVSDKIGVITNLLEKVDSLLIGGGMAYTFIKAKGYEIGKSLLE
HHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
EDKIELAKEIMEKAKQKGVNFMLPVDTVIAKELKSGVPYEVVDIDKMPEDQIGVDIGPKT
HHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCEEEEECCCCCCHHCCCCCCHHH
IEEYSKVIKHAMTVVWNGPMGVFEIPEFAKGTKAIAKALSECKGTTIVGGGDSAAAIEQL
HHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHC
GYADKVTHISTGGGASLEFLEGKVLPGIDILNDK
CCHHHEEEEECCCCCEEHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336