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The map label for this gene is trpC

Identifier: 20808009

GI number: 20808009

Start: 1536866

End: 1537636

Strand: Reverse

Name: trpC

Synonym: TTE1580

Alternate gene names: 20808009

Gene position: 1537636-1536866 (Counterclockwise)

Preceding gene: 20808010

Following gene: 20808008

Centisome position: 57.17

GC content: 36.58

Gene sequence:

>771_bases
ATGATTCTAGAGGAAATTGTGAATTTTAAAAAAGAAGAAGTGAGGAAGAAAAAAGAGTTAAAGCCTTACAACGAATTGCT
AAATGTCAACGCAGTATACAGAGGAGATTTTAAAAATTCTCTGAACAAAGGAAAGGTGGCAATTATAGGGGAGATAAAGA
GAGCTTCTCCTTCCAAAGGGATTATAAGAGAAGAATTTGACCTTGTAGAAATTGCAAAGACCTACGAAAAGGCAGAAGTT
GATGCCATATCTGTCTTGACAGAGAAAAGATTTTTTAAAGGCGAAGGTGGCTACATTCCTCAGGTAAAGAAGTTAACCAC
AAAGCCTGTTTTGAGGAAAGACTTTGTAATAGATGAGTATCAGATTTACGAGTCAAAATTTCTAGGGGCAGATGCAGTCT
TATTGATTGTGGCTATTTTGGAAGATAAGCTTAAGGGTTTTTGCGATATAGCAAAACAAATTGGGCTTGATGTGCTTGTC
GAGGTTCACGAGGAGGAAGAACTTGAGACTGCGCTAAAGGCAGGATGCGATATCATAGGGATAAATAATAGGGACTTGAA
GACTTTTAAAGTTGACATAAAAACAACGGAAAGACTTATAAAAAACATCCCTAAAGATAAGATAGTAGTATCTGAAAGTG
GCATAAAAACTCCAGAGGATGTATTGTATTTATCTTCCCTTGGGGTTAAGGCGGTTTTGATAGGTGAAAGTTTTATGAAA
ATGGATGAGGGAAGAATAAAGGAGTTTGTGAAAAAAGTGAGGGGAGGATAA

Upstream 100 bases:

>100_bases
ACTTAAAAGAAGGTGTTGAACTTGCGGAAAGGCTTCTTAATAGCGGTTTGGCTTATGAGAGGTTTTTGGAGATTTTAGGC
TACCAGAGGAGGATTATTTC

Downstream 100 bases:

>100_bases
AGTGGTAAAAGTAAAAATTTGCGGTTTAAGAAGGCTTGAAGATATCTATTATGCAAATCAGTTACAGCCAGATTTTATAG
GTTTTGTATTTTCTGAGAGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MILEEIVNFKKEEVRKKKELKPYNELLNVNAVYRGDFKNSLNKGKVAIIGEIKRASPSKGIIREEFDLVEIAKTYEKAEV
DAISVLTEKRFFKGEGGYIPQVKKLTTKPVLRKDFVIDEYQIYESKFLGADAVLLIVAILEDKLKGFCDIAKQIGLDVLV
EVHEEEELETALKAGCDIIGINNRDLKTFKVDIKTTERLIKNIPKDKIVVSESGIKTPEDVLYLSSLGVKAVLIGESFMK
MDEGRIKEFVKKVRGG

Sequences:

>Translated_256_residues
MILEEIVNFKKEEVRKKKELKPYNELLNVNAVYRGDFKNSLNKGKVAIIGEIKRASPSKGIIREEFDLVEIAKTYEKAEV
DAISVLTEKRFFKGEGGYIPQVKKLTTKPVLRKDFVIDEYQIYESKFLGADAVLLIVAILEDKLKGFCDIAKQIGLDVLV
EVHEEEELETALKAGCDIIGINNRDLKTFKVDIKTTERLIKNIPKDKIVVSESGIKTPEDVLYLSSLGVKAVLIGESFMK
MDEGRIKEFVKKVRGG
>Mature_256_residues
MILEEIVNFKKEEVRKKKELKPYNELLNVNAVYRGDFKNSLNKGKVAIIGEIKRASPSKGIIREEFDLVEIAKTYEKAEV
DAISVLTEKRFFKGEGGYIPQVKKLTTKPVLRKDFVIDEYQIYESKFLGADAVLLIVAILEDKLKGFCDIAKQIGLDVLV
EVHEEEELETALKAGCDIIGINNRDLKTFKVDIKTTERLIKNIPKDKIVVSESGIKTPEDVLYLSSLGVKAVLIGESFMK
MDEGRIKEFVKKVRGG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=243, Percent_Identity=37.8600823045267, Blast_Score=167, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=229, Percent_Identity=39.3013100436681, Blast_Score=149, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_THETN (Q8R9M7)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623180.1
- HSSP:   Q56319
- ProteinModelPortal:   Q8R9M7
- SMR:   Q8R9M7
- GeneID:   996012
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1580
- NMPDR:   fig|273068.3.peg.1527
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   TTEN273068:TTE1580-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28926; Mature: 28926

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEEIVNFKKEEVRKKKELKPYNELLNVNAVYRGDFKNSLNKGKVAIIGEIKRASPSKG
CCHHHHHCCHHHHHHHHHCCCCHHHHHCCCEEEECCHHHCCCCCCEEEEEEHHCCCCCCC
IIREEFDLVEIAKTYEKAEVDAISVLTEKRFFKGEGGYIPQVKKLTTKPVLRKDFVIDEY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHCCHHHH
QIYESKFLGADAVLLIVAILEDKLKGFCDIAKQIGLDVLVEVHEEEELETALKAGCDIIG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHCCCCEEE
INNRDLKTFKVDIKTTERLIKNIPKDKIVVSESGIKTPEDVLYLSSLGVKAVLIGESFMK
CCCCCCEEEEEEHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCEEEEEECHHHHH
MDEGRIKEFVKKVRGG
CCHHHHHHHHHHHCCC
>Mature Secondary Structure
MILEEIVNFKKEEVRKKKELKPYNELLNVNAVYRGDFKNSLNKGKVAIIGEIKRASPSKG
CCHHHHHCCHHHHHHHHHCCCCHHHHHCCCEEEECCHHHCCCCCCEEEEEEHHCCCCCCC
IIREEFDLVEIAKTYEKAEVDAISVLTEKRFFKGEGGYIPQVKKLTTKPVLRKDFVIDEY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHCCHHHH
QIYESKFLGADAVLLIVAILEDKLKGFCDIAKQIGLDVLVEVHEEEELETALKAGCDIIG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEHHHHHHHHHHHHCCCCEEE
INNRDLKTFKVDIKTTERLIKNIPKDKIVVSESGIKTPEDVLYLSSLGVKAVLIGESFMK
CCCCCCEEEEEEHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCEEEEEECHHHHH
MDEGRIKEFVKKVRGG
CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336