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The map label for this gene is gmk

Identifier: 20807954

GI number: 20807954

Start: 1476718

End: 1477338

Strand: Reverse

Name: gmk

Synonym: TTE1511

Alternate gene names: 20807954

Gene position: 1477338-1476718 (Counterclockwise)

Preceding gene: 20807955

Following gene: 20807953

Centisome position: 54.93

GC content: 37.2

Gene sequence:

>621_bases
TTGTCAATAAAAAAGCAAGGGCTTTTAATAGTAATATCTGGTCCTTCTGGGGCAGGAAAAGGCACCATCTGCAAAGCCTT
AATAGAAAAAGAAAAAGATTTAAAATTGAGCATATCTGCTACTACGCGTCAGCCGCGGGCAGGAGAAGTTGATGGTAAAA
ACTACTTTTTCAAGTCAGAAGAAGAGTTCAAAAGGATGATTGAAGAGGACGCCTTTTTGGAATGGGCAAAAGTTTATGAC
CATTACTACGGCACTCCGAAAGAATTTGTTTTAAAGAATTTAGAAGAAGGAAATGATGTTGTTTTAGAAATTGACATTCA
AGGGGCGCTTAAGGTAAAGGAAAAATTTCCTGAAGGAGTCTTTATCTTCATTCTCCCTCCTTCTATGGAAGAATTGAGGA
ACAGGATAAAGAAAAGAGGCACTGAAAGTGAAGAGGAAATAATAAAGAGATTTAAAAGTGCCTATGAAGAACTTAATTAC
GTGTCCAAGTACAATTATGTAGTGATAAATGACGATGTGGATAGAGCAGTAGAAAAAATTCGTGCTATAATTATAGCGGA
GAAGTGCCGTGTGGACAGAAATAAAGACCTGTACCTAAAGATAAGGGAGGAATCCGTATGA

Upstream 100 bases:

>100_bases
AGAGACTGTTGCAAATAGGCTGACTTCTAAGGAAATTATAGAAGACGAGTTTGAAGAAGAAGAGGAAGAAGAAGAGGGAG
AAGAGTAGGGGGAATTGAAT

Downstream 100 bases:

>100_bases
TTTTGTATCCGTCCATTGTGGATTTAATGGAAAAAGTGGATAGCAAGTACACTTTGTGCGCTCTGGTTGCAAAAAGGGCA
AGGCAGCTGGTGGCCGGGGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSIKKQGLLIVISGPSGAGKGTICKALIEKEKDLKLSISATTRQPRAGEVDGKNYFFKSEEEFKRMIEEDAFLEWAKVYD
HYYGTPKEFVLKNLEEGNDVVLEIDIQGALKVKEKFPEGVFIFILPPSMEELRNRIKKRGTESEEEIIKRFKSAYEELNY
VSKYNYVVINDDVDRAVEKIRAIIIAEKCRVDRNKDLYLKIREESV

Sequences:

>Translated_206_residues
MSIKKQGLLIVISGPSGAGKGTICKALIEKEKDLKLSISATTRQPRAGEVDGKNYFFKSEEEFKRMIEEDAFLEWAKVYD
HYYGTPKEFVLKNLEEGNDVVLEIDIQGALKVKEKFPEGVFIFILPPSMEELRNRIKKRGTESEEEIIKRFKSAYEELNY
VSKYNYVVINDDVDRAVEKIRAIIIAEKCRVDRNKDLYLKIREESV
>Mature_205_residues
SIKKQGLLIVISGPSGAGKGTICKALIEKEKDLKLSISATTRQPRAGEVDGKNYFFKSEEEFKRMIEEDAFLEWAKVYDH
YYGTPKEFVLKNLEEGNDVVLEIDIQGALKVKEKFPEGVFIFILPPSMEELRNRIKKRGTESEEEIIKRFKSAYEELNYV
SKYNYVVINDDVDRAVEKIRAIIIAEKCRVDRNKDLYLKIREESV

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=176, Percent_Identity=35.2272727272727, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI4504221, Length=176, Percent_Identity=35.2272727272727, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=35.2272727272727, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=28.0898876404494, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI186700629, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI186700627, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI186972120, Length=179, Percent_Identity=28.4916201117318, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI14780902, Length=187, Percent_Identity=25.668449197861, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=47.3958333333333, Blast_Score=193, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=41.8604651162791, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=41.8604651162791, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71988048, Length=180, Percent_Identity=26.1111111111111, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=180, Percent_Identity=26.1111111111111, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=46.195652173913, Blast_Score=157, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=36.8131868131868, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=24.8587570621469, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=24.8587570621469, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=24.8587570621469, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45554481, Length=177, Percent_Identity=24.8587570621469, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=24.8587570621469, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=24.8587570621469, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_THETN (Q8R9S6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623125.1
- ProteinModelPortal:   Q8R9S6
- SMR:   Q8R9S6
- GeneID:   997207
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1511
- NMPDR:   fig|273068.3.peg.1472
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   TTEN273068:TTE1511-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23823; Mature: 23692

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKKQGLLIVISGPSGAGKGTICKALIEKEKDLKLSISATTRQPRAGEVDGKNYFFKSE
CCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEECCH
EEFKRMIEEDAFLEWAKVYDHYYGTPKEFVLKNLEEGNDVVLEIDIQGALKVKEKFPEGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCE
FIFILPPSMEELRNRIKKRGTESEEEIIKRFKSAYEELNYVSKYNYVVINDDVDRAVEKI
EEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
RAIIIAEKCRVDRNKDLYLKIREESV
HHHHHHHHHCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SIKKQGLLIVISGPSGAGKGTICKALIEKEKDLKLSISATTRQPRAGEVDGKNYFFKSE
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEECCH
EEFKRMIEEDAFLEWAKVYDHYYGTPKEFVLKNLEEGNDVVLEIDIQGALKVKEKFPEGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCCE
FIFILPPSMEELRNRIKKRGTESEEEIIKRFKSAYEELNYVSKYNYVVINDDVDRAVEKI
EEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
RAIIIAEKCRVDRNKDLYLKIREESV
HHHHHHHHHCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336