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The map label for this gene is rnc

Identifier: 20807916

GI number: 20807916

Start: 1441896

End: 1442582

Strand: Reverse

Name: rnc

Synonym: TTE1469

Alternate gene names: 20807916

Gene position: 1442582-1441896 (Counterclockwise)

Preceding gene: 20807917

Following gene: 20807915

Centisome position: 53.64

GC content: 40.9

Gene sequence:

>687_bases
GTGTTGACTTATCTGGAACAGAAGATAAATTATGAGTTTAAAGATAAAACTCTGCTTTTAGAAGCCCTGACCCACAGTTC
ATGGGCTCACGAAGGCAAAAATGAAAAAGTGAGCAATGAGAGATTGGAATTTTTGGGCGACTCTGTTTTAAGCCTTGTGA
TAAGCGAATACCTGTATAAAAATAGAAAAGACTTAGAAGAGGGTTCTCTTTCCAAGTACAGGGCAGAGATAGTCTGCGAG
CCATCTCTTGCTAGATGTGCTCGAAAGATTGAGTTGGGCAGCTTTTTGAGAATGGGAAAAGGCGAAGAAATATCAGGAGG
CAGGGACAGGGATTCAATACTTGCGGATGCGATGGAGGCATTATTAGCTGCCGTATATTTGGATGGTGGTTTGGAAGCTG
TCAGAAGGGTGATTTTAGACCTCTTTAAGGAAATCATAGATGAAGTTTTAAAAGGGATAATTTACAGAGACTATAAGACG
AGGTTGCAGGAAGTGGTACAGAGCATGGAAGTTGGGAAGATAACCTATGAGCTTGTAGAAGAAATAGGACCTGACCACAA
CAAGACTTTCGTAACTCAAGTAAAAATTGGAGATGTAGTTTTAGGCATAGGACAAGGAAAGAGCAAAAAAGAATCTGAAC
AGGCAGCTGCTATGGAAGCATTGAGCAAGCTGGGGATATTGAAATGA

Upstream 100 bases:

>100_bases
GAAGTGAATTACGCCATTTCTAACTCTTTTGGTTTTGGCGGACACAATGCTACTTTGCTCTTTAAAAAATTTTGAAAGAG
GTATAAAGGTGAGTAAGAAG

Downstream 100 bases:

>100_bases
AGAGGAAAATGTATATAATTCCAATTTTCATCCCCCACTGGGGATGTTCTTTCAAATGTGTTTTTTGCAATCAGAACTTA
ATAACCGGTCAGAAAAAAGA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MLTYLEQKINYEFKDKTLLLEALTHSSWAHEGKNEKVSNERLEFLGDSVLSLVISEYLYKNRKDLEEGSLSKYRAEIVCE
PSLARCARKIELGSFLRMGKGEEISGGRDRDSILADAMEALLAAVYLDGGLEAVRRVILDLFKEIIDEVLKGIIYRDYKT
RLQEVVQSMEVGKITYELVEEIGPDHNKTFVTQVKIGDVVLGIGQGKSKKESEQAAAMEALSKLGILK

Sequences:

>Translated_228_residues
MLTYLEQKINYEFKDKTLLLEALTHSSWAHEGKNEKVSNERLEFLGDSVLSLVISEYLYKNRKDLEEGSLSKYRAEIVCE
PSLARCARKIELGSFLRMGKGEEISGGRDRDSILADAMEALLAAVYLDGGLEAVRRVILDLFKEIIDEVLKGIIYRDYKT
RLQEVVQSMEVGKITYELVEEIGPDHNKTFVTQVKIGDVVLGIGQGKSKKESEQAAAMEALSKLGILK
>Mature_228_residues
MLTYLEQKINYEFKDKTLLLEALTHSSWAHEGKNEKVSNERLEFLGDSVLSLVISEYLYKNRKDLEEGSLSKYRAEIVCE
PSLARCARKIELGSFLRMGKGEEISGGRDRDSILADAMEALLAAVYLDGGLEAVRRVILDLFKEIIDEVLKGIIYRDYKT
RLQEVVQSMEVGKITYELVEEIGPDHNKTFVTQVKIGDVVLGIGQGKSKKESEQAAAMEALSKLGILK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=234, Percent_Identity=29.4871794871795, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI155030234, Length=234, Percent_Identity=29.4871794871795, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI29294649, Length=258, Percent_Identity=25.1937984496124, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI29294651, Length=258, Percent_Identity=25.1937984496124, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=40.8888888888889, Blast_Score=147, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17506883, Length=176, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=176, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17552834, Length=265, Percent_Identity=25.6603773584906, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=29.8245614035088, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_THETN (Q8R9W3)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623087.1
- ProteinModelPortal:   Q8R9W3
- SMR:   Q8R9W3
- GeneID:   997900
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1469
- NMPDR:   fig|273068.3.peg.1434
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   TTEN273068:TTE1469-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25635; Mature: 25635

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYLEQKINYEFKDKTLLLEALTHSSWAHEGKNEKVSNERLEFLGDSVLSLVISEYLYK
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NRKDLEEGSLSKYRAEIVCEPSLARCARKIELGSFLRMGKGEEISGGRDRDSILADAMEA
CHHCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
LLAAVYLDGGLEAVRRVILDLFKEIIDEVLKGIIYRDYKTRLQEVVQSMEVGKITYELVE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGPDHNKTFVTQVKIGDVVLGIGQGKSKKESEQAAAMEALSKLGILK
HHCCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTYLEQKINYEFKDKTLLLEALTHSSWAHEGKNEKVSNERLEFLGDSVLSLVISEYLYK
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NRKDLEEGSLSKYRAEIVCEPSLARCARKIELGSFLRMGKGEEISGGRDRDSILADAMEA
CHHCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
LLAAVYLDGGLEAVRRVILDLFKEIIDEVLKGIIYRDYKTRLQEVVQSMEVGKITYELVE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIGPDHNKTFVTQVKIGDVVLGIGQGKSKKESEQAAAMEALSKLGILK
HHCCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336