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The map label for this gene is FabB [H]

Identifier: 20807917

GI number: 20807917

Start: 1442608

End: 1443837

Strand: Reverse

Name: FabB [H]

Synonym: TTE1470

Alternate gene names: 20807917

Gene position: 1443837-1442608 (Counterclockwise)

Preceding gene: 20807918

Following gene: 20807916

Centisome position: 53.69

GC content: 42.76

Gene sequence:

>1230_bases
ATGAACAGAGTAGTTGTAACAGGATTGGGAGTAATCAGCCCTTTAGGCAACACTGTTGAAAAGTTCTGGAATTCACTGAT
AAATGGAGAAAATGGAATAGGACTTGTCACCAAATTTGATACCTCTGAATTTCCCACAAAAGTGGCTGCTGAAGTGAAAG
ACTTTGACCCTACTTTATACATAGACAAAAAAGAAGCCAGAAGAATGGATAGGTTTATACAGTTTGCTGTGGCAAGCACA
AAACTTGCACTGGAGGATGCGGGGATTGAACTTGACAAAGTAGACTTAAATAGATTTGGAGTGATTTACGGGACAGGCAT
AGGGGGAATTGAGACCTTTGAAAATCAGATGAAAGTGATGTACGAAAAAGGCCCCAGCAAAGTAAGTCCCTTTTTCATCC
CTATGATGATAGCCAATATGGCAGCTGGGCAGATAGCCATAACCTTTGGCCTTAAGGGAATCAATGAGACTATAGTAAAT
GCATGTGCTTCCAGCACTAACGCCATAGGAGAAGCTTTTAAAGCCATTCAAAGAGGAGATGCAGATTTAATAGTGACTGG
AGGTACAGAAGCTGCGATAACTCCCATGTCCTTTGCAGGTTTTTGCGCTATGAAAGCTATGTCCACAAATCCTGACCCTT
CCACTGCTTCAAGGCCCTTTGATTTGAATAGAGATGGATTTGTTATGGGAGAAGGGTCTGCTACGTTGATTCTGGAGTCA
TTGGAACATGCTCAAAAAAGAGGGGCGAAGATATACGCAGAGATAATAGGGTATGGCGCTACAGATGATGCTTACCACAT
AACAGCTCCAGCTCCAGAAGGGGAAGGGGCAGCGAGAGCGATGGAAGCAGCCCTTAAAGACGGAAAAGTAAGTTATGATA
TGGTAGACTACATCAATGCCCATGGAACCTCTACAGAGTACAACGATAAGTTCGAAACTATGGCAATAAAGAAAGTTTTC
AAAGACCACGCTTATAAGCTCTGCGTAAGCTCTAATAAGTCCATGTTGGGACATTTGTTAGGAGCAGCAGGGGCAGTAGA
AGCTGTAGCTACGGTGCTGACCATAACTCACGGGATAGTGCCTCCAACCATTAATTACCAGACTCCCGATCCAGAGTGCG
ATTTAAACTACGTTCCAAACAAGGCAATAGAAAGGGAAGTGAATTACGCCATTTCTAACTCTTTTGGTTTTGGCGGACAC
AATGCTACTTTGCTCTTTAAAAAATTTTGA

Upstream 100 bases:

>100_bases
GACGGTAGGTGATGTCGTAGAGTACTTAAGCAATATTGTTGAGTAAATAAGGTCCCGCGCTGCGGGACTTTATGCAAATA
AAGATTTGGAGGTTAAGTTT

Downstream 100 bases:

>100_bases
AAGAGGTATAAAGGTGAGTAAGAAGGTGTTGACTTATCTGGAACAGAAGATAAATTATGAGTTTAAAGATAAAACTCTGC
TTTTAGAAGCCCTGACCCAC

Product: 3-oxoacyl-(acyl-carrier-protein) synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MNRVVVTGLGVISPLGNTVEKFWNSLINGENGIGLVTKFDTSEFPTKVAAEVKDFDPTLYIDKKEARRMDRFIQFAVAST
KLALEDAGIELDKVDLNRFGVIYGTGIGGIETFENQMKVMYEKGPSKVSPFFIPMMIANMAAGQIAITFGLKGINETIVN
ACASSTNAIGEAFKAIQRGDADLIVTGGTEAAITPMSFAGFCAMKAMSTNPDPSTASRPFDLNRDGFVMGEGSATLILES
LEHAQKRGAKIYAEIIGYGATDDAYHITAPAPEGEGAARAMEAALKDGKVSYDMVDYINAHGTSTEYNDKFETMAIKKVF
KDHAYKLCVSSNKSMLGHLLGAAGAVEAVATVLTITHGIVPPTINYQTPDPECDLNYVPNKAIEREVNYAISNSFGFGGH
NATLLFKKF

Sequences:

>Translated_409_residues
MNRVVVTGLGVISPLGNTVEKFWNSLINGENGIGLVTKFDTSEFPTKVAAEVKDFDPTLYIDKKEARRMDRFIQFAVAST
KLALEDAGIELDKVDLNRFGVIYGTGIGGIETFENQMKVMYEKGPSKVSPFFIPMMIANMAAGQIAITFGLKGINETIVN
ACASSTNAIGEAFKAIQRGDADLIVTGGTEAAITPMSFAGFCAMKAMSTNPDPSTASRPFDLNRDGFVMGEGSATLILES
LEHAQKRGAKIYAEIIGYGATDDAYHITAPAPEGEGAARAMEAALKDGKVSYDMVDYINAHGTSTEYNDKFETMAIKKVF
KDHAYKLCVSSNKSMLGHLLGAAGAVEAVATVLTITHGIVPPTINYQTPDPECDLNYVPNKAIEREVNYAISNSFGFGGH
NATLLFKKF
>Mature_409_residues
MNRVVVTGLGVISPLGNTVEKFWNSLINGENGIGLVTKFDTSEFPTKVAAEVKDFDPTLYIDKKEARRMDRFIQFAVAST
KLALEDAGIELDKVDLNRFGVIYGTGIGGIETFENQMKVMYEKGPSKVSPFFIPMMIANMAAGQIAITFGLKGINETIVN
ACASSTNAIGEAFKAIQRGDADLIVTGGTEAAITPMSFAGFCAMKAMSTNPDPSTASRPFDLNRDGFVMGEGSATLILES
LEHAQKRGAKIYAEIIGYGATDDAYHITAPAPEGEGAARAMEAALKDGKVSYDMVDYINAHGTSTEYNDKFETMAIKKVF
KDHAYKLCVSSNKSMLGHLLGAAGAVEAVATVLTITHGIVPPTINYQTPDPECDLNYVPNKAIEREVNYAISNSFGFGGH
NATLLFKKF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=413, Percent_Identity=47.2154963680387, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=160, Percent_Identity=55, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI41872631, Length=425, Percent_Identity=25.4117647058824, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=49.2718446601942, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=38.7019230769231, Blast_Score=258, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=36.5384615384615, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=39.3939393939394, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=427, Percent_Identity=25.5269320843091, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=275, Percent_Identity=28.7272727272727, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=38.0090497737557, Blast_Score=305, Evalue=6e-84,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=41.3301662707838, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI221330659, Length=425, Percent_Identity=24.9411764705882, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19920632, Length=425, Percent_Identity=24.9411764705882, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=25.2336448598131, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43973; Mature: 43973

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVVVTGLGVISPLGNTVEKFWNSLINGENGIGLVTKFDTSEFPTKVAAEVKDFDPTLY
CCCEEEECCCHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEE
IDKKEARRMDRFIQFAVASTKLALEDAGIELDKVDLNRFGVIYGTGIGGIETFENQMKVM
EEHHHHHHHHHHHHHHHHHHHEEEHHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
YEKGPSKVSPFFIPMMIANMAAGQIAITFGLKGINETIVNACASSTNAIGEAFKAIQRGD
HHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCC
ADLIVTGGTEAAITPMSFAGFCAMKAMSTNPDPSTASRPFDLNRDGFVMGEGSATLILES
CCEEEECCCCCEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
LEHAQKRGAKIYAEIIGYGATDDAYHITAPAPEGEGAARAMEAALKDGKVSYDMVDYINA
HHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHC
HGTSTEYNDKFETMAIKKVFKDHAYKLCVSSNKSMLGHLLGAAGAVEAVATVLTITHGIV
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPTINYQTPDPECDLNYVPNKAIEREVNYAISNSFGFGGHNATLLFKKF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MNRVVVTGLGVISPLGNTVEKFWNSLINGENGIGLVTKFDTSEFPTKVAAEVKDFDPTLY
CCCEEEECCCHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEE
IDKKEARRMDRFIQFAVASTKLALEDAGIELDKVDLNRFGVIYGTGIGGIETFENQMKVM
EEHHHHHHHHHHHHHHHHHHHEEEHHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
YEKGPSKVSPFFIPMMIANMAAGQIAITFGLKGINETIVNACASSTNAIGEAFKAIQRGD
HHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCC
ADLIVTGGTEAAITPMSFAGFCAMKAMSTNPDPSTASRPFDLNRDGFVMGEGSATLILES
CCEEEECCCCCEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHH
LEHAQKRGAKIYAEIIGYGATDDAYHITAPAPEGEGAARAMEAALKDGKVSYDMVDYINA
HHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHC
HGTSTEYNDKFETMAIKKVFKDHAYKLCVSSNKSMLGHLLGAAGAVEAVATVLTITHGIV
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PPTINYQTPDPECDLNYVPNKAIEREVNYAISNSFGFGGHNATLLFKKF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]