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The map label for this gene is mutL

Identifier: 20807805

GI number: 20807805

Start: 1340943

End: 1342715

Strand: Direct

Name: mutL

Synonym: TTE1358

Alternate gene names: 20807805

Gene position: 1340943-1342715 (Clockwise)

Preceding gene: 20807804

Following gene: 20807806

Centisome position: 49.86

GC content: 37.06

Gene sequence:

>1773_bases
ATGAATAAAATTCATCTTCTCGACGAAAAAACGGTAAACAAGATAGCTGCCGGAGAAGTGGTTGAAAGACCTGCCTCAAT
TGTCAAAGAGCTAGTAGAAAATTCTATTGATGCAGGAAGTAAAAACATCACAGTAGAAATTTTAGAAGGAGGTATCCCTT
ATATAAAGGTTACGGACGATGGATGCGGAATGAATGAGATTGATGCAGTTCTGGCTTTTGAAAGACATGCTACGAGTAAA
ATAAGATCCGATGAAGATCTTTTCAATATAACAACTTTGGGGTTTAGAGGAGAAGCACTCGCCAGCATTGCAGCTGTCTC
AAAAGTTGTATTACAGACGAAGGAAGAAAATGAGACTTTTGGCACTAGATTAGTAGTAGAGGGTGGAAAAATATTAGAAA
AGACTAGATGTGGATGCCAAAAGGGGACTTCTGTTGAAGTAAAAGATGTGTTTTTTAACACGCCTGCGAGAAGAAAATTT
TTAAAAAGGCCCTCTACAGAAGCGATGTACGTAACAGAAGTGGTTACTAGATTGTGTCTTTCAAACCCTGGCATTTCTTT
TAAGTACGTGAAAGACAAAAAGGTACAGTTTATCACTTCTGGAAATGGAAGTATAGAAGACGTAATTTTGAGGCTTTTTG
GCAAGGAGGTACATTCTGCCCTTATTTTTTCAGAATTTGAAGCGGAGGATTTGAAGGTAAAGGCTTTTGCCACAAAGAAT
TTTCTAAATTATTCTAACAGAAATATGCAGTTTTTTTATGTAAATGGCAGGTACGTAAAAAACAAGACTTTGTCGGCAGC
TGTTGATGAGGCTTTTAAAACTTATGTGCCTTCTGACAGATATCCAGGGGTGTTTTTATACCTTGAAATAAATCCTCGCT
TTATAGATGTCAATATTCACCCTTCAAAACTTGAAGTTAAATTTTCTGACGATAGAAGAATTTTTGAGTCTGTGTACAGG
ACCATAAGGGAAGCTCTCAGAGAAAGCAACTTAATACCAGAGGTAAAGCTGGAAAAAGACTTAAAAAATGAGGAAGGGCA
AATAGGAGAGCAGGTAAAATTATCTTTACCTCTTTTTGAAGTAAAAGAAAAAACTGATGATGGAGCTATTTTTGTAAGAG
AAGAGGTAAAAACTGAAGAAAAGATTGACAAAGCGCCTAAACATGAGAGTTCTTCTGACAGTGAAAGAAATGTAAAAAGA
CTCAGCGATATAAGGATAGTAGGGACTCTCTTTTCTACTTATGTGATTGTAGAAAAAGGTGATGTATTTTATATAATTGA
CCAGCATGCTGCTCACGAGAGAATTTTATACGAAAAGTTAGTCTCTCAATACGAAAGAGTGCAGTCAAGACAGGTGACTT
TCCCAATTGTTGTTGAATTGCAGCCTGGCGACATGGAAATTGTAGGCCAGGAAAGGGAGCTTTTATACAAGCTAGGGTAT
GTTTTTGAGGAATTTGGGAATAATTCTGTTGTGTTAAGAGAGGTTCCTGTAATCTTAGGTCAACCTGAGGCTAAAAAACT
GTTTGTAGAAATTGTAGAAAGGCTGCGGGACAAAGATTTTTCTAGTAAGGTTTCTTTTAAAGAGGAAGAAATAGCGACAA
TGGCCTGCAAGGCTGCAGTAAAAGCCATGGACACCCTTTCCGAAAATGAAATCTATAAGCTTTTTGAGGATTTAAAAATA
GCTGAAAATCCTTATACCTGTCCACATGGCAGGCCTGTCATAATTTCCATGACTAAGACCCAGCTTGAGAAGATGTTTAA
ACGAATCAAGTAA

Upstream 100 bases:

>100_bases
AGATTGCAAATTGCGATCCTGACAATATGACTCCTCTTCAGGCATTGACTTATCTTTATAAGCTGAAAGAGAAGGCTGCC
TCATTAAGGAGCGGAGTGAT

Downstream 100 bases:

>100_bases
GGGTGATGGGATGGCTATACAAATTGTTCTTATTGTAGGGCCTACTGCCACTGGAAAATCAAGATTGGCTGTTGATGTAG
CAAAGAGATTTAACGGTGAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MNKIHLLDEKTVNKIAAGEVVERPASIVKELVENSIDAGSKNITVEILEGGIPYIKVTDDGCGMNEIDAVLAFERHATSK
IRSDEDLFNITTLGFRGEALASIAAVSKVVLQTKEENETFGTRLVVEGGKILEKTRCGCQKGTSVEVKDVFFNTPARRKF
LKRPSTEAMYVTEVVTRLCLSNPGISFKYVKDKKVQFITSGNGSIEDVILRLFGKEVHSALIFSEFEAEDLKVKAFATKN
FLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYVPSDRYPGVFLYLEINPRFIDVNIHPSKLEVKFSDDRRIFESVYR
TIREALRESNLIPEVKLEKDLKNEEGQIGEQVKLSLPLFEVKEKTDDGAIFVREEVKTEEKIDKAPKHESSSDSERNVKR
LSDIRIVGTLFSTYVIVEKGDVFYIIDQHAAHERILYEKLVSQYERVQSRQVTFPIVVELQPGDMEIVGQERELLYKLGY
VFEEFGNNSVVLREVPVILGQPEAKKLFVEIVERLRDKDFSSKVSFKEEEIATMACKAAVKAMDTLSENEIYKLFEDLKI
AENPYTCPHGRPVIISMTKTQLEKMFKRIK

Sequences:

>Translated_590_residues
MNKIHLLDEKTVNKIAAGEVVERPASIVKELVENSIDAGSKNITVEILEGGIPYIKVTDDGCGMNEIDAVLAFERHATSK
IRSDEDLFNITTLGFRGEALASIAAVSKVVLQTKEENETFGTRLVVEGGKILEKTRCGCQKGTSVEVKDVFFNTPARRKF
LKRPSTEAMYVTEVVTRLCLSNPGISFKYVKDKKVQFITSGNGSIEDVILRLFGKEVHSALIFSEFEAEDLKVKAFATKN
FLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYVPSDRYPGVFLYLEINPRFIDVNIHPSKLEVKFSDDRRIFESVYR
TIREALRESNLIPEVKLEKDLKNEEGQIGEQVKLSLPLFEVKEKTDDGAIFVREEVKTEEKIDKAPKHESSSDSERNVKR
LSDIRIVGTLFSTYVIVEKGDVFYIIDQHAAHERILYEKLVSQYERVQSRQVTFPIVVELQPGDMEIVGQERELLYKLGY
VFEEFGNNSVVLREVPVILGQPEAKKLFVEIVERLRDKDFSSKVSFKEEEIATMACKAAVKAMDTLSENEIYKLFEDLKI
AENPYTCPHGRPVIISMTKTQLEKMFKRIK
>Mature_590_residues
MNKIHLLDEKTVNKIAAGEVVERPASIVKELVENSIDAGSKNITVEILEGGIPYIKVTDDGCGMNEIDAVLAFERHATSK
IRSDEDLFNITTLGFRGEALASIAAVSKVVLQTKEENETFGTRLVVEGGKILEKTRCGCQKGTSVEVKDVFFNTPARRKF
LKRPSTEAMYVTEVVTRLCLSNPGISFKYVKDKKVQFITSGNGSIEDVILRLFGKEVHSALIFSEFEAEDLKVKAFATKN
FLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYVPSDRYPGVFLYLEINPRFIDVNIHPSKLEVKFSDDRRIFESVYR
TIREALRESNLIPEVKLEKDLKNEEGQIGEQVKLSLPLFEVKEKTDDGAIFVREEVKTEEKIDKAPKHESSSDSERNVKR
LSDIRIVGTLFSTYVIVEKGDVFYIIDQHAAHERILYEKLVSQYERVQSRQVTFPIVVELQPGDMEIVGQERELLYKLGY
VFEEFGNNSVVLREVPVILGQPEAKKLFVEIVERLRDKDFSSKVSFKEEEIATMACKAAVKAMDTLSENEIYKLFEDLKI
AENPYTCPHGRPVIISMTKTQLEKMFKRIK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=390, Percent_Identity=37.4358974358974, Blast_Score=226, Evalue=7e-59,
Organism=Homo sapiens, GI4505913, Length=339, Percent_Identity=29.7935103244838, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI310128478, Length=339, Percent_Identity=29.7935103244838, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4505911, Length=314, Percent_Identity=29.2993630573248, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI189458898, Length=314, Percent_Identity=29.2993630573248, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI263191589, Length=296, Percent_Identity=33.445945945946, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI189458896, Length=306, Percent_Identity=31.3725490196078, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI310128480, Length=292, Percent_Identity=27.3972602739726, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI91992162, Length=268, Percent_Identity=30.2238805970149, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=268, Percent_Identity=30.2238805970149, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI263191733, Length=145, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI263191713, Length=145, Percent_Identity=31.0344827586207, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790612, Length=331, Percent_Identity=36.8580060422961, Blast_Score=228, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.0625, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=352, Percent_Identity=27.5568181818182, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=35.4354354354354, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=452, Percent_Identity=25.8849557522124, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=307, Percent_Identity=25.7328990228013, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=364, Percent_Identity=26.6483516483516, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136968, Length=389, Percent_Identity=33.4190231362468, Blast_Score=212, Evalue=6e-55,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.6106442577031, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_THETN (Q8RA70)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622976.1
- ProteinModelPortal:   Q8RA70
- SMR:   Q8RA70
- GeneID:   997771
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1358
- NMPDR:   fig|273068.3.peg.117
- HOGENOM:   HBG520262
- OMA:   MACKAAV
- ProtClustDB:   PRK00095
- BioCyc:   TTEN273068:TTE1358-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 67197; Mature: 67197

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIHLLDEKTVNKIAAGEVVERPASIVKELVENSIDAGSKNITVEILEGGIPYIKVTDD
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEECC
GCGMNEIDAVLAFERHATSKIRSDEDLFNITTLGFRGEALASIAAVSKVVLQTKEENETF
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC
GTRLVVEGGKILEKTRCGCQKGTSVEVKDVFFNTPARRKFLKRPSTEAMYVTEVVTRLCL
CEEEEEECCHHHHHHHCCCCCCCCEEEEHEEECCHHHHHHHHCCCCCHHHHHHHHHHHHH
SNPGISFKYVKDKKVQFITSGNGSIEDVILRLFGKEVHSALIFSEFEAEDLKVKAFATKN
CCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHH
FLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYVPSDRYPGVFLYLEINPRFIDVNIH
HHCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEEC
PSKLEVKFSDDRRIFESVYRTIREALRESNLIPEVKLEKDLKNEEGQIGEQVKLSLPLFE
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCCCCEEEEECCHHH
VKEKTDDGAIFVREEVKTEEKIDKAPKHESSSDSERNVKRLSDIRIVGTLFSTYVIVEKG
HHCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEEHHHEEEEEECC
DVFYIIDQHAAHERILYEKLVSQYERVQSRQVTFPIVVELQPGDMEIVGQERELLYKLGY
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCHHHHHHHHHH
VFEEFGNNSVVLREVPVILGQPEAKKLFVEIVERLRDKDFSSKVSFKEEEIATMACKAAV
HHHHHCCCCEEEEECCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
KAMDTLSENEIYKLFEDLKIAENPYTCPHGRPVIISMTKTQLEKMFKRIK
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHCC
>Mature Secondary Structure
MNKIHLLDEKTVNKIAAGEVVERPASIVKELVENSIDAGSKNITVEILEGGIPYIKVTDD
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEECC
GCGMNEIDAVLAFERHATSKIRSDEDLFNITTLGFRGEALASIAAVSKVVLQTKEENETF
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCC
GTRLVVEGGKILEKTRCGCQKGTSVEVKDVFFNTPARRKFLKRPSTEAMYVTEVVTRLCL
CEEEEEECCHHHHHHHCCCCCCCCEEEEHEEECCHHHHHHHHCCCCCHHHHHHHHHHHHH
SNPGISFKYVKDKKVQFITSGNGSIEDVILRLFGKEVHSALIFSEFEAEDLKVKAFATKN
CCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHH
FLNYSNRNMQFFYVNGRYVKNKTLSAAVDEAFKTYVPSDRYPGVFLYLEINPRFIDVNIH
HHCCCCCCEEEEEECCEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEEEEC
PSKLEVKFSDDRRIFESVYRTIREALRESNLIPEVKLEKDLKNEEGQIGEQVKLSLPLFE
CCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHCCCCCCCCCCEEEEECCHHH
VKEKTDDGAIFVREEVKTEEKIDKAPKHESSSDSERNVKRLSDIRIVGTLFSTYVIVEKG
HHCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHEEHHHEEEEEECC
DVFYIIDQHAAHERILYEKLVSQYERVQSRQVTFPIVVELQPGDMEIVGQERELLYKLGY
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCHHHHHHHHHH
VFEEFGNNSVVLREVPVILGQPEAKKLFVEIVERLRDKDFSSKVSFKEEEIATMACKAAV
HHHHHCCCCEEEEECCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
KAMDTLSENEIYKLFEDLKIAENPYTCPHGRPVIISMTKTQLEKMFKRIK
HHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336