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The map label for this gene is GdhA2 [H]

Identifier: 20807791

GI number: 20807791

Start: 1327193

End: 1328443

Strand: Direct

Name: GdhA2 [H]

Synonym: TTE1344

Alternate gene names: 20807791

Gene position: 1327193-1328443 (Clockwise)

Preceding gene: 20807790

Following gene: 20807792

Centisome position: 49.35

GC content: 41.09

Gene sequence:

>1251_bases
ATGTCCACAGAATCATTAAATCCATTGGTAATTGCTCAAAAGCAAATAAAGAAAGCTTGTGACATTTTAGGAGTTGAGGA
GTCAGTTTACGAGCTTTTGAAAGAGCCAATGAGAGTTCTGGAGGTTTCCATCCCTGTGCAAATGGACGATGGAAGCATAA
AAGTCTTCAAGGGATATAGATCGCAGCACAACGATGCACTAGGTCCTACAAAAGGAGGAATAAGATTCCATCCGGATGTG
ACTTTAGATGAAGTAAAAGCTTTATCCATGTGGATGACCTTTAAATGCGGAGTAGTAGGTCTTCCCTATGGCGGAGCTAA
AGGTGGAGTGGTTGTAAATCCAAAAGAACTCTCCAATGATGAACTTCAGAGGCTGAGCAGGGGTTATATAAGGGCTATAG
CAAGCATAATAGGACCTGAAAAAGACATACCAGCTCCTGATGTTGGAACAAACGCCCAGATTATGGCTTGGATGGTAGAT
GAATACAATAAAATTGTGGGTTACAACAGCCCTGCTGTGATTACGGGAAAACCCCTCATTTACGGCGGTTCAAAAGGGAG
AGTGGCAGCTACAGGCTACGGAGTTGCTCTAATGGCAAGGGAAGCAGTAAAACGTTTAAACATGGATTTTAAGGACTGTA
CTGTAGCAATTCAGGGGTTTGGAAATGTTGGAAGCCATGCCGGTTTAAGTCTCCAGAGGTTAGGAGCTAAAATTATAGCA
GTGAGCGATGTGTACGGAGGAATATACAATGAAAAAGGAATTGATGCAGAGAAGTTAGTAGAACATGTAAACAAAACAGG
AACTGTGTGCAATTTTGAGGGAACCACTCCCATCACAAATGAAGAGCTTTTGACGATGAAGGTGGACATATTAGTGTTGG
CAGCTTTAGAAAACCAGATTACCTCTGCTAATGCAAATGAAGTAAAGGCAAAGATAATATGTGAAGGTGCTAACGGACCC
ACAACTCCAGAAGCCGACAAGATACTTTCTGAAAAAGGTGTTTTTGTAGTGCCTGATATACTTGCTAATTCTGGAGGAGT
CATAGTCTCTTACTTTGAGTGGGTACAGAATTTGATGAACTATTACTGGACTGAGAAAGAAGTAGAAGAGAGGCAGGAAA
TCATGATGGTAAATGCTTTTAACTCTATATATGATTTAGCACAGCAGTATAAAGTAGACATGAGAACTGCAGCCTACATG
ATTTCAATAAAGAGAGTATATGAGGCCATGAAAGTCAGAGGTTGGCTGTAA

Upstream 100 bases:

>100_bases
ACTTTTGAAAAACTGGAGAGCATCTGGGATGAATATGGCGTATATATTTCAAAGCAAGGCTAAAAATTTGATTTTAAAAT
AAAGAATAGGAGGATGAAAA

Downstream 100 bases:

>100_bases
AGACCTTCGTTGAAGGTCTCGGTTTGTTGACAAAATTAGAGAAGTGGCATTTTGTGTGTAAATGCGACTTGTTACAAAGC
GGTAACAAAACTTAGCGAGC

Product: glutamate dehydrogenase/leucine dehydrogenase

Products: NA

Alternate protein names: NAD-GDH [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSTESLNPLVIAQKQIKKACDILGVEESVYELLKEPMRVLEVSIPVQMDDGSIKVFKGYRSQHNDALGPTKGGIRFHPDV
TLDEVKALSMWMTFKCGVVGLPYGGAKGGVVVNPKELSNDELQRLSRGYIRAIASIIGPEKDIPAPDVGTNAQIMAWMVD
EYNKIVGYNSPAVITGKPLIYGGSKGRVAATGYGVALMAREAVKRLNMDFKDCTVAIQGFGNVGSHAGLSLQRLGAKIIA
VSDVYGGIYNEKGIDAEKLVEHVNKTGTVCNFEGTTPITNEELLTMKVDILVLAALENQITSANANEVKAKIICEGANGP
TTPEADKILSEKGVFVVPDILANSGGVIVSYFEWVQNLMNYYWTEKEVEERQEIMMVNAFNSIYDLAQQYKVDMRTAAYM
ISIKRVYEAMKVRGWL

Sequences:

>Translated_416_residues
MSTESLNPLVIAQKQIKKACDILGVEESVYELLKEPMRVLEVSIPVQMDDGSIKVFKGYRSQHNDALGPTKGGIRFHPDV
TLDEVKALSMWMTFKCGVVGLPYGGAKGGVVVNPKELSNDELQRLSRGYIRAIASIIGPEKDIPAPDVGTNAQIMAWMVD
EYNKIVGYNSPAVITGKPLIYGGSKGRVAATGYGVALMAREAVKRLNMDFKDCTVAIQGFGNVGSHAGLSLQRLGAKIIA
VSDVYGGIYNEKGIDAEKLVEHVNKTGTVCNFEGTTPITNEELLTMKVDILVLAALENQITSANANEVKAKIICEGANGP
TTPEADKILSEKGVFVVPDILANSGGVIVSYFEWVQNLMNYYWTEKEVEERQEIMMVNAFNSIYDLAQQYKVDMRTAAYM
ISIKRVYEAMKVRGWL
>Mature_415_residues
STESLNPLVIAQKQIKKACDILGVEESVYELLKEPMRVLEVSIPVQMDDGSIKVFKGYRSQHNDALGPTKGGIRFHPDVT
LDEVKALSMWMTFKCGVVGLPYGGAKGGVVVNPKELSNDELQRLSRGYIRAIASIIGPEKDIPAPDVGTNAQIMAWMVDE
YNKIVGYNSPAVITGKPLIYGGSKGRVAATGYGVALMAREAVKRLNMDFKDCTVAIQGFGNVGSHAGLSLQRLGAKIIAV
SDVYGGIYNEKGIDAEKLVEHVNKTGTVCNFEGTTPITNEELLTMKVDILVLAALENQITSANANEVKAKIICEGANGPT
TPEADKILSEKGVFVVPDILANSGGVIVSYFEWVQNLMNYYWTEKEVEERQEIMMVNAFNSIYDLAQQYKVDMRTAAYMI
SIKRVYEAMKVRGWL

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=343, Percent_Identity=45.1895043731778, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI4885281, Length=343, Percent_Identity=45.1895043731778, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1788059, Length=361, Percent_Identity=33.5180055401662, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17544676, Length=444, Percent_Identity=37.6126126126126, Blast_Score=278, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324951, Length=417, Percent_Identity=31.4148681055156, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319256, Length=402, Percent_Identity=31.8407960199005, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45549226, Length=341, Percent_Identity=44.8680351906158, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI45553475, Length=449, Percent_Identity=38.3073496659243, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24649283, Length=369, Percent_Identity=41.4634146341463, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24649460, Length=280, Percent_Identity=44.6428571428571, Blast_Score=240, Evalue=1e-63,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.2 [H]

Molecular weight: Translated: 45547; Mature: 45416

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTESLNPLVIAQKQIKKACDILGVEESVYELLKEPMRVLEVSIPVQMDDGSIKVFKGYR
CCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCEEECCCCEEEEECCH
SQHNDALGPTKGGIRFHPDVTLDEVKALSMWMTFKCGVVGLPYGGAKGGVVVNPKELSND
HCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHEEECCEEECCCCCCCCCEEECHHHCCHH
ELQRLSRGYIRAIASIIGPEKDIPAPDVGTNAQIMAWMVDEYNKIVGYNSPAVITGKPLI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCEEEECCEEE
YGGSKGRVAATGYGVALMAREAVKRLNMDFKDCTVAIQGFGNVGSHAGLSLQRLGAKIIA
EECCCCCEEECCCHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCCCCCHHHCCCEEEE
VSDVYGGIYNEKGIDAEKLVEHVNKTGTVCNFEGTTPITNEELLTMKVDILVLAALENQI
EEHHHCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEEEHHHHEEHHHHHH
TSANANEVKAKIICEGANGPTTPEADKILSEKGVFVVPDILANSGGVIVSYFEWVQNLMN
CCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEECHHHCCCCCEEEHHHHHHHHHHH
YYWTEKEVEERQEIMMVNAFNSIYDLAQQYKVDMRTAAYMISIKRVYEAMKVRGWL
HHCCHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STESLNPLVIAQKQIKKACDILGVEESVYELLKEPMRVLEVSIPVQMDDGSIKVFKGYR
CCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCEEECCCCEEEEECCH
SQHNDALGPTKGGIRFHPDVTLDEVKALSMWMTFKCGVVGLPYGGAKGGVVVNPKELSND
HCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHEEECCEEECCCCCCCCCEEECHHHCCHH
ELQRLSRGYIRAIASIIGPEKDIPAPDVGTNAQIMAWMVDEYNKIVGYNSPAVITGKPLI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCCCEEEECCEEE
YGGSKGRVAATGYGVALMAREAVKRLNMDFKDCTVAIQGFGNVGSHAGLSLQRLGAKIIA
EECCCCCEEECCCHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCCCCCHHHCCCEEEE
VSDVYGGIYNEKGIDAEKLVEHVNKTGTVCNFEGTTPITNEELLTMKVDILVLAALENQI
EEHHHCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCEEEEEEHHHHEEHHHHHH
TSANANEVKAKIICEGANGPTTPEADKILSEKGVFVVPDILANSGGVIVSYFEWVQNLMN
CCCCCCCEEEEEEEECCCCCCCCCHHHHHHCCCCEEECHHHCCCCCEEEHHHHHHHHHHH
YYWTEKEVEERQEIMMVNAFNSIYDLAQQYKVDMRTAAYMISIKRVYEAMKVRGWL
HHCCHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA