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The map label for this gene is xseA

Identifier: 20807743

GI number: 20807743

Start: 1284735

End: 1285949

Strand: Direct

Name: xseA

Synonym: TTE1294

Alternate gene names: 20807743

Gene position: 1284735-1285949 (Clockwise)

Preceding gene: 20807742

Following gene: 20807744

Centisome position: 47.77

GC content: 39.67

Gene sequence:

>1215_bases
ATGCAGTTAAAAGCCTTTAGTGTTAGTGAAGTGACGGAATATATAAAGAAAGTTATGGACAACGACATAATATTGAGAAA
TGTGAGAGTGAGAGGGGAAATTTCTAATTTAAAATACCACTCTACAGCAGTGTACTTTACCTTAAAAGACGAAGGAGCAG
CTTTAAAATGCGTAATGTTTAACGACTACAGCAGGTCCCTTGAATTTACTTTGCAGGATGGAATGTCTGTAATTGCTACA
GGCAGGATAACAGTGTACGAAAAAGGCGGACTTTACCAGCTGTACGTTCAGTCTGTGCAGATGGATGGAATAGGAGCTTT
GTACATTGCTTTTAACAAACTAAAAGAAAAGCTCCAAAAAGAAGGCCTATTTGATTTAGATAAGAAAAAACCTATTCCAA
AGCATCCGAGGAAAATTGCTGTGGTCACCTCTCCGACAGGGGCTGTAATACGCGATATAATAACGATTTCACGGAGGAGA
AATCCGACTGTTGATATAATGGTAGTGCCTGTTTTGGTGCAGGGGAGCTCTGCTGCGGATGAAATTTCAAATGCTCTTCG
CATTTTAAACAAGAGGAAGGATATCGATGTTATAATAGTGGCAAGAGGAGGCGGGTCTTTAGAGGAAATCTGGCCTTTCA
ATGAGGAGAAGGTGGCTCGCAGTATTTTTGCCTCCCGCATTCCTGTGGTTTCTGCTGTAGGGCATGAGACGGATTTCACT
ATTGCTGATTTTGTAGCGGATTTGAGAGCCCCTACTCCCTCTGCTGCTGCCGAATTGGTGGTTCCAGACATAAAGGTGTA
TCAAAGGGAGTTGTTCTTATTAAAGACAAAGATAATGAATTTGATGAAAGCTCAAGTGCTTCACAGCAAAAAGGAATTTG
AAGGATTAAAAAGAGCACTTTATTTAAACAACCCCATTAAGAAGAACGAAGTTTTAAAGCAGAGAGTAAAAAACCTAAAA
AAATCTCTAACTAAAGAGATGCTTTCCATTTTCAATCAAAAAAAGAATGAGCTTTTGGTGCTCAACGAAAAGTTAGATTC
TTTAAGTCCGTTGAAAGTCTTGACAAGGGGATATACTATTGTGCTTAATAAGGAAGGACAAGTGATCACTTCCTCTAGAA
AAGTGAAAACTTCTGAAGAAGTGGGCATCCTCTTCAGTGACGGAAGGGCTACGGCAGTGGTGAAAGAGGTGAAAGAAGAT
GGAGAAAGAATTTAA

Upstream 100 bases:

>100_bases
TCAATTAAGGACAAGGCTTCTTATGTAACCCCTGTGCCGGGAGGAGTTGGACCTGTAACTACAGCCATGATTCTCAAAAA
TACCCTGGAGGCTTTTAAAT

Downstream 100 bases:

>100_bases
TTTTGAAGAAGATTTGAAAAGGTTAGAGGAGATTGTAGATACGCTAGAAAAAGGCAATTTGATGCTGGAGGAGTCTTTTA
ATTTATTCAAAGAAGGAGTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQLKAFSVSEVTEYIKKVMDNDIILRNVRVRGEISNLKYHSTAVYFTLKDEGAALKCVMFNDYSRSLEFTLQDGMSVIAT
GRITVYEKGGLYQLYVQSVQMDGIGALYIAFNKLKEKLQKEGLFDLDKKKPIPKHPRKIAVVTSPTGAVIRDIITISRRR
NPTVDIMVVPVLVQGSSAADEISNALRILNKRKDIDVIIVARGGGSLEEIWPFNEEKVARSIFASRIPVVSAVGHETDFT
IADFVADLRAPTPSAAAELVVPDIKVYQRELFLLKTKIMNLMKAQVLHSKKEFEGLKRALYLNNPIKKNEVLKQRVKNLK
KSLTKEMLSIFNQKKNELLVLNEKLDSLSPLKVLTRGYTIVLNKEGQVITSSRKVKTSEEVGILFSDGRATAVVKEVKED
GERI

Sequences:

>Translated_404_residues
MQLKAFSVSEVTEYIKKVMDNDIILRNVRVRGEISNLKYHSTAVYFTLKDEGAALKCVMFNDYSRSLEFTLQDGMSVIAT
GRITVYEKGGLYQLYVQSVQMDGIGALYIAFNKLKEKLQKEGLFDLDKKKPIPKHPRKIAVVTSPTGAVIRDIITISRRR
NPTVDIMVVPVLVQGSSAADEISNALRILNKRKDIDVIIVARGGGSLEEIWPFNEEKVARSIFASRIPVVSAVGHETDFT
IADFVADLRAPTPSAAAELVVPDIKVYQRELFLLKTKIMNLMKAQVLHSKKEFEGLKRALYLNNPIKKNEVLKQRVKNLK
KSLTKEMLSIFNQKKNELLVLNEKLDSLSPLKVLTRGYTIVLNKEGQVITSSRKVKTSEEVGILFSDGRATAVVKEVKED
GERI
>Mature_404_residues
MQLKAFSVSEVTEYIKKVMDNDIILRNVRVRGEISNLKYHSTAVYFTLKDEGAALKCVMFNDYSRSLEFTLQDGMSVIAT
GRITVYEKGGLYQLYVQSVQMDGIGALYIAFNKLKEKLQKEGLFDLDKKKPIPKHPRKIAVVTSPTGAVIRDIITISRRR
NPTVDIMVVPVLVQGSSAADEISNALRILNKRKDIDVIIVARGGGSLEEIWPFNEEKVARSIFASRIPVVSAVGHETDFT
IADFVADLRAPTPSAAAELVVPDIKVYQRELFLLKTKIMNLMKAQVLHSKKEFEGLKRALYLNNPIKKNEVLKQRVKNLK
KSLTKEMLSIFNQKKNELLVLNEKLDSLSPLKVLTRGYTIVLNKEGQVITSSRKVKTSEEVGILFSDGRATAVVKEVKED
GERI

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=439, Percent_Identity=35.0797266514806, Blast_Score=274, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_THETN (Q8RAC9)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622914.1
- GeneID:   997647
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1294
- NMPDR:   fig|273068.3.peg.1185
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   TTEN273068:TTE1294-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 45384; Mature: 45384

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKAFSVSEVTEYIKKVMDNDIILRNVRVRGEISNLKYHSTAVYFTLKDEGAALKCVMF
CCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEEEEEEEEECCCCEEEEEEE
NDYSRSLEFTLQDGMSVIATGRITVYEKGGLYQLYVQSVQMDGIGALYIAFNKLKEKLQK
CCCCCCEEEEECCCCEEEEECEEEEEECCCEEEEEEEHEEECCCEEEEHHHHHHHHHHHH
EGLFDLDKKKPIPKHPRKIAVVTSPTGAVIRDIITISRRRNPTVDIMVVPVLVQGSSAAD
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHH
EISNALRILNKRKDIDVIIVARGGGSLEEIWPFNEEKVARSIFASRIPVVSAVGHETDFT
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCH
IADFVADLRAPTPSAAAELVVPDIKVYQRELFLLKTKIMNLMKAQVLHSKKEFEGLKRAL
HHHHHHHHCCCCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLNNPIKKNEVLKQRVKNLKKSLTKEMLSIFNQKKNELLVLNEKLDSLSPLKVLTRGYTI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCEEE
VLNKEGQVITSSRKVKTSEEVGILFSDGRATAVVKEVKEDGERI
EECCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQLKAFSVSEVTEYIKKVMDNDIILRNVRVRGEISNLKYHSTAVYFTLKDEGAALKCVMF
CCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEEEEEEEEEEECCCCEEEEEEE
NDYSRSLEFTLQDGMSVIATGRITVYEKGGLYQLYVQSVQMDGIGALYIAFNKLKEKLQK
CCCCCCEEEEECCCCEEEEECEEEEEECCCEEEEEEEHEEECCCEEEEHHHHHHHHHHHH
EGLFDLDKKKPIPKHPRKIAVVTSPTGAVIRDIITISRRRNPTVDIMVVPVLVQGSSAAD
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHH
EISNALRILNKRKDIDVIIVARGGGSLEEIWPFNEEKVARSIFASRIPVVSAVGHETDFT
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCCH
IADFVADLRAPTPSAAAELVVPDIKVYQRELFLLKTKIMNLMKAQVLHSKKEFEGLKRAL
HHHHHHHHCCCCCCCCHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLNNPIKKNEVLKQRVKNLKKSLTKEMLSIFNQKKNELLVLNEKLDSLSPLKVLTRGYTI
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCEEE
VLNKEGQVITSSRKVKTSEEVGILFSDGRATAVVKEVKEDGERI
EECCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336