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The map label for this gene is Sbm2 [H]

Identifier: 20807673

GI number: 20807673

Start: 1220647

End: 1221054

Strand: Direct

Name: Sbm2 [H]

Synonym: TTE1218

Alternate gene names: 20807673

Gene position: 1220647-1221054 (Clockwise)

Preceding gene: 20807672

Following gene: 20807674

Centisome position: 45.39

GC content: 44.61

Gene sequence:

>408_bases
ATGGAAAGGCCAATAAGAGTTTTAGTAGCAAAACCCGGCTTGGACGGGCATGACAGGGGAGCAAAGGTGATAGCGAGAGC
CTTAAGAGATGCGGGAATGGAAGTAATATACACAGGATTAAGGCAGACACCTGAGCAAATAGTAGAAGCAGCCATACAGG
AAGACGTGGACGTAGTCGCATTGAGTATACTCTCAGGCGCTCACAATACACTTTTTCCCAAAATAACAAAGCTTCTAAAA
GAGAGAGGGGCAGAGGACATATTGGTGATAGGCGGAGGTGTGATACCAGAAGAAGATATTCCCTTTTTGAAAGAGCACGG
CATAGCAGAGATATTCACCCCTGGCACTCCCACTTCAGCAGTCATTGAATATATAAAAGCCAATGTTAAGAGGTTGGCAA
AAAAATGA

Upstream 100 bases:

>100_bases
AAAAGCCTATGCTACATTAGGAGAGATCTGTGGGGTAATGAGAGAAGTATTTGGAGAATACAAAGCACCAAGCATATTTT
AGCTCCAGGAGGTTATAGTT

Downstream 100 bases:

>100_bases
TGGAATTAGAAAAGCTGCTTCTTAATAGAGACAAAAGAGCAATAGCAAGAGCCATAACCTACGCTGAAGACGATAAAGAA
AAAATGCTGGTAAGAAGATT

Product: methylmalonyl-CoA mutase C-terminal domain-containing protein

Products: succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MERPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEQIVEAAIQEDVDVVALSILSGAHNTLFPKITKLLK
ERGAEDILVIGGGVIPEEDIPFLKEHGIAEIFTPGTPTSAVIEYIKANVKRLAKK

Sequences:

>Translated_135_residues
MERPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEQIVEAAIQEDVDVVALSILSGAHNTLFPKITKLLK
ERGAEDILVIGGGVIPEEDIPFLKEHGIAEIFTPGTPTSAVIEYIKANVKRLAKK
>Mature_135_residues
MERPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEQIVEAAIQEDVDVVALSILSGAHNTLFPKITKLLK
ERGAEDILVIGGGVIPEEDIPFLKEHGIAEIFTPGTPTSAVIEYIKANVKRLAKK

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=121, Percent_Identity=49.5867768595041, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789284, Length=115, Percent_Identity=52.1739130434783, Blast_Score=120, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144500, Length=131, Percent_Identity=45.0381679389313, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: NA

Molecular weight: Translated: 14629; Mature: 14629

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEQIVEAAIQEDVDVVA
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LSILSGAHNTLFPKITKLLKERGAEDILVIGGGVIPEEDIPFLKEHGIAEIFTPGTPTSA
HHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCCEEEECCCCCHHH
VIEYIKANVKRLAKK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MERPIRVLVAKPGLDGHDRGAKVIARALRDAGMEVIYTGLRQTPEQIVEAAIQEDVDVVA
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LSILSGAHNTLFPKITKLLKERGAEDILVIGGGVIPEEDIPFLKEHGIAEIFTPGTPTSA
HHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHCCCEEEECCCCCHHH
VIEYIKANVKRLAKK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Co [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-methylmalonyl-CoA [C]

Specific reaction: L-methylmalonyl-CoA = succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]