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The map label for this gene is Sbm [H]

Identifier: 20807672

GI number: 20807672

Start: 1218949

End: 1220628

Strand: Direct

Name: Sbm [H]

Synonym: TTE1217

Alternate gene names: 20807672

Gene position: 1218949-1220628 (Clockwise)

Preceding gene: 20807671

Following gene: 20807673

Centisome position: 45.32

GC content: 41.55

Gene sequence:

>1680_bases
ATGTGGGAGGAAAAAGAGCTGGAAAGGATAAAGAAAGCGAAAGAAGAATGGGAACAGGATGTAGTTAGCAAGGTACTTAG
TAAGTTTTCAGAAAGGAGAGAAAAATTTGAAACAAGTTCAGGGATAGAAATTAAAAGGCTTTATACTCCGCTGGACTTAA
AAGAATTTGACTACAATGAAAAGCTGGGCTTTCCGGGAGAATATCCCTTCACAAGAGGGATACAGCCTACCATGTACAGA
GGTAGATTTTGGACGATGAGGCAGTATGCAGGTTTTGCTACTGCCGAAGAATCCAACAAGAGATACAAATACCTTTTAGA
ACAGGGGCAAATGGGCTTAAGCGTGGCTTTTGACCTTCCCACGCAGATAGGCTATGACTCTGACCATCCTCTTGCAGAAG
GGGAAGTAGGGAAAGTAGGGGTAGCTATAGATTCGCTGCAGGACATGGAGATACTCTTCGATGGGATTCCCCTTGACAAA
GTAAGCACTTCCATGACAATAAACGCTCCGGCAGCAGTATTACTGGCCATGTATATAGCAGTGGCAGAAAAACAGGGAAT
AACTCCAGACAAGCTCGATGGGACAATACAAAATGACATACTAAAGGAATACGTGGCAAGAGGGACCTACATTTTTCCTG
TTGAACCCTCAATGAGATTAATAACAGACATTTTTGAATACTGTTCAAAAAATGTTCCAAAATGGAACACAATAAGCATA
AGCGGCTATCACATGAGAGAAGCTGGAGCCACAGCCGTGCAGGAAGTAGCTTTTACCTTTGCAAACGCCATAGCATATGT
AGAAGCGGCCCTAAAAGCAGGCCTTGAGATAGATGACTTTGCACCAAGGCTTTCATTTTTCTTTAGCGCCCACAACAACC
TTTTTGAAGAGGTAGCAAAATTTAGAGCTGCGCGAAGACTCTGGGCAAAGATAATGAAAGAAAGATTTGGTGCCAAAAAT
CCTCGCTCAATGATGCTGAGATTCCACACCCAGACGGCGGGCTCCACATTAACTGCCCAGCAGCCAGACAACAACATAAT
AAGAGTCACAATTCAGGCTTTGGCTGCAGTACTGGGAGGTACACAGTCATTACACACGAACAGCAGAGATGAAGCTCTGG
CTCTTCCTACAGAAGACTCAGTGAGGATTGCCCTGAGGACACAGCAGATAATAGCCTATGAGAGTGGAGTAGCTGACGTG
GTTGATCCTTTAGGTGGTTCTTACTACGTAGAATACCTCACAGATGAAATAGAGAAAAAGGCAATGGAATACATAGAAAA
AATAGATAAAATGGGGGGAGCGACAGCGGCGATTGAAAGTGGATACATGCAGAGAGAAATTCAGAACAGCGCATATAATT
ACCAGAAGGAAATAGAATCAAAAGAAAAAATTGTAGTAGGGGTAAACATGTTTCAGATAGAAGAAGAACCTCCTAAAAAC
TTATTAAAAGTGGACCCTAAAGTAGAAGAACTGCAAAAACAAAAACTTAAAAAATTGAGAAAAGAAAGAGATAACGAAAA
AGTGCAAAAAGTATTGAATGACTTAAAAAAAGCCTGCAAAGGTACAGATAACCTGATGCCATATATTTTGGAAGCAGTAA
AAGCCTATGCTACATTAGGAGAGATCTGTGGGGTAATGAGAGAAGTATTTGGAGAATACAAAGCACCAAGCATATTTTAG

Upstream 100 bases:

>100_bases
GAAGAAAAATGCATAAAATGCGGATTATGTGAGATGTACTGTCCCGATTATGCCATTTACATTGAAGAGGTATGAAGCAA
TTTACAGGGAGGGATAAAAA

Downstream 100 bases:

>100_bases
CTCCAGGAGGTTATAGTTATGGAAAGGCCAATAAGAGTTTTAGTAGCAAAACCCGGCTTGGACGGGCATGACAGGGGAGC
AAAGGTGATAGCGAGAGCCT

Product: methylmalonyl-CoA mutase N-terminal domain-containing protein

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MWEEKELERIKKAKEEWEQDVVSKVLSKFSERREKFETSSGIEIKRLYTPLDLKEFDYNEKLGFPGEYPFTRGIQPTMYR
GRFWTMRQYAGFATAEESNKRYKYLLEQGQMGLSVAFDLPTQIGYDSDHPLAEGEVGKVGVAIDSLQDMEILFDGIPLDK
VSTSMTINAPAAVLLAMYIAVAEKQGITPDKLDGTIQNDILKEYVARGTYIFPVEPSMRLITDIFEYCSKNVPKWNTISI
SGYHMREAGATAVQEVAFTFANAIAYVEAALKAGLEIDDFAPRLSFFFSAHNNLFEEVAKFRAARRLWAKIMKERFGAKN
PRSMMLRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVADV
VDPLGGSYYVEYLTDEIEKKAMEYIEKIDKMGGATAAIESGYMQREIQNSAYNYQKEIESKEKIVVGVNMFQIEEEPPKN
LLKVDPKVEELQKQKLKKLRKERDNEKVQKVLNDLKKACKGTDNLMPYILEAVKAYATLGEICGVMREVFGEYKAPSIF

Sequences:

>Translated_559_residues
MWEEKELERIKKAKEEWEQDVVSKVLSKFSERREKFETSSGIEIKRLYTPLDLKEFDYNEKLGFPGEYPFTRGIQPTMYR
GRFWTMRQYAGFATAEESNKRYKYLLEQGQMGLSVAFDLPTQIGYDSDHPLAEGEVGKVGVAIDSLQDMEILFDGIPLDK
VSTSMTINAPAAVLLAMYIAVAEKQGITPDKLDGTIQNDILKEYVARGTYIFPVEPSMRLITDIFEYCSKNVPKWNTISI
SGYHMREAGATAVQEVAFTFANAIAYVEAALKAGLEIDDFAPRLSFFFSAHNNLFEEVAKFRAARRLWAKIMKERFGAKN
PRSMMLRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVADV
VDPLGGSYYVEYLTDEIEKKAMEYIEKIDKMGGATAAIESGYMQREIQNSAYNYQKEIESKEKIVVGVNMFQIEEEPPKN
LLKVDPKVEELQKQKLKKLRKERDNEKVQKVLNDLKKACKGTDNLMPYILEAVKAYATLGEICGVMREVFGEYKAPSIF
>Mature_559_residues
MWEEKELERIKKAKEEWEQDVVSKVLSKFSERREKFETSSGIEIKRLYTPLDLKEFDYNEKLGFPGEYPFTRGIQPTMYR
GRFWTMRQYAGFATAEESNKRYKYLLEQGQMGLSVAFDLPTQIGYDSDHPLAEGEVGKVGVAIDSLQDMEILFDGIPLDK
VSTSMTINAPAAVLLAMYIAVAEKQGITPDKLDGTIQNDILKEYVARGTYIFPVEPSMRLITDIFEYCSKNVPKWNTISI
SGYHMREAGATAVQEVAFTFANAIAYVEAALKAGLEIDDFAPRLSFFFSAHNNLFEEVAKFRAARRLWAKIMKERFGAKN
PRSMMLRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVADV
VDPLGGSYYVEYLTDEIEKKAMEYIEKIDKMGGATAAIESGYMQREIQNSAYNYQKEIESKEKIVVGVNMFQIEEEPPKN
LLKVDPKVEELQKQKLKKLRKERDNEKVQKVLNDLKKACKGTDNLMPYILEAVKAYATLGEICGVMREVFGEYKAPSIF

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=522, Percent_Identity=51.3409961685824, Blast_Score=528, Evalue=1e-150,
Organism=Escherichia coli, GI1789284, Length=550, Percent_Identity=52, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25144500, Length=521, Percent_Identity=53.9347408829175, Blast_Score=557, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 63318; Mature: 63318

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEEKELERIKKAKEEWEQDVVSKVLSKFSERREKFETSSGIEIKRLYTPLDLKEFDYNE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCCC
KLGFPGEYPFTRGIQPTMYRGRFWTMRQYAGFATAEESNKRYKYLLEQGQMGLSVAFDLP
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCHHCCHHHHHHHHCCCCCEEEEEECC
TQIGYDSDHPLAEGEVGKVGVAIDSLQDMEILFDGIPLDKVSTSMTINAPAAVLLAMYIA
HHCCCCCCCCCCCCCCCEEEHHHHCHHHHHHHHCCCCHHHCCCCEEECCHHHHHHHHHHH
VAEKQGITPDKLDGTIQNDILKEYVARGTYIFPVEPSMRLITDIFEYCSKNVPKWNTISI
HHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCEEEEE
SGYHMREAGATAVQEVAFTFANAIAYVEAALKAGLEIDDFAPRLSFFFSAHNNLFEEVAK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FRAARRLWAKIMKERFGAKNPRSMMLRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGG
HHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCCEEECCCCCCCEEEHHHHHHHHHHCC
TQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVADVVDPLGGSYYVEYLTDEIEKK
CHHCCCCCCCCEEECCCCCCEEEEEEHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHH
AMEYIEKIDKMGGATAAIESGYMQREIQNSAYNYQKEIESKEKIVVGVNMFQIEEEPPKN
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEEEECCCCCHH
LLKVDPKVEELQKQKLKKLRKERDNEKVQKVLNDLKKACKGTDNLMPYILEAVKAYATLG
HEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EICGVMREVFGEYKAPSIF
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MWEEKELERIKKAKEEWEQDVVSKVLSKFSERREKFETSSGIEIKRLYTPLDLKEFDYNE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCCC
KLGFPGEYPFTRGIQPTMYRGRFWTMRQYAGFATAEESNKRYKYLLEQGQMGLSVAFDLP
CCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCCCCCHHCCHHHHHHHHCCCCCEEEEEECC
TQIGYDSDHPLAEGEVGKVGVAIDSLQDMEILFDGIPLDKVSTSMTINAPAAVLLAMYIA
HHCCCCCCCCCCCCCCCEEEHHHHCHHHHHHHHCCCCHHHCCCCEEECCHHHHHHHHHHH
VAEKQGITPDKLDGTIQNDILKEYVARGTYIFPVEPSMRLITDIFEYCSKNVPKWNTISI
HHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCEEEEE
SGYHMREAGATAVQEVAFTFANAIAYVEAALKAGLEIDDFAPRLSFFFSAHNNLFEEVAK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FRAARRLWAKIMKERFGAKNPRSMMLRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGG
HHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCCEEECCCCCCCEEEHHHHHHHHHHCC
TQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVADVVDPLGGSYYVEYLTDEIEKK
CHHCCCCCCCCEEECCCCCCEEEEEEHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHH
AMEYIEKIDKMGGATAAIESGYMQREIQNSAYNYQKEIESKEKIVVGVNMFQIEEEPPKN
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECEEEEECCCCCHH
LLKVDPKVEELQKQKLKKLRKERDNEKVQKVLNDLKKACKGTDNLMPYILEAVKAYATLG
HEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EICGVMREVFGEYKAPSIF
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]