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The map label for this gene is Alr

Identifier: 20807662

GI number: 20807662

Start: 1207235

End: 1208401

Strand: Direct

Name: Alr

Synonym: TTE1207

Alternate gene names: 20807662

Gene position: 1207235-1208401 (Clockwise)

Preceding gene: 20807661

Following gene: 20807663

Centisome position: 44.89

GC content: 35.56

Gene sequence:

>1167_bases
GTGAAATTTGACGGGGTAAGACCCACCCGCGTAGAAGTATATCTAGATGCAATAACACATAACTTCAGAGAAATAAAGAA
GATAGTTGGAAAAAATGTGAAAATAATGGCGGTGATAAAAGGGGATGCATATGGTCATGGAGCTTCATATGTAGCCAAAT
TTTTAGAAAAAGAAGGGGTAGACTATTTCGGAGTAGCAACTACAGAAGAAGCTTTAGAGTTGAGGGAAAAGGGAATAAAA
ACTCCTATTCTAATTTTTGGTTATACTCCTCCTACACAGTTAAGACAAATAGTTAAACATGACCTTACTCAAACGGTGTA
CGATATAAAATATGCGAAAGAGTTAGAGAAAGAAAGTCTAAAACAAAACAAAAGAGCAAAAGTCCATATAAAAATTGATA
CAGGTTTGGGACGAATCGGATATATTGATTTTGATTTAGCGCAGAAAGAGATTCTAGAAATGGCAAACATGAGAGGATTA
ATATTGGAAGGGATATACAGTCATTTTGCTGCCGCATCCGAAGATGATAGGGATTATTGCAAAGAGCAGTTCGACAAATT
CATGAATCTAATTAGTAGTTTGGAGAAAAAAAGGTTAAAAATTCCTTTAAAACATATAGCCAATGCGGCAGCTATTTTAA
ATCTCAATTATTCTCATTTAGATATGGTAAGGCCGGGTATAATTTTGTTCGGTGCATATCCTTCAAAGAGAGTAGAACGA
AAGGTAGAATTGAGAGAAACACTGAGGTTTACTACGCGGGTGGTCCATTTAAAAGATGTACCAGCGGGATTTTTTATAGG
CTACGGCAAAAGTTTTGTGACAAAAAGAAAAAGTGTAATAGCTACTATCCCCGTGGGGTATGCGGATGGACTTGATAGGA
GATTATCTAATAACTATAAATTGCTATTAAAGGGAAAGTATGTTCCAATAGTAGGCAGAGTATGTATGGACCAGTGCATG
ATAGATGTTACTGATGTAGAAGGTGTGGAAATAGGAGATGAGGTGGTTATTATAGGGACACAAAACAATGAGACAGTTTC
TGTAGAATCTATGGCTGATAAAATTGAAACTATTCCTCAAGAAGTTTTTTCTAGAATTAGCAGAAGGGTGCCTAGAGTGT
ATTTTTATGATGGAATAAAGATTGGAGAAGTAAATTACTTAAAGTGA

Upstream 100 bases:

>100_bases
TCATACGCAACCTCTATGGAAAACATAGAAAAAGGACTTGACAGAATTGAAAACTTCTTGAATAAGATTTAGAACTTTTA
AGTAGGAGGAGTTGATAAAG

Downstream 100 bases:

>100_bases
GGTGAAGGACTGTAAACCATGGAAAGGAGAGTTAAAATAACAGAAACAGTTCTAAGAGATGCCCATCAGTCTTTGATGGC
TACTCGCATGACTACAGAGG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKFDGVRPTRVEVYLDAITHNFREIKKIVGKNVKIMAVIKGDAYGHGASYVAKFLEKEGVDYFGVATTEEALELREKGIK
TPILIFGYTPPTQLRQIVKHDLTQTVYDIKYAKELEKESLKQNKRAKVHIKIDTGLGRIGYIDFDLAQKEILEMANMRGL
ILEGIYSHFAAASEDDRDYCKEQFDKFMNLISSLEKKRLKIPLKHIANAAAILNLNYSHLDMVRPGIILFGAYPSKRVER
KVELRETLRFTTRVVHLKDVPAGFFIGYGKSFVTKRKSVIATIPVGYADGLDRRLSNNYKLLLKGKYVPIVGRVCMDQCM
IDVTDVEGVEIGDEVVIIGTQNNETVSVESMADKIETIPQEVFSRISRRVPRVYFYDGIKIGEVNYLK

Sequences:

>Translated_388_residues
MKFDGVRPTRVEVYLDAITHNFREIKKIVGKNVKIMAVIKGDAYGHGASYVAKFLEKEGVDYFGVATTEEALELREKGIK
TPILIFGYTPPTQLRQIVKHDLTQTVYDIKYAKELEKESLKQNKRAKVHIKIDTGLGRIGYIDFDLAQKEILEMANMRGL
ILEGIYSHFAAASEDDRDYCKEQFDKFMNLISSLEKKRLKIPLKHIANAAAILNLNYSHLDMVRPGIILFGAYPSKRVER
KVELRETLRFTTRVVHLKDVPAGFFIGYGKSFVTKRKSVIATIPVGYADGLDRRLSNNYKLLLKGKYVPIVGRVCMDQCM
IDVTDVEGVEIGDEVVIIGTQNNETVSVESMADKIETIPQEVFSRISRRVPRVYFYDGIKIGEVNYLK
>Mature_388_residues
MKFDGVRPTRVEVYLDAITHNFREIKKIVGKNVKIMAVIKGDAYGHGASYVAKFLEKEGVDYFGVATTEEALELREKGIK
TPILIFGYTPPTQLRQIVKHDLTQTVYDIKYAKELEKESLKQNKRAKVHIKIDTGLGRIGYIDFDLAQKEILEMANMRGL
ILEGIYSHFAAASEDDRDYCKEQFDKFMNLISSLEKKRLKIPLKHIANAAAILNLNYSHLDMVRPGIILFGAYPSKRVER
KVELRETLRFTTRVVHLKDVPAGFFIGYGKSFVTKRKSVIATIPVGYADGLDRRLSNNYKLLLKGKYVPIVGRVCMDQCM
IDVTDVEGVEIGDEVVIIGTQNNETVSVESMADKIETIPQEVFSRISRRVPRVYFYDGIKIGEVNYLK

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=364, Percent_Identity=30.4945054945055, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787439, Length=373, Percent_Identity=27.6139410187668, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR1_THETN (Q8RAK6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622833.1
- ProteinModelPortal:   Q8RAK6
- GeneID:   997687
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1207
- NMPDR:   fig|273068.3.peg.949
- HOGENOM:   HBG712172
- OMA:   KKIKVHL
- ProtClustDB:   CLSK901100
- BioCyc:   TTEN273068:TTE1207-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 44127; Mature: 44127

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 40-40 ACT_SITE 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDGVRPTRVEVYLDAITHNFREIKKIVGKNVKIMAVIKGDAYGHGASYVAKFLEKEGV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCC
DYFGVATTEEALELREKGIKTPILIFGYTPPTQLRQIVKHDLTQTVYDIKYAKELEKESL
CEEEECCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQNKRAKVHIKIDTGLGRIGYIDFDLAQKEILEMANMRGLILEGIYSHFAAASEDDRDYC
HCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHH
KEQFDKFMNLISSLEKKRLKIPLKHIANAAAILNLNYSHLDMVRPGIILFGAYPSKRVER
HHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCHHHHHCCCCEEEEECCCHHHHHH
KVELRETLRFTTRVVHLKDVPAGFFIGYGKSFVTKRKSVIATIPVGYADGLDRRLSNNYK
HHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHHCCCEEEEECCCCCCCHHHHHCCCCE
LLLKGKYVPIVGRVCMDQCMIDVTDVEGVEIGDEVVIIGTQNNETVSVESMADKIETIPQ
EEEECCCCHHHHHHHHHHHCEEEECCCCEEECCEEEEEECCCCCEEEHHHHHHHHHHHHH
EVFSRISRRVPRVYFYDGIKIGEVNYLK
HHHHHHHHCCCEEEEECCEEECCCCCCC
>Mature Secondary Structure
MKFDGVRPTRVEVYLDAITHNFREIKKIVGKNVKIMAVIKGDAYGHGASYVAKFLEKEGV
CCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCC
DYFGVATTEEALELREKGIKTPILIFGYTPPTQLRQIVKHDLTQTVYDIKYAKELEKESL
CEEEECCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQNKRAKVHIKIDTGLGRIGYIDFDLAQKEILEMANMRGLILEGIYSHFAAASEDDRDYC
HCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHH
KEQFDKFMNLISSLEKKRLKIPLKHIANAAAILNLNYSHLDMVRPGIILFGAYPSKRVER
HHHHHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCHHHHHCCCCEEEEECCCHHHHHH
KVELRETLRFTTRVVHLKDVPAGFFIGYGKSFVTKRKSVIATIPVGYADGLDRRLSNNYK
HHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHHCCCEEEEECCCCCCCHHHHHCCCCE
LLLKGKYVPIVGRVCMDQCMIDVTDVEGVEIGDEVVIIGTQNNETVSVESMADKIETIPQ
EEEECCCCHHHHHHHHHHHCEEEECCCCEEECCEEEEEECCCCCEEEHHHHHHHHHHHHH
EVFSRISRRVPRVYFYDGIKIGEVNYLK
HHHHHHHHCCCEEEEECCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336