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The map label for this gene is Apt [H]

Identifier: 20807649

GI number: 20807649

Start: 1193301

End: 1193822

Strand: Direct

Name: Apt [H]

Synonym: TTE1194

Alternate gene names: 20807649

Gene position: 1193301-1193822 (Clockwise)

Preceding gene: 20807648

Following gene: 20807650

Centisome position: 44.37

GC content: 40.61

Gene sequence:

>522_bases
ATGACGCTTGACGACATAAAGGAAATGATTAGAGAGATACCAGATTTTCCTAAAAAAGGAATAAGATTTAAAGATATAAC
TCCTGTTTTAAAAGACGCCAAAGCTTTTAACTATTCTATAGAGATGCTTGCTAAAGCGTTAGAGGGGAGGAAATTTGACC
TTATCGCAGCTCCAGAGGCGAGAGGATTCTTGTTTGGAGCACCTCTTGCTTTTCGCTTAGGAGTGGGATTTGTTCCGGTG
AGAAAACCCGGGAAGTTACCTGCTGAAACCTTAAGCTACGAATATGAACTAGAGTACGGCCTGGATTCTCTTGAGATACA
CAAAGATGCGGTAGTTAAGGGGCAGAGAGTTGTGATAGTGGATGACCTTCTGGCTACAGGGGGAACTGTTTACGCTTCAG
CCAAGCTTGTAGAAAGCTTGGGAGGAGTAGTGGATTCTATTTTGTTTTTGACGGAACTGACATTTCTAGATGGTAGAAAA
AAGCTTGACGGATATGATATAATTTCATTAATAAAGTTCTAA

Upstream 100 bases:

>100_bases
TACCGCCTGCTGGGGCTGGGAAAGTCTGAAGGGCGGACTACAAATACCCCAGCTATCTAAACTGTACATTTTTGTACAGT
TTGGGTAACCAGGTTTTAAA

Downstream 100 bases:

>100_bases
ATATCTTTAAAGTGGCATTTTGCCACTTTAAATTATAAGGTGTGATGACTGTGATAGAAAAAGTAATAAATAGAGTAAAA
CAATACATGGGGGAAAATGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MTLDDIKEMIREIPDFPKKGIRFKDITPVLKDAKAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAFRLGVGFVPV
RKPGKLPAETLSYEYELEYGLDSLEIHKDAVVKGQRVVIVDDLLATGGTVYASAKLVESLGGVVDSILFLTELTFLDGRK
KLDGYDIISLIKF

Sequences:

>Translated_173_residues
MTLDDIKEMIREIPDFPKKGIRFKDITPVLKDAKAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAFRLGVGFVPV
RKPGKLPAETLSYEYELEYGLDSLEIHKDAVVKGQRVVIVDDLLATGGTVYASAKLVESLGGVVDSILFLTELTFLDGRK
KLDGYDIISLIKF
>Mature_172_residues
TLDDIKEMIREIPDFPKKGIRFKDITPVLKDAKAFNYSIEMLAKALEGRKFDLIAAPEARGFLFGAPLAFRLGVGFVPVR
KPGKLPAETLSYEYELEYGLDSLEIHKDAVVKGQRVVIVDDLLATGGTVYASAKLVESLGGVVDSILFLTELTFLDGRKK
LDGYDIISLIKF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=50, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=55.2, Blast_Score=129, Evalue=1e-30,
Organism=Escherichia coli, GI1786675, Length=167, Percent_Identity=51.497005988024, Blast_Score=166, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=44.7058823529412, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=165, Percent_Identity=44.8484848484849, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=38.4146341463415, Blast_Score=94, Evalue=8e-21,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=46.8208092485549, Blast_Score=145, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19158; Mature: 19026

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDDIKEMIREIPDFPKKGIRFKDITPVLKDAKAFNYSIEMLAKALEGRKFDLIAAPEA
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
RGFLFGAPLAFRLGVGFVPVRKPGKLPAETLSYEYELEYGLDSLEIHKDAVVKGQRVVIV
CCEEEECCHHHHHCCCCEECCCCCCCCHHHHCEEEEECCCCCHHHHHHHHHHCCCEEEEE
DDLLATGGTVYASAKLVESLGGVVDSILFLTELTFLDGRKKLDGYDIISLIKF
EHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TLDDIKEMIREIPDFPKKGIRFKDITPVLKDAKAFNYSIEMLAKALEGRKFDLIAAPEA
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
RGFLFGAPLAFRLGVGFVPVRKPGKLPAETLSYEYELEYGLDSLEIHKDAVVKGQRVVIV
CCEEEECCHHHHHCCCCEECCCCCCCCHHHHCEEEEECCCCCHHHHHHHHHHCCCEEEEE
DDLLATGGTVYASAKLVESLGGVVDSILFLTELTFLDGRKKLDGYDIISLIKF
EHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA