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The map label for this gene is ruvA

Identifier: 20807635

GI number: 20807635

Start: 1177702

End: 1178265

Strand: Direct

Name: ruvA

Synonym: TTE1179

Alternate gene names: 20807635

Gene position: 1177702-1178265 (Clockwise)

Preceding gene: 20807634

Following gene: 20807636

Centisome position: 43.79

GC content: 39.72

Gene sequence:

>564_bases
ATGATTGAGTACATAAGGGGAATTATTGAAGACATAGGACCAGATCATGTGATAATCGACCTTATGGGCATAGGTATAAA
AATTTTTGTGCCCTTTTCTACTATGAAGGAGTTGCCTCCCAAAGGAAATATAACAAAGCTTTACACATACCTTTACGTCA
GGGAAGATGGATTTCAGATTTTTGGCTTTAAGAGAAAAGAAGAGCTAGAACTTTTTGAGAAATTACTTTCTGTGAGCGGC
GTAGGACCTAAAGGTGCTCTTTCTATTCTCTCTGTTGTGCCAATAGAAAGCTTTATAAAGGCAGTAAACAGCGGTGATTA
CAAAATTTTAACAGCAGCTCCTGGCATAGGAAAGAAGACAGCAGAGAGGATCATATTAGAGCTCAAGGATAAAGTGCCCA
AAGAGGTTGTAGTCCCGAAAGAGGACAGCCTGTTAAATGAGGCTTTAGAGGCTTTGCTAGCATTGGGTTATACTAAAAGT
GAGGCTATTTACGCTCTTTCTGATGTAAACTGTGAAAGTGTGGAACAGGCTGTCAAAGAGGCGCTGAAAAAATTGGCGAA
ATAG

Upstream 100 bases:

>100_bases
TTGATGAGATACCAAAGCCAGATGATGTGGCTGATGCGCTGGCCGTTGCCATTTGCCACTGCCACAGCAATAATATGTTG
GAAAGACTGGGGTATGGGCG

Downstream 100 bases:

>100_bases
GGTGAAGTAAATGGAAGAAAGGATATTGACTCAAAATTTTACTCAAGAGGATGCGACGGAATACAGTCTCCGTCCCAGGT
GGCTTTCTGAGTACATAGGA

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MIEYIRGIIEDIGPDHVIIDLMGIGIKIFVPFSTMKELPPKGNITKLYTYLYVREDGFQIFGFKRKEELELFEKLLSVSG
VGPKGALSILSVVPIESFIKAVNSGDYKILTAAPGIGKKTAERIILELKDKVPKEVVVPKEDSLLNEALEALLALGYTKS
EAIYALSDVNCESVEQAVKEALKKLAK

Sequences:

>Translated_187_residues
MIEYIRGIIEDIGPDHVIIDLMGIGIKIFVPFSTMKELPPKGNITKLYTYLYVREDGFQIFGFKRKEELELFEKLLSVSG
VGPKGALSILSVVPIESFIKAVNSGDYKILTAAPGIGKKTAERIILELKDKVPKEVVVPKEDSLLNEALEALLALGYTKS
EAIYALSDVNCESVEQAVKEALKKLAK
>Mature_187_residues
MIEYIRGIIEDIGPDHVIIDLMGIGIKIFVPFSTMKELPPKGNITKLYTYLYVREDGFQIFGFKRKEELELFEKLLSVSG
VGPKGALSILSVVPIESFIKAVNSGDYKILTAAPGIGKKTAERIILELKDKVPKEVVVPKEDSLLNEALEALLALGYTKS
EAIYALSDVNCESVEQAVKEALKKLAK

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=200, Percent_Identity=38, Blast_Score=123, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_THETN (Q8RAN3)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622806.1
- ProteinModelPortal:   Q8RAN3
- SMR:   Q8RAN3
- GeneID:   995526
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1179
- NMPDR:   fig|273068.3.peg.876
- HOGENOM:   HBG635309
- OMA:   LFGFAQK
- ProtClustDB:   PRK00116
- BioCyc:   TTEN273068:TTE1179-MONOMER
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278
- TIGRFAMs:   TIGR00084

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like; SSF46929 RuvA_C-like

EC number: =3.6.4.12

Molecular weight: Translated: 20629; Mature: 20629

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEYIRGIIEDIGPDHVIIDLMGIGIKIFVPFSTMKELPPKGNITKLYTYLYVREDGFQI
CHHHHHHHHHHCCCCEEEEEEECCCEEEEECHHHHHHCCCCCCCEEEEEEEEEECCCCEE
FGFKRKEELELFEKLLSVSGVGPKGALSILSVVPIESFIKAVNSGDYKILTAAPGIGKKT
ECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
AERIILELKDKVPKEVVVPKEDSLLNEALEALLALGYTKSEAIYALSDVNCESVEQAVKE
HHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
ALKKLAK
HHHHHCC
>Mature Secondary Structure
MIEYIRGIIEDIGPDHVIIDLMGIGIKIFVPFSTMKELPPKGNITKLYTYLYVREDGFQI
CHHHHHHHHHHCCCCEEEEEEECCCEEEEECHHHHHHCCCCCCCEEEEEEEEEECCCCEE
FGFKRKEELELFEKLLSVSGVGPKGALSILSVVPIESFIKAVNSGDYKILTAAPGIGKKT
ECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
AERIILELKDKVPKEVVVPKEDSLLNEALEALLALGYTKSEAIYALSDVNCESVEQAVKE
HHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
ALKKLAK
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336