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The map label for this gene is AcuC

Identifier: 20807582

GI number: 20807582

Start: 1122650

End: 1123957

Strand: Direct

Name: AcuC

Synonym: TTE1122

Alternate gene names: NA

Gene position: 1122650-1123957 (Clockwise)

Preceding gene: 20807581

Following gene: 20807586

Centisome position: 41.74

GC content: 34.1

Gene sequence:

>1308_bases
ATGATTAAAGCTAAAAATAGATTGGGCATTGTATTCTTTCCTGCTTTTGACTGGGCTATTAGTCCTACTCATCCAGAAAG
AGAAGAAAGACTCCTTTATACTCAAGATCAAATTTTTGAAGAAGGAATTGAAGACATTGAAGGAATTAAATTTTATAATC
CAATTATTGCTGAAGAAAAAGATATTAACAGAGTACATTTTGTAGTGCCAGATGTAAAATCTGTAGTTACTCAATCTCAC
CTCATATCCGCCGGTGGAGCTATTAAAGCCCTTCAAGCAGTGATGGAAAAAGAAGTAGATAAAGCCTTTGCTTTAGTTCG
TCCCCCAGGGCACCATGCTCAGAGAGTAGTTTATGGAGATAGAGGTTTTTGTATAATCAATGTGGAAGCAGTAATGCTAG
AAAGAATAAGGCAAGAATATGGAAATTTAAGAGTCGCCATTGTAGATACAGATTGTCACCACGGTGATGGCACTCAAGAT
ATCTATTGGAACGACAAAGATACTTTGTTTATTTCTCTCCATCAAGACGGAAGAACTCTCTATCCTGGAACAGGATTTAT
AGAAGAATTTGGAGGCCCAGCTGCTTATGGGTACAATATAAATATCCCCTTACCTCCTGGAACAGGAGAAGAAGGTTTTC
TATACGTATTAGATAATGTGGTAATACCTATTTTAGAGGAATATAAACCTGATATAATAATAAACTCTGCTGGCCAAGAC
AACCATTATACAGACCCGCTTACCAATATGAACTTTACAGCTCAAGGATATGCAAAATTAAACGAACGACTAAATCCTGA
TATCGCAGTTCTTGAAGGAGGCTATTCTATTGAAGGAGCTTTGCCTTATGTTAATTTGGGAATAATATTAGCTATGGCAG
GTATTGACTACTCTAGAGTGCGTGAACCAGATTATGATGAAGAGAAATTAAAACAGCCAAAAGATATTACAGAATATATC
AAAAAATTGTCAGAAATAGTATATAACCGCTGGAGAAATAAAGATGACTTGCGATTAAAAGAATTTAAAGATGTGAATTA
TGTAAAAAGACCTAGACGAGTGTATTATGATACAGATGGTATATTAGAAACACAAGTTCAAAATTTTAAAATATGTAACA
AGTGCTCTGGAGTAAATACAATTGAGTCAAAAAGTGATAGAGGATATCATATATTTGCTATAACTATTCCTAGAGATGCC
TGCCCTAATTGTATTGATGAAGGATACAAACTGTATAAAAATGCTTCTTCTCATTATACAAATGTGTATTTACAAGATAG
AGTAAATGACGAATATTATTCTAAATAA

Upstream 100 bases:

>100_bases
CTTCAATATGGTAAGAGGATTTTATACTATCGGAAAGAACATGCGAATTAAAGCTCAGGTAAAACCAGGACTTATCCAAT
AAATTGAGAGGTGAATGAGA

Downstream 100 bases:

>100_bases
AAACACTATCTGGTGTTAGTATATTATTGTAATAATAAGTCTCAAAAAAGTTCAAAGACTAAAAAAATCAATAAAAGCGC
TAAAAATTAACTCAAAAAGC

Product: deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIKAKNRLGIVFFPAFDWAISPTHPEREERLLYTQDQIFEEGIEDIEGIKFYNPIIAEEKDINRVHFVVPDVKSVVTQSH
LISAGGAIKALQAVMEKEVDKAFALVRPPGHHAQRVVYGDRGFCIINVEAVMLERIRQEYGNLRVAIVDTDCHHGDGTQD
IYWNDKDTLFISLHQDGRTLYPGTGFIEEFGGPAAYGYNINIPLPPGTGEEGFLYVLDNVVIPILEEYKPDIIINSAGQD
NHYTDPLTNMNFTAQGYAKLNERLNPDIAVLEGGYSIEGALPYVNLGIILAMAGIDYSRVREPDYDEEKLKQPKDITEYI
KKLSEIVYNRWRNKDDLRLKEFKDVNYVKRPRRVYYDTDGILETQVQNFKICNKCSGVNTIESKSDRGYHIFAITIPRDA
CPNCIDEGYKLYKNASSHYTNVYLQDRVNDEYYSK

Sequences:

>Translated_435_residues
MIKAKNRLGIVFFPAFDWAISPTHPEREERLLYTQDQIFEEGIEDIEGIKFYNPIIAEEKDINRVHFVVPDVKSVVTQSH
LISAGGAIKALQAVMEKEVDKAFALVRPPGHHAQRVVYGDRGFCIINVEAVMLERIRQEYGNLRVAIVDTDCHHGDGTQD
IYWNDKDTLFISLHQDGRTLYPGTGFIEEFGGPAAYGYNINIPLPPGTGEEGFLYVLDNVVIPILEEYKPDIIINSAGQD
NHYTDPLTNMNFTAQGYAKLNERLNPDIAVLEGGYSIEGALPYVNLGIILAMAGIDYSRVREPDYDEEKLKQPKDITEYI
KKLSEIVYNRWRNKDDLRLKEFKDVNYVKRPRRVYYDTDGILETQVQNFKICNKCSGVNTIESKSDRGYHIFAITIPRDA
CPNCIDEGYKLYKNASSHYTNVYLQDRVNDEYYSK
>Mature_435_residues
MIKAKNRLGIVFFPAFDWAISPTHPEREERLLYTQDQIFEEGIEDIEGIKFYNPIIAEEKDINRVHFVVPDVKSVVTQSH
LISAGGAIKALQAVMEKEVDKAFALVRPPGHHAQRVVYGDRGFCIINVEAVMLERIRQEYGNLRVAIVDTDCHHGDGTQD
IYWNDKDTLFISLHQDGRTLYPGTGFIEEFGGPAAYGYNINIPLPPGTGEEGFLYVLDNVVIPILEEYKPDIIINSAGQD
NHYTDPLTNMNFTAQGYAKLNERLNPDIAVLEGGYSIEGALPYVNLGIILAMAGIDYSRVREPDYDEEKLKQPKDITEYI
KKLSEIVYNRWRNKDDLRLKEFKDVNYVKRPRRVYYDTDGILETQVQNFKICNKCSGVNTIESKSDRGYHIFAITIPRDA
CPNCIDEGYKLYKNASSHYTNVYLQDRVNDEYYSK

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI148539870, Length=207, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI169234807, Length=207, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI17158039, Length=208, Percent_Identity=34.6153846153846, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI30795204, Length=208, Percent_Identity=34.6153846153846, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI30795202, Length=208, Percent_Identity=34.6153846153846, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI153085395, Length=272, Percent_Identity=31.6176470588235, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI13128864, Length=206, Percent_Identity=35.4368932038835, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI62750349, Length=252, Percent_Identity=32.5396825396825, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI62750347, Length=252, Percent_Identity=32.5396825396825, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI20070354, Length=293, Percent_Identity=28.6689419795222, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI226529806, Length=293, Percent_Identity=26.962457337884, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI13128860, Length=203, Percent_Identity=28.0788177339901, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI13128862, Length=291, Percent_Identity=22.680412371134, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI293336691, Length=182, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI8923769, Length=198, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI262073088, Length=160, Percent_Identity=28.75, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=293, Percent_Identity=29.0102389078498, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193206283, Length=294, Percent_Identity=30.2721088435374, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17540332, Length=293, Percent_Identity=29.0102389078498, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193209491, Length=261, Percent_Identity=30.2681992337165, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25154020, Length=210, Percent_Identity=34.2857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25154022, Length=210, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=238, Percent_Identity=28.9915966386555, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508561, Length=201, Percent_Identity=26.3681592039801, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17561978, Length=200, Percent_Identity=27.5, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534739, Length=198, Percent_Identity=30.8080808080808, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324307, Length=265, Percent_Identity=33.2075471698113, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323999, Length=203, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321244, Length=199, Percent_Identity=24.6231155778894, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325325, Length=152, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325141, Length=65, Percent_Identity=46.1538461538462, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24642146, Length=266, Percent_Identity=30.0751879699248, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24642144, Length=266, Percent_Identity=30.0751879699248, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24642142, Length=266, Percent_Identity=30.0751879699248, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281360899, Length=266, Percent_Identity=30.0751879699248, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360801, Length=209, Percent_Identity=32.5358851674641, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641720, Length=209, Percent_Identity=32.5358851674641, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360799, Length=209, Percent_Identity=32.5358851674641, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644244, Length=293, Percent_Identity=24.9146757679181, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24657891, Length=201, Percent_Identity=27.363184079602, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 49732; Mature: 49732

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKAKNRLGIVFFPAFDWAISPTHPEREERLLYTQDQIFEEGIEDIEGIKFYNPIIAEEK
CCCCCCCEEEEEEECCCCEECCCCCCHHHCEEHHHHHHHHHHHHHHCCCEEECCCCCCCC
DINRVHFVVPDVKSVVTQSHLISAGGAIKALQAVMEKEVDKAFALVRPPGHHAQRVVYGD
CCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEECC
RGFCIINVEAVMLERIRQEYGNLRVAIVDTDCHHGDGTQDIYWNDKDTLFISLHQDGRTL
CCEEEEEHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEECCCCEEEEEEECCCCEE
YPGTGFIEEFGGPAAYGYNINIPLPPGTGEEGFLYVLDNVVIPILEEYKPDIIINSAGQD
CCCCCHHHHCCCCEEECEEEEEECCCCCCCCCEEEEEHHHHHHHHHHCCCCEEEECCCCC
NHYTDPLTNMNFTAQGYAKLNERLNPDIAVLEGGYSIEGALPYVNLGIILAMAGIDYSRV
CCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEECCCCCCHHHHHHHHHHCCCHHHC
REPDYDEEKLKQPKDITEYIKKLSEIVYNRWRNKDDLRLKEFKDVNYVKRPRRVYYDTDG
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHCCCEEEECCCC
ILETQVQNFKICNKCSGVNTIESKSDRGYHIFAITIPRDACPNCIDEGYKLYKNASSHYT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEE
NVYLQDRVNDEYYSK
EEEEEECCCCHHCCC
>Mature Secondary Structure
MIKAKNRLGIVFFPAFDWAISPTHPEREERLLYTQDQIFEEGIEDIEGIKFYNPIIAEEK
CCCCCCCEEEEEEECCCCEECCCCCCHHHCEEHHHHHHHHHHHHHHCCCEEECCCCCCCC
DINRVHFVVPDVKSVVTQSHLISAGGAIKALQAVMEKEVDKAFALVRPPGHHAQRVVYGD
CCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEECC
RGFCIINVEAVMLERIRQEYGNLRVAIVDTDCHHGDGTQDIYWNDKDTLFISLHQDGRTL
CCEEEEEHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCEEECCCCEEEEEEECCCCEE
YPGTGFIEEFGGPAAYGYNINIPLPPGTGEEGFLYVLDNVVIPILEEYKPDIIINSAGQD
CCCCCHHHHCCCCEEECEEEEEECCCCCCCCCEEEEEHHHHHHHHHHCCCCEEEECCCCC
NHYTDPLTNMNFTAQGYAKLNERLNPDIAVLEGGYSIEGALPYVNLGIILAMAGIDYSRV
CCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCEEECCCCCCHHHHHHHHHHCCCHHHC
REPDYDEEKLKQPKDITEYIKKLSEIVYNRWRNKDDLRLKEFKDVNYVKRPRRVYYDTDG
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHCCCEEEECCCC
ILETQVQNFKICNKCSGVNTIESKSDRGYHIFAITIPRDACPNCIDEGYKLYKNASSHYT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEE
NVYLQDRVNDEYYSK
EEEEEECCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]