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The map label for this gene is hgdC [H]

Identifier: 20807576

GI number: 20807576

Start: 1114704

End: 1116326

Strand: Direct

Name: hgdC [H]

Synonym: TTE1113

Alternate gene names: 20807576

Gene position: 1114704-1116326 (Clockwise)

Preceding gene: 20807575

Following gene: 20807577

Centisome position: 41.45

GC content: 34.87

Gene sequence:

>1623_bases
TTGATAGGGTACATTTGTAAATACACGCCTGTAGAAATAATCGAAGCCTTTGGAGAAGAACCGGTAAGACTTGAGTCAGG
ATATAAGTCTCATGAGCGTGCTGAAGCACTGATTCATTCAAATATGTGCAGTTTTGCAAAAGGGGTTTTGGAAAATATAA
TTGAAAATAATATTGAAGAGGTTATATTAACTGCGTGTTGTGATAGTATAAAAAGGCTTTATGATGTATTAAAAGATAAA
GTAAAATTTATCCATCTTCTGGACCTGCCTAGAAAAAAAGATCCTCTCGCAATAGATCTTTTTTACAATGAAATAATTGA
ATTTATAAAAGCGTATCAGGCCTTTAAAAACAAGAATTTTGCTGAAGAGAATTTGCTAAAAATTCTAGAAAGCAAGTCTT
TTACTAAAGAAAAACAATCTGCTGAAAGCATTGCTATATTAGGCGCGAGGCTTAAAGATGATGTTATAGAAAAAATCAGA
AATTCTTGTACAGCAAAGGTAATAAATTTTACCTGCACAGGTGAAGAAAGAGTATTCAATATCGAAGCAAAAGATAATTT
ATTAAAAAGCTACGCGGAATCGCTTCTTAATTTAACACCTTGTATGAGAATGGCAGAAGATCGAAGCAAGTTAATCAATA
AAGAATTCAAGGGGATAATATACAACACCATAAAGTTCTGTGATTTTTATTCCTATGAGTATGCTGAGCTCAAAAGCAAA
GCAGACCTCCCACTTTTAAAAATTGAAACTGACTATAACGATTCAAATAGCGGACAGATTTTAACAAGAATAGATGCTTT
TTTGGAATCAACCGGTATTAAAAAGATGGAAAAACAGAAAGCCAAGAAAGGATATTTTGTAGGAGTGGATAGTGGCTCTA
CTTCTACAAATGTAGTCATAATCGACGAAAACAAAAACATAATATCATATTCTATTATTCCAACAGGTCCTAAAGCTCTA
GAAAGTGCTTTTAAAGCTTTTGAAATTGCTTTAAAAAATGCAGGACTTCAAGAAAAGGATATTACATCAATAGTAGCAAC
AGGGTATGGAAGAGTAAGCATTCCCTTTGCAGATAGAATTGTAACCGAAATTACCTGTCACGGAAAAGGCGCGTTTTTTA
TAGACAATACTGTTAGAACTGTTATAGATATAGGCGGACAGGATAGCAAAGTGATAAGGTTAGATGACAGCGGCAATGTC
ATTGATTTTGTAATGAATGACAAATGTTCAGCAGGGACAGGTCGGTTTCTTGAAGTAATGGCGAGAACATTAGGCATTTC
AATAGAAGAAATGGCAAAAGTGCATAAGGAAGTAAAAGAAAATATCACGATTACCAGTATGTGTACTGTATTTGCAGAAT
CAGAAGTAATATCTCTTATTGCGCAAAATAAGGATCAAAGGGATATAATACATGCCCTCAATAAAGCCGTTGCTTCAAAA
GCTATTTCCCTGGTCGACAGAATAGGGAGAAAAGGAAAATACATGATGACAGGGGGCGTTGCCAAAAATCAGGGAGTAGT
TTATGCCATCGAAAGCAGGCTGGGCGAAAAACTTATAATTCCATTTGAACCTCAGATTATCGGAGCGCTTGGAGCAGCGC
TAATTTCACTTGAAGGTAAATGA

Upstream 100 bases:

>100_bases
GGGGATTGTGTAGACAAAAGAAATAATCAAGAGGGACAGAATAGGACAAGGCTCGAAGCCTTTCTTGAAATGCTCTAGTA
ATCCTTCTGGAGGTGAAAAA

Downstream 100 bases:

>100_bases
GGGTATCACTATAGGCTTTACTCATGTATTTATAGAGATTGAATTTTTAAAATTTGATCAAGTCCAAATTTTTGCGTAGA
ATCCCTCTGGTTAGAATACG

Product: 2-hydroxyglutaryl-CoA dehydratase activator

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MIGYICKYTPVEIIEAFGEEPVRLESGYKSHERAEALIHSNMCSFAKGVLENIIENNIEEVILTACCDSIKRLYDVLKDK
VKFIHLLDLPRKKDPLAIDLFYNEIIEFIKAYQAFKNKNFAEENLLKILESKSFTKEKQSAESIAILGARLKDDVIEKIR
NSCTAKVINFTCTGEERVFNIEAKDNLLKSYAESLLNLTPCMRMAEDRSKLINKEFKGIIYNTIKFCDFYSYEYAELKSK
ADLPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVIIDENKNIISYSIIPTGPKAL
ESAFKAFEIALKNAGLQEKDITSIVATGYGRVSIPFADRIVTEITCHGKGAFFIDNTVRTVIDIGGQDSKVIRLDDSGNV
IDFVMNDKCSAGTGRFLEVMARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKAVASK
AISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK

Sequences:

>Translated_540_residues
MIGYICKYTPVEIIEAFGEEPVRLESGYKSHERAEALIHSNMCSFAKGVLENIIENNIEEVILTACCDSIKRLYDVLKDK
VKFIHLLDLPRKKDPLAIDLFYNEIIEFIKAYQAFKNKNFAEENLLKILESKSFTKEKQSAESIAILGARLKDDVIEKIR
NSCTAKVINFTCTGEERVFNIEAKDNLLKSYAESLLNLTPCMRMAEDRSKLINKEFKGIIYNTIKFCDFYSYEYAELKSK
ADLPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVIIDENKNIISYSIIPTGPKAL
ESAFKAFEIALKNAGLQEKDITSIVATGYGRVSIPFADRIVTEITCHGKGAFFIDNTVRTVIDIGGQDSKVIRLDDSGNV
IDFVMNDKCSAGTGRFLEVMARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKAVASK
AISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK
>Mature_540_residues
MIGYICKYTPVEIIEAFGEEPVRLESGYKSHERAEALIHSNMCSFAKGVLENIIENNIEEVILTACCDSIKRLYDVLKDK
VKFIHLLDLPRKKDPLAIDLFYNEIIEFIKAYQAFKNKNFAEENLLKILESKSFTKEKQSAESIAILGARLKDDVIEKIR
NSCTAKVINFTCTGEERVFNIEAKDNLLKSYAESLLNLTPCMRMAEDRSKLINKEFKGIIYNTIKFCDFYSYEYAELKSK
ADLPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVIIDENKNIISYSIIPTGPKAL
ESAFKAFEIALKNAGLQEKDITSIVATGYGRVSIPFADRIVTEITCHGKGAFFIDNTVRTVIDIGGQDSKVIRLDDSGNV
IDFVMNDKCSAGTGRFLEVMARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKAVASK
AISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=254, Percent_Identity=43.3070866141732, Blast_Score=192, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 60137; Mature: 60137

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGYICKYTPVEIIEAFGEEPVRLESGYKSHERAEALIHSNMCSFAKGVLENIIENNIEE
CCCCEECCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VILTACCDSIKRLYDVLKDKVKFIHLLDLPRKKDPLAIDLFYNEIIEFIKAYQAFKNKNF
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
AEENLLKILESKSFTKEKQSAESIAILGARLKDDVIEKIRNSCTAKVINFTCTGEERVFN
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEE
IEAKDNLLKSYAESLLNLTPCMRMAEDRSKLINKEFKGIIYNTIKFCDFYSYEYAELKSK
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
ADLPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVI
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCEEEEE
IDENKNIISYSIIPTGPKALESAFKAFEIALKNAGLQEKDITSIVATGYGRVSIPFADRI
EECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCHHHHH
VTEITCHGKGAFFIDNTVRTVIDIGGQDSKVIRLDDSGNVIDFVMNDKCSAGTGRFLEVM
HHHEEECCCCEEEECCHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
ARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKAVASK
HHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK
HHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIGYICKYTPVEIIEAFGEEPVRLESGYKSHERAEALIHSNMCSFAKGVLENIIENNIEE
CCCCEECCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VILTACCDSIKRLYDVLKDKVKFIHLLDLPRKKDPLAIDLFYNEIIEFIKAYQAFKNKNF
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
AEENLLKILESKSFTKEKQSAESIAILGARLKDDVIEKIRNSCTAKVINFTCTGEERVFN
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEE
IEAKDNLLKSYAESLLNLTPCMRMAEDRSKLINKEFKGIIYNTIKFCDFYSYEYAELKSK
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
ADLPLLKIETDYNDSNSGQILTRIDAFLESTGIKKMEKQKAKKGYFVGVDSGSTSTNVVI
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCCCEEEEE
IDENKNIISYSIIPTGPKALESAFKAFEIALKNAGLQEKDITSIVATGYGRVSIPFADRI
EECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCHHHHH
VTEITCHGKGAFFIDNTVRTVIDIGGQDSKVIRLDDSGNVIDFVMNDKCSAGTGRFLEVM
HHHEEECCCCEEEECCHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHH
ARTLGISIEEMAKVHKEVKENITITSMCTVFAESEVISLIAQNKDQRDIIHALNKAVASK
HHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AISLVDRIGRKGKYMMTGGVAKNQGVVYAIESRLGEKLIIPFEPQIIGALGAALISLEGK
HHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]