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The map label for this gene is hgdA [H]

Identifier: 20807575

GI number: 20807575

Start: 1113431

End: 1114681

Strand: Direct

Name: hgdA [H]

Synonym: TTE1112

Alternate gene names: 20807575

Gene position: 1113431-1114681 (Clockwise)

Preceding gene: 20807574

Following gene: 20807576

Centisome position: 41.4

GC content: 32.93

Gene sequence:

>1251_bases
ATGGATACAGTAAAGATTTATGCCAATATTATAAAAGAGAATATGGACAGTCCGGAAAAAGTAAATAAGCTGATAAACCT
TGGTCTTACCACTGCTTATTATTATGTGAGCTTTTTCAAAGACAGGAGGATTCCCAAATCTCTTCATTACCTAAATAAAT
ACTGTATAAAAAGCATAAAAGACTCTCTAGCAAATCCTCAAAATTCTGCTTGGGTAAACCTCTTTGCACCCTCTGAATTT
TTGATTGCCATGGACATAAAACCCTTATTTATTGAAGCATATTCTTCTTTCATGTCAGGCTTCTTCATTGAAGATTATCT
TATTGATACTGCCGAATCGAGAGGCATGTCAAATACTTTATGCAGTTACCATAAAACTTTTATAGGAGCCAGTGAGCTTA
ATATTCTCAAAAAACCTAAATTTATGATGACTACTTCTATGATCTGTGATGCGAATATACCTACTTTCAAGTATCTTTCA
AAAAAACACGGGGTTCCACTGTACATTATTGATATTCCCTACAAATATTCTAAAAACGCCGTAATGTATGTAAAAAAGCA
GCTTTTGGAAGTGGCGGAAAAGCTTGGGGAAGTTTTTAATAGAAAGCTTGATATTGATAAATTGAGGGAAGTTGTAAAAA
CGGAAAATAAAACAAGAGCACTTATGAGAGAATATTTAAATTATGCGGGAGAAAAAAGATTTATACCTACTATGACCTTT
GAAATGTATATGCTCTTTGCATCCCATGTATTCATTGGAAGCAAGGAAGTATTACATTTTTATGAGATGTTAGTGGAGGA
TATAAAAAGAGCTCCTGAAAGAAGTGGAAAAAGCATATTTTTTATACACCTTCTTCCTATATTTGAGAAAAATTTTAAAG
ATTACTTTAACTTCAGCGATAAATTTCACATTGCTGGTAGTGACTTAAATTATGATTTTCTTGATGAAATTGATGAAAAC
GACCCTTTCAAGGGAATCGCTGAAAAGCTTATCTTAAACTCTTTTAATGGTGAAATAAATAGAAGAGTTGCAAGAATCAA
AGAACTGATAGAAAAAATAAAACCGGACGGCATTATACAGTTTTGTCATTTGGGCTGTAAACAGTCGATGGGTGGAACGT
TTATAATTAAAAATCTTGCTTCAGAATTGGGTATTCCATTTCTTTATTTAGATGGGGATTGTGTAGACAAAAGAAATAAT
CAAGAGGGACAGAATAGGACAAGGCTCGAAGCCTTTCTTGAAATGCTCTAG

Upstream 100 bases:

>100_bases
GACACGCACTTTTGTATTTGACGCGGCTACAAAATTTTATAAAAATGTGGTAACATTAATTAAAAGATCAAAAAAGAAGA
GTTTACGGGGCAGTGATAAA

Downstream 100 bases:

>100_bases
TAATCCTTCTGGAGGTGAAAAATTGATAGGGTACATTTGTAAATACACGCCTGTAGAAATAATCGAAGCCTTTGGAGAAG
AACCGGTAAGACTTGAGTCA

Product: 2-hydroxyglutaryl-CoA dehydratase, subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDTVKIYANIIKENMDSPEKVNKLINLGLTTAYYYVSFFKDRRIPKSLHYLNKYCIKSIKDSLANPQNSAWVNLFAPSEF
LIAMDIKPLFIEAYSSFMSGFFIEDYLIDTAESRGMSNTLCSYHKTFIGASELNILKKPKFMMTTSMICDANIPTFKYLS
KKHGVPLYIIDIPYKYSKNAVMYVKKQLLEVAEKLGEVFNRKLDIDKLREVVKTENKTRALMREYLNYAGEKRFIPTMTF
EMYMLFASHVFIGSKEVLHFYEMLVEDIKRAPERSGKSIFFIHLLPIFEKNFKDYFNFSDKFHIAGSDLNYDFLDEIDEN
DPFKGIAEKLILNSFNGEINRRVARIKELIEKIKPDGIIQFCHLGCKQSMGGTFIIKNLASELGIPFLYLDGDCVDKRNN
QEGQNRTRLEAFLEML

Sequences:

>Translated_416_residues
MDTVKIYANIIKENMDSPEKVNKLINLGLTTAYYYVSFFKDRRIPKSLHYLNKYCIKSIKDSLANPQNSAWVNLFAPSEF
LIAMDIKPLFIEAYSSFMSGFFIEDYLIDTAESRGMSNTLCSYHKTFIGASELNILKKPKFMMTTSMICDANIPTFKYLS
KKHGVPLYIIDIPYKYSKNAVMYVKKQLLEVAEKLGEVFNRKLDIDKLREVVKTENKTRALMREYLNYAGEKRFIPTMTF
EMYMLFASHVFIGSKEVLHFYEMLVEDIKRAPERSGKSIFFIHLLPIFEKNFKDYFNFSDKFHIAGSDLNYDFLDEIDEN
DPFKGIAEKLILNSFNGEINRRVARIKELIEKIKPDGIIQFCHLGCKQSMGGTFIIKNLASELGIPFLYLDGDCVDKRNN
QEGQNRTRLEAFLEML
>Mature_416_residues
MDTVKIYANIIKENMDSPEKVNKLINLGLTTAYYYVSFFKDRRIPKSLHYLNKYCIKSIKDSLANPQNSAWVNLFAPSEF
LIAMDIKPLFIEAYSSFMSGFFIEDYLIDTAESRGMSNTLCSYHKTFIGASELNILKKPKFMMTTSMICDANIPTFKYLS
KKHGVPLYIIDIPYKYSKNAVMYVKKQLLEVAEKLGEVFNRKLDIDKLREVVKTENKTRALMREYLNYAGEKRFIPTMTF
EMYMLFASHVFIGSKEVLHFYEMLVEDIKRAPERSGKSIFFIHLLPIFEKNFKDYFNFSDKFHIAGSDLNYDFLDEIDEN
DPFKGIAEKLILNSFNGEINRRVARIKELIEKIKPDGIIQFCHLGCKQSMGGTFIIKNLASELGIPFLYLDGDCVDKRNN
QEGQNRTRLEAFLEML

Specific function: Catalyzes the reversible dehydration of 2- hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the fermentation of glutamate. It is activated by hgdC [H]

COG id: COG1775

COG function: function code E; Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010327 [H]

Pfam domain/function: PF06050 HGD-D [H]

EC number: NA

Molecular weight: Translated: 48359; Mature: 48359

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTVKIYANIIKENMDSPEKVNKLINLGLTTAYYYVSFFKDRRIPKSLHYLNKYCIKSIK
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
DSLANPQNSAWVNLFAPSEFLIAMDIKPLFIEAYSSFMSGFFIEDYLIDTAESRGMSNTL
HHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
CSYHKTFIGASELNILKKPKFMMTTSMICDANIPTFKYLSKKHGVPLYIIDIPYKYSKNA
HHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCH
VMYVKKQLLEVAEKLGEVFNRKLDIDKLREVVKTENKTRALMREYLNYAGEKRFIPTMTF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHH
EMYMLFASHVFIGSKEVLHFYEMLVEDIKRAPERSGKSIFFIHLLPIFEKNFKDYFNFSD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCCC
KFHIAGSDLNYDFLDEIDENDPFKGIAEKLILNSFNGEINRRVARIKELIEKIKPDGIIQ
EEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHH
FCHLGCKQSMGGTFIIKNLASELGIPFLYLDGDCVDKRNNQEGQNRTRLEAFLEML
HHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MDTVKIYANIIKENMDSPEKVNKLINLGLTTAYYYVSFFKDRRIPKSLHYLNKYCIKSIK
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
DSLANPQNSAWVNLFAPSEFLIAMDIKPLFIEAYSSFMSGFFIEDYLIDTAESRGMSNTL
HHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
CSYHKTFIGASELNILKKPKFMMTTSMICDANIPTFKYLSKKHGVPLYIIDIPYKYSKNA
HHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCH
VMYVKKQLLEVAEKLGEVFNRKLDIDKLREVVKTENKTRALMREYLNYAGEKRFIPTMTF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHH
EMYMLFASHVFIGSKEVLHFYEMLVEDIKRAPERSGKSIFFIHLLPIFEKNFKDYFNFSD
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCCCC
KFHIAGSDLNYDFLDEIDENDPFKGIAEKLILNSFNGEINRRVARIKELIEKIKPDGIIQ
EEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHH
FCHLGCKQSMGGTFIIKNLASELGIPFLYLDGDCVDKRNNQEGQNRTRLEAFLEML
HHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659350; 3691501; 8365476; 11106419 [H]