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The map label for this gene is era

Identifier: 20807454

GI number: 20807454

Start: 976619

End: 977515

Strand: Direct

Name: era

Synonym: TTE0974

Alternate gene names: 20807454

Gene position: 976619-977515 (Clockwise)

Preceding gene: 20807453

Following gene: 20807455

Centisome position: 36.31

GC content: 40.02

Gene sequence:

>897_bases
ATGGCCTACAGAGCTGGCTTTGTAGCGTTGATTGGAAGGACAAATGTAGGAAAATCAACCCTTTTAAACGCCATATTGAA
AGAAAAAGTTGCTATTACTTCTCCAAAGCCCCAGACCACCCGCAATACCATAAGGGGTATATTGACTACAGAAGATTACC
AGATTATTTTTGTGGACACTCCTGGAATTCATAAACCTAAATCTAAACTGAGTGAATTCATGATTGAAGTAGCAAAAAGG
ACTCTAAAAGATGTAGATTTAATTTTGTACATGGTGGAGCCCGATACTTCGATAGGCCCTGGAGATAGGTATATTTTGGA
TAATCTAAAAGAGGTGGATACTCCAGTTATTTTGGTGGTCAATAAAATTGACTTGGTGCCTGCTGAGAGAGTAGAAGAGG
CTATTAAGGTTTTTAAAAGCGAGTACAATTTTAAGGATGTGGTGGCCATTTCTGCTTCTTTGGGCACTAATGTGGAGGTT
TTGAAAGAGAAGATAGTTTCTTTCTTGCCAGAAGGACCTAGGTACTATCTTGATGACTATATAACTGACCAGCCCGAGAA
GTTGATAGTTGCGGAGATAATCAGAGAAAAAATGCTTTATTTTCTGGAGGAGGAAGTTCCTCATGGAGTCTATGTAGAAG
TGGAATCCATAAAAGAGAGGGAGGACAAAGAGATAGTAGACATTGACGCTTATATTTACTGTGAGAAAGAGTCCCACAAA
GGAATAATCATAGGAAAGAATGGGCAGATGTTAAAGAAGATAGGGCAGGCGGCAAGGCAGGACTTGGAAGAATTTTATGG
AAAGCAGGTATTTTTGCAGCTGTGGGTTAAAGTGAGGAAAGGCTGGAGGGACAATGAGAAGCTTCTCAGGAAATTGGGCT
ATGCCATTGACAAGTAA

Upstream 100 bases:

>100_bases
CAAGATTCACACTTTTTCTCAGGTTTTTGTCGGGGCAATTTTAGGGATTTTGTTTACAGTGTTAATTTTTCAGATTATAA
GGTGAAGGGAAGGTGAAAAA

Downstream 100 bases:

>100_bases
GCTTTTAGAGTAGTAAATTATAGGAGAAAGATGTTGAAAAAGGAGGAATCTTTAATGAACATAGCTAAGATGATAGACCA
CACTCTTTTAAAGCCAAATG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAYRAGFVALIGRTNVGKSTLLNAILKEKVAITSPKPQTTRNTIRGILTTEDYQIIFVDTPGIHKPKSKLSEFMIEVAKR
TLKDVDLILYMVEPDTSIGPGDRYILDNLKEVDTPVILVVNKIDLVPAERVEEAIKVFKSEYNFKDVVAISASLGTNVEV
LKEKIVSFLPEGPRYYLDDYITDQPEKLIVAEIIREKMLYFLEEEVPHGVYVEVESIKEREDKEIVDIDAYIYCEKESHK
GIIIGKNGQMLKKIGQAARQDLEEFYGKQVFLQLWVKVRKGWRDNEKLLRKLGYAIDK

Sequences:

>Translated_298_residues
MAYRAGFVALIGRTNVGKSTLLNAILKEKVAITSPKPQTTRNTIRGILTTEDYQIIFVDTPGIHKPKSKLSEFMIEVAKR
TLKDVDLILYMVEPDTSIGPGDRYILDNLKEVDTPVILVVNKIDLVPAERVEEAIKVFKSEYNFKDVVAISASLGTNVEV
LKEKIVSFLPEGPRYYLDDYITDQPEKLIVAEIIREKMLYFLEEEVPHGVYVEVESIKEREDKEIVDIDAYIYCEKESHK
GIIIGKNGQMLKKIGQAARQDLEEFYGKQVFLQLWVKVRKGWRDNEKLLRKLGYAIDK
>Mature_297_residues
AYRAGFVALIGRTNVGKSTLLNAILKEKVAITSPKPQTTRNTIRGILTTEDYQIIFVDTPGIHKPKSKLSEFMIEVAKRT
LKDVDLILYMVEPDTSIGPGDRYILDNLKEVDTPVILVVNKIDLVPAERVEEAIKVFKSEYNFKDVVAISASLGTNVEVL
KEKIVSFLPEGPRYYLDDYITDQPEKLIVAEIIREKMLYFLEEEVPHGVYVEVESIKEREDKEIVDIDAYIYCEKESHKG
IIIGKNGQMLKKIGQAARQDLEEFYGKQVFLQLWVKVRKGWRDNEKLLRKLGYAIDK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=326, Percent_Identity=27.6073619631902, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=43.2432432432432, Blast_Score=240, Evalue=7e-65,
Organism=Escherichia coli, GI87082120, Length=160, Percent_Identity=32.5, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367268, Length=162, Percent_Identity=27.1604938271605, Blast_Score=61, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323665, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646434, Length=315, Percent_Identity=26.984126984127, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_THETN (Q8RB50)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622625.1
- ProteinModelPortal:   Q8RB50
- SMR:   Q8RB50
- GeneID:   995826
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0974
- NMPDR:   fig|273068.3.peg.397
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   TTEN273068:TTE0974-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR003593
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- SMART:   SM00382
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34114; Mature: 33983

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRAGFVALIGRTNVGKSTLLNAILKEKVAITSPKPQTTRNTIRGILTTEDYQIIFVDT
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCEEEEEEEC
PGIHKPKSKLSEFMIEVAKRTLKDVDLILYMVEPDTSIGPGDRYILDNLKEVDTPVILVV
CCCCCCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEE
NKIDLVPAERVEEAIKVFKSEYNFKDVVAISASLGTNVEVLKEKIVSFLPEGPRYYLDDY
ECCCCCCHHHHHHHHHHHHHCCCCHHHEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHH
ITDQPEKLIVAEIIREKMLYFLEEEVPHGVYVEVESIKEREDKEIVDIDAYIYCEKESHK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCEEEEEEEEEEECCCCC
GIIIGKNGQMLKKIGQAARQDLEEFYGKQVFLQLWVKVRKGWRDNEKLLRKLGYAIDK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYRAGFVALIGRTNVGKSTLLNAILKEKVAITSPKPQTTRNTIRGILTTEDYQIIFVDT
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCEEEEEEEC
PGIHKPKSKLSEFMIEVAKRTLKDVDLILYMVEPDTSIGPGDRYILDNLKEVDTPVILVV
CCCCCCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEE
NKIDLVPAERVEEAIKVFKSEYNFKDVVAISASLGTNVEVLKEKIVSFLPEGPRYYLDDY
ECCCCCCHHHHHHHHHHHHHCCCCHHHEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHH
ITDQPEKLIVAEIIREKMLYFLEEEVPHGVYVEVESIKEREDKEIVDIDAYIYCEKESHK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCEEEEEEEEEEECCCCC
GIIIGKNGQMLKKIGQAARQDLEEFYGKQVFLQLWVKVRKGWRDNEKLLRKLGYAIDK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336