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The map label for this gene is DacC [H]

Identifier: 20807406

GI number: 20807406

Start: 930383

End: 931633

Strand: Reverse

Name: DacC [H]

Synonym: TTE0925

Alternate gene names: 20807406

Gene position: 931633-930383 (Counterclockwise)

Preceding gene: 20807409

Following gene: 20807364

Centisome position: 34.64

GC content: 38.53

Gene sequence:

>1251_bases
ATGGCGAAGAAAATAATTGCTTTACTTATAATAATTGTTTTTGCTTTTCTCTCAGTCCCAGCGCATGCAGAAACTCCACA
ACCTCCAGAAATTGTCGGACCTACAGCGGTATTGATGGACTTCACTACAGGACAGGTACTGTATGACAAAAACATGCACA
AAAGGATGTATCCAGCAAGCACTACAAAAATCCTAACTGCAATTATTGCCTTGGAAAAGGGAAAGCTAGACGATGTTGTC
ACCTGTAGTGAAAATGTGACTAAAATTGAGGGGAATTCAATATTTTTATCTCCAGGAGAGCAACTCACACTTGAGCAGCT
GCTTTACGCTTTAATGCTGGAATCTGCAAATGATGCTGCAATAGCAATTGCAGAGCATATAGGTGGGAGCGTAGAAAATT
TTGCCAAAATGATGAATGAAAAAGCGAGAGAAATAGGCGCTTACAACAGCCATTTTGTAAATCCGAACGGGTTGCCCGAT
GAAAACCATTATTCCACACCTTATGATATGGCACAAATTGCAAGATACGCCATGCAAAATGCTGAATTTAGAAAAATTGT
AAGCACTCTGCATTATCAAATTCCTCCGACAAATAAGTTCGACAAACCAAGAGACTTATGGATAAGCAATCGCTTACTTA
AACCTTCCCGCTTCCACTATGAAGGAGCAGATGGAGTAAAAACGGGCTACACTGTTGCTGCAGGACAAGTGTTGGTGGCT
TCCGCAACCCGAGATGGGCACAGGCTCATCTCTGTTATAATGGGAGATGAAGGCATAAACATTTGGACAGACACTATAAA
GCTTTTGGATTACGGTTTTCAAAACTTTTCTCTTGTAAAAGTAACGCAAAAGGACGAAGTGATAACTTCTATAGAACTTG
GGAAAGGCGGATTTAAGCTTCCTTTAATTGCGCAAAAGGACTTTTATTATGAAGTGCCCAAAGGTAAAGAAAATTCTATA
AAAACAGAAGTTGTGCTTAAAGAAGACATAAAAGCTCCCATTCAAAAAGGTGAAGTCCTGGGGTATATAAAGTACACACT
TGACGGAAAGGAGATAGGGACAAACCCGCTAATTGCCTCAGAAGATGTGTATAAAAACTTCTTGGGGAATTACTATAATG
AAAAGGAAAAAAATCCTATTGTACATCCTCTAAAATTGATCTTTGGCATAGCTTCTTTTAGCATGGCATTTTTACTCTGG
AGAAGGCAAAGAATAAGGCAAAGAAAAAAATTTATATTTTCTAAGTATTAA

Upstream 100 bases:

>100_bases
AAGCTCCTTTATTTATTTCTACGTCCATTAAAAAATTCCTTTTTATTTTTATCATTTTTTTGGTATACTTTAAGTATGAC
AACATGATGGGGGCATAAAA

Downstream 100 bases:

>100_bases
AAAGGAGGGCAGTACCCTCCTTTTTGAGTGTTTTTTTACCGAATATAAAAGCCAAACCTGCCAAGATATCAACCTCCTTT
TGCAAAAATAAAAGGGCGCA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 5*; PBP-5* [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAKKIIALLIIIVFAFLSVPAHAETPQPPEIVGPTAVLMDFTTGQVLYDKNMHKRMYPASTTKILTAIIALEKGKLDDVV
TCSENVTKIEGNSIFLSPGEQLTLEQLLYALMLESANDAAIAIAEHIGGSVENFAKMMNEKAREIGAYNSHFVNPNGLPD
ENHYSTPYDMAQIARYAMQNAEFRKIVSTLHYQIPPTNKFDKPRDLWISNRLLKPSRFHYEGADGVKTGYTVAAGQVLVA
SATRDGHRLISVIMGDEGINIWTDTIKLLDYGFQNFSLVKVTQKDEVITSIELGKGGFKLPLIAQKDFYYEVPKGKENSI
KTEVVLKEDIKAPIQKGEVLGYIKYTLDGKEIGTNPLIASEDVYKNFLGNYYNEKEKNPIVHPLKLIFGIASFSMAFLLW
RRQRIRQRKKFIFSKY

Sequences:

>Translated_416_residues
MAKKIIALLIIIVFAFLSVPAHAETPQPPEIVGPTAVLMDFTTGQVLYDKNMHKRMYPASTTKILTAIIALEKGKLDDVV
TCSENVTKIEGNSIFLSPGEQLTLEQLLYALMLESANDAAIAIAEHIGGSVENFAKMMNEKAREIGAYNSHFVNPNGLPD
ENHYSTPYDMAQIARYAMQNAEFRKIVSTLHYQIPPTNKFDKPRDLWISNRLLKPSRFHYEGADGVKTGYTVAAGQVLVA
SATRDGHRLISVIMGDEGINIWTDTIKLLDYGFQNFSLVKVTQKDEVITSIELGKGGFKLPLIAQKDFYYEVPKGKENSI
KTEVVLKEDIKAPIQKGEVLGYIKYTLDGKEIGTNPLIASEDVYKNFLGNYYNEKEKNPIVHPLKLIFGIASFSMAFLLW
RRQRIRQRKKFIFSKY
>Mature_415_residues
AKKIIALLIIIVFAFLSVPAHAETPQPPEIVGPTAVLMDFTTGQVLYDKNMHKRMYPASTTKILTAIIALEKGKLDDVVT
CSENVTKIEGNSIFLSPGEQLTLEQLLYALMLESANDAAIAIAEHIGGSVENFAKMMNEKAREIGAYNSHFVNPNGLPDE
NHYSTPYDMAQIARYAMQNAEFRKIVSTLHYQIPPTNKFDKPRDLWISNRLLKPSRFHYEGADGVKTGYTVAAGQVLVAS
ATRDGHRLISVIMGDEGINIWTDTIKLLDYGFQNFSLVKVTQKDEVITSIELGKGGFKLPLIAQKDFYYEVPKGKENSIK
TEVVLKEDIKAPIQKGEVLGYIKYTLDGKEIGTNPLIASEDVYKNFLGNYYNEKEKNPIVHPLKLIFGIASFSMAFLLWR
RQRIRQRKKFIFSKY

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Required specifically for the synthesis of the spore form of peptidoglycan (cortex) [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Forespore outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=382, Percent_Identity=32.7225130890052, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1786851, Length=408, Percent_Identity=31.3725490196078, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI87082022, Length=398, Percent_Identity=29.3969849246231, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082054, Length=262, Percent_Identity=25.5725190839695, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 46795; Mature: 46664

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKIIALLIIIVFAFLSVPAHAETPQPPEIVGPTAVLMDFTTGQVLYDKNMHKRMYPAS
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCHHHCCCCH
TTKILTAIIALEKGKLDDVVTCSENVTKIEGNSIFLSPGEQLTLEQLLYALMLESANDAA
HHHHHHHHHHHCCCCCCCEEECCCCCEEEECCEEEECCCCCHHHHHHHHHHHHCCCCCCE
IAIAEHIGGSVENFAKMMNEKAREIGAYNSHFVNPNGLPDENHYSTPYDMAQIARYAMQN
EEEHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
AEFRKIVSTLHYQIPPTNKFDKPRDLWISNRLLKPSRFHYEGADGVKTGYTVAAGQVLVA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCEEEE
SATRDGHRLISVIMGDEGINIWTDTIKLLDYGFQNFSLVKVTQKDEVITSIELGKGGFKL
ECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCEE
PLIAQKDFYYEVPKGKENSIKTEVVLKEDIKAPIQKGEVLGYIKYTLDGKEIGTNPLIAS
EEEECCCCEEECCCCCCCCCEEEEEEHHHHHCHHHCCCEEEEEEEEECCHHCCCCCCCCC
EDVYKNFLGNYYNEKEKNPIVHPLKLIFGIASFSMAFLLWRRQRIRQRKKFIFSKY
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKKIIALLIIIVFAFLSVPAHAETPQPPEIVGPTAVLMDFTTGQVLYDKNMHKRMYPAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCHHHCCCCH
TTKILTAIIALEKGKLDDVVTCSENVTKIEGNSIFLSPGEQLTLEQLLYALMLESANDAA
HHHHHHHHHHHCCCCCCCEEECCCCCEEEECCEEEECCCCCHHHHHHHHHHHHCCCCCCE
IAIAEHIGGSVENFAKMMNEKAREIGAYNSHFVNPNGLPDENHYSTPYDMAQIARYAMQN
EEEHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
AEFRKIVSTLHYQIPPTNKFDKPRDLWISNRLLKPSRFHYEGADGVKTGYTVAAGQVLVA
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCEEEE
SATRDGHRLISVIMGDEGINIWTDTIKLLDYGFQNFSLVKVTQKDEVITSIELGKGGFKL
ECCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCEE
PLIAQKDFYYEVPKGKENSIKTEVVLKEDIKAPIQKGEVLGYIKYTLDGKEIGTNPLIAS
EEEECCCCEEECCCCCCCCCEEEEEEHHHHHCHHHCCCEEEEEEEEECCHHCCCCCCCCC
EDVYKNFLGNYYNEKEKNPIVHPLKLIFGIASFSMAFLLWRRQRIRQRKKFIFSKY
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1548223; 7934829; 9384377 [H]