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The map label for this gene is SppA [H]

Identifier: 20807332

GI number: 20807332

Start: 859336

End: 860253

Strand: Direct

Name: SppA [H]

Synonym: TTE0850

Alternate gene names: 20807332

Gene position: 859336-860253 (Clockwise)

Preceding gene: 20807331

Following gene: 20807333

Centisome position: 31.95

GC content: 39.65

Gene sequence:

>918_bases
ATGAGCAAAAAGGCATTAGGAGGAATTGTAATATTGGCTCTTGTGTTTGCAATAGTCCTTGCTTCTTTATTTTTAACCCA
GCCTTCTACAGAGAGCCAAAAAACGGTTTCCTCTAACACTATAGGAGTTGTAACGATTGAGGGAGTAATAGGAGACTTTT
CAAACATACTTGGAATTCCTCAGTTTACGCCTGATCCAGTAGAGCAGATAAGAAGAGCGCAGGAAGATAACACTGTAAAG
GCAATCGTTGTCAAAATAAACAGCCCTGGAGGTTCTGCAGCAAAGTCTGTAGAAATATACACAGAGCTTAAAAGGTTAAA
AGAAACAGGGAAAAAGGTGATAGTTTCAATGGGAGATGCAGCTGCATCAGGGGGATACATGGCGGCCTGTGGCGGAGACA
TAATAGTGGCAAATCCGGCTACAATAACTGGAAGCATTGGGGTTATAATGCAGTATACAAATTATGAAGGACTTTACGAT
AAATTGGGATTAAAAGAAATCACAATAAAGAGCGGTCCTTATAAAGATATGGGTTCTCCTACGAGAGATTTGACTCCGGA
AGAGAAAAAGATATTGCAGGGGATTATAGATGATACTTATGAACAATTTGTAGAGATTGTATCTGAAGGGAGAAAGATGC
CCATAGAAAAAGTAAAAGAATTAGCAGATGGCAGAATATTCACAGGAAGGCAGGCTCTTAAAGTTGGTCTTGTGGATAAA
TTAGGGGATTTTTACGATGCGGTTGACATTGCAGCAAAAGAGGCTGGCATACAGGGCAAACCCGTGTTAAAATATTACAC
AACTCCAAACCCTTTGAGTATACTTTTTGGAGGCGGGGCAAAGAGCAATTTAGAAGGCACGGGACTTGAGATATTAAGGC
TTTTGTTTATTGATAAATGGAGCTTAAATTACAAGTAG

Upstream 100 bases:

>100_bases
ATAGAAATTTTGATAATACTGGCAGATTTAAAACTTTATTCTTTAACAAAGGATTTTGCAACAAAACTTTATTTTGAAAA
AGAATAGGGGGTTTTTAAAA

Downstream 100 bases:

>100_bases
AGATGAGTTTGTTATGTGAGGATAAAGTTTATGTTTTATGAAATAGATGGTGTCTTTTATGACAAAGAAAAATTAAGTGA
GTTTGTGAAAGAATACGAGC

Product: periplasmic serine protease (ClpP class)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSKKALGGIVILALVFAIVLASLFLTQPSTESQKTVSSNTIGVVTIEGVIGDFSNILGIPQFTPDPVEQIRRAQEDNTVK
AIVVKINSPGGSAAKSVEIYTELKRLKETGKKVIVSMGDAAASGGYMAACGGDIIVANPATITGSIGVIMQYTNYEGLYD
KLGLKEITIKSGPYKDMGSPTRDLTPEEKKILQGIIDDTYEQFVEIVSEGRKMPIEKVKELADGRIFTGRQALKVGLVDK
LGDFYDAVDIAAKEAGIQGKPVLKYYTTPNPLSILFGGGAKSNLEGTGLEILRLLFIDKWSLNYK

Sequences:

>Translated_305_residues
MSKKALGGIVILALVFAIVLASLFLTQPSTESQKTVSSNTIGVVTIEGVIGDFSNILGIPQFTPDPVEQIRRAQEDNTVK
AIVVKINSPGGSAAKSVEIYTELKRLKETGKKVIVSMGDAAASGGYMAACGGDIIVANPATITGSIGVIMQYTNYEGLYD
KLGLKEITIKSGPYKDMGSPTRDLTPEEKKILQGIIDDTYEQFVEIVSEGRKMPIEKVKELADGRIFTGRQALKVGLVDK
LGDFYDAVDIAAKEAGIQGKPVLKYYTTPNPLSILFGGGAKSNLEGTGLEILRLLFIDKWSLNYK
>Mature_304_residues
SKKALGGIVILALVFAIVLASLFLTQPSTESQKTVSSNTIGVVTIEGVIGDFSNILGIPQFTPDPVEQIRRAQEDNTVKA
IVVKINSPGGSAAKSVEIYTELKRLKETGKKVIVSMGDAAASGGYMAACGGDIIVANPATITGSIGVIMQYTNYEGLYDK
LGLKEITIKSGPYKDMGSPTRDLTPEEKKILQGIIDDTYEQFVEIVSEGRKMPIEKVKELADGRIFTGRQALKVGLVDKL
GDFYDAVDIAAKEAGIQGKPVLKYYTTPNPLSILFGGGAKSNLEGTGLEILRLLFIDKWSLNYK

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=229, Percent_Identity=41.0480349344978, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1787527, Length=164, Percent_Identity=32.3170731707317, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 32756; Mature: 32625

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKALGGIVILALVFAIVLASLFLTQPSTESQKTVSSNTIGVVTIEGVIGDFSNILGIP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHCCCC
QFTPDPVEQIRRAQEDNTVKAIVVKINSPGGSAAKSVEIYTELKRLKETGKKVIVSMGDA
CCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
AASGGYMAACGGDIIVANPATITGSIGVIMQYTNYEGLYDKLGLKEITIKSGPYKDMGSP
CCCCCEEEECCCCEEEECCCEEECCCEEEEEECCCCCHHHHCCCEEEEECCCCCCCCCCC
TRDLTPEEKKILQGIIDDTYEQFVEIVSEGRKMPIEKVKELADGRIFTGRQALKVGLVDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEECHHHHHHHHHHH
LGDFYDAVDIAAKEAGIQGKPVLKYYTTPNPLSILFGGGAKSNLEGTGLEILRLLFIDKW
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCC
SLNYK
CCCCC
>Mature Secondary Structure 
SKKALGGIVILALVFAIVLASLFLTQPSTESQKTVSSNTIGVVTIEGVIGDFSNILGIP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHCCCC
QFTPDPVEQIRRAQEDNTVKAIVVKINSPGGSAAKSVEIYTELKRLKETGKKVIVSMGDA
CCCCCHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
AASGGYMAACGGDIIVANPATITGSIGVIMQYTNYEGLYDKLGLKEITIKSGPYKDMGSP
CCCCCEEEECCCCEEEECCCEEECCCEEEEEECCCCCHHHHCCCEEEEECCCCCCCCCCC
TRDLTPEEKKILQGIIDDTYEQFVEIVSEGRKMPIEKVKELADGRIFTGRQALKVGLVDK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEECHHHHHHHHHHH
LGDFYDAVDIAAKEAGIQGKPVLKYYTTPNPLSILFGGGAKSNLEGTGLEILRLLFIDKW
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCC
SLNYK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]