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The map label for this gene is CpsG [H]

Identifier: 20807218

GI number: 20807218

Start: 734231

End: 735598

Strand: Direct

Name: CpsG [H]

Synonym: TTE0731

Alternate gene names: 20807218

Gene position: 734231-735598 (Clockwise)

Preceding gene: 20807217

Following gene: 20807219

Centisome position: 27.3

GC content: 39.77

Gene sequence:

>1368_bases
ATGAGATTAAATGAGAACATGTTTAGAATGTACGACATAAGAGGCATATGGGGAGAAGACCTGACTGAAGAGACTGCAGA
GGTCATAGGTAAAGCTTTTGGAACTTATGTAAAACAAAAGGGAATTAATAGTGTGCTGGTTGGTAGAGACAACAGGATTT
CTTCAAAGCCCATAAGAGATGCTCTAATAAAAGGACTTACTTCTACTGGTTGTGACGTTTTGGATGTAGGGGTTTTAACG
ACTCCAGCCTTTTATTATTCCAATATTTTATACAATTCCCAGGCAGGTATGATGATAACAGCAAGCCACAACCCGCCGCA
GTTTAACGGCTTTAAAGTTATGGTGGGACCTTCTACCATCTATGGTGAAGAGCTTAAGAAAATTTATTACATAGCAGAAA
AGGGGGAATTTGAAAAAGGCTCTGGAGAGGTAAAATACGCTTATCCGATAAATTCTTACATCAATATGATAAAGGAAAAA
GTTAAACTGGGAGATAGAAAATTAAAAGTTGTTGTGGACTGTGGGAATGGCACTGCTTCGCTTTTCTATCCAGATGTCAT
ATACAATTTGGGCTGTGAGGTATATCCCCTCTACTGCGAATCAGACCCAACTTTTCCCAATCATTTCCCTGACCCTGTAA
AAGAAGAGAATTTGAAGGATTTGATAGAGGAAGTAAAGAGAGTAAAGGCAGATTTGGGGATAGCTTTTGATGGAGATGGA
GACAGGATTGGAGTGGTGGATGAAAAGGGCAATATAATCTGGGGAGACATGTTGATGATTCTCTACTGGAGAGAAATAAT
GAAGAAACACCCAGGCGCTGAAGCAATTGTGGAAGTGAAGTGTTCTCAGGCTTTGGTTGAAGAAATTGAGAAACTGGGTG
GAAAACCTGTATTTTACAAAACAGGTCATTCCCTCATAAAAGCTAAGATGAAAGAAATGAATGCGGTCTTCACAGGAGAG
ATGTCAGGACACATGTTCTTTGCAGATGAGTACTATGGGTTTGACGATGCAGCATATGCGGCTGCAAGGCTTTTGAGAAT
ACTTTCTAATACGGATAAAAGTCTATCTGAGCTTTTAGCTGATGTTCCAAAATATCCATCAACTCCTGAGATAAGGCTTG
AGTGCAGTGATGAGAGGAAATTTGATGTAGTAAAAGGGGTGACGGAGTACTTTAGAGAAAAAGGTTATAACATAATTGAT
GTTGATGGAGCGAGAGTGCTCTTTGATGGAGGATGGGGATTGGTCAGAGCTTCTAATACTGGGCCAGAGCTTATTGTGAG
ATGTGAAGCTAGAACTTCAGAAAAGCTTGAGGAAATTAAAAAAGAACTTTCAGAGGCTTTAGCCAAGTTTGGCGTGAAGT
TTGAATAA

Upstream 100 bases:

>100_bases
TAAAGTAGCAGGAGAAGTGAAGAGCGTAGACTTGGGGCTTGAAATTGTTGAGAAAATAGTTTTAGTTTGAAAATAACAAT
AAACAAAGGAGGGGTGCCAA

Downstream 100 bases:

>100_bases
CGGAAGAGGGGAAAGTTAATGAAAATAAAGAAAGCGATAATTCCAGCAGCGGGCCTTGGTACCAGGTTTTTACCTGCTAC
CAAGGCTCAGCCTAAGGAAA

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRLNENMFRMYDIRGIWGEDLTEETAEVIGKAFGTYVKQKGINSVLVGRDNRISSKPIRDALIKGLTSTGCDVLDVGVLT
TPAFYYSNILYNSQAGMMITASHNPPQFNGFKVMVGPSTIYGEELKKIYYIAEKGEFEKGSGEVKYAYPINSYINMIKEK
VKLGDRKLKVVVDCGNGTASLFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVKADLGIAFDGDG
DRIGVVDEKGNIIWGDMLMILYWREIMKKHPGAEAIVEVKCSQALVEEIEKLGGKPVFYKTGHSLIKAKMKEMNAVFTGE
MSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLADVPKYPSTPEIRLECSDERKFDVVKGVTEYFREKGYNIID
VDGARVLFDGGWGLVRASNTGPELIVRCEARTSEKLEEIKKELSEALAKFGVKFE

Sequences:

>Translated_455_residues
MRLNENMFRMYDIRGIWGEDLTEETAEVIGKAFGTYVKQKGINSVLVGRDNRISSKPIRDALIKGLTSTGCDVLDVGVLT
TPAFYYSNILYNSQAGMMITASHNPPQFNGFKVMVGPSTIYGEELKKIYYIAEKGEFEKGSGEVKYAYPINSYINMIKEK
VKLGDRKLKVVVDCGNGTASLFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVKADLGIAFDGDG
DRIGVVDEKGNIIWGDMLMILYWREIMKKHPGAEAIVEVKCSQALVEEIEKLGGKPVFYKTGHSLIKAKMKEMNAVFTGE
MSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLADVPKYPSTPEIRLECSDERKFDVVKGVTEYFREKGYNIID
VDGARVLFDGGWGLVRASNTGPELIVRCEARTSEKLEEIKKELSEALAKFGVKFE
>Mature_455_residues
MRLNENMFRMYDIRGIWGEDLTEETAEVIGKAFGTYVKQKGINSVLVGRDNRISSKPIRDALIKGLTSTGCDVLDVGVLT
TPAFYYSNILYNSQAGMMITASHNPPQFNGFKVMVGPSTIYGEELKKIYYIAEKGEFEKGSGEVKYAYPINSYINMIKEK
VKLGDRKLKVVVDCGNGTASLFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVKADLGIAFDGDG
DRIGVVDEKGNIIWGDMLMILYWREIMKKHPGAEAIVEVKCSQALVEEIEKLGGKPVFYKTGHSLIKAKMKEMNAVFTGE
MSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLADVPKYPSTPEIRLECSDERKFDVVKGVTEYFREKGYNIID
VDGARVLFDGGWGLVRASNTGPELIVRCEARTSEKLEEIKKELSEALAKFGVKFE

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=446, Percent_Identity=32.0627802690583, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1789566, Length=460, Percent_Identity=29.3478260869565, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51076; Mature: 51076

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNENMFRMYDIRGIWGEDLTEETAEVIGKAFGTYVKQKGINSVLVGRDNRISSKPIRD
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHH
ALIKGLTSTGCDVLDVGVLTTPAFYYSNILYNSQAGMMITASHNPPQFNGFKVMVGPSTI
HHHHHHCCCCCCEEECCHHHCCHHHHHHHEEECCCCEEEEECCCCCCCCCEEEEECCCHH
YGEELKKIYYIAEKGEFEKGSGEVKYAYPINSYINMIKEKVKLGDRKLKVVVDCGNGTAS
HHHHHHHEEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCCE
LFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVKADLGIAFDGDG
EEEHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCC
DRIGVVDEKGNIIWGDMLMILYWREIMKKHPGAEAIVEVKCSQALVEEIEKLGGKPVFYK
CEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEE
TGHSLIKAKMKEMNAVFTGEMSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLA
CCHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
DVPKYPSTPEIRLECSDERKFDVVKGVTEYFREKGYNIIDVDGARVLFDGGWGLVRASNT
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCC
GPELIVRCEARTSEKLEEIKKELSEALAKFGVKFE
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLNENMFRMYDIRGIWGEDLTEETAEVIGKAFGTYVKQKGINSVLVGRDNRISSKPIRD
CCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHH
ALIKGLTSTGCDVLDVGVLTTPAFYYSNILYNSQAGMMITASHNPPQFNGFKVMVGPSTI
HHHHHHCCCCCCEEECCHHHCCHHHHHHHEEECCCCEEEEECCCCCCCCCEEEEECCCHH
YGEELKKIYYIAEKGEFEKGSGEVKYAYPINSYINMIKEKVKLGDRKLKVVVDCGNGTAS
HHHHHHHEEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCCE
LFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVKADLGIAFDGDG
EEEHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCC
DRIGVVDEKGNIIWGDMLMILYWREIMKKHPGAEAIVEVKCSQALVEEIEKLGGKPVFYK
CEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEEE
TGHSLIKAKMKEMNAVFTGEMSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLA
CCHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
DVPKYPSTPEIRLECSDERKFDVVKGVTEYFREKGYNIIDVDGARVLFDGGWGLVRASNT
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCC
GPELIVRCEARTSEKLEEIKKELSEALAKFGVKFE
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]