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The map label for this gene is AtoD [H]

Identifier: 20807207

GI number: 20807207

Start: 722461

End: 723126

Strand: Direct

Name: AtoD [H]

Synonym: TTE0720

Alternate gene names: 20807207

Gene position: 722461-723126 (Clockwise)

Preceding gene: 20807206

Following gene: 20807208

Centisome position: 26.86

GC content: 39.49

Gene sequence:

>666_bases
ATGAGGAAGGTTGTTACTTTTGAAGAGTTGAAGCCTTTATTTAAAGATGGAATGACCTTGATGATCGGTGGATTTCTTGC
AAATGGCACACCTGAGAAATTAATTGACCTTCTCATAGAATTAAACGTTAAAGACCTTACTATAATTGCCAATGATACCA
GTTTTCCAGACAGGGGTATAGGGCGTTTGGTTGTGGCCGGCCTTGTGAAGAAAGTTATAACTTCTCATATAGGTACTAAC
CCTGTTACAGGAAAATTGATGAATGAAGGAAAAATTGAAGTAGAGCTCGTTCCACAGGGGACACTTGCAGAAAGGATAAG
AGCTTATGGAGCAGGTTTGGGAGGTATCTTGACTCCTACAGGAGTCGGCACAATGGTAGAAGAAGGGAAACAAAAAATAA
CTGTGAATGGAAAAGAGTATCTCCTTGAACTTCCACTGGGAGCAGATATAGCGCTTATTAGAGGAAGTATTGTAGATGAG
TTTGGAAATATCTATTACAAAGGTACGACGAGAAATTTCAATCCTATAATGGCTCTTGCAGCTAAAACAGTTATCGTTGA
GGCAGAAAAAATAGTCAAAGTAGGAGAAATAAAGCCAGAAGATGTCATGACGCCAGGAGTATTAGTGGATTATATCGTAA
AAGGAGGGGAAGGCGATGATAACTGA

Upstream 100 bases:

>100_bases
GTGAGCTTGTAGAAAAAGTAGTGAGAATTGCTAGAGAGTTAGGTAGAGAAATTGCAACCCCTGATGAGGCCAGAAAAATA
TTAGGGTTAGAGGTGAAGCC

Downstream 100 bases:

>100_bases
TCAGGAACTGGCAAAGCAGATAATAGCAAAAAGAATTGCAAAAGAGCTCAAACATGGAGAGCTGGTGAATTTGGGAATTG
GTCTTCCCACTCTAGTAGCC

Product: Acyl-CoA:acetate CoA transferase alpha subunit

Products: NA

Alternate protein names: Coat A; Acetoacetyl-CoA:acetate/butyrate:CoA transferase subunit A [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRKVVTFEELKPLFKDGMTLMIGGFLANGTPEKLIDLLIELNVKDLTIIANDTSFPDRGIGRLVVAGLVKKVITSHIGTN
PVTGKLMNEGKIEVELVPQGTLAERIRAYGAGLGGILTPTGVGTMVEEGKQKITVNGKEYLLELPLGADIALIRGSIVDE
FGNIYYKGTTRNFNPIMALAAKTVIVEAEKIVKVGEIKPEDVMTPGVLVDYIVKGGEGDDN

Sequences:

>Translated_221_residues
MRKVVTFEELKPLFKDGMTLMIGGFLANGTPEKLIDLLIELNVKDLTIIANDTSFPDRGIGRLVVAGLVKKVITSHIGTN
PVTGKLMNEGKIEVELVPQGTLAERIRAYGAGLGGILTPTGVGTMVEEGKQKITVNGKEYLLELPLGADIALIRGSIVDE
FGNIYYKGTTRNFNPIMALAAKTVIVEAEKIVKVGEIKPEDVMTPGVLVDYIVKGGEGDDN
>Mature_221_residues
MRKVVTFEELKPLFKDGMTLMIGGFLANGTPEKLIDLLIELNVKDLTIIANDTSFPDRGIGRLVVAGLVKKVITSHIGTN
PVTGKLMNEGKIEVELVPQGTLAERIRAYGAGLGGILTPTGVGTMVEEGKQKITVNGKEYLLELPLGADIALIRGSIVDE
FGNIYYKGTTRNFNPIMALAAKTVIVEAEKIVKVGEIKPEDVMTPGVLVDYIVKGGEGDDN

Specific function: Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation [H]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=218, Percent_Identity=38.9908256880734, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI11545841, Length=219, Percent_Identity=41.0958904109589, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1788551, Length=215, Percent_Identity=55.3488372093023, Blast_Score=250, Evalue=4e-68,
Organism=Escherichia coli, GI1787985, Length=176, Percent_Identity=30.1136363636364, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17531517, Length=220, Percent_Identity=38.1818181818182, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21358325, Length=219, Percent_Identity=37.8995433789954, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24655794, Length=219, Percent_Identity=37.8995433789954, Blast_Score=150, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.9 [H]

Molecular weight: Translated: 23722; Mature: 23722

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVVTFEELKPLFKDGMTLMIGGFLANGTPEKLIDLLIELNVKDLTIIANDTSFPDRGI
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCH
GRLVVAGLVKKVITSHIGTNPVTGKLMNEGKIEVELVPQGTLAERIRAYGAGLGGILTPT
HHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCC
GVGTMVEEGKQKITVNGKEYLLELPLGADIALIRGSIVDEFGNIYYKGTTRNFNPIMALA
CCHHHHHCCCEEEEECCHHEEEECCCCCCHHHHHHHHHHHHCCEEEECCCCCCCHHHHHH
AKTVIVEAEKIVKVGEIKPEDVMTPGVLVDYIVKGGEGDDN
HHHHEEEHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRKVVTFEELKPLFKDGMTLMIGGFLANGTPEKLIDLLIELNVKDLTIIANDTSFPDRGI
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCH
GRLVVAGLVKKVITSHIGTNPVTGKLMNEGKIEVELVPQGTLAERIRAYGAGLGGILTPT
HHHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCC
GVGTMVEEGKQKITVNGKEYLLELPLGADIALIRGSIVDEFGNIYYKGTTRNFNPIMALA
CCHHHHHCCCEEEEECCHHEEEECCCCCCHHHHHHHHHHHHCCEEEECCCCCCCHHHHHH
AKTVIVEAEKIVKVGEIKPEDVMTPGVLVDYIVKGGEGDDN
HHHHEEEHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226639; 8423010; 11466286; 8300540; 2383002 [H]