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The map label for this gene is clpX

Identifier: 20807120

GI number: 20807120

Start: 630955

End: 632232

Strand: Direct

Name: clpX

Synonym: TTE0626

Alternate gene names: 20807120

Gene position: 630955-632232 (Clockwise)

Preceding gene: 20807119

Following gene: 20807121

Centisome position: 23.46

GC content: 41.55

Gene sequence:

>1278_bases
ATGGCTAAATACGACGACCACAAGCAATTAAAGTGTTCATTTTGCGGCAAGACTCAGGACCAGGTAAGGAGACTGGTGGC
AGGGCCCGGAGTGTATATCTGTGACGAATGCATAGAACTCTGTCAGGAGATTATAAACGAAGAATTTGAAGAGGATATGG
ACATGGCTATGAGAGATTTGCCAAAGCCAAAAGAAATAAAAGCTTTCCTTGACCAGTATGTTATTGGTCAGGACAGAGCT
AAAAAAGCTTTGGCAGTTGCTGTCTACAATCATTACAAGCGCATAAATTCTAAAGTTAAGTCAGACGATGTGGAGCTTCA
AAAGAGCAACATCTTACTTCTGGGTCCAACAGGATCTGGCAAAACTCTTTTGGCTCAGACTCTTGCTAAGCTTTTGAATG
TTCCTTTTGCGATAGCAGATGCAACTACCCTGACTGAAGCAGGATATGTGGGAGAAGACGTGGAGAACATCTTATTGAGG
CTCATACAGGCAGCAGATTACGATATAGAGAGGGCAGAGAAGGGAATAATCTACATCGATGAAATAGACAAAATAGCTAG
AAAGTCAGAAAATCCTTCTATAACCAGGGATGTTTCAGGCGAAGGCGTTCAACAGGCTCTTTTAAAAATACTGGAGGGGA
CAATTGCCAATGTGCCTCCGCAGGGCGGTAGAAAACATCCTCACCAGGAGTTTATACAGATAGATACAACGAACATACTC
TTTATATGTGGAGGCGCATTTGAAGGAATAGACAAAATAATAGAATCAAGGATTGGGAAAAAGAGCCTTGGATTTGGCGC
AGAGGTTCAGAGCAAGAAAGAAAAAGACGTTGGAGAAATTTTAAAACACATCATGCCAGAAGACCTGTTGAAATTTGGGA
TGATTCCAGAGTTTATAGGCAGAGTCCCAATAGTTGTAACTTTGGACCCTCTCACAAAGGATGACCTTGTCAGAATACTG
ACAGAGCCTAAGAATGCTCTTGTAAAGCAGTACGAAAAGTTGTTTGAAATGGACGGTGTAAAGCTTGAATTTGAGAAAAA
AGCTTTAGACTTGATTGCAGAAATGGCTCTAGAAAGAGGAACTGGTGCAAGGGGCTTGAGGGCTATTCTTGAAGACATAA
TGCTTGATGTGATGTATGAAATTCCTTCTGATGAGACGATAGAAAAGTGCATTATTACAGAAGAGACGGTGCGGAAAATT
GCTCCTCCCACACTGGTTTATGCAGATGCCCAGAAGATAGGCAGGAAAAAAGCTAAAAAGACAGAGTCTGTTTCATAA

Upstream 100 bases:

>100_bases
GATTACTTCATGACTGCAGAGGAAGCTAAGACTTACGGCATAATAGATGACATACTTGTAAGGCACAAAAAATGAGGCCC
CCCAAAAGAGGTGAAATTTT

Downstream 100 bases:

>100_bases
AAAATAAGTTTTTACATTAACTCCCCTTCTCCTTCACATACTAAAATAGTGAATGGGAAGGGGTTTGATTATATTGCGAA
AAATGAGGTGAGGTCATGGC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MAKYDDHKQLKCSFCGKTQDQVRRLVAGPGVYICDECIELCQEIINEEFEEDMDMAMRDLPKPKEIKAFLDQYVIGQDRA
KKALAVAVYNHYKRINSKVKSDDVELQKSNILLLGPTGSGKTLLAQTLAKLLNVPFAIADATTLTEAGYVGEDVENILLR
LIQAADYDIERAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNIL
FICGGAFEGIDKIIESRIGKKSLGFGAEVQSKKEKDVGEILKHIMPEDLLKFGMIPEFIGRVPIVVTLDPLTKDDLVRIL
TEPKNALVKQYEKLFEMDGVKLEFEKKALDLIAEMALERGTGARGLRAILEDIMLDVMYEIPSDETIEKCIITEETVRKI
APPTLVYADAQKIGRKKAKKTESVS

Sequences:

>Translated_425_residues
MAKYDDHKQLKCSFCGKTQDQVRRLVAGPGVYICDECIELCQEIINEEFEEDMDMAMRDLPKPKEIKAFLDQYVIGQDRA
KKALAVAVYNHYKRINSKVKSDDVELQKSNILLLGPTGSGKTLLAQTLAKLLNVPFAIADATTLTEAGYVGEDVENILLR
LIQAADYDIERAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNIL
FICGGAFEGIDKIIESRIGKKSLGFGAEVQSKKEKDVGEILKHIMPEDLLKFGMIPEFIGRVPIVVTLDPLTKDDLVRIL
TEPKNALVKQYEKLFEMDGVKLEFEKKALDLIAEMALERGTGARGLRAILEDIMLDVMYEIPSDETIEKCIITEETVRKI
APPTLVYADAQKIGRKKAKKTESVS
>Mature_424_residues
AKYDDHKQLKCSFCGKTQDQVRRLVAGPGVYICDECIELCQEIINEEFEEDMDMAMRDLPKPKEIKAFLDQYVIGQDRAK
KALAVAVYNHYKRINSKVKSDDVELQKSNILLLGPTGSGKTLLAQTLAKLLNVPFAIADATTLTEAGYVGEDVENILLRL
IQAADYDIERAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNILF
ICGGAFEGIDKIIESRIGKKSLGFGAEVQSKKEKDVGEILKHIMPEDLLKFGMIPEFIGRVPIVVTLDPLTKDDLVRILT
EPKNALVKQYEKLFEMDGVKLEFEKKALDLIAEMALERGTGARGLRAILEDIMLDVMYEIPSDETIEKCIITEETVRKIA
PPTLVYADAQKIGRKKAKKTESVS

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=332, Percent_Identity=50.3012048192771, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1786642, Length=404, Percent_Identity=63.1188118811881, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=45.7142857142857, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=315, Percent_Identity=46.031746031746, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71982908, Length=315, Percent_Identity=46.031746031746, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71988663, Length=407, Percent_Identity=38.5749385749386, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71988660, Length=251, Percent_Identity=39.8406374501992, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6319704, Length=427, Percent_Identity=42.8571428571429, Blast_Score=302, Evalue=5e-83,
Organism=Drosophila melanogaster, GI24648289, Length=323, Percent_Identity=48.9164086687306, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24648291, Length=323, Percent_Identity=48.9164086687306, Blast_Score=306, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_THETN (Q8RC24)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622291.1
- ProteinModelPortal:   Q8RC24
- GeneID:   996556
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0626
- NMPDR:   fig|273068.3.peg.209
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   TTEN273068:TTE0626-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47450; Mature: 47318

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKYDDHKQLKCSFCGKTQDQVRRLVAGPGVYICDECIELCQEIINEEFEEDMDMAMRDL
CCCCCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKPKEIKAFLDQYVIGQDRAKKALAVAVYNHYKRINSKVKSDDVELQKSNILLLGPTGSG
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEECCCCCC
KTLLAQTLAKLLNVPFAIADATTLTEAGYVGEDVENILLRLIQAADYDIERAEKGIIYID
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHCCCEEEEH
EIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNIL
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEECCCEEE
FICGGAFEGIDKIIESRIGKKSLGFGAEVQSKKEKDVGEILKHIMPEDLLKFGMIPEFIG
EEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHCHHHHHHHCCCHHHHC
RVPIVVTLDPLTKDDLVRILTEPKNALVKQYEKLFEMDGVKLEFEKKALDLIAEMALERG
CCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCC
TGARGLRAILEDIMLDVMYEIPSDETIEKCIITEETVRKIAPPTLVYADAQKIGRKKAKK
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCCCCEEECCHHHHHHHHHHH
TESVS
CCCCC
>Mature Secondary Structure 
AKYDDHKQLKCSFCGKTQDQVRRLVAGPGVYICDECIELCQEIINEEFEEDMDMAMRDL
CCCCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKPKEIKAFLDQYVIGQDRAKKALAVAVYNHYKRINSKVKSDDVELQKSNILLLGPTGSG
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEECCCCCC
KTLLAQTLAKLLNVPFAIADATTLTEAGYVGEDVENILLRLIQAADYDIERAEKGIIYID
HHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHCCCEEEEH
EIDKIARKSENPSITRDVSGEGVQQALLKILEGTIANVPPQGGRKHPHQEFIQIDTTNIL
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEECCCEEE
FICGGAFEGIDKIIESRIGKKSLGFGAEVQSKKEKDVGEILKHIMPEDLLKFGMIPEFIG
EEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHCHHHHHHHCCCHHHHC
RVPIVVTLDPLTKDDLVRILTEPKNALVKQYEKLFEMDGVKLEFEKKALDLIAEMALERG
CCCEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCC
TGARGLRAILEDIMLDVMYEIPSDETIEKCIITEETVRKIAPPTLVYADAQKIGRKKAKK
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHCCCCCEEECCHHHHHHHHHHH
TESVS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336