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The map label for this gene is Lon [H]

Identifier: 20807121

GI number: 20807121

Start: 632328

End: 634664

Strand: Direct

Name: Lon [H]

Synonym: TTE0627

Alternate gene names: 20807121

Gene position: 632328-634664 (Clockwise)

Preceding gene: 20807120

Following gene: 20807122

Centisome position: 23.51

GC content: 40.91

Gene sequence:

>2337_bases
ATGGCAGAAAAAAGGTACACACTCCCTATGATTCCATTAAGAGGATTAACAATTTTCCCTTATATGGTAATTCATTTTGA
TATAGGGCGAGAGAAATCCATAAGGGCTTTAGAAGAGGCCTTTATGAAAAATCAGCTTATATTTGTAACTACTCAGAAGG
ACCCAGAGCTTGAAGACCCATCAATTGAGGACGTTTACAAGGTGGGGACTATAACTAAAGTCAAACAGATGTTGAAACTT
CCCGGGGAGCTCATAAGAATTTTGGTTGAAGGTATAAGCAGAGCCGAGATTGACAAAGTCACAAGAGAAGACGAATTTTT
TGAGGTGGAGGTAGTTGAAAAAGAGGAGCAGGCAGAGATTGAAAAGACTCCAGAGTTAGAAGCGCTGATGAGAAGTGTGG
TCTCTGCTTTTGAAGAGTATGTAAATATGACTTCCCGCGTCCCCATTGAAAGCTTATACAATGTAATTAGCATAGAAGAG
CCGGGAAGGCTTGCGGACATGATTGCAGCCCACATTTCTTTGAGCACAGCGCAAAATCAAGAGCTCTTAGAGTGCTTTGA
TGTGAAAAAGAGGTTAGAAATTTTACTGGGCTTTTTAATGAAGGAGCTGGAAATATTAAAAATTGAGAGAGAAATAAATG
CAAAAGTGAGAAGCCAGATTGACAAGCTTCAAAAGGAATATTATTTGAGGGAACAGCTAAAGGCCATAAAGGCAGAGTTA
GGGGAAACGGAAGATTTTGACAGCGAGATAGAAGAGTATGAGAGGAAAATAGAAGAAAAGGATTTGCCTGAGGAAGTGAG
AAAAAAGGCGAAAGAGGAGTTAAAGAGATTATCTAAAATGCCTCCCGGTTCTGCTGAGGCCTCTGTTGTAAGAACTTACC
TTGACTGGATACTGGAACTTCCATGGAACTACGAGACAGAGGATATTCTAGATTTAAAAAGGGCTCAAAGGATACTGGAT
GAGGACCACTACGGGCTTAAAAAAGTAAAAGAGAGGATAATAGAGTTTTTGGCAGTGAGAGCCTTTTACAATAAAGTTAA
AAGCCCGATCTTATGCCTTGTAGGTCCTCCAGGAGTGGGCAAGACCTCCTTAGGAAGGTCAATAGCTAAAGCTATGAACA
GAAAATTTGTAAGGCTTTCTCTTGGCGGCGTCAGAGATGAAGCGGAGATAAGAGGGCACAGGCGTACTTACGTTGGAGCT
ATACCAGGAGGGATTATAAACTCTATAAAAATTGCAGGTTCAAAAAACCCTGTTTTTTTGCTGGACGAGATAGACAAGAT
GAGTTCTGACTTTAGAGGCGACCCTGCTTCTGCTATGCTGGAAGTATTAGACCCCGAGCAGAATTCCACTTTTAGAGACC
ATTATTTAGATTTGCCCTTTGACTTATCTAAAGTACTTTTTATAACCACAGCCAATACAACTGACACTATTCCCGCTCCT
CTTTTGGACAGGATGGAAGTTATATACATATCAGGATACACTGAAGAGGAGAAGTTTCACATTGCTAAAGGCTATCTCAT
ACCAAAGATTTTGAAAGAACACGGTGTTCCGGACAATAAAATAATAATACAGGACTCAGCCATTAAAGGAATTATTTCTG
AATATACTCGTGAAGCAGGAGTGAGAGGGCTTGAGAAACACCTTGCCACAATTGTGAGAAAAGCCATTAGAAAGATAATG
GAAGATAATGTGCCTTACGTGAAGGTAGGCAAAAAGAACTTGCAGTCTTACTTGGGCAAGCCTCTTTTTAGACCCGACAA
AGCCAATGAAAAGAGCGAAATCGGAACGGTGATGGGCCTTGCGTGGACCAGAGTTGGAGGAGAAATTTTGACTGTAGAGG
CTTCTATAATGCCAGGAAGCGGAAAATTAAACCTCACAGGTCAATTGGGGGATGTGATGAAAGAATCTGCTCAGGCGGGC
CTTAGTTATATAAGAGCAAATGCTGAAAGACTTGGCATTGATAAAGATTTTTACAAAAATGTCGATATACATATACACGT
GCCTGAAGGATCTATTCCAAAGGATGGACCTTCAGCGGGCGTTACCATGGTGACTGCTATGGTCTCAGCCCTTGTGAAAG
TGCCTGTCAGAAAAGATGTCGCCATGACAGGGGAAATAACTTTAACTGGAAGAGTTTTGCCTATAGGCGGTGTGAAAGAA
AAAGTTCTGGCAGCTCACAGAGCAGGCATAAAAAGAGTGATTCTCCCTATGGAAAACAAGAGAGATTTAGATGAAATTCC
ACAGAGCGTAAAAAAGAAACTGGAGTTTAAATTTGTAGAAAGAATAGACGAGGTGTTGGAGTACGCTTTAGTCAAGGAGG
AAAAACATGAAAATTAA

Upstream 100 bases:

>100_bases
CATAAAAAATAAGTTTTTACATTAACTCCCCTTCTCCTTCACATACTAAAATAGTGAATGGGAAGGGGTTTGATTATATT
GCGAAAAATGAGGTGAGGTC

Downstream 100 bases:

>100_bases
AACAGCTGAGTTTGTAGGAAGTGCTTTTAATGAAAGTCAATATCCAAAGGATAAAATCCCCCAAATAGCAATTGTGGGAA
AATCCAATGTGGGCAAGTCC

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 778; Mature: 777

Protein sequence:

>778_residues
MAEKRYTLPMIPLRGLTIFPYMVIHFDIGREKSIRALEEAFMKNQLIFVTTQKDPELEDPSIEDVYKVGTITKVKQMLKL
PGELIRILVEGISRAEIDKVTREDEFFEVEVVEKEEQAEIEKTPELEALMRSVVSAFEEYVNMTSRVPIESLYNVISIEE
PGRLADMIAAHISLSTAQNQELLECFDVKKRLEILLGFLMKELEILKIEREINAKVRSQIDKLQKEYYLREQLKAIKAEL
GETEDFDSEIEEYERKIEEKDLPEEVRKKAKEELKRLSKMPPGSAEASVVRTYLDWILELPWNYETEDILDLKRAQRILD
EDHYGLKKVKERIIEFLAVRAFYNKVKSPILCLVGPPGVGKTSLGRSIAKAMNRKFVRLSLGGVRDEAEIRGHRRTYVGA
IPGGIINSIKIAGSKNPVFLLDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTTDTIPAP
LLDRMEVIYISGYTEEEKFHIAKGYLIPKILKEHGVPDNKIIIQDSAIKGIISEYTREAGVRGLEKHLATIVRKAIRKIM
EDNVPYVKVGKKNLQSYLGKPLFRPDKANEKSEIGTVMGLAWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAG
LSYIRANAERLGIDKDFYKNVDIHIHVPEGSIPKDGPSAGVTMVTAMVSALVKVPVRKDVAMTGEITLTGRVLPIGGVKE
KVLAAHRAGIKRVILPMENKRDLDEIPQSVKKKLEFKFVERIDEVLEYALVKEEKHEN

Sequences:

>Translated_778_residues
MAEKRYTLPMIPLRGLTIFPYMVIHFDIGREKSIRALEEAFMKNQLIFVTTQKDPELEDPSIEDVYKVGTITKVKQMLKL
PGELIRILVEGISRAEIDKVTREDEFFEVEVVEKEEQAEIEKTPELEALMRSVVSAFEEYVNMTSRVPIESLYNVISIEE
PGRLADMIAAHISLSTAQNQELLECFDVKKRLEILLGFLMKELEILKIEREINAKVRSQIDKLQKEYYLREQLKAIKAEL
GETEDFDSEIEEYERKIEEKDLPEEVRKKAKEELKRLSKMPPGSAEASVVRTYLDWILELPWNYETEDILDLKRAQRILD
EDHYGLKKVKERIIEFLAVRAFYNKVKSPILCLVGPPGVGKTSLGRSIAKAMNRKFVRLSLGGVRDEAEIRGHRRTYVGA
IPGGIINSIKIAGSKNPVFLLDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTTDTIPAP
LLDRMEVIYISGYTEEEKFHIAKGYLIPKILKEHGVPDNKIIIQDSAIKGIISEYTREAGVRGLEKHLATIVRKAIRKIM
EDNVPYVKVGKKNLQSYLGKPLFRPDKANEKSEIGTVMGLAWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAG
LSYIRANAERLGIDKDFYKNVDIHIHVPEGSIPKDGPSAGVTMVTAMVSALVKVPVRKDVAMTGEITLTGRVLPIGGVKE
KVLAAHRAGIKRVILPMENKRDLDEIPQSVKKKLEFKFVERIDEVLEYALVKEEKHEN
>Mature_777_residues
AEKRYTLPMIPLRGLTIFPYMVIHFDIGREKSIRALEEAFMKNQLIFVTTQKDPELEDPSIEDVYKVGTITKVKQMLKLP
GELIRILVEGISRAEIDKVTREDEFFEVEVVEKEEQAEIEKTPELEALMRSVVSAFEEYVNMTSRVPIESLYNVISIEEP
GRLADMIAAHISLSTAQNQELLECFDVKKRLEILLGFLMKELEILKIEREINAKVRSQIDKLQKEYYLREQLKAIKAELG
ETEDFDSEIEEYERKIEEKDLPEEVRKKAKEELKRLSKMPPGSAEASVVRTYLDWILELPWNYETEDILDLKRAQRILDE
DHYGLKKVKERIIEFLAVRAFYNKVKSPILCLVGPPGVGKTSLGRSIAKAMNRKFVRLSLGGVRDEAEIRGHRRTYVGAI
PGGIINSIKIAGSKNPVFLLDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTTDTIPAPL
LDRMEVIYISGYTEEEKFHIAKGYLIPKILKEHGVPDNKIIIQDSAIKGIISEYTREAGVRGLEKHLATIVRKAIRKIME
DNVPYVKVGKKNLQSYLGKPLFRPDKANEKSEIGTVMGLAWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAGL
SYIRANAERLGIDKDFYKNVDIHIHVPEGSIPKDGPSAGVTMVTAMVSALVKVPVRKDVAMTGEITLTGRVLPIGGVKEK
VLAAHRAGIKRVILPMENKRDLDEIPQSVKKKLEFKFVERIDEVLEYALVKEEKHEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=829, Percent_Identity=38.962605548854, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI31377667, Length=772, Percent_Identity=40.8031088082902, Blast_Score=570, Evalue=1e-162,
Organism=Escherichia coli, GI1786643, Length=771, Percent_Identity=53.0479896238651, Blast_Score=835, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=700, Percent_Identity=42.4285714285714, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17556486, Length=789, Percent_Identity=35.9949302915082, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6319449, Length=715, Percent_Identity=40.979020979021, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221513036, Length=679, Percent_Identity=43.298969072165, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24666867, Length=679, Percent_Identity=43.298969072165, Blast_Score=563, Evalue=1e-160,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88086; Mature: 87954

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKRYTLPMIPLRGLTIFPYMVIHFDIGREKSIRALEEAFMKNQLIFVTTQKDPELEDP
CCCCCCCCCCCCCCCHHHHCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
SIEDVYKVGTITKVKQMLKLPGELIRILVEGISRAEIDKVTREDEFFEVEVVEKEEQAEI
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
EKTPELEALMRSVVSAFEEYVNMTSRVPIESLYNVISIEEPGRLADMIAAHISLSTAQNQ
HCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCH
ELLECFDVKKRLEILLGFLMKELEILKIEREINAKVRSQIDKLQKEYYLREQLKAIKAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GETEDFDSEIEEYERKIEEKDLPEEVRKKAKEELKRLSKMPPGSAEASVVRTYLDWILEL
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
PWNYETEDILDLKRAQRILDEDHYGLKKVKERIIEFLAVRAFYNKVKSPILCLVGPPGVG
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGRSIAKAMNRKFVRLSLGGVRDEAEIRGHRRTYVGAIPGGIINSIKIAGSKNPVFL
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCEEEECCCCHHHHCEEEECCCCCEEE
LDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTTDTIPAP
EHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCHH
LLDRMEVIYISGYTEEEKFHIAKGYLIPKILKEHGVPDNKIIIQDSAIKGIISEYTREAG
HHCCEEEEEEECCCCCCCEEHHHCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHH
VRGLEKHLATIVRKAIRKIMEDNVPYVKVGKKNLQSYLGKPLFRPDKANEKSEIGTVMGL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAGLSYIRANAERLGIDKDFYKN
HHHHCCCEEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
VDIHIHVPEGSIPKDGPSAGVTMVTAMVSALVKVPVRKDVAMTGEITLTGRVLPIGGVKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEEEEECCCHHH
KVLAAHRAGIKRVILPMENKRDLDEIPQSVKKKLEFKFVERIDEVLEYALVKEEKHEN
HHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEKRYTLPMIPLRGLTIFPYMVIHFDIGREKSIRALEEAFMKNQLIFVTTQKDPELEDP
CCCCCCCCCCCCCCHHHHCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCC
SIEDVYKVGTITKVKQMLKLPGELIRILVEGISRAEIDKVTREDEFFEVEVVEKEEQAEI
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
EKTPELEALMRSVVSAFEEYVNMTSRVPIESLYNVISIEEPGRLADMIAAHISLSTAQNQ
HCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCH
ELLECFDVKKRLEILLGFLMKELEILKIEREINAKVRSQIDKLQKEYYLREQLKAIKAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GETEDFDSEIEEYERKIEEKDLPEEVRKKAKEELKRLSKMPPGSAEASVVRTYLDWILEL
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
PWNYETEDILDLKRAQRILDEDHYGLKKVKERIIEFLAVRAFYNKVKSPILCLVGPPGVG
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGRSIAKAMNRKFVRLSLGGVRDEAEIRGHRRTYVGAIPGGIINSIKIAGSKNPVFL
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHCCCCCEEEECCCCHHHHCEEEECCCCCEEE
LDEIDKMSSDFRGDPASAMLEVLDPEQNSTFRDHYLDLPFDLSKVLFITTANTTDTIPAP
EHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCCHH
LLDRMEVIYISGYTEEEKFHIAKGYLIPKILKEHGVPDNKIIIQDSAIKGIISEYTREAG
HHCCEEEEEEECCCCCCCEEHHHCHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHH
VRGLEKHLATIVRKAIRKIMEDNVPYVKVGKKNLQSYLGKPLFRPDKANEKSEIGTVMGL
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AWTRVGGEILTVEASIMPGSGKLNLTGQLGDVMKESAQAGLSYIRANAERLGIDKDFYKN
HHHHCCCEEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
VDIHIHVPEGSIPKDGPSAGVTMVTAMVSALVKVPVRKDVAMTGEITLTGRVLPIGGVKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEEEEEEEEEECCCHHH
KVLAAHRAGIKRVILPMENKRDLDEIPQSVKKKLEFKFVERIDEVLEYALVKEEKHEN
HHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA