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The map label for this gene is UvrD [H]

Identifier: 20807099

GI number: 20807099

Start: 605527

End: 607668

Strand: Direct

Name: UvrD [H]

Synonym: TTE0604

Alternate gene names: 20807099

Gene position: 605527-607668 (Clockwise)

Preceding gene: 20807098

Following gene: 20807100

Centisome position: 22.51

GC content: 36.97

Gene sequence:

>2142_bases
TTGATTGGAGTGAAAAAGATGAAAGAGATTCTAGCTAATTTGAATGAACAGCAAAAAGAAGCAGTAACCACCACAGAAGG
GCCTCTTTTAATACTGGCAGGTGCTGGAAGTGGAAAAACTAGAGTTTTGACCCACAGAATTGCCTATCTCATAAAGGAAA
AAAAGGTCTCTCCTTCCAATATCCTCGCAATAACCTTTACCAATAAAGCGGCAGAGGAAATGAAGACGAGAGTGGAAAAT
TTGCTGGGATACGTCGGAGACCTGTGGGTGTCTACTTTTCATTCCGCCTGTGTCAGAATCTTGAGAAGAGATATTGATAA
ACTGGGTTACGACAGAAATTTTGTAATATTTGATACGACTGACCAGAAGGCACTAGTCCAGGAATGCCTTAAAGAACTAG
ACTTAAGCGAAAAGCAATACCCGATAAAAATGGTATTAAATGCCATCTCATCTGCAAAAGATAAAATGGTATATCCAGAC
GATTACATTGATTTTTTTGGAGATACCTATAGGAATAGAAAAATAAAGGAAATTTACAAGCTTTATCAGCACAAACTAAA
AAAGATAAATGCTCTTGACTTTGACGACATTATCATAAAAACGATAGAGTTATTTAAAGAAAATCCAGAAATTTTAGAAT
TTTATCAAAGAAAATTTAGATACATAATGGTGGACGAGTATCAGGACACAAATACTCCTCAGTATTACTTTGTAAATTTG
TTAGCGCAAAGGCACAGAAATTTATGTGTTGTAGGGGATGATGACCAGAGCATTTACGGCTGGAGAGGGGCAGATGTGAG
AAACATATTAAACTTTGAAAAAGATTATCCCGAAGCAAAAGTGATAAAATTAGAACAAAACTATAGGTCTACAAAAATCA
TACTGGAGGCTGCCAATCACGTCATAGACAACAATGTATATCGAAAGAAAAAATCCCTCTGGACACAAAATAAAGAGGGA
GAGAAAATAGTTCTGTGTGAGCTGGAAAATGAAAGAGAAGAGGCAGAATTTGTTATACAGGAGATAATAAAACTAAAAGA
AAGAGAAAACAGAAGCTTTAAAGACTTTGCGATACTCTACAGGACAAACGCCCAGTCAAGGCCTTTTGAAGAAGCTCTGA
TGAAAGTAAAAGTGCCTTATAAAGTGGTGGGAGCCCTAAGATTTTATGACAGGAAAGAGATAAAAGATATACTTGCTTAT
CTTCGCCTCATTGTAAATCCTTATGACGACATATCCTTCAAAAGGATAGTAAATGTTCCAAGAAGAGGCATTGGTCCTGC
TACGATTGAGGCATTGGAGAAGGTAGCGAGGGAAAAAGATACTAGTCTTTTTTTTGCAATAGAGGATTTAAAAAACGCAA
GGAACAAAGGAAGCCTTCTTCAGTTTAAACAGTTTATTTTGGATTTAATTGATAAAAAAGATGCAATGAGTGTCAGCGAT
TTGATAAAATATATTCTGGAGCAGACAGGTTATATAGAAGAGTTAAAAAGGGAAGAATCTGAAGAAGCAGAGGGAAGGAT
AGAAAACTTAAACGAATTTTTAAATGCTGCCTATGAGTTTGAAGAATCTTCTGAAGATAAGTCTTTGGAAGCATTTTTGG
CGGGCATAACTTTAGTTTCTGATATAGACATGGCTGGAGATATTGGAGAAAGTGTAGTTCTGATGACACTTCATTCTGCC
AAGGGATTGGAATTTCCTGTAGTTTTTATGGTAGGGATGGAAGAAGGACTGTTTCCTTCTTACAGCTCCTTTGAAGATGA
CCACGAGCTGGAAGAAGAAAGGCGCCTTTGTTACGTGGGAATTACCAGATCCAAAGAAAGATTGTATTTAACTTATGCTA
GGCAGAGAAACCTTTACGGTAGGTCCCAGTACAATTCTTACTCCAGGTTTATAAGTGAAATACCTGAGAGGCTAATTGTG
AGGTATAATATACCGACTTCCAAAAAAACGGGCTTTGTTTCCGTCCATACTTTTTCAGATGTTTATGAAAGGTCTTTTTC
GCTTGGGGATAAGGTGGAGCACAAGATATGGGGAATAGGGACTGTTGTTAAAGTGGAAGGGGAAGAGATTACAGTAGCCT
TTCCGAACGTTGGTATAAAAAAGCTTGATTTGAGATTTGCTCCTATTAAGGCAATTTCTTAA

Upstream 100 bases:

>100_bases
AACAGGGCATTGAATTATGGCGCAAATGGATATAAAATTATATTGGAAAGGTTGGAAGCTGATTCTGAATCCCGGGATTA
ATTCCCGGCTTTTTTAAAAC

Downstream 100 bases:

>100_bases
AACCGGAGGGGAATTTATGGATAGGGAAGAGGCAAGAAAGAGGATAGAGGAGTTAAGGGAAAAAATAAACTATCACAACT
ACAGGTATTATGTGTTGGAC

Product: superfamily I DNA/RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MIGVKKMKEILANLNEQQKEAVTTTEGPLLILAGAGSGKTRVLTHRIAYLIKEKKVSPSNILAITFTNKAAEEMKTRVEN
LLGYVGDLWVSTFHSACVRILRRDIDKLGYDRNFVIFDTTDQKALVQECLKELDLSEKQYPIKMVLNAISSAKDKMVYPD
DYIDFFGDTYRNRKIKEIYKLYQHKLKKINALDFDDIIIKTIELFKENPEILEFYQRKFRYIMVDEYQDTNTPQYYFVNL
LAQRHRNLCVVGDDDQSIYGWRGADVRNILNFEKDYPEAKVIKLEQNYRSTKIILEAANHVIDNNVYRKKKSLWTQNKEG
EKIVLCELENEREEAEFVIQEIIKLKERENRSFKDFAILYRTNAQSRPFEEALMKVKVPYKVVGALRFYDRKEIKDILAY
LRLIVNPYDDISFKRIVNVPRRGIGPATIEALEKVAREKDTSLFFAIEDLKNARNKGSLLQFKQFILDLIDKKDAMSVSD
LIKYILEQTGYIEELKREESEEAEGRIENLNEFLNAAYEFEESSEDKSLEAFLAGITLVSDIDMAGDIGESVVLMTLHSA
KGLEFPVVFMVGMEEGLFPSYSSFEDDHELEEERRLCYVGITRSKERLYLTYARQRNLYGRSQYNSYSRFISEIPERLIV
RYNIPTSKKTGFVSVHTFSDVYERSFSLGDKVEHKIWGIGTVVKVEGEEITVAFPNVGIKKLDLRFAPIKAIS

Sequences:

>Translated_713_residues
MIGVKKMKEILANLNEQQKEAVTTTEGPLLILAGAGSGKTRVLTHRIAYLIKEKKVSPSNILAITFTNKAAEEMKTRVEN
LLGYVGDLWVSTFHSACVRILRRDIDKLGYDRNFVIFDTTDQKALVQECLKELDLSEKQYPIKMVLNAISSAKDKMVYPD
DYIDFFGDTYRNRKIKEIYKLYQHKLKKINALDFDDIIIKTIELFKENPEILEFYQRKFRYIMVDEYQDTNTPQYYFVNL
LAQRHRNLCVVGDDDQSIYGWRGADVRNILNFEKDYPEAKVIKLEQNYRSTKIILEAANHVIDNNVYRKKKSLWTQNKEG
EKIVLCELENEREEAEFVIQEIIKLKERENRSFKDFAILYRTNAQSRPFEEALMKVKVPYKVVGALRFYDRKEIKDILAY
LRLIVNPYDDISFKRIVNVPRRGIGPATIEALEKVAREKDTSLFFAIEDLKNARNKGSLLQFKQFILDLIDKKDAMSVSD
LIKYILEQTGYIEELKREESEEAEGRIENLNEFLNAAYEFEESSEDKSLEAFLAGITLVSDIDMAGDIGESVVLMTLHSA
KGLEFPVVFMVGMEEGLFPSYSSFEDDHELEEERRLCYVGITRSKERLYLTYARQRNLYGRSQYNSYSRFISEIPERLIV
RYNIPTSKKTGFVSVHTFSDVYERSFSLGDKVEHKIWGIGTVVKVEGEEITVAFPNVGIKKLDLRFAPIKAIS
>Mature_713_residues
MIGVKKMKEILANLNEQQKEAVTTTEGPLLILAGAGSGKTRVLTHRIAYLIKEKKVSPSNILAITFTNKAAEEMKTRVEN
LLGYVGDLWVSTFHSACVRILRRDIDKLGYDRNFVIFDTTDQKALVQECLKELDLSEKQYPIKMVLNAISSAKDKMVYPD
DYIDFFGDTYRNRKIKEIYKLYQHKLKKINALDFDDIIIKTIELFKENPEILEFYQRKFRYIMVDEYQDTNTPQYYFVNL
LAQRHRNLCVVGDDDQSIYGWRGADVRNILNFEKDYPEAKVIKLEQNYRSTKIILEAANHVIDNNVYRKKKSLWTQNKEG
EKIVLCELENEREEAEFVIQEIIKLKERENRSFKDFAILYRTNAQSRPFEEALMKVKVPYKVVGALRFYDRKEIKDILAY
LRLIVNPYDDISFKRIVNVPRRGIGPATIEALEKVAREKDTSLFFAIEDLKNARNKGSLLQFKQFILDLIDKKDAMSVSD
LIKYILEQTGYIEELKREESEEAEGRIENLNEFLNAAYEFEESSEDKSLEAFLAGITLVSDIDMAGDIGESVVLMTLHSA
KGLEFPVVFMVGMEEGLFPSYSSFEDDHELEEERRLCYVGITRSKERLYLTYARQRNLYGRSQYNSYSRFISEIPERLIV
RYNIPTSKKTGFVSVHTFSDVYERSFSLGDKVEHKIWGIGTVVKVEGEEITVAFPNVGIKKLDLRFAPIKAIS

Specific function: DNA helicase used for plasmid rolling-circle replication and also involved in UV repair [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=718, Percent_Identity=41.6434540389972, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI48994965, Length=640, Percent_Identity=41.875, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1787196, Length=341, Percent_Identity=29.6187683284457, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=734, Percent_Identity=28.6103542234332, Blast_Score=233, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6324477, Length=683, Percent_Identity=24.4509516837482, Blast_Score=117, Evalue=5e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 82801; Mature: 82801

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVKKMKEILANLNEQQKEAVTTTEGPLLILAGAGSGKTRVLTHRIAYLIKEKKVSPSN
CCCHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
ILAITFTNKAAEEMKTRVENLLGYVGDLWVSTFHSACVRILRRDIDKLGYDRNFVIFDTT
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DQKALVQECLKELDLSEKQYPIKMVLNAISSAKDKMVYPDDYIDFFGDTYRNRKIKEIYK
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHCCCHHHHHHH
LYQHKLKKINALDFDDIIIKTIELFKENPEILEFYQRKFRYIMVDEYQDTNTPQYYFVNL
HHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHH
LAQRHRNLCVVGDDDQSIYGWRGADVRNILNFEKDYPEAKVIKLEQNYRSTKIILEAANH
HHHHCCCEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHH
VIDNNVYRKKKSLWTQNKEGEKIVLCELENEREEAEFVIQEIIKLKERENRSFKDFAILY
HHCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
RTNAQSRPFEEALMKVKVPYKVVGALRFYDRKEIKDILAYLRLIVNPYDDISFKRIVNVP
ECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
RRGIGPATIEALEKVAREKDTSLFFAIEDLKNARNKGSLLQFKQFILDLIDKKDAMSVSD
CCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
LIKYILEQTGYIEELKREESEEAEGRIENLNEFLNAAYEFEESSEDKSLEAFLAGITLVS
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DIDMAGDIGESVVLMTLHSAKGLEFPVVFMVGMEEGLFPSYSSFEDDHELEEERRLCYVG
CCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCEEEEE
ITRSKERLYLTYARQRNLYGRSQYNSYSRFISEIPERLIVRYNIPTSKKTGFVSVHTFSD
EECCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEHHHH
VYERSFSLGDKVEHKIWGIGTVVKVEGEEITVAFPNVGIKKLDLRFAPIKAIS
HHHHHCCCCCHHHHHHCCCEEEEEEECCEEEEECCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MIGVKKMKEILANLNEQQKEAVTTTEGPLLILAGAGSGKTRVLTHRIAYLIKEKKVSPSN
CCCHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
ILAITFTNKAAEEMKTRVENLLGYVGDLWVSTFHSACVRILRRDIDKLGYDRNFVIFDTT
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DQKALVQECLKELDLSEKQYPIKMVLNAISSAKDKMVYPDDYIDFFGDTYRNRKIKEIYK
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHCCCHHHHHHH
LYQHKLKKINALDFDDIIIKTIELFKENPEILEFYQRKFRYIMVDEYQDTNTPQYYFVNL
HHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHH
LAQRHRNLCVVGDDDQSIYGWRGADVRNILNFEKDYPEAKVIKLEQNYRSTKIILEAANH
HHHHCCCEEEECCCCCCEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHH
VIDNNVYRKKKSLWTQNKEGEKIVLCELENEREEAEFVIQEIIKLKERENRSFKDFAILY
HHCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
RTNAQSRPFEEALMKVKVPYKVVGALRFYDRKEIKDILAYLRLIVNPYDDISFKRIVNVP
ECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCC
RRGIGPATIEALEKVAREKDTSLFFAIEDLKNARNKGSLLQFKQFILDLIDKKDAMSVSD
CCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHH
LIKYILEQTGYIEELKREESEEAEGRIENLNEFLNAAYEFEESSEDKSLEAFLAGITLVS
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DIDMAGDIGESVVLMTLHSAKGLEFPVVFMVGMEEGLFPSYSSFEDDHELEEERRLCYVG
CCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCEEEEE
ITRSKERLYLTYARQRNLYGRSQYNSYSRFISEIPERLIVRYNIPTSKKTGFVSVHTFSD
EECCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEEHHHH
VYERSFSLGDKVEHKIWGIGTVVKVEGEEITVAFPNVGIKKLDLRFAPIKAIS
HHHHHCCCCCHHHHHHCCCEEEEEEECCEEEEECCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9701819; 9384377 [H]