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The map label for this gene is purH

Identifier: 20807087

GI number: 20807087

Start: 593139

End: 594665

Strand: Direct

Name: purH

Synonym: TTE0592

Alternate gene names: 20807087

Gene position: 593139-594665 (Clockwise)

Preceding gene: 20807086

Following gene: 20807088

Centisome position: 22.05

GC content: 40.86

Gene sequence:

>1527_bases
ATGTCAAGGAGAGCGTTGATAAGTGTTTCAAAAAAAGATGGAATAGTGGAATTTGCGAAAAAGCTTGAAGACCTGGGTTA
TGAGATAATATCTACTGGCGGCACTTACAATCTCCTTAAAGAAAGCGGTGTAAAGGTGATAAAGGTCTCTGAGGTTACGG
GTTTTCCAGAGATTATGGGAGGAAGAGTAAAGACTTTACACCCCAAAATTCACGGTGGAATTCTTGCTGTGAGAGACAAG
AAAGAGCATTTAAAAGACCTTAATGATCATGGCATTGTTCCTATAGACTTGGTAGCCATAAATTTATACCCCTTTAAAGA
GACTATTTCCAGGGAAAAGGTTGCTCTTGAGGAGGCAATTGAAAATATTGACATTGGCGGGCCTGCCATGATAAGAGCGG
CGGCAAAGAACTATAAATATGTAACTGTCCTTGTGGATCCTGTAGACTATGAAAAAGTGATTGAGGAAATAAAGCTTTAT
GGGGATACAAAAGAAGAGACGAGGTTTTATCTGGCAGCGAAGGCTTTTGGTCATACGGCTTTTTACGATTCGCTCATATA
TGAGTATTTTAGAGAGAAGACTAATATGGAATTTCCTAAAGTCATCACTTTTGCCTATGAAAAAGTGCAGGATTTGAGAT
ATGGGGAAAATCCGCACCAAAAAGCGGCCTTTTACAAAAACCCGGTCAAATCTTACGGAATTGCAGAATGCCTGCAGTTA
CACGGAAAAGAGCTTTCTTTTAACAACATAAATGATGCAAATGCTGCAATAGAACTTGTGAGGGAATTTAGTGAACCTGT
GGCGGTCGCTATAAAACACACCAATCCCTGTGGCGTAGCTGTTGGGAATAGCATATATGAGGCTTACTTAAAGGCCTATG
AAGCTGACCCCGTTTCAATTTTTGGCGGAATTGTTGCCTTTAACGGAAAAGTTGATGTAGATACTGCGAAAGAGCTTGTG
AAAATATTTCTAGAGATTGTAATAGCTCCAGATTTTGAAGAGGAAGCTTTAGAGATATTAATGTCTAAGAAGAACTTGAG
AGTGCTCAAATTGAAGGAAGGCTATTACAGAGAATTTGACCTCAAAAAAGTAGAAGGAGGAGTGTTAGTCCAGCAAAAGG
ATGAAATAGATTTAGATGAAAGTAGTATCAAAGTCGTAACTAAAAGGGCGCCGACAGGAAAAGAAATGAAGGATTTGAAG
TTCGCCTGGAAAGTAGTAAAGCACGTCAAGTCAAATGCTATAGTTTTAGCAAAGGATGGGGTTACTGTAGGCATTGGAGT
TGGGCAGGTCAACAGGATTTGGCCTACTGAGCAGGCGATAAAACAGGCAGGAGAGAGGGCGAAAGGAAGTGTCTTAGCAT
CAGATGCTTTCTTCCCCTTCCCTGATGTAGTTGAAGCGGCCGCAAGAGGAGGAATTACTGCAATAATTCAGCCTGGCGGT
TCCCAGAATGACCAGCTTTCAATTGAGGCAGCTGACAGAGCAGGTATTGCGATGATTTTTACTGGAATAAGGCATTTTAA
GCATTGA

Upstream 100 bases:

>100_bases
TAGAGCACAAAGTCCTGCCTTATGCGGTTAAACTTTTTGTTGAAGGGAAATTAAAAGTGGAAGGTAGAAGAGTGAAAGTA
CTTGACAAGGAGGATTTGTG

Downstream 100 bases:

>100_bases
GGAGGGGTTGACTTTGAAAGTATTAGTAGTTGGGGGAGGAGGAAGAGAACACGCAATTGTGCACAAGCTTTCCCAAAGCG
ATCGGGTAGAAAAAATTTAC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSRRALISVSKKDGIVEFAKKLEDLGYEIISTGGTYNLLKESGVKVIKVSEVTGFPEIMGGRVKTLHPKIHGGILAVRDK
KEHLKDLNDHGIVPIDLVAINLYPFKETISREKVALEEAIENIDIGGPAMIRAAAKNYKYVTVLVDPVDYEKVIEEIKLY
GDTKEETRFYLAAKAFGHTAFYDSLIYEYFREKTNMEFPKVITFAYEKVQDLRYGENPHQKAAFYKNPVKSYGIAECLQL
HGKELSFNNINDANAAIELVREFSEPVAVAIKHTNPCGVAVGNSIYEAYLKAYEADPVSIFGGIVAFNGKVDVDTAKELV
KIFLEIVIAPDFEEEALEILMSKKNLRVLKLKEGYYREFDLKKVEGGVLVQQKDEIDLDESSIKVVTKRAPTGKEMKDLK
FAWKVVKHVKSNAIVLAKDGVTVGIGVGQVNRIWPTEQAIKQAGERAKGSVLASDAFFPFPDVVEAAARGGITAIIQPGG
SQNDQLSIEAADRAGIAMIFTGIRHFKH

Sequences:

>Translated_508_residues
MSRRALISVSKKDGIVEFAKKLEDLGYEIISTGGTYNLLKESGVKVIKVSEVTGFPEIMGGRVKTLHPKIHGGILAVRDK
KEHLKDLNDHGIVPIDLVAINLYPFKETISREKVALEEAIENIDIGGPAMIRAAAKNYKYVTVLVDPVDYEKVIEEIKLY
GDTKEETRFYLAAKAFGHTAFYDSLIYEYFREKTNMEFPKVITFAYEKVQDLRYGENPHQKAAFYKNPVKSYGIAECLQL
HGKELSFNNINDANAAIELVREFSEPVAVAIKHTNPCGVAVGNSIYEAYLKAYEADPVSIFGGIVAFNGKVDVDTAKELV
KIFLEIVIAPDFEEEALEILMSKKNLRVLKLKEGYYREFDLKKVEGGVLVQQKDEIDLDESSIKVVTKRAPTGKEMKDLK
FAWKVVKHVKSNAIVLAKDGVTVGIGVGQVNRIWPTEQAIKQAGERAKGSVLASDAFFPFPDVVEAAARGGITAIIQPGG
SQNDQLSIEAADRAGIAMIFTGIRHFKH
>Mature_507_residues
SRRALISVSKKDGIVEFAKKLEDLGYEIISTGGTYNLLKESGVKVIKVSEVTGFPEIMGGRVKTLHPKIHGGILAVRDKK
EHLKDLNDHGIVPIDLVAINLYPFKETISREKVALEEAIENIDIGGPAMIRAAAKNYKYVTVLVDPVDYEKVIEEIKLYG
DTKEETRFYLAAKAFGHTAFYDSLIYEYFREKTNMEFPKVITFAYEKVQDLRYGENPHQKAAFYKNPVKSYGIAECLQLH
GKELSFNNINDANAAIELVREFSEPVAVAIKHTNPCGVAVGNSIYEAYLKAYEADPVSIFGGIVAFNGKVDVDTAKELVK
IFLEIVIAPDFEEEALEILMSKKNLRVLKLKEGYYREFDLKKVEGGVLVQQKDEIDLDESSIKVVTKRAPTGKEMKDLKF
AWKVVKHVKSNAIVLAKDGVTVGIGVGQVNRIWPTEQAIKQAGERAKGSVLASDAFFPFPDVVEAAARGGITAIIQPGGS
QNDQLSIEAADRAGIAMIFTGIRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=477, Percent_Identity=39.832285115304, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1790439, Length=524, Percent_Identity=51.1450381679389, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI71985564, Length=608, Percent_Identity=33.7171052631579, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71985574, Length=329, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323056, Length=471, Percent_Identity=37.791932059448, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6323768, Length=478, Percent_Identity=36.6108786610879, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24649832, Length=476, Percent_Identity=39.7058823529412, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_THETN (Q8RC55)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622258.1
- ProteinModelPortal:   Q8RC55
- SMR:   Q8RC55
- GeneID:   996381
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0592
- NMPDR:   fig|273068.3.peg.69
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   TTEN273068:TTE0592-MONOMER
- BRENDA:   2.1.2.3
- BRENDA:   3.5.4.10
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56363; Mature: 56231

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRALISVSKKDGIVEFAKKLEDLGYEIISTGGTYNLLKESGVKVIKVSEVTGFPEIMG
CCCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHCCCEEEEEECCCCCHHHHC
GRVKTLHPKIHGGILAVRDKKEHLKDLNDHGIVPIDLVAINLYPFKETISREKVALEEAI
CCEEEECCHHCCCEEEEECCHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHH
ENIDIGGPAMIRAAAKNYKYVTVLVDPVDYEKVIEEIKLYGDTKEETRFYLAAKAFGHTA
HHCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHEEEEEHHHHCCHH
FYDSLIYEYFREKTNMEFPKVITFAYEKVQDLRYGENPHQKAAFYKNPVKSYGIAECLQL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHCCHHHHHHH
HGKELSFNNINDANAAIELVREFSEPVAVAIKHTNPCGVAVGNSIYEAYLKAYEADPVSI
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHCHHHHHHHHHHHCCCCHHE
FGGIVAFNGKVDVDTAKELVKIFLEIVIAPDFEEEALEILMSKKNLRVLKLKEGYYREFD
ECCEEEECCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCC
LKKVEGGVLVQQKDEIDLDESSIKVVTKRAPTGKEMKDLKFAWKVVKHVKSNAIVLAKDG
CEECCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECC
VTVGIGVGQVNRIWPTEQAIKQAGERAKGSVLASDAFFPFPDVVEAAARGGITAIIQPGG
EEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEEECCCC
SQNDQLSIEAADRAGIAMIFTGIRHFKH
CCCCEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SRRALISVSKKDGIVEFAKKLEDLGYEIISTGGTYNLLKESGVKVIKVSEVTGFPEIMG
CCCEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHCCCEEEEEECCCCCHHHHC
GRVKTLHPKIHGGILAVRDKKEHLKDLNDHGIVPIDLVAINLYPFKETISREKVALEEAI
CCEEEECCHHCCCEEEEECCHHHHHCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHHHH
ENIDIGGPAMIRAAAKNYKYVTVLVDPVDYEKVIEEIKLYGDTKEETRFYLAAKAFGHTA
HHCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHEEEEEHHHHCCHH
FYDSLIYEYFREKTNMEFPKVITFAYEKVQDLRYGENPHQKAAFYKNPVKSYGIAECLQL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHCCHHHHHHH
HGKELSFNNINDANAAIELVREFSEPVAVAIKHTNPCGVAVGNSIYEAYLKAYEADPVSI
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHCHHHHHHHHHHHCCCCHHE
FGGIVAFNGKVDVDTAKELVKIFLEIVIAPDFEEEALEILMSKKNLRVLKLKEGYYREFD
ECCEEEECCEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCC
LKKVEGGVLVQQKDEIDLDESSIKVVTKRAPTGKEMKDLKFAWKVVKHVKSNAIVLAKDG
CEECCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECC
VTVGIGVGQVNRIWPTEQAIKQAGERAKGSVLASDAFFPFPDVVEAAARGGITAIIQPGG
EEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEEECCCC
SQNDQLSIEAADRAGIAMIFTGIRHFKH
CCCCEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336