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The map label for this gene is Ach1 [H]

Identifier: 20807055

GI number: 20807055

Start: 560700

End: 561995

Strand: Direct

Name: Ach1 [H]

Synonym: TTE0554

Alternate gene names: 20807055

Gene position: 560700-561995 (Clockwise)

Preceding gene: 20807054

Following gene: 20807056

Centisome position: 20.85

GC content: 35.11

Gene sequence:

>1296_bases
ATGGACTATAAAGAACTGTACAAGAGAAAACTAGTTTCGGTAGAAGAAATTTTATCAAAAATTAATAGTGGGGATGAAAT
TGTTTCTGCTATGGCTGCTTCAGAACCCCAGGGCATTTTAAGTAAACTTCATACTATAAAAGATAGAGTGGAAAATGTGA
CAGTGGTTGTATGCCTTCCAATGAAAAATTACGATTTCTTTATGGATCCTTCGATGAAGGGCCATTTCCTTACTGAATCA
TGGTTTTATACTGCGGGATTACGAGAAGCACATAAATATGGAACAGTATCTTTTATACCTAATCATCTTCATTTAGCTTC
AACAAAGAGATTACATTATAGAAAACCCAGGTTTTTCCTAGGTACGGCGACTCCTATGGACAAACATGGATATTTTTCCT
TGTCTCTAGGTGTTACTTATGAAAAAGATATCCTAGAGAATGCTGATTATGTAGTGCTAGAAATAAATGAAAATTTGCCA
AGAACTTATGGTGATACGCAAATACACATAACTGAAGTAGATTTTATTGTTGAAAACAATTATCCTGTTCCTGAACTTTC
CATTGTAGAGCCTAATGAAAAAGACAAGATAATAGGAGGATATATCTCAGAATTAGTAGAAGACGGTTCAACAATTCAGC
TGGGTATAGGAGGAATCCCTAATGCGGTTGCACAAGCTCTTATGAATAAAAAAGACCTTGGGATACACACTGAAATGTTC
ACCGATGGAATGGTAGATTTATTTGAAGCGGGAGTTATTACAAATAGGAAAAAAACTTTGTGGAAAGGTAAATCTATAGC
TACATTTGCATTGGGTACGAAAAAACTTTATGACTTTATAGATGACAATATGGGAGTAGAATTTCATAGGGGTAGAGTTG
TCAATGATCCTTATGTAATAGGGCAAAATTACAAGATGGTATCTATAAATACTGCACTCCAAGTAGATTTAACAGGCCAG
GTTTGTTCAGAATCTTTAGGTATAAGACAGTTTAGCGGAACTGGAGGGCAAGCAGATACTGCAATAGGAGCTCAAATTTC
AAAAGGAGGCAAATCTATAATAGCATTGTACTCATCAGTAAAAAACGATACTATATCTACAATAGTTCCTACATTAACAG
AAGGTGCCGCAGTAACTTTATCAAGAAATGATGTAGACTATATTGTTACAGAGTATGGTATTGCAGAAATGAGAGGACGG
TCGATAAGAGACAGAGTCAGAAATTTAATAAACATTGCTCATCCTAAATTTAGAGATGAGCTCAGGGAAAAGGCTAAAGA
GCTTATGATATGGTAA

Upstream 100 bases:

>100_bases
TAAGTGCGGGTATAGGATATGTATGGGATGCAATAACGATAAAATGGGGACCTATAGAGTAAATTTTATAGCATAAATTT
TACGGCAGGAGGTTTTGAAA

Downstream 100 bases:

>100_bases
TATTTGAATGTTAAAGATAAAATGTCAATAGAAAAGGTGGAACAATTTATGAGGAAGCTAAGAGTATTTCCTCTATTGGT
AATAATGTCGTTGTTATTAT

Product: Acetyl-CoA hydrolase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MDYKELYKRKLVSVEEILSKINSGDEIVSAMAASEPQGILSKLHTIKDRVENVTVVVCLPMKNYDFFMDPSMKGHFLTES
WFYTAGLREAHKYGTVSFIPNHLHLASTKRLHYRKPRFFLGTATPMDKHGYFSLSLGVTYEKDILENADYVVLEINENLP
RTYGDTQIHITEVDFIVENNYPVPELSIVEPNEKDKIIGGYISELVEDGSTIQLGIGGIPNAVAQALMNKKDLGIHTEMF
TDGMVDLFEAGVITNRKKTLWKGKSIATFALGTKKLYDFIDDNMGVEFHRGRVVNDPYVIGQNYKMVSINTALQVDLTGQ
VCSESLGIRQFSGTGGQADTAIGAQISKGGKSIIALYSSVKNDTISTIVPTLTEGAAVTLSRNDVDYIVTEYGIAEMRGR
SIRDRVRNLINIAHPKFRDELREKAKELMIW

Sequences:

>Translated_431_residues
MDYKELYKRKLVSVEEILSKINSGDEIVSAMAASEPQGILSKLHTIKDRVENVTVVVCLPMKNYDFFMDPSMKGHFLTES
WFYTAGLREAHKYGTVSFIPNHLHLASTKRLHYRKPRFFLGTATPMDKHGYFSLSLGVTYEKDILENADYVVLEINENLP
RTYGDTQIHITEVDFIVENNYPVPELSIVEPNEKDKIIGGYISELVEDGSTIQLGIGGIPNAVAQALMNKKDLGIHTEMF
TDGMVDLFEAGVITNRKKTLWKGKSIATFALGTKKLYDFIDDNMGVEFHRGRVVNDPYVIGQNYKMVSINTALQVDLTGQ
VCSESLGIRQFSGTGGQADTAIGAQISKGGKSIIALYSSVKNDTISTIVPTLTEGAAVTLSRNDVDYIVTEYGIAEMRGR
SIRDRVRNLINIAHPKFRDELREKAKELMIW
>Mature_431_residues
MDYKELYKRKLVSVEEILSKINSGDEIVSAMAASEPQGILSKLHTIKDRVENVTVVVCLPMKNYDFFMDPSMKGHFLTES
WFYTAGLREAHKYGTVSFIPNHLHLASTKRLHYRKPRFFLGTATPMDKHGYFSLSLGVTYEKDILENADYVVLEINENLP
RTYGDTQIHITEVDFIVENNYPVPELSIVEPNEKDKIIGGYISELVEDGSTIQLGIGGIPNAVAQALMNKKDLGIHTEMF
TDGMVDLFEAGVITNRKKTLWKGKSIATFALGTKKLYDFIDDNMGVEFHRGRVVNDPYVIGQNYKMVSINTALQVDLTGQ
VCSESLGIRQFSGTGGQADTAIGAQISKGGKSIIALYSSVKNDTISTIVPTLTEGAAVTLSRNDVDYIVTEYGIAEMRGR
SIRDRVRNLINIAHPKFRDELREKAKELMIW

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=221, Percent_Identity=30.316742081448, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32563853, Length=427, Percent_Identity=38.1733021077283, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17538151, Length=433, Percent_Identity=36.0277136258661, Blast_Score=238, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319456, Length=223, Percent_Identity=32.7354260089686, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358615, Length=426, Percent_Identity=40.1408450704225, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 48224; Mature: 48224

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKELYKRKLVSVEEILSKINSGDEIVSAMAASEPQGILSKLHTIKDRVENVTVVVCLP
CCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEE
MKNYDFFMDPSMKGHFLTESWFYTAGLREAHKYGTVSFIPNHLHLASTKRLHYRKPRFFL
CCCCCEEECCCCCCCEEECCCEEECCHHHHHHCCCEEECCCCEEECCCCHHHCCCCCEEE
GTATPMDKHGYFSLSLGVTYEKDILENADYVVLEINENLPRTYGDTQIHITEVDFIVENN
ECCCCCCCCCEEEEEECCEECHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEEECC
YPVPELSIVEPNEKDKIIGGYISELVEDGSTIQLGIGGIPNAVAQALMNKKDLGIHTEMF
CCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCHHHH
TDGMVDLFEAGVITNRKKTLWKGKSIATFALGTKKLYDFIDDNMGVEFHRGRVVNDPYVI
HCHHHHHHHCCCCCCCCHHHCCCCCEEEEECCHHHHHHHHCCCCCCEEECCEECCCCEEE
GQNYKMVSINTALQVDLTGQVCSESLGIRQFSGTGGQADTAIGAQISKGGKSIIALYSSV
CCCEEEEEEEEEEEEEECHHHHHHCCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHH
KNDTISTIVPTLTEGAAVTLSRNDVDYIVTEYGIAEMRGRSIRDRVRNLINIAHPKFRDE
CCCHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHHHCCHHHHHH
LREKAKELMIW
HHHHHHHHCCC
>Mature Secondary Structure
MDYKELYKRKLVSVEEILSKINSGDEIVSAMAASEPQGILSKLHTIKDRVENVTVVVCLP
CCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEE
MKNYDFFMDPSMKGHFLTESWFYTAGLREAHKYGTVSFIPNHLHLASTKRLHYRKPRFFL
CCCCCEEECCCCCCCEEECCCEEECCHHHHHHCCCEEECCCCEEECCCCHHHCCCCCEEE
GTATPMDKHGYFSLSLGVTYEKDILENADYVVLEINENLPRTYGDTQIHITEVDFIVENN
ECCCCCCCCCEEEEEECCEECHHHHCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEEECC
YPVPELSIVEPNEKDKIIGGYISELVEDGSTIQLGIGGIPNAVAQALMNKKDLGIHTEMF
CCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCHHHH
TDGMVDLFEAGVITNRKKTLWKGKSIATFALGTKKLYDFIDDNMGVEFHRGRVVNDPYVI
HCHHHHHHHCCCCCCCCHHHCCCCCEEEEECCHHHHHHHHCCCCCCEEECCEECCCCEEE
GQNYKMVSINTALQVDLTGQVCSESLGIRQFSGTGGQADTAIGAQISKGGKSIIALYSSV
CCCEEEEEEEEEEEEEECHHHHHHCCCCEEECCCCCCCCHHHCCCCCCCCHHHHHHHHHH
KNDTISTIVPTLTEGAAVTLSRNDVDYIVTEYGIAEMRGRSIRDRVRNLINIAHPKFRDE
CCCHHHHHHHHCCCCEEEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHHHCCHHHHHH
LREKAKELMIW
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]