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The map label for this gene is SerA [C]

Identifier: 20807040

GI number: 20807040

Start: 545201

End: 546145

Strand: Direct

Name: SerA [C]

Synonym: TTE0539

Alternate gene names: 20807040

Gene position: 545201-546145 (Clockwise)

Preceding gene: 161760536

Following gene: 20807042

Centisome position: 20.27

GC content: 39.47

Gene sequence:

>945_bases
ATGAAGAATATTTTGCTTTTTACGAAGGTGAAAGAGGATTATATTGAGGAGATTAGGAGGGTGATGGAAGGGTATAGAGT
AGTTCCTGCGGAAGAAGTGAAAGAGGAAGACTACAAAGATGCCGAGATAATCATTAGCTTTGATTTTGAGTTTAGAGAAG
AGGCAGTAGACAAAGCACCAAACCTCAAATGGATTCACCTTTTAAGCGCTGGAGCTGATACATTGCCTTTTGAGAAGCTG
AGAGAAAAAGGAGTCGTCGTGACAAATTCGAGAGATGTACATAAATACCAAATTTCTCAGCAGGTATTAGGTTACATGCT
CATGTTTGAGAGGAGTTTGCACGTATTTTTGAGGAATCAACTTAAAAAAGTATGGGATAGGTCAGTGAGAGTATCAGAAT
TGACAGGGAAAATAGCTCTCATCATAGGAGTTGGCAGCATAGGGGAAGAGATTGCAAGGCTTTTAAAAGAGTTTGGAATG
AAAATATATGGGGTACGCAGTTCAGGTAGACCCTCTCCTTATGTAGAGAAGATGTATACTTCTATTGGTGAATGTGACAT
CCTTTCAGAGGCTGACTATGTCATATCAATACTCCCCCTTACCAAGGAGACGTATCACTTGATAGGGAAAAATGTCTTTG
AAAGGATGAAAAAAGAAGCTATTTTTATAAATGTCGGAAGGGGCAAGGTGGTAAAAGAAGAAGAGCTTATTGAAGCATTG
CAGAAAGGCACTATAGGTGGAGCAGCTCTTGATGTTTTTGAAGAAGAGCCTTTGAGTGAAAAAAGCCCTTTGTGGGAGAT
GGAAAATGTGATAATCACTCCTCACACTGCAGGGGTGACTCCTCACTATATGAAGAGGGCAATGGAGATATTAAGGTACA
ACTTAAAAGCATATAAAGAAGGAAAGCCTCTTAAAAATATTGTGGACCTTCACAAGGGGTATTAA

Upstream 100 bases:

>100_bases
GGATAACTCTGTGGATATTGTGCTTAACTATATTTCATTTCATTTACTGGAATGAAATGAGAAAAAAATTTATTAAAAAT
AAATAGAGGGGGAATTTGAA

Downstream 100 bases:

>100_bases
GCGGGTTTTACCCGCTTAATTTTTCCCATTCCCTGTACATTTCTTCTAGTTTTTCTTTTAGGGCAGTGTATTCTTTCTGT
ATTTCTACAATTTCTCCCGT

Product: phosphoglycerate dehydrogenase and related dehydrogenase

Products: glycerate; NADP; NADPH; glyoxylate; 2-Dehydro-D-gluconate; 5-ketogluconate; L-idonate [C]

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKNILLFTKVKEDYIEEIRRVMEGYRVVPAEEVKEEDYKDAEIIISFDFEFREEAVDKAPNLKWIHLLSAGADTLPFEKL
REKGVVVTNSRDVHKYQISQQVLGYMLMFERSLHVFLRNQLKKVWDRSVRVSELTGKIALIIGVGSIGEEIARLLKEFGM
KIYGVRSSGRPSPYVEKMYTSIGECDILSEADYVISILPLTKETYHLIGKNVFERMKKEAIFINVGRGKVVKEEELIEAL
QKGTIGGAALDVFEEEPLSEKSPLWEMENVIITPHTAGVTPHYMKRAMEILRYNLKAYKEGKPLKNIVDLHKGY

Sequences:

>Translated_314_residues
MKNILLFTKVKEDYIEEIRRVMEGYRVVPAEEVKEEDYKDAEIIISFDFEFREEAVDKAPNLKWIHLLSAGADTLPFEKL
REKGVVVTNSRDVHKYQISQQVLGYMLMFERSLHVFLRNQLKKVWDRSVRVSELTGKIALIIGVGSIGEEIARLLKEFGM
KIYGVRSSGRPSPYVEKMYTSIGECDILSEADYVISILPLTKETYHLIGKNVFERMKKEAIFINVGRGKVVKEEELIEAL
QKGTIGGAALDVFEEEPLSEKSPLWEMENVIITPHTAGVTPHYMKRAMEILRYNLKAYKEGKPLKNIVDLHKGY
>Mature_314_residues
MKNILLFTKVKEDYIEEIRRVMEGYRVVPAEEVKEEDYKDAEIIISFDFEFREEAVDKAPNLKWIHLLSAGADTLPFEKL
REKGVVVTNSRDVHKYQISQQVLGYMLMFERSLHVFLRNQLKKVWDRSVRVSELTGKIALIIGVGSIGEEIARLLKEFGM
KIYGVRSSGRPSPYVEKMYTSIGECDILSEADYVISILPLTKETYHLIGKNVFERMKKEAIFINVGRGKVVKEEELIEAL
QKGTIGGAALDVFEEEPLSEKSPLWEMENVIITPHTAGVTPHYMKRAMEILRYNLKAYKEGKPLKNIVDLHKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=31.640625, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI23308577, Length=300, Percent_Identity=27.3333333333333, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI61743967, Length=245, Percent_Identity=29.3877551020408, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4557497, Length=243, Percent_Identity=28.8065843621399, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=29.7959183673469, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=29.9065420560748, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787645, Length=270, Percent_Identity=27.037037037037, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI87081824, Length=174, Percent_Identity=31.6091954022989, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789279, Length=288, Percent_Identity=26.7361111111111, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17532191, Length=272, Percent_Identity=29.0441176470588, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=298, Percent_Identity=28.1879194630872, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=297, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=320, Percent_Identity=24.6875, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=234, Percent_Identity=27.3504273504274, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=145, Percent_Identity=31.7241379310345, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=167, Percent_Identity=30.5389221556886, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=27.5862068965517, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=27.0992366412214, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=27.0992366412214, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=27.0992366412214, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=27.6515151515151, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=27.6515151515151, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=28.1746031746032, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28571528, Length=271, Percent_Identity=29.1512915129151, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921140, Length=306, Percent_Identity=27.1241830065359, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646446, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646448, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646452, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646450, Length=242, Percent_Identity=26.0330578512397, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI62472511, Length=242, Percent_Identity=26.0330578512397, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 36105; Mature: 36105

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILLFTKVKEDYIEEIRRVMEGYRVVPAEEVKEEDYKDAEIIISFDFEFREEAVDKAP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCHHHHHHHHCCC
NLKWIHLLSAGADTLPFEKLREKGVVVTNSRDVHKYQISQQVLGYMLMFERSLHVFLRNQ
CCEEEEEEECCCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKVWDRSVRVSELTGKIALIIGVGSIGEEIARLLKEFGMKIYGVRSSGRPSPYVEKMYT
HHHHHHCCCCHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH
SIGECDILSEADYVISILPLTKETYHLIGKNVFERMKKEAIFINVGRGKVVKEEELIEAL
HCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCEEEEECCCCCEECHHHHHHHH
QKGTIGGAALDVFEEEPLSEKSPLWEMENVIITPHTAGVTPHYMKRAMEILRYNLKAYKE
HHCCCCCHHHHHHHCCCCCCCCCCCHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
GKPLKNIVDLHKGY
CCCHHHHHHHHCCC
>Mature Secondary Structure
MKNILLFTKVKEDYIEEIRRVMEGYRVVPAEEVKEEDYKDAEIIISFDFEFREEAVDKAP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCHHHHHHHHCCC
NLKWIHLLSAGADTLPFEKLREKGVVVTNSRDVHKYQISQQVLGYMLMFERSLHVFLRNQ
CCEEEEEEECCCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKVWDRSVRVSELTGKIALIIGVGSIGEEIARLLKEFGMKIYGVRSSGRPSPYVEKMYT
HHHHHHCCCCHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH
SIGECDILSEADYVISILPLTKETYHLIGKNVFERMKKEAIFINVGRGKVVKEEELIEAL
HCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCEEEEECCCCCEECHHHHHHHH
QKGTIGGAALDVFEEEPLSEKSPLWEMENVIITPHTAGVTPHYMKRAMEILRYNLKAYKE
HHCCCCCHHHHHHHCCCCCCCCCCCHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCC
GKPLKNIVDLHKGY
CCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxypyruvate; NADPH; glycolate; NADP; gluconate; 2,5-diketo-D-gluconate; 2-keto-L-gulonate [C]

Specific reaction: hydroxypyruvate + NADPH = glycerate + NADP glycolate + NADP = NADPH + glyoxylate NADP + gluconate = NADPH + 2-Dehydro-D-gluconate 2,5-diketo-D-gluconate + NADPH = 5-ketogluconate + NADP 2-keto-L-gulonate + NADPH = L-idonate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]