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The map label for this gene is AcoB [H]

Identifier: 20806713

GI number: 20806713

Start: 190706

End: 191686

Strand: Direct

Name: AcoB [H]

Synonym: TTE0187

Alternate gene names: 20806713

Gene position: 190706-191686 (Clockwise)

Preceding gene: 20806712

Following gene: 20806714

Centisome position: 7.09

GC content: 40.98

Gene sequence:

>981_bases
ATGGCAGAAAAGCTCTATATAGAAGCGCTGGCAGAAGCAATAAAAGAAGAGTTTGAAAGAGACCCTAACGTTTTTATGAT
GGGCGAGGATATAGGAATATATGGAGGAGCTTTTGGAGTAACAAAGGGTATGTATCCTAAGTACAAAGACAAACTAATAG
AGACACCAATTTCAGAAGCTAGCATAGTAGGTGCAGGAGTAGGTGCAGCTCTTGTAGGTATGCGACCTATTGTAGAAATA
ATGTTTTCTGACTTTATGATGGATGCGATGGAGTGGATAGTAAACCAGGCTGCAAAACTAAGGTATATGACAGGAGGACA
ACTTAAAGTACCTCTTGTAATAAGGTCTCCTATGGGTAGTGGGACAGGTGCAGCAGCACAGCATTCTCAAAGTTTGCCTG
CCATGTTTGCCCACATACCGGGTCTTAAAGTAGTGATGCCTGCAACTCCTTATGATGTAAAGGGGCTTTTTAAAGCGGCT
GTAAGGGATGACAACCCAGTAATATTTTTTGAGCATAAACTCCTCTATTGGACAAAAGGGGAAGTGCCTGAAGGAGACTA
TATAGTTCCAATAGGAAAAGCCGATGTGAAAAGAGAGGGGAAAGATATAACCATAATAGCTGGGTCTATAACAGTAATAA
GGTCACTAGAGGCTGCAGAAAAATTAAAAGGTGAAGGAATAGATGTAGAAGTAATAGATGTAAGGAGCTTGTCACCACTT
GATACAGAAACTATAGTAAACTCAGTAATAAAGACAGGTAAAGTGCTGATAGTAGAGGATGACAACAAAAGCTATGGTTG
GGGTGCGGAAGTTTTGTCGAGAATTGTAGAAAGTGATGCTTTTGACTATCTCGACTACCCAATACAGAGATTGGGTGGGA
AGGATGTGCCAATTCCTTACAATCCCAAGTTAGAGAGAGCGGCTGTACCTCAAGTAGAAGACATAATAGAGGCAGTAAAA
GCTATATTTGGCAAGGAGTGA

Upstream 100 bases:

>100_bases
CAAAAGAGATAGAAGAGGCCTATCAATTTGCAGTAGAAAGTCCTGAACCCAAGGTAGAAGACCTGGCAAAATACGTTTAT
GCAGAGGAGGGAGAGTAAAG

Downstream 100 bases:

>100_bases
TTGAAGGATGGCAAATGTAAAACTTATGCCTAAGTTAGGTATGACTATGACAGCTGGCAAAGTAGTTAGATGGTTGAAAA
AAGAAGGTGAAAAAGTAGAA

Product: thiamine pyrophosphate-dependent dehydrogenase, E1 component beta subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAEKLYIEALAEAIKEEFERDPNVFMMGEDIGIYGGAFGVTKGMYPKYKDKLIETPISEASIVGAGVGAALVGMRPIVEI
MFSDFMMDAMEWIVNQAAKLRYMTGGQLKVPLVIRSPMGSGTGAAAQHSQSLPAMFAHIPGLKVVMPATPYDVKGLFKAA
VRDDNPVIFFEHKLLYWTKGEVPEGDYIVPIGKADVKREGKDITIIAGSITVIRSLEAAEKLKGEGIDVEVIDVRSLSPL
DTETIVNSVIKTGKVLIVEDDNKSYGWGAEVLSRIVESDAFDYLDYPIQRLGGKDVPIPYNPKLERAAVPQVEDIIEAVK
AIFGKE

Sequences:

>Translated_326_residues
MAEKLYIEALAEAIKEEFERDPNVFMMGEDIGIYGGAFGVTKGMYPKYKDKLIETPISEASIVGAGVGAALVGMRPIVEI
MFSDFMMDAMEWIVNQAAKLRYMTGGQLKVPLVIRSPMGSGTGAAAQHSQSLPAMFAHIPGLKVVMPATPYDVKGLFKAA
VRDDNPVIFFEHKLLYWTKGEVPEGDYIVPIGKADVKREGKDITIIAGSITVIRSLEAAEKLKGEGIDVEVIDVRSLSPL
DTETIVNSVIKTGKVLIVEDDNKSYGWGAEVLSRIVESDAFDYLDYPIQRLGGKDVPIPYNPKLERAAVPQVEDIIEAVK
AIFGKE
>Mature_325_residues
AEKLYIEALAEAIKEEFERDPNVFMMGEDIGIYGGAFGVTKGMYPKYKDKLIETPISEASIVGAGVGAALVGMRPIVEIM
FSDFMMDAMEWIVNQAAKLRYMTGGQLKVPLVIRSPMGSGTGAAAQHSQSLPAMFAHIPGLKVVMPATPYDVKGLFKAAV
RDDNPVIFFEHKLLYWTKGEVPEGDYIVPIGKADVKREGKDITIIAGSITVIRSLEAAEKLKGEGIDVEVIDVRSLSPLD
TETIVNSVIKTGKVLIVEDDNKSYGWGAEVLSRIVESDAFDYLDYPIQRLGGKDVPIPYNPKLERAAVPQVEDIIEAVKA
IFGKE

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=318, Percent_Identity=46.5408805031447, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI291084858, Length=318, Percent_Identity=44.0251572327044, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4557353, Length=299, Percent_Identity=41.1371237458194, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI34101272, Length=299, Percent_Identity=41.1371237458194, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI133778974, Length=242, Percent_Identity=28.5123966942149, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=318, Percent_Identity=47.4842767295598, Blast_Score=299, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17506935, Length=318, Percent_Identity=39.3081761006289, Blast_Score=203, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17539652, Length=262, Percent_Identity=27.4809160305344, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319698, Length=325, Percent_Identity=45.8461538461538, Blast_Score=288, Evalue=9e-79,
Organism=Drosophila melanogaster, GI21358145, Length=322, Percent_Identity=46.583850931677, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24650940, Length=322, Percent_Identity=46.583850931677, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI160714828, Length=321, Percent_Identity=38.6292834890966, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI160714832, Length=321, Percent_Identity=38.6292834890966, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24650943, Length=85, Percent_Identity=43.5294117647059, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650945, Length=85, Percent_Identity=43.5294117647059, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35615; Mature: 35484

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKLYIEALAEAIKEEFERDPNVFMMGEDIGIYGGAFGVTKGMYPKYKDKLIETPISEA
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCHHHHCCCCCCHHHHHHHHCCCCHH
SIVGAGVGAALVGMRPIVEIMFSDFMMDAMEWIVNQAAKLRYMTGGQLKVPLVIRSPMGS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCC
GTGAAAQHSQSLPAMFAHIPGLKVVMPATPYDVKGLFKAAVRDDNPVIFFEHKLLYWTKG
CCCCHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECC
EVPEGDYIVPIGKADVKREGKDITIIAGSITVIRSLEAAEKLKGEGIDVEVIDVRSLSPL
CCCCCCEEEEECCHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
DTETIVNSVIKTGKVLIVEDDNKSYGWGAEVLSRIVESDAFDYLDYPIQRLGGKDVPIPY
CHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
NPKLERAAVPQVEDIIEAVKAIFGKE
CCCCCHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEKLYIEALAEAIKEEFERDPNVFMMGEDIGIYGGAFGVTKGMYPKYKDKLIETPISEA
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECCHHHHCCCCCCHHHHHHHHCCCCHH
SIVGAGVGAALVGMRPIVEIMFSDFMMDAMEWIVNQAAKLRYMTGGQLKVPLVIRSPMGS
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCC
GTGAAAQHSQSLPAMFAHIPGLKVVMPATPYDVKGLFKAAVRDDNPVIFFEHKLLYWTKG
CCCCHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECC
EVPEGDYIVPIGKADVKREGKDITIIAGSITVIRSLEAAEKLKGEGIDVEVIDVRSLSPL
CCCCCCEEEEECCHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
DTETIVNSVIKTGKVLIVEDDNKSYGWGAEVLSRIVESDAFDYLDYPIQRLGGKDVPIPY
CHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
NPKLERAAVPQVEDIIEAVKAIFGKE
CCCCCHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]